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Chunk #25 — 3. RESULTS — 3.2 MRI Outcome Measures — ICV-normalized CSF volumes

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Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence.
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When the larger sample of 117 ALC was analyzed, the results were consistent with those reported here in the smaller ALC sample: effect sizes were essentially the same while the significant p-values reported here became even smaller. Thus, our findings in the smaller ALC sample were representative of the larger sample and not obtained by chance. Furthermore, excluding the six females in the ALC and LD groups from analyses did not significantly change the group means or any of the statistical analyses (e.g., tGM in LD changed from 101.7 ± 4.7 with inclusion of women to 101.8 ± 4.9 without women, while the tGM means for ALC changed from 98.2 ± 5.0 with to 98.5 ± 4.8 without women; the corresponding p-values of the t-tests changed from 0.008 to 0.011, respectively).