Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative.
paper
Cited
Public
Unavailable
- Authors
- Nurnberger, J I; Blehar, M C; Kaufmann, C A; York-Cooler, C; Simpson, S G; Harkavy-Friedman, J; Severe, J B; Malaspina, D; Reich, T
- Year
- 1994
- Journal
- Archives of general psychiatry
- PMID
- 7944874
- DOI
- 10.1001/archpsyc.1994.03950110009002
This article reports on the development and reliability of the Diagnostic Interview for Genetic Studies (DIGS), a clinical interview especially constructed for the assessment of major mood and psychotic disorders and their spectrum conditions. The DIGS, which was developed and piloted as a collaborative effort of investigators from sites in the National Institute of Mental Health (NIMH) Genetics Initiative, has the following additional features: (1) polydiagnostic capacity; (2) a detailed assessment of the course of the illness, chronology of psychotic and mood syndromes, and comorbidity; (3) additional phenomenologic assessments of symptoms; and (4) algorithmic scoring capability. The DIGS is designed to be employed by interviewers who exercise significant clinical judgment and who summarize information in narrative form as well as in ratings. A two-phase test-retest (within-site, between-site) reliability study was carried out for DSM-III-R criteria-based major depression, bipolar disorder, schizophrenia, and schizoaffective disorder. Reliabilities using algorithms were excellent (0.73 to 0.95), except for schizoaffective disorder, for which disagreement on estimates of duration of mood syndromes relative to psychosis reduced reliability. A final best-estimate process using medical records and information from relatives as well as algorithmic diagnoses is expected to be more reliable in making these distinctions. The DIGS should be useful as part of archival data gathering for genetic studies of major affective disorders, schizophrenia, and related conditions.
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| Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders. | Van Den Bossche MJ et al. | β | 2012 | β |
| Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26. | McAuley EZ et al. | β | 2012 | β |
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| Impaired visual cortical plasticity in schizophrenia. | CavuΕ I et al. | β | 2012 | β |
| Is processing speed a valid cognitive endophenotype for bipolar disorder? | Daban C et al. | β | 2012 | β |
| Low maternal hemoglobin during pregnancy and diminished neuromotor and neurocognitive performance in offspring with schizophrenia. | Ellman LM et al. | β | 2012 | β |
| Low maternal retinol as a risk factor for schizophrenia in adult offspring. | Bao Y et al. | β | 2012 | β |
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| Modality-specific alterations in the perception of emotional stimuli in Bipolar Disorder compared to Healthy Controls and Major Depressive Disorder. | Vederman AC et al. | β | 2012 | β |
| Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder. | Perron H et al. | β | 2012 | β |
| Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging. | Hutcheson NL et al. | β | 2012 | β |
| Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. | Stephens SH et al. | β | 2012 | β |
| Neural correlates of cognitive flexibility in children at risk for bipolar disorder. | Kim P et al. | β | 2012 | β |
| Neurocognitive and clinical dysfunction in adult Chinese, nonpsychotic relatives of patients with schizophrenia: Findings from the Changsha study and evidence for schizotaxia. | Stone WS et al. | β | 2012 | β |
| Nicotine, Auditory Sensory Memory, and sustained Attention in a Human Ketamine Model of Schizophrenia: Moderating Influence of a Hallucinatory Trait. | Knott V et al. | β | 2012 | β |
| Obsessive compulsive symptoms in individuals at clinical risk for psychosis: association with depressive symptoms and suicidal ideation. | DeVylder JE et al. | β | 2012 | β |
| Ocular convergence deficits in schizophrenia. | Bolding MS et al. | β | 2012 | β |
| Olfactory acuity is associated with mood and function in a pilot study of stable bipolar disorder patients. | Hardy C et al. | β | 2012 | β |
| Olfactory processing, sex effects and heterogeneity in schizophrenia. | Malaspina D et al. | β | 2012 | β |
| P50 amplitude reduction: a nicotinic receptor-mediated deficit in first-degree relatives of schizophrenia patients. | Turetsky BI et al. | β | 2012 | β |
| Patterns of Tobacco Consumption among Indian Men with Schizophrenia Compared to Their Male Siblings. | Vatss S et al. | β | 2012 | β |
| Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia. | Choi JS et al. | β | 2012 | β |
| Premorbid school performance in twins concordant and discordant for bipolar disorder. | Vonk R et al. | β | 2012 | β |
| Principal domains of quantitative anxiety trait in subjects with lifetime history of mania. | Contreras J et al. | β | 2012 | β |
| Rare copy number variants in neuropsychiatric disorders: Specific phenotype or not? | Van Den Bossche MJ et al. | β | 2012 | β |
| Reduced mismatch negativity predates the onset of psychosis. | Shaikh M et al. | β | 2012 | β |
| Regional cortical thinning in subjects with high genetic loading for schizophrenia. | Byun MS et al. | β | 2012 | β |
| Regional decoupling of N-acetyl-aspartate and glutamate in schizophrenia. | Kraguljac NV et al. | β | 2012 | β |
| Re-sequencing of ankyrin 3 exon 48 and case-control association analysis of rare variants in bipolar disorder type I. | Doyle GA et al. | β | 2012 | β |
| Schizophrenia comorbid with panic disorder: evidence for distinct cognitive profiles. | Rapp EK et al. | β | 2012 | β |
| Semantic clustering of category fluency in schizophrenia examined with singular value decomposition. | Sung K et al. | β | 2012 | β |
| Serotonin transporter polymorphism modulates N-back task performance and fMRI BOLD signal intensity in healthy women. | Jonassen R et al. | β | 2012 | β |
| Short telomeres in depression and the general population are associated with a hypocortisolemic state. | Wikgren M et al. | β | 2012 | β |
| Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample. | McLean D et al. | β | 2012 | β |
| Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder. | Deveney CM et al. | β | 2012 | β |
| Structural abnormalities in language circuits in genetic high-risk subjects and schizophrenia patients. | Li X et al. | β | 2012 | β |
| Structural angle and power images reveal interrelated gray and white matter abnormalities in schizophrenia. | Xu L et al. | β | 2012 | β |
| Sustained attention in bipolar I disorder patients with familial psychosis and their first-degree relatives. | Walshe M et al. | β | 2012 | β |
| The Affective Reactivity Index: a concise irritability scale for clinical and research settings. | Stringaris A et al. | β | 2012 | β |
| The effects of the serotonin transporter polymorphism and age on frontal white matter integrity in healthy adult women. | Jonassen R et al. | β | 2012 | β |
| The nature of schizotypy among multigenerational multiplex schizophrenia families. | Tarbox SI et al. | β | 2012 | β |
| The role of perfectionism in postpartum depression and symptomatology. | Maia BR et al. | β | 2012 | β |
| Total white matter hyperintensity volume in bipolar disorder patients and their healthy relatives. | Tighe SK et al. | β | 2012 | β |
| Unique topology of language processing brain network: a systems-level biomarker of schizophrenia. | Li X et al. | β | 2012 | β |
| Abnormalities of neuronal oscillations and temporal integration to low- and high-frequency auditory stimulation in schizophrenia. | Hamm JP et al. | β | 2011 | β |
| Abnormal mechanisms of antisaccade generation in schizophrenia patients and unaffected biological relatives of schizophrenia patients. | Kang SS et al. | β | 2011 | β |
| Abnormal modulation of amygdala activity in schizophrenia in response to direct- and averted-gaze threat-related facial expressions. | Pinkham AE et al. | β | 2011 | β |
| Actively paranoid patients with schizophrenia over attribute anger to neutral faces. | Pinkham AE et al. | β | 2011 | β |
| A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings. | Thermenos HW et al. | β | 2011 | β |
| A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits. | Lien YJ et al. | β | 2011 | β |
| A high-risk study of bipolar disorder. Childhood clinical phenotypes as precursors of major mood disorders. | Nurnberger JI et al. | β | 2011 | β |
| Alertness can be improved by an interaction between orienting attention and alerting attention in schizophrenia. | Amado I et al. | β | 2011 | β |
| Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. | Greenwood TA et al. | β | 2011 | β |
| A potential diagnostic blood test for attention deficit hyperactivity disorder. | Woodruff DB et al. | β | 2011 | β |
| Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder. | Perlis RH et al. | β | 2011 | β |
| Association of an UCP4 (SLC25A27) haplotype with ultra-resistant schizophrenia. | Mouaffak F et al. | β | 2011 | β |
| Association of catechol-O-methyl transferase (COMT) gene -287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population. | Liu S et al. | β | 2011 | β |
| Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia. | Mouaffak F et al. | β | 2011 | β |
| Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia. | Brown AS et al. | β | 2011 | β |
| Associations between DRDs and schizophrenia in a Korean population: multi-stage association analyses. | Lee KY et al. | β | 2011 | β |
| Association study of DRD3 gene in schizophrenia in Mexican sib-pairs. | Urraca N et al. | β | 2011 | β |
| Attentional functions in major depressive disorders with and without comorbid anxiety. | Lyche P et al. | β | 2011 | β |
| Bipolar Disorder and the TCI: Higher Self-Transcendence in Bipolar Disorder Compared to Major Depression. | Harley JA et al. | β | 2011 | β |
| Cannabis involvement in individuals with bipolar disorder. | Agrawal A et al. | β | 2011 | β |
| Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism. | Estrada G et al. | β | 2011 | β |
| Clinical correlates of olfactory hallucinations in schizophrenia. | Langdon R et al. | β | 2011 | β |
| Cognitive regulation of emotion in bipolar I disorder and unaffected biological relatives. | Green MJ et al. | β | 2011 | β |
| Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families. | Olvera RL et al. | β | 2011 | β |
| Comparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees. | Mitchell PB et al. | β | 2011 | β |
| Correlations of cerebello-thalamo-prefrontal structure and neurological soft signs in patients with first-episode psychosis. | Mouchet-Mages S et al. | β | 2011 | β |
| Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in schizophrenia. | Kang SS et al. | β | 2011 | β |
| Distinguishing the relevant features of frequent suicide attempters. | Lopez-Castroman J et al. | β | 2011 | β |
| Ethnic disparities in the perception of ethical risks from psychiatric genetic studies. | Nwulia EA et al. | β | 2011 | β |
| Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population. | Ceulemans S et al. | β | 2011 | β |
| Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene. | Sears C et al. | β | 2011 | β |
| Genetic association of bipolar disorder with the Ξ²(3) nicotinic receptor subunit gene. | Hartz SM et al. | β | 2011 | β |
| Genetic association of the Phosphoinositide-3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism. | Carrard A et al. | β | 2011 | β |
| Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia. | Gysin R et al. | β | 2011 | β |
| Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. | Belmonte Mahon P et al. | β | 2011 | β |
| Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. | Kendler KS et al. | β | 2011 | β |
| Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. | Cichon S et al. | β | 2011 | β |
| Genome-wide association study in bipolar patients stratified by co-morbidity. | Kerner B et al. | β | 2011 | β |
| Genome-wide association study of personality traits in bipolar patients. | Alliey-Rodriguez N et al. | β | 2011 | β |
| Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS). | Stone WS et al. | β | 2011 | β |
| Handedness and schizotypy in non-psychotic relatives of patients with schizophrenia. | Tsuang HC et al. | β | 2011 | β |
| Heterogeneity of auditory verbal working memory in schizophrenia. | Bruder GE et al. | β | 2011 | β |
| High-frequency prefrontal repetitive transcranial magnetic stimulation for the negative symptoms of schizophrenia: a case series. | Stanford AD et al. | β | 2011 | β |
| Inflexible information acquisition strategies mediate visuo-spatial reasoning in stabilized schizophrenia patients. | Landgraf S et al. | β | 2011 | β |
| Intact and impaired cognitive-control processes in schizophrenia. | Smith EE et al. | β | 2011 | β |
| Is insomnia in late pregnancy a risk factor for postpartum depression/depressive symptomatology? | Marques M et al. | β | 2011 | β |
| Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. | Moon E et al. | β | 2011 | β |
| Maternal-fetal blood incompatibility and neuromorphologic anomalies in schizophrenia: Preliminary findings. | Freedman D et al. | β | 2011 | β |
| MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. | Lai CY et al. | β | 2011 | β |
| Mother's personality and infant temperament. | Macedo A et al. | β | 2011 | β |
| MRI exploration of pineal volume in bipolar disorder. | Sarrazin S et al. | β | 2011 | β |
| Multivoxel proton MR spectroscopy used to distinguish anterior cingulate metabolic abnormalities in patients with schizophrenia. | Hardy CJ et al. | β | 2011 | β |
| Neurological soft signs in OCD patients with early age at onset, versus patients with schizophrenia and healthy subjects. | Jaafari N et al. | β | 2011 | β |
| Parental alcohol dependence, socioeconomic disadvantage and alcohol and cannabis dependence among young adults in the community. | Melchior M et al. | β | 2011 | β |
| Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis. | Lee H et al. | β | 2011 | β |
| Presence of co-morbid substance use disorder in bipolar patients worsens their social functioning to the level observed in patients with schizophrenia. | Jaworski F et al. | β | 2011 | β |
| Reduced prefrontal functional connectivity in the default mode network is related to greater psychopathology in subjects with high genetic loading for schizophrenia. | Jang JH et al. | β | 2011 | β |
| Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI. | Pinkham A et al. | β | 2011 | β |
| Separate and combined effects of low dose ketamine and nicotine on behavioural and neural correlates of sustained attention. | Knott VJ et al. | β | 2011 | β |
| Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives. | Glatt SJ et al. | β | 2011 | β |
| SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. | Libert S et al. | β | 2011 | β |
| Temporal lobe structures and facial emotion recognition in schizophrenia patients and nonpsychotic relatives. | Goghari VM et al. | β | 2011 | β |
| Theory of Mind in patients at clinical high risk for psychosis. | Stanford AD et al. | β | 2011 | β |
| The postpartum depression screening scale: is it valid to screen for antenatal depression? | Pereira AT et al. | β | 2011 | β |
| The Vulnerable Personality Style Questionnaire: psychometric properties in Spanish postpartum women. | Gelabert E et al. | β | 2011 | β |
| Verbal memory functions in unipolar major depression with and without co-morbid anxiety. | Lyche P et al. | β | 2011 | β |
| Visuo-spatial cognition in schizophrenia: confirmation of a preference for local information processing. | Landgraf S et al. | β | 2011 | β |
| Visuospatial working memory deficits in remitted patients with bipolar disorder: susceptibility to the effects of GABAergic agonists. | Pan YJ et al. | β | 2011 | β |
| Aberrant regulation of endogenous ouabain-like factor in bipolar subjects. | El-Mallakh RS et al. | β | 2010 | β |
| A genome-wide association study of bipolar disorder and comorbid migraine. | Oedegaard KJ et al. | β | 2010 | β |
| A genome-wide association study of neuroticism in a population-based sample. | Calboli FC et al. | β | 2010 | β |
| A genome-wide quantitative trait loci scan of neurocognitive performances in families with schizophrenia. | Lien YJ et al. | β | 2010 | β |
| Altered expression of circadian rhythm genes among individuals with a history of depression. | Gouin JP et al. | β | 2010 | β |
| An investigation of candidate regions for association with bipolar disorder. | Knight J et al. | β | 2010 | β |
| Assessing oxidative pathway genes as risk factors for bipolar disorder. | Fullerton JM et al. | β | 2010 | β |
| Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia. | Reid MA et al. | β | 2010 | β |
| Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder. | Bloch PJ et al. | β | 2010 | β |
| Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder. | Lee KY et al. | β | 2010 | β |
| Association of serotonin transporter promoter gene polymorphism (5-HTTLPR) with depression in Costa Rican schizophrenic patients. | Contreras J et al. | β | 2010 | β |
| Case-control association study of TGOLN2 in attempted suicide. | Mahon PB et al. | β | 2010 | β |
| Cognitive Control Functions in Unipolar Major Depression with and without Co-Morbid Anxiety Disorder. | Lyche P et al. | β | 2010 | β |
| Deficit of inhibition motor control in untreated patients with schizophrenia: further support from visually guided saccade paradigms. | Krebs MO et al. | β | 2010 | β |
| Defining bipolar mood states with quantitative measurement of inhibition/activation and emotional reactivity. | Henry C et al. | β | 2010 | β |
| Do we recognize facial expressions of emotions from persons with schizophrenia? | Healey KM et al. | β | 2010 | β |
| EGR3 as a potential susceptibility gene for schizophrenia in Korea. | Kim SH et al. | β | 2010 | β |
| ERP generator patterns in schizophrenia during tonal and phonetic oddball tasks: effects of response hand and silent count. | Kayser J et al. | β | 2010 | β |
| Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs. | Zhang P et al. | β | 2010 | β |
| Genetic and environmental influences on focal brain density in bipolar disorder. | van der Schot AC et al. | β | 2010 | β |
| Genetic Association Study of the Alpha 7 Nicotinic Receptor (CHRNA7) with the Development of Schizophrenia and Bipolar Disorder in Korean Population. | Joo EJ et al. | β | 2010 | β |
| Genome-wide association study of suicide attempts in mood disorder patients. | Perlis RH et al. | β | 2010 | β |
| Genome-wide linkage scan of bipolar disorder in a Colombian population isolate replicates Loci on chromosomes 7p21-22, 1p31, 16p12 and 21q21-22 and identifies a novel locus on chromosome 12q. | Kremeyer B et al. | β | 2010 | β |
| Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia. | Bertisch H et al. | β | 2010 | β |
| Impulsivity and sensation seeking in cannabis abusing patients with schizophrenia. | Dervaux A et al. | β | 2010 | β |
| Influence of the serotonin transporter gene polymorphism, cannabis and childhood sexual abuse on phenotype of bipolar disorder: a preliminary study. | De Pradier M et al. | β | 2010 | β |
| Lack of association between genetic polymorphisms of ARRB2 and alcohol dependence in a Caucasian population. | Oneda B et al. | β | 2010 | β |
| Mutation analysis of the C1QTNF3 gene in patients with schizophrenia. | Bespalova I et al. | β | 2010 | β |
| Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls. | Delorme R et al. | β | 2010 | β |
| Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia. | Kayser J et al. | β | 2010 | β |
| New copy number variations in schizophrenia. | Magri C et al. | β | 2010 | β |
| Prediction of real-world functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. | Bowie CR et al. | β | 2010 | β |
| Preferential association between childhood emotional abuse and bipolar disorder. | Etain B et al. | β | 2010 | β |
| Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia. | Bergman O et al. | β | 2010 | β |
| Real world referencing and schizophrenia: are we experiencing the same reality? | Landgraf S et al. | β | 2010 | β |
| Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study. | Rosso IM et al. | β | 2010 | β |
| Reliability of a scale of work-related self-efficacy for people with psychiatric disabilities. | Harris M et al. | β | 2010 | β |
| Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder. | Delorme R et al. | β | 2010 | β |
| Selective attention impairment in Schizophrenia: can it explain source monitoring failure? | Ferchiou A et al. | β | 2010 | β |
| Social competence and observer-rated social functioning in bipolar disorder. | Depp CA et al. | β | 2010 | β |
| Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8. | Ellman LM et al. | β | 2010 | β |
| The effect of algorithms on copy number variant detection. | Tsuang DW et al. | β | 2010 | β |
| The Internet-based MGS2 control sample: self report of mental illness. | Sanders AR et al. | β | 2010 | β |
| The Portuguese version of the postpartum depression screening scale. | Pereira AT et al. | β | 2010 | β |
| Variable individual sensitivity to cannabis in patients with schizophrenia. | Goldberger C et al. | β | 2010 | β |
| White matter volume abnormalities and associations with symptomatology in schizophrenia. | Makris N et al. | β | 2010 | β |