respiratory movements) with their front paws on the bar for 10 s was scored. Rectal temperature was determined using a telethermometer (Physitemp Instruments, Inc., Clifton, New Jersey) by inserting a thermocouple probe 4.5 cm into the rectum. The rats were assessed for locomotor activity, nociception, catalepsy, and temperature at 20, 25, 40 and 60 min, respectively, after the i.p. injection as previously described (Lichtman, et al 1995; Little, et al 1988). Pre-injection measures for rectal temperature and tail flick were obtained. The subjects were randomly assigned to one of the following three treatment conditions: 1) intrahippocampal vehicle and i.p. vehicle; 2) intrahippocampal vehicle and i.p. CP-55,940 (0.15 mg/kg); and 3) intrahippocampal rimonabant (0.6 μg total) and i.p. CP-55,940 (0.15 mg/kg).
