The genome screen for both the Australian and Finnish NAG samples was comprised of 381 autosomal microsatellite markers spaced at approximately 10 cM across the genome. Our analyses are based on the deCODE genetic map (Kong et al., 2002). The few markers included that were not a part of the deCODE set were assigned genetic map positions based on interpolation of the physical map obtained from build 36.2 of the human reference genome [National Center for Biotechnology Information (NCBI)]. The Australian NAG sample was genotyped at the Australian Genome Research Facility (AGRF) and the Finnish NAG sample was genotyped at the Finnish Genome Center (FGC). The AGRF used an ABI (Applied Biosystems) genotyping platform, and the FGC used both ABI and MegaBACE (Amersham Biosciences) platforms (Saccone et al., 2007a; Loukola et al., 2008). PedCheck (version 1.1; O’Connell and Weeks, 1998), RelCheck (version 0.67; Boehnke and Cox, 1997; Broman and Weber, 1998) and PREST (version 3.0; McPeek and Sun, 2000) were used to screen for Mendelian errors and familial misspecifications, such as cases of non-paternity, and genotypes producing Mendelian errors were
