ALDH2 protective_against alcohol dependence

Subject: ALDH2
Relation: protective_against
Object: alcohol dependence
p-value: —

Evidence from: primary | all sources

Evidence (4 sources)

The genetics of alcohol dependence: advancing towards systems-based approaches. (2012) PMID:22854292 cited

Differences in the functionality of the ALDH ... have been linked to protection against developing AD.

confidence: 0.94

The impact of gene-environment interaction on alcohol use disorders. (2012) PMID:23134047 cited

one of the most widely replicated genetic associations with alcohol dependence is the protective role of a genetic variant responsible for the enzyme aldehyde dehydrogenase (i.e., ALDH2).

confidence: 0.96

Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007) PMID:17718398 cited

protective ALDH2*2 allele

confidence: 0.85

The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (2007) PMID:17718394 cited

The presence of even a single ALDH2*2 allele is strongly protective against alcohol dependence.

confidence: 0.96