Synaptic Plasticity and its Modulation by Alcohol.
paper
Cited
Public
- Authors
- Avchalumov, Yosef; Mandyam, Chitra D
- Year
- 2020
- Journal
- Brain plasticity (Amsterdam, Netherlands)
- PMID
- 33680849
- DOI
- 10.3233/BPL-190089
- PMCID
- PMC7902982
Alcohol is one of the oldest pharmacological agents used for its sedative/hypnotic effects, and alcohol abuse and alcohol use disorder (AUD) continues to be major public health issue. AUD is strongly indicated to be a brain disorder, and the molecular and cellular mechanism/s by which alcohol produces its effects in the brain are only now beginning to be understood. In the brain, synaptic plasticity or strengthening or weakening of synapses, can be enhanced or reduced by a variety of stimulation paradigms. Synaptic plasticity is thought to be responsible for important processes involved in the cellular mechanisms of learning and memory. Long-term potentiation (LTP) is a form of synaptic plasticity, and occurs via N-methyl-D-aspartate type glutamate receptor (NMDAR or GluN) dependent and independent mechanisms. In particular, NMDARs are a major target of alcohol, and are implicated in different types of learning and memory. Therefore, understanding the effect of alcohol on synaptic plasticity and transmission mediated by glutamatergic signaling is becoming important, and this will help us understand the significant contribution of the glutamatergic system in AUD. In the first part of this review, we will briefly discuss the mechanisms underlying long term synaptic plasticity in the dorsal striatum, neocortex and the hippocampus. In the second part we will discuss how alcohol (ethanol, EtOH) can modulate long term synaptic plasticity in these three brain regions, mainly from neurophysiological and electrophysiological studies. Taken together, understanding the mechanism(s) underlying alcohol induced changes in brain function may lead to the development of more effective therapeutic agents to reduce AUDs.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. | 2025 | 41083468 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Effects of legal-market cannabis and alcohol on verbal learning and memory. | Gowin JL et al. | — | 2026 | → |
| The frequency of binge-like ethanol exposure bidirectionally regulates hippocampal mGlu-LTD via synaptic mechanisms and this effect is reversed by minocycline. | Debris M et al. | — | 2026 | → |
| Ethanol-Induced Depression: Exploring the Underlying Molecular Mechanisms. | Mashayekhi-Sardoo H et al. | — | 2025 | → |
| Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. | Green NC et al. | — | 2025 | → |
| Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice. | Reina-Campos M et al. | — | 2025 | → |
| Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling. | Tong M et al. | — | 2025 | → |
| Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway. | Qi Y et al. | — | 2025 | → |
| Abstinence and Fear Experienced during This Period Produce Distinct Cortical and Hippocampal Adaptations in Alcohol-Dependent Rats. | Steiner NL et al. | — | 2024 | → |
| Differential effects of moderate chronic ethanol consumption on neurobehavior, white matter glial protein expression, and mTOR pathway signaling with adolescent brain maturation. | Yalcin EB et al. | — | 2024 | → |
| Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies. | Hilal FF et al. | — | 2024 | → |
| Fermented <i>Protaetia brevitarsis</i> Larvae Improves Neurotoxicity in Chronic Ethanol-Induced-Dementia Mice via Suppressing AKT and NF-κB Signaling Pathway. | Lee HL et al. | — | 2024 | → |
| Mixing energy drinks and alcohol during adolescence impairs brain function: A study of rat hippocampal plasticity. | Biggio F et al. | — | 2024 | → |
| Safflower Yellow Alleviates Cognitive Impairment in Mice by Modulating Cholinergic System Function, Oxidative Stress, and CREB/BDNF/TrkB Signaling Pathway | qi y et al. | — | 2024 | — |
| Temporal differential effects of post-injury alcohol consumption in a mouse model of blast-induced traumatic brain injury. | Zhang Z et al. | — | 2024 | → |
| The potential of 5-methoxy-N,N-dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action. | Tap SC | — | 2024 | → |
| Acute ethanol exposure leads to long-term effects on memory, behavior, and transcriptional regulation in the zebrafish brain. | Sartori BM et al. | — | 2023 | → |
| The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder. | Nuñez-delMoral A et al. | — | 2023 | → |
| Compulsive-like eating of high-fat high-sugar food is associated with 'addiction-like' glutamatergic dysfunction in obesity prone rats. | Sketriene D et al. | — | 2022 | → |
| Does propofol definitely improve postoperative cognitive dysfunction?-a review of propofol-related cognitive impairment. | Liu P et al. | — | 2022 | → |
| Neuroligin Plays a Role in Ethanol-Induced Disruption of Memory and Corresponding Modulation of Glutamate Receptor Expression. | Rose JK et al. | — | 2022 | → |
| Non-coding RNA in alcohol use disorder by affecting synaptic plasticity. | Zhu S et al. | — | 2022 | → |
| Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression. | Grigsby K et al. | — | 2022 | → |
| Caveolin-1 Expression in the Dorsal Striatum Drives Methamphetamine Addiction-Like Behavior. | Avchalumov Y et al. | — | 2021 | → |
| The Role of Thyroid Function in Alzheimer's Disease. | Ge F et al. | — | 2021 | → |
| SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD. | Avchalumov Y et al. | — | 2020 | → |