E
Edenberg, Howard J
Also known as: Edenberg, H, Edenberg, Howard, Edenberg, H J
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Research Summary
Howard J. Edenberg’s research centers on the genetics and neurobiology of substance‑use disorders, especially alcohol use disorder (AUD), using large‑scale GWAS, polygenic‑score analyses, and functional genomics. He has contributed dozens of genome‑wide risk loci for AUD, nicotine dependence, and obsessive‑compulsive disorder, demonstrated how AUD‑associated variants drive cell‑type‑specific transcriptional and chromatin changes in the human caudate (including dysregulated medium‑spiny neurons, microglia, and astrocytes), and linked polygenic risk to clinical outcomes such as suicide attempts, remission trajectories, developmental patterns of drinking, and gene‑environment interplay (e.g., genetic nurture, social support). His work also bridges genetics to mechanistic studies in human iPSC‑derived neurons and microglia, revealing how variants in genes like KCNJ6 (GIRK2) modulate neuronal excitability and ethanol responses.
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Resolved affiliation
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
May be outdated — new papers have been added.
Raw imported affiliations (112)
| Affiliation |
|---|
| Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana , USA. |
| Departments of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. |
| Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. |
| Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202. |
| From the, Department of Biochemistry and Molecular Biology, (KST, HJE), Indiana University School of Medicine, Indianapolis, Indiana. |
| From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; the Departments of Genetics, Psychiatry, and Nutrition, University of North Carolina, Chapel Hill, N.C.; the Department of Psychiatry, Washington University School of Medicine, St Louis; the Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Oslo and Oslo University Hospital, Oslo; the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; the Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; the Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark; the Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London; the National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London; the Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; the Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, Bonn, Germany; the Institute of Neuroscience and Medicine, Juelich, Germany; the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N.Y.; the Department of Psychiatry, Yale University, New Haven, Conn.; the Department of Psychiatry and the Genetics Institute, University of Florida, Gainesville; the Department of Psychiatry, University of California-San Diego, La Jolla, Calif., the Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, and the Department of Psychiatry, Massachusetts General Hospital, Boston; the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass.; and the MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, U.K. |
| From the Department of Psychiatry and the Institute for Genomic Medicine, University of California San Diego, La Jolla; 23andMe, Inc., Mountain View, Calif.; the Division of Psychiatry, the Department of Psychology, and the Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, U.K.; the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis; and the Translational Research Laboratories, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia. |
| Indiana University. |
| Indiana University. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN. |
| Indiana University. Department of Medical and Molecular Genetics, Indiana University School of Medicine. Indianapolis, IN. |
| Indiana University, Department of Psychiatry, Indianapolis, IN, USA. |
| Indiana University, Dept. of Biochemistry and Molecular Biology, Indianapolis, IN, USA. |
| Indiana University, (HJE, JIN), Indianapolis, Indiana. |
| Indiana University School of Medicine. |
| Indiana University School of Medicine, Biochemistry and Molecular Biology, Indianapolis, IN, USA. |
| Indiana University School of Medicine, Department of Medical and Molecular Genetics, Indianapolis, Indiana 46202, United States. |
| Indiana University School of Medicine, Departments of Biochemistry and Molecular Biology, Psychiatry, Indianapolis, IN, USA. |
| Indiana University School of Medicine, (HJE), Indianapolis, Indiana. |
| Indiana University School of Medicine, Indianapolis. |
| Indiana University School of Medicine, Indianapolis 46202-5122, USA. |