ADH1C risk_factor_for alcohol dependence
Evidence from:
primary |
all sources
Evidence (9 sources)
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
(2019)
PMID:30940813
primary
Three previously associated with alcohol dependence—ADH1B, ADH1C, and ADH4.
confidence: 0.97
Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity.
(2017)
PMID:28134463
cited
a variant of the alcohol dehydrogenase 1C gene, ADH1C*2, ... are associated with alcohol dependence
confidence: 0.90
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
genetic variation in the alcohol metabolizing genes ... risk for alcohol dependence.
confidence: 0.90
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
(2015)
PMID:26267224
cited
differences observed between AAs and EAs in AD GWAS outcomes of ADH1C
confidence: 0.80
genes in the ethanol metabolic pathway (e.g., ADH1C ...) are candidates for alcohol dependence
confidence: 0.95
The genetics of alcohol dependence: advancing towards systems-based approaches.
(2012)
PMID:22854292
cited
variants within the genes encoding the hepatic forms, ... ADH1C, have been related to alcohol dependence.
confidence: 0.93
The genetics of alcohol dependence: advancing towards systems-based approaches.
(2012)
PMID:22854292
cited
the ADH1C gene, which has over 50 publications linking it to alcohol use/alcoholism/AD
confidence: 0.96
ADH1C ... described ... as a susceptibility locus for both alcohol dependence ...
confidence: 0.96
Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago.
(2007)
PMID:17718398
cited
people with at least one ADH1C*2 allele were at higher risk of developing alcohol dependence
confidence: 0.95