Summary statistics from the genome-wide meta-analyses are available on the Psychiatric Genomics Consortium’s downloads page (http://www.med.unc.edu/pgc/results-and-downloads), including the source data for Figures 1 and 2. Individual-level data from the genotyped cohorts and cohort-level summary statistics will be made available to researchers following an approved analysis proposal through the PGC Substance Use Disorder group with agreement of the cohort PIs; contact the corresponding authors for details. Cohort data are also available from dbGaP except where prohibited by IRB or European Union data restrictions. Expression data used to evaluate variants in ADH1B is available from GTEx (https://gtexportal.org/home/). Hi-C data used to evaluate the chromosome 3 variant can be queried with HUGIn (https://yunliweb.its.unc.edu/hugin/). Publicly available genome-wide summary statistics used for testing genetic correlations are accessible through LD Hub (http://ldsc.broadinstitute.org/), or from the Psychiatric Genomics Consortium (http://www.med.unc.edu/pgc/results-and-downloads), the Social Science Genetic Association Consortium (SSGAC; https://www.thessgac.org/data), Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA; http://enigma.ini.usc.edu/research/download-enigma-gwas-results/), and the Neale Lab (http://www.nealelab.is/uk-biobank); for availability of summary statistics from other studies contact the respective authors. The source data for Figure 3 is included in Supplementary Table S6.
