In addition to interfering with mnemonic processes, systemically administered cannabinoid receptor agonists produce a wide range of sensorimotor, physiological, and subjective effects (Jarbe and McMillan 1980; Little, et al 1988). Accordingly, the second goal of the present study was to determine whether intrahippocampal administration of rimonabant would block non-mnemonic pharmacological effects of cannabinoids using the tetrad assay (Smith, et al 1994), which assesses rodents for locomotor activity, antinociception, catalepsy, and hypothermia.
