The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings.

paper Cited Public

Authors: Agrawal, Arpana; Grant, Julia D; Lynskey, Michael T; Madden, Pamela A F; Heath, Andrew C; Bucholz, Kathleen K; Sartor, Carolyn E
Year: 2016
Journal: Drug and alcohol dependence
PMID: 27114204
DOI: 10.1016/j.drugalcdep.2016.04.011
PMCID: PMC4904709

#	Section	Preview
20	2. MATERIALS AND METHODS — 2.3 Data Analysis: Twin-Sibling Modeling	A bivariate model was fitted to raw categorical data from twins and siblings in the statistical…
21	3. RESULTS — 3.1 Substance Use	Cigarette use was more common in EAs (75.3%) relative to AAs (64.2%) while cannabis use was…
22	3. RESULTS — 3.2 Twin-Sibling Models	Twin and sibling pair correlations were lower in AA compared to EA women (Table 2). Details of the…
23	3. RESULTS — 3.2 Twin-Sibling Models	Based on this pattern of results, for both racial/ethnic groups and substances, we proceeded with a…
24	3. RESULTS — 3.2 Twin-Sibling Models	Finally, we estimated the extent of genetic (rA), broad familial environmental (rC+T) and…
25	4. DISCUSSION	To our knowledge, this is the first study to examine the role of genetic and environmental…
26	4. DISCUSSION	We have previously reported on univariate estimates for cigarette use in the same sample (Sartor et…
27	4. DISCUSSION	The relative contribution of individual-specific environmental factors varied, both across…
28	4. DISCUSSION	towards and relative availability of substances across ethnic groups, and within the EA twins, to…
29	4. DISCUSSION	Despite differences in the relative magnitude of E influences on variance in cannabis and cigarette…
30	4. DISCUSSION	In contrast to the variability in estimates of E on individual differences in and between cannabis…
31	4. DISCUSSION	et al., 2011). Alternatively, genes related to cigarette use may also be linked to onset of cannabis…
32	4. DISCUSSION	While we could not disentangle shared and special twin environmental influences from each other,…
33	4. DISCUSSION	Other notable limitations of our study include the possibility of retrospective recall bias; however…
34	4. DISCUSSION	2008), its role should be carefully examined in international samples where the practice is common…
35	4. DISCUSSION	Our study indicates that while heritable variation in cigarette and cannabis use is comparable…

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In this knowledge base

Title	Year	PMID
Phenotypic and familial associations between childhood maltreatment and cannabis initiation and problems in young adult European-American and African-American women.	2017	28779616

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