GO annotation of the PL DV genes revealed a significant enrichment in genes associated with signal transduction (FDR < 1 × 10−6), cell to cell signaling (FDR < 1 × 10−4) and neuron part (FDR < 8 × 10−9) (Supplementary Table S6). The signaling genes overlap with those noted above but also include Nos1 and Gm3. The PL DV genes were enriched (p < 3 × 10−10) in a single network module, brown. GO annotations for the brown module included neuron part (FDR < 5 × 10−11), PDZ domain signaling (FDR < 1 × 10−2) and cell to cell signaling (FDR < 7 × 10−11). The signaling genes (N = 49) largely overlap the signaling genes in the blue and magenta modules noted above and include a large number (N = 18) of protocadherins, also seen prominently in the SH results. Focusing on the brown module DV genes, average intramodular connectivity differed between the High vs. Low lines (0.72 vs. 0.40; p < 5 × 10−20). Genes showing large differences in hub status (High > > Low) included Syt10, Dgkh, Grin2a, and Adra1a.
