Cytochrome P450 2D6 (CYP2D6) is a p450 enzyme that metabolizes methamphetamine (Lin et al. 1997). Otani et al. (2008) investigated the effect of CYP2D6 polymorphisms in methamphetamine dependent patients in a case-control study, and found the lower activity CYP2D6*10 and CYP2D6*14 alleles were under-represented in patients, suggesting that these alleles are protective against development of methamphetamine dependence.
