Chunk #24 — RESULTS — Matching hallmark enrichment scores to protein level phenotypes — SMAD3 and TGF-β (Figure 3F)

Source

The Molecular Signatures Database (MSigDB) hallmark gene set collection.

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yes

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TGF-β interacts with TGF-β receptors and leads to phosphorylation of SMAD2 and SMAD3 proteins (Akhurst and Hata, 2012). The profile of SMAD3 protein expression matches activity of the TGF-β hallmark (IC = 0.396, p < 4.8×10−7).