STAT5 is a member of JAK/STAT signaling network (Stark and Darnell, 2012). During erythroid differentiation, erythropoietin activates STAT5, which in turn activates transcription of genes defining erythroid lineage (Ferbeyre and Moriggl, 2011). Consistent with this relationship, the heme metabolism hallmark (IC = 0.494, p < 4.76×10−7) attains high scores against the profile of STAT5A. Activation of STAT5 by IL2 in T lymphocytes, on the other hand, turns on expression of a different group of genes that play a role in a variety of immune responses. Accordingly, the hallmark for IL2 STAT5 signaling pathway is also associated with the STAT5A protein (IC = 0.368, p = 2.44×10−4).
