CHRNA5 associated_with nicotine
Evidence from:
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Evidence (26 sources)
In addition to the CHRNA3–CHRNA5–CHRNB4 locus, ... was identified as associated with nicotine dependence (FTND)...
confidence: 0.96
Variants ... in CHRNA5 ... were identified as associated with nicotine dependence
confidence: 0.95
Following the discovery of its association with nicotine dependence...
confidence: 0.95
Identification of CHRNA5 rare variants in African-American heavy smokers.
(2014)
PMID:24682045
cited
association with the Fagerström Test for Nicotine Dependence
confidence: 0.90
Identification of CHRNA5 rare variants in African-American heavy smokers.
(2014)
PMID:24682045
cited
association of rare variants in CHRNA5 ... with nicotine dependence
confidence: 0.95
Identification of CHRNA5 rare variants in African-American heavy smokers.
(2014)
PMID:24682045
cited
The boundaries of the region associated with nicotine dependence stretches both upstream and downstream of CHRNA5
confidence: 0.80
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes.
(2012)
PMID:22290489
cited
genetic variants in the α5/α3/β4 nAChR gene cluster as associated with nicotine dependence
confidence: 0.95
Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.
(2011)
PMID:21079997
cited
The α5α3β4 cholinergic nicotinic receptor cluster ... is now unequivocally associated with nicotine dependence.
confidence: 0.96
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
The chromosome 15q25 region containing CHRNA5-CHRNA3-CHRNB4 has been consistently associated with nicotine dependence...
confidence: 0.96
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
Evidence for association was observed ... for CHRNA5-CHRNA3-CHRNB4 ... in the development of nicotine dependence.
confidence: 0.95
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
different levels of expression for CHRNA5 messenger RNA (mRNA) ... are associated with nicotine dependence
confidence: 0.90
Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.
(2010)
PMID:20624154
cited
association between non-synonymous polymorphism on the nicotinic receptor gene CHRNA5 ... and nicotine dependence
confidence: 0.94
Weiss et al. found a significant association of the cluster with ND only in early-onset smokers
confidence: 0.95
Genome-wide and candidate gene association study of cigarette smoking behaviors.
(2009)
PMID:19247474
cited
SNPs in nicotinic receptors ... including the chr15p25.1 nicotinic receptor loci to be associated with nicotine dependence
confidence: 0.94
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
(2009)
PMID:19654303
cited
CHRNA genes ... playing a role in development of nicotine dependence
confidence: 0.80
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.
(2009)
PMID:19132693
cited
replicated the association of CHRNA5 ... with smoking and nicotine dependence.
confidence: 0.95
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
test them for association with nicotine dependence
confidence: 0.60
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.
(2009)
PMID:19132693
cited
CHRNA5 ... locus is associated with ... nicotine dependence ...
confidence: 0.95
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
association study of nicotine dependence across the CHRNA5-CHRNA3-CHRNB4 region
confidence: 0.90
association between this gene cluster and ND
confidence: 0.94
KO mice for nAChR subunits α3–α9 ... deletion of these genes alters many effects of nicotine.
confidence: 0.90
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
(2008)
PMID:18783506
cited
early smoking experiences may mediate nicotine dependence, involving not only alpha-5 subunits ...
confidence: 0.85
Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation.
(2008)
PMID:18593715
cited
associations of SNPs in ... nAChR subunit genes with nicotine dependence
confidence: 0.80
Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation.
(2008)
PMID:18593715
cited
CHRNA3/CHRNA5 gene cluster associated with nicotine dependence in recent reports
confidence: 0.95
One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility.
(2008)
PMID:18936755
cited
variations in the same gene cluster as significantly associated with nicotine dependence
confidence: 0.95
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
(2008)
PMID:18783506
cited
most significant associations were for SNPs in ... CHRNA5 ... showing P-values less than 10−4 ... associated with nicotine dependence in Caucasians
confidence: 0.95