Putting the 'epi' into epigenetics research in psychiatry.

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Authors: El-Sayed, Abdulrahman M; Koenen, Karestan C; Galea, Sandro
Year: 2013
Journal: Journal of epidemiology and community health
PMID: 23572534
DOI: 10.1136/jech-2013-202430
PMCID: PMC4348573

#	Section	Preview
20	Challenges in analyzing the role of epigenetic change in psychopathology — Measuring Epigenetic Modification	A third challenge in epigenetic studies of psychopathology is the appropriate measurement of…
21	Challenges in analyzing the role of epigenetic change in psychopathology — Measuring Epigenetic Modification	The question of what to measure is crucial. As discussed above, epigenetic modifications involve DNA…
22	Challenges in analyzing the role of epigenetic change in psychopathology — Measuring Epigenetic Modification	With respect to the question of where to measure, studies about epigenetic modification in the…
23	Challenges in analyzing the role of epigenetic change in psychopathology — Measuring Epigenetic Modification	At the same time, however, the measurement of epigenetic changes in postmortem brain tissue may also…
24	Challenges in analyzing the role of epigenetic change in psychopathology — Measuring Epigenetic Modification	turn is likely to predict the viability of brain tissue. This imposes considerable limitations to…
25	Challenges in analyzing the role of epigenetic change in psychopathology — Measuring Epigenetic Modification	Lastly, the question of how to measure epigenetic modification remains a challenge for investigators…
26	Challenges in analyzing the role of epigenetic change in psychopathology — Disease-discordant monozygotic twin studies	Investigators have advocated the use of disease-discordant monozygotic twin analyses as a convenient…
27	Challenges in analyzing the role of epigenetic change in psychopathology — Disease-discordant monozygotic twin studies	While disease-discordant monozygotic twin studies pose a unique study design because they control…
28	Challenges in analyzing the role of epigenetic change in psychopathology — Disease-discordant monozygotic twin studies	Second, the challenge of generalizability persists, and may, in fact, be more acute in the setting…
29	Bridging the gap: Directions for epigenetic research in psychopathology	With the potential to unite population health and neurobiology around a coherent, unified approach…
30	Bridging the gap: Directions for epigenetic research in psychopathology	More specifically, the first methodological challenge to address is the specification and employment…
31	Bridging the gap: Directions for epigenetic research in psychopathology	We offer here several directions for future work. Addressing the first challenge regarding causal…
32	Bridging the gap: Directions for epigenetic research in psychopathology	Moreover, future studies will need to consider more deeply the potentially confounding effects of…
33	Bridging the gap: Directions for epigenetic research in psychopathology	We also considered the challenge of obtaining samples that are adequate in size and…
34	Bridging the gap: Directions for epigenetic research in psychopathology	We considered the questions of where, when, how, and what to measure with respect to epigenetic…
35	Bridging the gap: Directions for epigenetic research in psychopathology	Addressing the questions of where and when to measure epigenetic modification is considerably more…
36	Bridging the gap: Directions for epigenetic research in psychopathology	While, at this point, this trade-off is unavoidable in population studies (save sampling the highly…
37	Bridging the gap: Directions for epigenetic research in psychopathology	There remain a number of important questions regarding the role of epigenetic modifications in the…

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