Genetic and environmental factors in complex neurodevelopmental disorders.

paper Cited Public

Authors: van Loo, K M J; Martens, G J M
Year: 2007
Journal: Current genomics
PMID: 19412416
DOI: 10.2174/138920207783591717
PMCID: PMC2647153

#	Section	Preview
20	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Major Depression	Like bipolar disorder, depression is a major mood disorder. Although many clinical aspects are…
21	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — ADHD	ADHD was first described in 1845 and affects up to 1 in 20 children [34, 35]. The principal problem…
22	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — ADHD	Twin studies have indicated a relatively high genetic contribution reaching an average of 70% [36].…
23	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Tourette’s Syndrome	Tourette’s syndrome (also called Gilles de la Tourette syndrome) is a neuropsychiatric disorder…
24	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Dyslexia (Reading Disability)	Dyslexia affects 5–10% of school-age children [55] and is characterized by problems with word…
25	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Epilepsy (Seizure Disorder)	Epilepsy is a heterogeneous group of disorders with abnormal electrical brain activity. In adults,…
26	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Epilepsy (Seizure Disorder)	in subsequent association analysis [64, 65]. In addition, a number of other candidate genes have…
27	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Mental Retardation	Mental retardation (MR) occurs in approximately 2-3% of the population in developed countries [76].…
28	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Mental Retardation	Although it is evident that a genetic factor is involved in the aetiology of MR and the genetic…
29	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Addictive Disorders	Many twin studies have been performed on addictive disorders (both alcohol and drug abuse), which…
30	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Fetal Alcohol Syndrome	During pregnancy, alcohol use by the mother may lead to fetal alcohol syndrome (FAS) that occurs at…
31	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Anxiety Disorders	Panic disorder, OCD, separation anxiety, overanxious disorder, agoraphobia and other phobias all…
32	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Anxiety Disorders	Besides linkage analysis, many case-control design studies on candidate genes for anxiety…
33	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Anxiety Disorders	Besides association with panic disorder, a number of susceptibility genes have been found to…
34	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Posttraumatic Stress Disorder	Posttraumatic stress disorder (PTSD) can occur in a subset of individuals exposed to extreme…
35	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Eating Disorders	Anorexia and bulimia nervosa are two major eating disorders with still unknown risk factors. For a…
36	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Spina Bifida	Spina bifida is caused by unsuccessful closure of the neural tube during early development (between…
37	SUSCEPTIBILITY LOCI AND GENES OF COMPLEX NEURODEVELOPMENTAL DISORDERS — Hydrocephalus	Hydrocephalus occurs at a frequency of approximately 0.5 in 1000 births [176, 177] and is…
38	COMPLEX NEURODEVELOPMENTAL DISORDERS AND THE ENVIRONMENT	Since in general complex neurodevelopmental disorders have an estimated heritability lower than 100%…
39	COMPLEX NEURODEVELOPMENTAL DISORDERS AND THE ENVIRONMENT	The type and timing of the early environmental risk factors to which an organism is exposed appear…

Name	Type
5-HTTLPR	variant
5-HTTLPR_long local	variant
5-HTTLPR_short local	variant
Abnormal behavior local	phenotype
ACE	gene
ACSL4 local	gene
addiction	phenotype
ADH1B	gene
ADHD	phenotype
adolescents	cohort
adoption local	phenotype
Adora2a	gene
affected offspring local	cohort
affected phenotype local	phenotype
agoraphobia	phenotype
alcohol	phenotype
alcoholism	phenotype
amphetamine	drug
aneuploidy local	phenotype
animal models	cohort
anorexia nervosa	phenotype
anxiety-related personality traits local	phenotype
Arched-back nursing local	phenotype
ARHGEF6	gene
ARX	gene
Asperger’s disorder local	phenotype
ATR-X Syndrome local	phenotype
attention deficit hyperactivity disorder	phenotype
autism	phenotype
autism spectrum disorder	phenotype
bacterial artificial chromosome clone local	drug
Bdnf	gene
behavioral selection models local	cohort
bipolar disorder	phenotype
Bleeding local	phenotype
brain lesion models local	cohort
brain tissue	anatomy
Broad anxiety phenotype local	phenotype
bulimia nervosa	phenotype
Caesarean birth local	phenotype
CAMKK2	gene
cannabis use	phenotype
case-control sample	cohort
cases	cohort
causal SNP	cohort
Cck	gene
cerebrospinal fluid	drug
CFL1	gene
CGG repeat expansion local	variant
Childhood disintegrative disorder local	phenotype
Chrna4	gene
chromosomal micro-deletions local	phenotype
cocaine	phenotype
Cognitive disturbances local	phenotype
complex neurodevelopmental disorder local	phenotype
complex neurodevelopmental disorders local	phenotype
Complex neurodevelopmental disorders local	phenotype
Complex Neurodevelopmental Disorders local	phenotype
COMT	gene
conduct disorder	phenotype
control	cohort
controls	cohort
copy-number variants	variant
copy number variation	variant
CpG islands	drug
Crem	gene
CSF2RA	gene
CSNK1G2 local	gene
CYP2E1	gene
daily smoking	phenotype
DAO	gene
DAOA	gene
DBH	gene
DBI	gene
DCDC2 local	gene
December-March births local	phenotype
deletion	variant
depression	phenotype
depressive illness	phenotype
Depressive_symptoms local	phenotype
Developing brain structures local	anatomy
diabetes	phenotype
DISC1	gene
DNA methylation	drug
DNA polymorphism local	variant
dopamine	drug
Down's syndrome local	phenotype
Down syndrome	phenotype
DRD2	gene
DRD3	gene
DRD4	gene
DRD5	gene
DSM-IV	phenotype
DTNBP1	gene
duplication	variant
Dyslexia	phenotype
DYX1C1 local	gene
eating disorders	phenotype
Eating disturbances local	phenotype
endophenotype	phenotype
environment	drug
environmental factors	drug
environmental manipulations local	cohort
epilepsy	phenotype
exon-intron boundary SNP local	variant
families	cohort
Febrile seizures local	phenotype
fetal alcohol syndrome	phenotype
FMR1	gene
FMR2	gene
folate	drug
Folic acid	drug
fragile X syndrome	phenotype
Gabrb3	gene
Gabrg2	gene
GAD1	gene
GDI1 local	gene
gene-dosage imbalances local	variant
gene promoter region SNP local	variant
generalized anxiety disorder	phenotype
genetic animal models local	cohort
genetic factors	cohort
genetic marker	variant
genetic variants	cohort
genomic rearrangements local	variant
ghrelin	drug
GHSR local	gene
glutamate	drug
GPR98 local	gene
GRIN2B	gene
GRM3	gene
GRM4	gene
GWA study	cohort
harm avoidance	phenotype
heavy drinking	phenotype
High LG/ABN offspring local	cohort
hippocampus	anatomy
histone	drug
Homocysteine	drug
HPA response local	phenotype
Htr1a	gene
Htr1b	gene
Htr2a	gene
HTR2C	gene
Hydrocephalus local	phenotype
ICD-10 criteria local	phenotype
ICF Syndrome local	phenotype
IL1B	gene
IL1RAPL1	gene
IL1RN local	gene
immigration local	phenotype
Immunodeficiency local	phenotype
IMPA2 local	gene
Incubator local	drug
Influenza virus local	drug
Insufficient maternal nutrition local	phenotype
intellectual disability	phenotype
inversions	variant
Large groups of individuals local	cohort
Larger cohorts local	cohort
learning disabilities	phenotype
Licking and grooming local	phenotype
lithium	drug
L-methionine local	drug
low-MAF SNP local	variant
major depressive disorder	phenotype
malnutrition	phenotype
MAOA	gene
March births local	phenotype
March-May births local	phenotype
MeCP2	gene
Medicine usage local	drug
mental retardation	phenotype
Methionine_allele local	variant
mice	cohort
MLC1 local	gene
MTHFR	gene
MTRR local	gene
Multiple susceptibility genes local	gene
mutations	variant
NCAM1	gene
negative symptoms	phenotype
nervous system disorders local	phenotype
neurodevelopmental disorder	phenotype
neuroticism	phenotype
nicotine	drug
non-synonymous SNP	variant
NOS3	gene
NPY	gene
Nr3c1	gene
NRG1	gene
obsessive-compulsive disorder	phenotype
Obstetrical complications local	phenotype
OCD	phenotype
oligonucleotide local	drug
OPHN1	gene
oppositional defiant disorder	phenotype
Other phobias local	phenotype
Overanxious disorder local	phenotype
PAK3 local	gene
panic disorder	phenotype
parents	cohort
PCMT1 local	gene
PDGFRA	gene
Personality Disorder Not Otherwise Specified local	phenotype
Pervasive Developmental Disorders local	cohort
pharmacological selection models local	cohort
phenotype	phenotype
phobic anxiety	phenotype
population	cohort
Post-Traumatic Stress Disorder	phenotype
Pregnant mice (gestational day 9) local	cohort
Premature membrane rupture local	phenotype
prepulse inhibition	phenotype
preterm birth	phenotype
Protective alleles local	variant
psychiatric disorders	phenotype
psychosis	phenotype
Psychotic_symptoms local	phenotype
rare variant	cohort
Reeler mouse local	cohort
Reln	gene
Repeated psychological stress local	phenotype
Resuscitation local	drug
Rett syndrome	phenotype
RGS4	gene
Rhesus incompatibility local	phenotype
ROBO1	gene
RPS6KA3 local	gene
rs4129148	variant
rs4680	variant
rural-born local	phenotype
S-adenosylmethionine	drug
SAM	drug
schizoaffective disorder	phenotype
schizophrenia	phenotype
schizophrenia GWAS cohort local	cohort
Schizophrenic Patients Cohort local	cohort
Schizophreniform_disorders local	phenotype
Scn1a	gene
separation anxiety disorder	phenotype
serotonin	drug
Serum folate local	drug
Severe smoking local	phenotype
single-base polymorphism local	variant
SLC12A6 local	gene
SLC6A3	gene
SLC6A4	gene
smoking	phenotype
Snap25	gene
SNP	cohort
social phobia	phenotype
specific phobia	phenotype
spina bifida local	phenotype
Spina bifida local	phenotype
stressful life events	phenotype
stress response	phenotype
structural variant	cohort
susceptibility genes	cohort
SYNGR1	gene
temporal lobe	anatomy
temporal lobe epilepsy	anatomy
Tourette’s syndrome	phenotype
Tourette syndrome	phenotype
Trio-study cohort local	cohort
trisomy 21 local	variant
TSPAN7 local	gene
TSPO local	gene
Twin cohort	cohort
urban-born local	phenotype
Val158Met	gene
Val66Met local	variant
Valine_allele local	variant
Valproic acid	drug
viral infection	phenotype
vitamin B12	drug
Wellcome Trust case control consortium	cohort
William's-Beuren syndrome local	phenotype
winter-spring births local	phenotype

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In this knowledge base

Title	Year	PMID
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	2019	30087005

External

Title	Authors	Journal	Year	Link
Cumulative environmental exposures adversely impact social behaviour and are associated with dysregulation of genes and proteins involved in epigenetic, ribosomal, and immune regulation in male mice.	Bucknor MC et al.	—	2026	→
Limitations and opportunities in multi-omics integration for neurodevelopmental, neurodegenerative and psychiatric disorders: A systematic review.	Behrens LMP et al.	—	2026	→
A peripheral irritant motor response (PIMR) assay to identify chemical-induced locomotor deficits in larval zebrafish (Danio rerio).	McAtee D et al.	—	2025	→
GLUT1 and Cerebral Glucose Hypometabolism in Human Focal Cortical Dysplasia Is Associated with Hypermethylation of Key Glucose Regulatory Genes.	Ghosh C et al.	—	2025	→
Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice.	Dudas A et al.	—	2025	→
Parents' perspectives on conversations about prognosis and an assessment of prognostic information available online: A mixed-methods study.	Gokoolparsadh A et al.	—	2025	→
Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.	Al-Beltagi M et al.	—	2025	→
A Comprehensive Review on Current Insights Into Epileptic Encephalopathy: Pathogenesis and Therapeutic Strategies.	Patil R et al.	—	2024	→
Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model.	Hsieh CC et al.	—	2024	→
An examination of the association between infant non-nutritive suck and developmental outcomes at 12 months.	Martens A et al.	—	2024	→
A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0.	Locubiche S et al.	—	2024	→
Bisphenol A (BPA) and neurological disorders: An overview.	Hyun SA et al.	—	2024	→
Case Report: Intellectual disability and borderline intellectual functioning in two sisters with a 12p11.22 loss.	Choi H et al.	—	2024	→
Exploring hub genes and crucial pathways linked to oxidative stress in bipolar disorder depressive episodes through bioinformatics analysis.	Wu S et al.	—	2024	→
Neuropsychological profile in a child with Buschke-Ollendorff syndrome: A case report	Covuccia M et al.	—	2024	—
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems.	Rokach M et al.	—	2024	→
The early life exposome and autism risk: a role for the maternal microbiome?	Di Gesù CM et al.	—	2024	→
Tactile sensory processing as a precursor of executive attention: Toward early detection of attention impairments and neurodevelopmental disorders.	Anquetil M et al.	—	2023	→
Epidemiological Profile of Children with Neurodevelopmental Disorders in a Diagnostic Center in Southern Puerto Rico, 2006-2017.	Pacheco M et al.	—	2022	→
Identifying Boys With Autism Spectrum Disorder Based on Whole-Brain Resting-State Interregional Functional Connections Using a Boruta-Based Support Vector Machine Approach.	Zhao L et al.	—	2022	→
Integrated Analysis of miRNA and mRNA Expression Profiles Reveals the Molecular Mechanism of Posttraumatic Stress Disorder and Therapeutic Drugs.	Gan C et al.	—	2022	→
Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan.	Perfilyeva A et al.	—	2022	→
Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update.	Asgharian P et al.	—	2022	→
Role of melatonin in autism spectrum disorders in a male murine transgenic model: Study in the prefrontal cortex.	Borsani E et al.	—	2022	→
The Crosstalk Between Neurons and Glia in Methamphetamine-Induced Neuroinflammation.	Shi S et al.	—	2022	→
Association of maternal diabetes with neurodevelopmental disorders: autism spectrum disorders, attention-deficit/hyperactivity disorder and intellectual disability.	Chen S et al.	—	2021	→
Co-Design of a Neurodevelopment Assessment Scale: A Study Protocol.	Masi A et al.	—	2021	→
Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia.	Mike JK et al.	—	2021	→
Exposure to 3'Sialyllactose-Poor Milk during Lactation Impairs Cognitive Capabilities in Adulthood.	Pisa E et al.	—	2021	→
Novel frameshift mutation in PURA gene causes severe encephalopathy of unclear cause.	Spangenberg L et al.	—	2021	→
Pituitary stalk interruption syndrome.	Voutetakis A	—	2021	→
Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle.	Bonnycastle K et al.	—	2021	→
Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.	Siemann JK et al.	—	2021	→
SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants.	Figueiredo CP et al.	—	2021	→
A Bibliometric Insight of Genetic Factors in ASD: Emerging Trends and New Developments.	Wang K et al.	—	2020	→
A Pilot Randomized Control Trial With the Probiotic Strain <i>Lactobacillus rhamnosus</i> GG (LGG) in ADHD: Children and Adolescents Report Better Health-Related Quality of Life.	Kumperscak HG et al.	—	2020	→
Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology.	Cheroni C et al.	—	2020	→
CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.	Xu Q et al.	—	2020	→
Increased RNA editing in maternal immune activation model of neurodevelopmental disease.	Tsivion-Visbord H et al.	—	2020	→
Reproducible differentiation and characterization of neurons from mouse embryonic stem cells.	Saxena S et al.	—	2020	→
Right Place at the Right Time: How Changes in Protocadherins Affect Synaptic Connections Contributing to the Etiology of Neurodevelopmental Disorders.	Mancini M et al.	—	2020	→
Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes.	Ilan Y	—	2020	→
Zebrafish as a Model of Neurodevelopmental Disorders.	de Abreu MS et al.	—	2020	→
Artificial intelligence for precision medicine in neurodevelopmental disorders.	Uddin M et al.	—	2019	→
Contemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders.	Seo DO et al.	—	2019	→
Management of Self-injurious Behaviors in Children with Neurodevelopmental Disorders: A Pharmacotherapy Overview.	Sabus A et al.	—	2019	→
Neuronal migration in the CNS during development and disease: insights from <i>in vivo</i> and <i>in vitro</i> models.	Buchsbaum IY et al.	—	2019	→
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	Scarnati MS et al.	—	2019	→
Developmental trajectories of children with Down syndrome by socio-economic status: the case of Latin America.	Arango PS et al.	—	2018	→
Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II.	Dixit AB et al.	—	2018	→
Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.	Fisher NM et al.	—	2018	→
Mother-newborn separation at birth in hospitals: A possible risk for neurodevelopmental disorders?	Császár-Nagy N et al.	—	2018	→
Opportunities for an enhanced integration of neuroscience and genomics.	Moore AA et al.	—	2018	→
Optimizing an eHealth insomnia intervention for children with neurodevelopmental disorders: a Delphi study.	Ali N et al.	—	2018	→
Reanalysis of exome sequencing data of intellectual disability samples: Yields and benefits.	Al-Nabhani M et al.	—	2018	→
Understanding Neurodevelopmental Disorders: The Promise of Regulatory Variation in the 3'UTRome.	Wanke KA et al.	—	2018	→
E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration.	Upadhyay A et al.	—	2017	→
Environmental Pollutants and Neurodevelopment: Review of Benefits From Closure of a Coal-Burning Power Plant in Tongliang, China.	Kalia V et al.	—	2017	→
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders.	Neniskyte U et al.	—	2017	→
Gut microbiota and attention deficit hyperactivity disorder: new perspectives for a challenging condition.	Cenit MC et al.	—	2017	→
Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during <i>in-Vitro</i> Human Embryonic Cortical Neurogenesis.	Parween S et al.	—	2017	→
Influence of gut microbiota on neuropsychiatric disorders.	Cenit MC et al.	—	2017	→
Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring.	Banik A et al.	—	2017	→
Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.	Philippat C et al.	—	2017	→
Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children.	Levy RJ et al.	—	2016	→
Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review.	Blackmer AB et al.	—	2016	→
Oxytocin reversed MK-801-induced social interaction and aggression deficits in zebrafish.	Zimmermann FF et al.	—	2016	→
RNA-binding proteins, neural development and the addictions.	Bryant CD et al.	—	2016	→
Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders.	Schubert D et al.	—	2015	→
The impact of obstetric mode of delivery on childhood behavior.	Al Khalaf SY et al.	—	2015	→
An inside job: how endosomal Na(+)/H(+) exchangers link to autism and neurological disease.	Kondapalli KC et al.	—	2014	→
Modeling neurodevelopmental disorders using human pluripotent stem cells.	Telias M et al.	—	2014	→
Novel homozygous DEAF1 variant suspected in causing white matter disease, intellectual disability, and microcephaly.	Faqeih EA et al.	—	2014	→
Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.	Hashimoto-Torii K et al.	—	2014	→
Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins.	Li J et al.	—	2013	→
A review on genetics of sleep disorders.	Bidaki R et al.	—	2012	→
Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.	Zain MA et al.	—	2012	→
Signals controlling rest and reactivation of T helper memory lymphocytes in bone marrow.	Tokoyoda K et al.	—	2012	→
Molecular cytogenetics and cytogenomics of brain diseases.	Iourov IY et al.	—	2008	→