DNA methylation regulates gene expression

for PEG3, MEG3 and H19, we identified frequent aberrant hypermethylation with corresponding silencing of gene expression in hPSCs

DNA methylation and gene expression were anti-correlated (R < −0.50) for many of these genes.

greater amounts of CpG methylation are associated with lower amounts of mRNA production

Each of these modifications can alter the interaction between the histones and the DNA, and thus alter gene expression.

its importance for gene expression

Cytosine methylation ... has remarkable importance for gene activity, or expression.