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Chrnb4 associated_with nicotine

Subject
Chrnb4
Relation
associated_with
Object
nicotine
p-value
—
Evidence from: primary | all sources

Evidence (14 sources)

Genetics of substance use disorders in the era of big data. (2021) PMID:34211176 cited
In addition to the CHRNA3–CHRNA5–CHRNB4 locus, ... was identified as associated with nicotine dependence (FTND)...
confidence: 0.96
Genetics of substance use disorders in the era of big data. (2021) PMID:34211176 cited
Variants ... in CHRNB4 ... were identified as associated with nicotine dependence
confidence: 0.95
Identification of CHRNA5 rare variants in African-American heavy smokers. (2014) PMID:24682045 cited
association with the Fagerström Test for Nicotine Dependence
confidence: 0.90
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited
genetic variants in the α5/α3/β4 nAChR gene cluster as associated with nicotine dependence
confidence: 0.95
Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. (2011) PMID:21079997 cited
The α5α3β4 cholinergic nicotinic receptor cluster ... is now unequivocally associated with nicotine dependence.
confidence: 0.96
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited
The chromosome 15q25 region containing CHRNA5-CHRNA3-CHRNB4 has been consistently associated with nicotine dependence...
confidence: 0.96
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited
Evidence for association was observed ... for CHRNA5-CHRNA3-CHRNB4 ... in the development of nicotine dependence.
confidence: 0.95
Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009) PMID:19247474 cited
SNPs in nicotinic receptors ... including the chr15p25.1 nicotinic receptor loci to be associated with nicotine dependence
confidence: 0.94
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. (2009) PMID:19132693 cited
CHRNB4 ... locus is associated with ... nicotine dependence ...
confidence: 0.95
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. (2009) PMID:19706762 cited
association study of nicotine dependence across the CHRNA5-CHRNA3-CHRNB4 region
confidence: 0.90
New insights into the genetics of addiction. (2009) PMID:19238175 cited
association between this gene cluster and ND
confidence: 0.94
New insights into the genetics of addiction. (2009) PMID:19238175 cited
KO mice for nAChR subunits ... β2–β4 have shown that the deletion of these genes alters many effects of nicotine.
confidence: 0.90
New insights into the genetics of addiction. (2009) PMID:19238175 cited
Weiss et al. found a significant association of the cluster with ND only in early-onset smokers
confidence: 0.95
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. (2009) PMID:19132693 cited
association between variants at the CHRNA5, CHRNA3, and CHRNB4 loci ... heavy smoking/nicotine dependence.
confidence: 0.90