Shh gene

Aliases

SHH, SHH C25II, Sonic hedgehog, sonic hedgehog

External links

NCBI Gene · Ensembl · GeneCards · UniProt

Related entities (4)

Mentioned in (152)

Papers in which this entity is mentioned.

• Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models. (2026)
• Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. (2024)
• Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
• Gene-alcohol interactions in birth defects. (2023)
• High-throughput detection of craniofacial defects in fluorescent zebrafish. (2023)
• The pro-apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation-stage alcohol exposure. (2022)
• Fetal Alcohol Spectrum Disorders: Awareness to Insight in Just 50 Years. (2022)
• FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. (2021)
• Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. (2021)
• Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling. (2021)
• Atrial and Sinoatrial Node Development in the Zebrafish Heart. (2021)
• Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway. (2021)
• Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube. (2021)
• Multifactorial Genetic and Environmental Hedgehog Pathway Disruption Sensitizes Embryos to Alcohol-Induced Craniofacial Defects. (2020)
• Tead transcription factors differentially regulate cortical development. (2020)
• Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia. (2020)
• Transcriptome-Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure. (2020)
• Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
• Novel Ethanol-Sensitive Mutants Identified in an F3 Forward Genetic Screen. (2020)
• Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction. (2019)
• Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. (2019)
• Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish. (2019)
• De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies. (2019)
• Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE. (2018)
• Combined Face-Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders. (2018)
• Knockdown of Mns1 Increases Susceptibility to Craniofacial Defects Following Gastrulation-Stage Alcohol Exposure in Mice. (2018)
• Diving into the world of alcohol teratogenesis: a review of zebrafish models of fetal alcohol spectrum disorder. (2018)
• Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. (2018)
• Long-term behavioral change as a result of acute ethanol exposure in zebrafish: Evidence for a role for sonic hedgehog but not retinoic acid signaling. (2017)
• Genetic vulnerabilities to prenatal alcohol exposure: Limb defects in sonic hedgehog and GLI2 heterozygous mice. (2017)
• Gene-environment interactions in development and disease. (2017)
• Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. (2017)
• Ethanol itself is a holoprosencephaly-inducing teratogen. (2017)
• Transcriptome Profiling Identifies Ribosome Biogenesis as a Target of Alcohol Teratogenicity and Vulnerability during Early Embryogenesis. (2017)
• Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation. (2017)
• Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia. (2017)
• Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. (2016)
• Pituitary lacks sexual dimorphism and displays reduced signal intensity on T1-weighted MRI in adolescents with histories of heavy prenatal alcohol exposure. (2016)
• Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics. (2016)
• An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull. (2016)
• Pdgfra and Pdgfrb genetically interact during craniofacial development. (2016)
• Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum. (2016)
• Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice. (2016)
• Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. (2016)
• The Genetics of Fetal Alcohol Spectrum Disorders. (2016)
• Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function. (2016)
• Chronic up-regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice. (2016)
• Mechanisms of retinoic acid signalling and its roles in organ and limb development. (2015)
• Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement. (2015)
• Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish. (2015)
• Endocannabinoids are conserved inhibitors of the Hedgehog pathway. (2015)
• Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate. (2015)
• Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology. (2015)
• A screen of zebrafish mutants identifies ethanol-sensitive genetic loci. (2014)
• The role of BAF (mSWI/SNF) complexes in mammalian neural development. (2014)
• Maternal periconceptional alcohol consumption and congenital limb deficiencies. (2014)
• Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. (2014)
• Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD. (2014)
• Neural crest development in fetal alcohol syndrome. (2014)
• Gene-ethanol interactions underlying fetal alcohol spectrum disorders. (2014)
• A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity. (2014)
• Modeling hippocampal neurogenesis using human pluripotent stem cells. (2014)
• The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse. (2014)
• Developmental age strengthens barriers to ethanol accumulation in zebrafish. (2014)
• Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly. (2014)
• Development of thalamocortical connectivity during infancy and its cognitive correlations. (2014)
• Ethanol alters gene expression and cell organization during optic vesicle evagination. (2013)
• Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. (2013)
• The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. (2013)
• Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects. (2013)
• Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment. (2013)
• Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. (2013)
• Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. (2013)
• Commonality in Down and fetal alcohol syndromes. (2013)
• Hand in glove: brain and skull in development and dysmorphogenesis. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function. (2013)
• The Aplnr GPCR regulates myocardial progenitor development via a novel cell-non-autonomous, Gα(i/o) protein-independent pathway. (2012)
• Distinct spatiotemporal roles of hedgehog signalling during chick and mouse cranial base and axial skeleton development. (2012)
• SOX2 hypomorphism disrupts development of the prechordal floor and optic cup. (2012)
• An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. (2012)
• Fine-grained facial phenotype-genotype analysis in Wolf-Hirschhorn syndrome. (2012)
• Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. (2012)
• Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. (2012)
• Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. (2012)
• Examination of a palatogenic gene program in zebrafish. (2011)
• A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. (2011)
• Facial phenotypes in subgroups of prepubertal boys with autism spectrum disorders are correlated with clinical phenotypes. (2011)
• Teratogenic effects of thalidomide: molecular mechanisms. (2011)
• Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesis. (2011)
• Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. (2011)
• Down syndrome: searching for the genetic culprits. (2011)
• Cleft lip and palate: understanding genetic and environmental influences. (2011)
• Mechanisms that underlie co-variation of the brain and face. (2011)
• Ventromedian forebrain dysgenesis follows early prenatal ethanol exposure in mice. (2011)
• Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. (2011)
• S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors. (2011)
• Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. (2011)
• Alteration of gene expression by alcohol exposure at early neurulation. (2011)
• Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications. (2010)
• Analysis of genotype-phenotype correlations in human holoprosencephaly. (2010)
• Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. (2010)
• Genesis of teratogen-induced holoprosencephaly in mice. (2010)
• The molecular genetics of holoprosencephaly. (2010)
• Genetic and epigenetic insights into fetal alcohol spectrum disorders. (2010)
• Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (2010)
• Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7. (2010)
• The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example. (2010)
• Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. (2009)
• Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. (2009)
• Pathogenesis of holoprosencephaly. (2009)
• A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. (2009)
• Evolution of the neocortex: a perspective from developmental biology. (2009)
• The embryonic preoptic area is a novel source of cortical GABAergic interneurons. (2009)
• A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm. (2009)
• Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. (2008)
• Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. (2008)
• MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. (2008)
• Development and tissue origins of the mammalian cranial base. (2008)
• The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. (2008)
• High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database. (2008)
• Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. (2008)
• Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. (2008)
• The power of comparative and developmental studies for mouse models of Down syndrome. (2007)
• Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos. (2007)
• Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. (2007)
• Perlecan controls neurogenesis in the developing telencephalon. (2007)
• Transcriptional regulation of cortical interneuron development. (2007)
• Defects in eye development in transgenic mice overexpressing the heparan sulfate proteoglycan agrin. (2007)
• Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. (2007)
• The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. (2007)
• Holoprosencephaly. (2007)
• Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. (2006)
• Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. (2006)
• Development of the upper lip: morphogenetic and molecular mechanisms. (2006)
• Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. (2006)
• Origin of oligodendrocytes in the subventricular zone of the adult brain. (2006)
• Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. (2006)
• Activation of heterotrimeric G proteins by Smoothened. (2006)
• Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. (2005)
• Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. (2004)
• Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. (2004)
• Origins of cortical interneuron subtypes. (2004)
• Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. (2003)
• Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features. (2003)
• Layer specification of transplanted interneurons in developing mouse neocortex. (2003)
• Small molecule modulation of Smoothened activity. (2002)
• Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. (2002)
• Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. (2002)
• The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly. (2000)
• Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer. (2000)
• Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos. (1997)

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