Genetic and environmental factors in complex neurodevelopmental disorders.

paper Cited Public

Authors: van Loo, K M J; Martens, G J M
Year: 2007
Journal: Current genomics
PMID: 19412416
DOI: 10.2174/138920207783591717
PMCID: PMC2647153

#	Section	Preview
40	COMPLEX NEURODEVELOPMENTAL DISORDERS AND THE ENVIRONMENT	One obvious gene-environment link concerns the season in which birth took place. An excess of…
41	GENE-ENVIRONMENT INTERACTIONS IN COMPLEX NEURODEVELOPMENTAL DISORDERS	One of the reasons that the genetic and environmental factors in complex neurodevelopmental…
42	GENE-ENVIRONMENT INTERACTIONS IN COMPLEX NEURODEVELOPMENTAL DISORDERS	An example of a gene-environment interaction concerns the influence of stressful life events on…
43	COMPLEX NEURODEVELOPMENTAL DISORDERS AND EPIGENETICS	Epigenetics is defined as heritable changes in gene expression patterns that occur without changing…
44	COMPLEX NEURODEVELOPMENTAL DISORDERS AND EPIGENETICS	An apparent link between the methylation status and gene transcription levels has led to the…
45	COMPLEX NEURODEVELOPMENTAL DISORDERS AND EPIGENETICS	in the DNA methylation process. Also, some patients with depressive illness and schizophrenia…
46	COMPLICATING FACTORS IN ASSOCIATION STUDIES	Although numerous studies suggest that genetic variants play a significant role in the aetiology of…
47	COMPLICATING FACTORS IN ASSOCIATION STUDIES — Definition of Phenotype	In the genetics of psychiatric disorders, the definition of a phenotype is one of the main problems.…
48	COMPLICATING FACTORS IN ASSOCIATION STUDIES — Population Stratification	Genetic variations often occur among (geographically or ethnically) different populations and this…
49	COMPLICATING FACTORS IN ASSOCIATION STUDIES — Gene-Environment Interactions	Another complicating factor in the identification of susceptibility genes for neurodevelopmental…
50	COMPLICATING FACTORS IN ASSOCIATION STUDIES — Multiple Genes Hypothesis	The search for susceptibility genes is further complicated when the aetiology of a complex…
51	COMPLICATING FACTORS IN ASSOCIATION STUDIES — Common Disease-Common Variant or Rare-Variant Hypothesis	At present, it is not clear whether only a relatively small number of common genetic variants are…
52	CONCLUSIONS AND FUTURE DIRECTIONS	Our summary of the current knowledge of the genetic, environmental and epigenetic contribution to…
53	CONCLUSIONS AND FUTURE DIRECTIONS	Up to now, in general, a presumptive susceptibility gene appears to be linked to a single…
54	CONCLUSIONS AND FUTURE DIRECTIONS	For a better understanding of the aetiologies involved, it will be fruitful to obtain detailed…
55	CONCLUSIONS AND FUTURE DIRECTIONS	Undoubtedly, in the near future many more GWA studies with the 500K and even larger SNP arrays will…
56	CONCLUSIONS AND FUTURE DIRECTIONS	a SNP may need an additional polymorphism(s) to explain the phenotype (multiple genes hypothesis),…
57	CONCLUSIONS AND FUTURE DIRECTIONS	This review has attempted to provide an overview of the aetiologies of complex neurodevelopmental…

Name	Type
5-HTTLPR	variant
5-HTTLPR_long local	variant
5-HTTLPR_short local	variant
Abnormal behavior local	phenotype
ACE	gene
ACSL4 local	gene
addiction	phenotype
ADH1B	gene
ADHD	phenotype
adolescents	cohort
adoption local	phenotype
Adora2a	gene
affected offspring local	cohort
affected phenotype local	phenotype
agoraphobia	phenotype
alcohol	phenotype
alcoholism	phenotype
amphetamine	drug
aneuploidy local	phenotype
animal models	cohort
anorexia nervosa	phenotype
anxiety-related personality traits local	phenotype
Arched-back nursing local	phenotype
ARHGEF6	gene
ARX	gene
Asperger’s disorder local	phenotype
ATR-X Syndrome local	phenotype
attention deficit hyperactivity disorder	phenotype
autism	phenotype
autism spectrum disorder	phenotype
bacterial artificial chromosome clone local	drug
Bdnf	gene
behavioral selection models local	cohort
bipolar disorder	phenotype
Bleeding local	phenotype
brain lesion models local	cohort
brain tissue	anatomy
Broad anxiety phenotype local	phenotype
bulimia nervosa	phenotype
Caesarean birth local	phenotype
CAMKK2	gene
cannabis use	phenotype
case-control sample	cohort
cases	cohort
causal SNP	cohort
Cck	gene
cerebrospinal fluid	drug
CFL1	gene
CGG repeat expansion local	variant
Childhood disintegrative disorder local	phenotype
Chrna4	gene
chromosomal micro-deletions local	phenotype
cocaine	phenotype
Cognitive disturbances local	phenotype
complex neurodevelopmental disorder local	phenotype
complex neurodevelopmental disorders local	phenotype
Complex neurodevelopmental disorders local	phenotype
Complex Neurodevelopmental Disorders local	phenotype
COMT	gene
conduct disorder	phenotype
control	cohort
controls	cohort
copy-number variants	variant
copy number variation	variant
CpG islands	drug
Crem	gene
CSF2RA	gene
CSNK1G2 local	gene
CYP2E1	gene
daily smoking	phenotype
DAO	gene
DAOA	gene
DBH	gene
DBI	gene
DCDC2 local	gene
December-March births local	phenotype
deletion	variant
depression	phenotype
depressive illness	phenotype
Depressive_symptoms local	phenotype
Developing brain structures local	anatomy
diabetes	phenotype
DISC1	gene
DNA methylation	drug
DNA polymorphism local	variant
dopamine	drug
Down's syndrome local	phenotype
Down syndrome	phenotype
DRD2	gene
DRD3	gene
DRD4	gene
DRD5	gene
DSM-IV	phenotype
DTNBP1	gene
duplication	variant
Dyslexia	phenotype
DYX1C1 local	gene
eating disorders	phenotype
Eating disturbances local	phenotype
endophenotype	phenotype
environment	drug
environmental factors	drug
environmental manipulations local	cohort
epilepsy	phenotype
exon-intron boundary SNP local	variant
families	cohort
Febrile seizures local	phenotype
fetal alcohol syndrome	phenotype
FMR1	gene
FMR2	gene
folate	drug
Folic acid	drug
fragile X syndrome	phenotype
Gabrb3	gene
Gabrg2	gene
GAD1	gene
GDI1 local	gene
gene-dosage imbalances local	variant
gene promoter region SNP local	variant
generalized anxiety disorder	phenotype
genetic animal models local	cohort
genetic factors	cohort
genetic marker	variant
genetic variants	cohort
genomic rearrangements local	variant
ghrelin	drug
GHSR local	gene
glutamate	drug
GPR98 local	gene
GRIN2B	gene
GRM3	gene
GRM4	gene
GWA study	cohort
harm avoidance	phenotype
heavy drinking	phenotype
High LG/ABN offspring local	cohort
hippocampus	anatomy
histone	drug
Homocysteine	drug
HPA response local	phenotype
Htr1a	gene
Htr1b	gene
Htr2a	gene
HTR2C	gene
Hydrocephalus local	phenotype
ICD-10 criteria local	phenotype
ICF Syndrome local	phenotype
IL1B	gene
IL1RAPL1	gene
IL1RN local	gene
immigration local	phenotype
Immunodeficiency local	phenotype
IMPA2 local	gene
Incubator local	drug
Influenza virus local	drug
Insufficient maternal nutrition local	phenotype
intellectual disability	phenotype
inversions	variant
Large groups of individuals local	cohort
Larger cohorts local	cohort
learning disabilities	phenotype
Licking and grooming local	phenotype
lithium	drug
L-methionine local	drug
low-MAF SNP local	variant
major depressive disorder	phenotype
malnutrition	phenotype
MAOA	gene
March births local	phenotype
March-May births local	phenotype
MeCP2	gene
Medicine usage local	drug
mental retardation	phenotype
Methionine_allele local	variant
mice	cohort
MLC1 local	gene
MTHFR	gene
MTRR local	gene
Multiple susceptibility genes local	gene
mutations	variant
NCAM1	gene
negative symptoms	phenotype
nervous system disorders local	phenotype
neurodevelopmental disorder	phenotype
neuroticism	phenotype
nicotine	drug
non-synonymous SNP	variant
NOS3	gene
NPY	gene
Nr3c1	gene
NRG1	gene
obsessive-compulsive disorder	phenotype
Obstetrical complications local	phenotype
OCD	phenotype
oligonucleotide local	drug
OPHN1	gene
oppositional defiant disorder	phenotype
Other phobias local	phenotype
Overanxious disorder local	phenotype
PAK3 local	gene
panic disorder	phenotype
parents	cohort
PCMT1 local	gene
PDGFRA	gene
Personality Disorder Not Otherwise Specified local	phenotype
Pervasive Developmental Disorders local	cohort
pharmacological selection models local	cohort
phenotype	phenotype
phobic anxiety	phenotype
population	cohort
Post-Traumatic Stress Disorder	phenotype
Pregnant mice (gestational day 9) local	cohort
Premature membrane rupture local	phenotype
prepulse inhibition	phenotype
preterm birth	phenotype
Protective alleles local	variant
psychiatric disorders	phenotype
psychosis	phenotype
Psychotic_symptoms local	phenotype
rare variant	cohort
Reeler mouse local	cohort
Reln	gene
Repeated psychological stress local	phenotype
Resuscitation local	drug
Rett syndrome	phenotype
RGS4	gene
Rhesus incompatibility local	phenotype
ROBO1	gene
RPS6KA3 local	gene
rs4129148	variant
rs4680	variant
rural-born local	phenotype
S-adenosylmethionine	drug
SAM	drug
schizoaffective disorder	phenotype
schizophrenia	phenotype
schizophrenia GWAS cohort local	cohort
Schizophrenic Patients Cohort local	cohort
Schizophreniform_disorders local	phenotype
Scn1a	gene
separation anxiety disorder	phenotype
serotonin	drug
Serum folate local	drug
Severe smoking local	phenotype
single-base polymorphism local	variant
SLC12A6 local	gene
SLC6A3	gene
SLC6A4	gene
smoking	phenotype
Snap25	gene
SNP	cohort
social phobia	phenotype
specific phobia	phenotype
spina bifida local	phenotype
Spina bifida local	phenotype
stressful life events	phenotype
stress response	phenotype
structural variant	cohort
susceptibility genes	cohort
SYNGR1	gene
temporal lobe	anatomy
temporal lobe epilepsy	anatomy
Tourette’s syndrome	phenotype
Tourette syndrome	phenotype
Trio-study cohort local	cohort
trisomy 21 local	variant
TSPAN7 local	gene
TSPO local	gene
Twin cohort	cohort
urban-born local	phenotype
Val158Met	gene
Val66Met local	variant
Valine_allele local	variant
Valproic acid	drug
viral infection	phenotype
vitamin B12	drug
Wellcome Trust case control consortium	cohort
William's-Beuren syndrome local	phenotype
winter-spring births local	phenotype

Filename	Size	Added
19412416.pdf	2326413 bytes	2026-05-15	View

Citation	PMID	DOI	Status
Abelson, J.F. et al., Science, 2005, Sequence variants in SLITRK1 are associated with Tourette's syndrome	16224024	10.1126/science.1116502	Cited
Allen, K.M. et al., Nat. Genet, 1998, PAK3 mutation in nonsyndromic X-linked mental retardation	9731525	10.1038/1675	Cited
Amir, R.E. et al., Nat. Genet, 1999, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2	10508514	10.1038/13810	Cited
Bachmann, A.W. et al., Psychoneuroendocrinology, 2005, Glucocorticoid receptor polymorphisms and post-traumatic stress disorder	15511603	10.1016/j.psyneuen.2004.08.006	Cited
Barr, C.L. et al., Am. J. Med. Genet, 1996, No evidence for a major gene effect of the dopamine D4 receptor gene in the susceptibility to Gilles de la Tourette syndrome in five Canadian families	8725747	10.1002/(SICI)1096-8628(19960531)67:3<301::AID-AJMG6>3.0.CO;2-P	Cited
Barr, C.L. et al., Am. J. Med. Genet, 1997, Linkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome	9034008	—	Cited
Batshaw, M.L, Pediatr. Clin. North Am, 1993, Mental retardation	8493062	10.1016/s0031-3955(16)38547-9	Cited
Baulac, S. et al., Nat. Genet, 2001, First genetic evidence of GABA(A) receptor dysfunction in epilepsy a mutation in the gamma2-subunit gene	11326274	10.1038/ng0501-46	Cited
Berrettini, W, Am. J. Med. Genet. C Semin. Med. Genet, 2003, Evidence for shared susceptibility in bipolar disorder and schizophrenia	14601037	10.1002/ajmg.c.20014	Cited
Billuart, P. et al., Nature, 1998, Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation	9582072	10.1038/31940	Cited
Blum, K. et al., JAMA, 1990, Allelic association of human dopamine D2 receptor gene in alcoholism	1969501	—	Cited
Boog, G, Eur. J. Obstet. Gynecol. Reprod. Biol, 2004, Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings is there a relationship?	15140504	10.1016/j.ejogrb.2003.09.041	Cited
Boutelet-Bochan, H. et al., Biochem. Biophys. Res. Commun, 1997, Expression of CYP2E1 during embryogenesis and fetogenesis in human cephalic tissues: implications for the fetal alcohol syndrome	9299528	10.1006/bbrc.1997.7296	Cited
Breslau, N. et al., Arch. Gen. Psychiatry, 1998, Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma	9672053	10.1001/archpsyc.55.7.626	Cited
Brett, P. et al., Lancet, 1993, Failure to find linkage and increased homozygosity for the dopamine D3 receptor gene in Tourette's syndrome	8098124	10.1016/0140-6736(93)91064-s	Cited
Brett, P.M. et al., Biol. Psychiatry, 1995, The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase	7619976	10.1016/0006-3223(94)00161-U	Cited
Brookes, K. et al., Mol. Psychiatry, 2006, The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder association signals in DRD4, DAT1 and 16 other genes	16894395	10.1038/sj.mp.4001869	Cited
Brown, K.S. et al., Birth Defects Res. A Clin. Mol. Teratol, 2004, Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus	15039923	10.1002/bdra.20002	Cited
Bulik, C.M. et al., Biol. Psychiatry, 1998, Heritability of binge-eating and broadly defined bulimia nervosa	9861464	10.1016/s0006-3223(98)00280-7	Cited
Burnet, P.W. et al., Psychiatr. Genet, 1999, Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder	10412190	10.1097/00041444-199906000-00009	Cited
Camarena, B. et al., Int. J. Neuropsychopharmacol, 2004, A family-based association study of the 5-HT-1Dbeta receptor gene in obsessive-compulsive disorder	14731309	10.1017/S1461145703003869	Cited
Campbell, D.A. et al., Lancet, 1998, Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa	9482450	10.1016/S0140-6736(05)78688-8	Cited
Cantor-Graae, E. et al., J. Child Psychol. Psychiatry, 2007, Risk for schizophrenia in intercountry adoptees: a Danish population-based cohort study	18030684	10.1111/j.1469-7610.2007.01788.x	Cited
Cardno, A.G. et al., Arch. Gen. Psychiatry, 1999, Heritability estimates for psychotic disorders the Maudsley twin psychosis series	10025441	10.1001/archpsyc.56.2.162	Cited
Cargill, M. et al., Nat. Genet, 1999, Characterization of single-nucleotide polymorphisms in coding regions of human genes	10391209	10.1038/10290	Cited
Carrie, A. et al., Nat. Genet, 1999, A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation	10471494	10.1038/12623	Cited
Caspi, A. et al., Biol. Psychiatry, 2005, Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction	15866551	10.1016/j.biopsych.2005.01.026	Cited
Caspi, A. et al., Science, 2003, Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene	12869766	10.1126/science.1083968	Cited
Caylak, E, Am. J. Med. Genet. B Neuropsychiatr. Genet, 2007, A review of association and linkage studies for genetical analyses of learning disorders	17510947	10.1002/ajmg.b.30537	Cited
Chelly, J. et al., Nat. Rev. Genet, 2001, Monogenic causes of X-linked mental retardation	11533716	10.1038/35088558	Cited
Clifford, C.A. et al., Psychol. Med, 1984, Genetic and environmental influences on obsessional traits and symptoms	6545413	10.1017/s0033291700019760	Cited
Cloninger, C.R. et al., Am. J. Med. Genet, 1998, Anxiety proneness linked to epistatic loci in genome scan of human personality traits	9674977	10.1002/(sici)1096-8628(19980710)81:4<313::aid-ajmg7>3.0.co;2-u	Primary
Collier, D.A. et al., Lancet, 1997, Association between 5-HT2A gene promoter polymorphism and anorexia nervosa	9259661	10.1016/S0140-6736(05)64135-9	Cited
Comings, D.E, Ann. N. Y. Acad. Sci, 2001, Clinical and molecular genetics of ADHD and Tourette syndrome Two related polygenic disorders	11462757	10.1111/j.1749-6632.2001.tb05773.x	Cited
Comings, D.E. et al., Am. J. Med. Genet, 1996, Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1	8725745	10.1002/(SICI)1096-8628(19960531)67:3<264::AID-AJMG4>3.0.CO;2-N	Cited
Comings, D.E. et al., Biol. Psychiatry, 1996, Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication	8874837	10.1016/0006-3223(95)00519-6	Cited
Comings, D.E. et al., Jama, 1991, The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders	1832466	—	Cited
Comings, D.E. et al., Lancet, 1993, Association between Tourette's syndrome and homozygosity at the dopamine D3 receptor gene	8096616	10.1016/0140-6736(93)93123-i	Cited
Comings, D.E. et al., Mol. Psychiatry, 1999, Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence	10523822	10.1038/sj.mp.4000542	Cited
Couvert, P. et al., Hum. Mol. Genet, 2001, MECP2 is highly mutated in X-linked mental retardation	11309367	10.1093/hmg/10.9.941	Cited
Craddock, N. et al., Br. Med. Bull, 1996, Modern molecular genetic approaches to psychiatric disease	8949248	10.1093/oxfordjournals.bmb.a011558	Cited
Curatolo, P. et al., Dev. Med. Child Neurol, 1995, Risk factors for the co-occurrence of partial epilepsy, cerebral palsy and mental retardation	7589860	10.1111/j.1469-8749.1995.tb12061.x	Cited
D'Adamo, P. et al., Nat. Genet, 1998, Mutations in GDI1 are responsible for X-linked non-specific mental retardation	9620768	10.1038/487	Cited
Deckert, J. et al., Hum. Mol. Genet, 1999, Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder	10072430	10.1093/hmg/8.4.621	Cited
Deckert, J. et al., Mol. Psychiatry, 1998, Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease	9491818	10.1038/sj.mp.4000345	Cited
Di Bella, D.D. et al., Mol. Psychiatry, 2000, Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa	10889521	10.1038/sj.mp.4000689	Cited
Domschke, K. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2003, Human nuclear transcription factor gene CREM genomic organization, mutation screening, and association analysis in panic disorder	12555239	10.1002/ajmg.b.10018	Cited
Domschke, K. et al., Int. J. Neuropsychopharmacol, 2004, Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women	15009906	10.1017/S146114570400416X	Cited
Duaux, E. et al., Mol. Psychiatry, 1998, Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence	9702742	10.1038/sj.mp.4000409	Cited
Eley, T.C. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2003, Association analysis of MAOA and COMT with neuroticism assessed by peers	12815746	10.1002/ajmg.b.20046	Cited
Erhardt, A. et al., J. Affect. Disord, 2007, Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders	17197037	10.1016/j.jad.2006.11.016	Cited
Faraone, S.V. et al., J. Clin. Psychiatry, 2006, Candidate gene studies of attention-deficit/hyperactivity disorder	16961425	—	Cited
Faraone, S.V. et al., World Psychiatry, 2003, The worldwide prevalence of ADHD: is it an American condition?	16946911	—	Cited
Farmer, A. et al., Curr. Opin. Psychiatry, 2007, The genetics of bipolar affective disorder	17143075	10.1097/YCO.0b013e3280117722	Cited
Fatemi, S.H. et al., Cell. Mol. Neurobiol, 2002, Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia	12064515	10.1023/A:1015337611258	Cited
Fernell, E. et al., Acta Paediatr. Scand, 1986, Epidemiology of infantile hydrocephalus in Sweden.I. Birth prevalence and general data	3564981	10.1111/j.1651-2227.1986.tb10326.x	Cited
Feucht, M. et al., Biol. Psychiatry, 1999, Possible association between childhood absence epilepsy and the gene encoding GABRB3	10509183	10.1016/s0006-3223(99)00039-6	Cited
Flint, J. et al., Psychol. Med, 2007, The endophenotype concept in psychiatric genetics	16978446	10.1017/S0033291706008750	Cited
Freitag, C.M, Mol. Psychiatry, 2007, The genetics of autistic disorders and its clinical relevance: a review of the literature	17033636	10.1038/sj.mp.4001896	Cited
Frey, L. et al., Epilepsia, 2003, Epidemiology of neural tube defects	12790881	10.1046/j.1528-1157.44.s3.2.x	Cited
Frieling, H. et al., Psychiatr. Genet, 2006, Association of catecholamine-O-methyltransferase and 5-HTTLPR genotype with eating disorder-related behavior and attitudes in females with eating disorders	16969275	10.1097/01.ypg.0000218620.50386.f1	Cited
Frisch, A. et al., Mol. Psychiatry, 1999, Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways	10483058	10.1038/sj.mp.4000536	Cited
Fullerton, J. et al., Am. J. Hum. Genet, 2003, Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism	12612864	10.1086/374178	Cited
Fyer, A.J. et al., Biol. Psychiatry, 2006, A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci	16919526	10.1016/j.biopsych.2006.04.018	Cited
Gade, R. et al., Mol. Psychiatry, 1998, Correlation of length of VNTR alleles at the X-linked MAOA gene and phenotypic effect in Tourette syndrome and drug abuse	9491813	10.1038/sj.mp.4000326	Cited
Gecz, J. et al., Nat. Genet, 1996, Identification of the gene FMR2, associated with FRAXE mental retardation	8673085	10.1038/ng0596-105	Cited
Gelernter, J. et al., Am. J. Psychiatry, 1993, Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor	8434661	10.1176/ajp.150.3.449	Cited
Gelernter, J. et al., Am. J. Psychiatry, 2004, Genome-wide linkage scan for loci predisposing to social phobia evidence for a chromosome 16 risk locus	14702251	10.1176/appi.ajp.161.1.59	Cited
Gelernter, J. et al., Arch. Gen. Psychiatry, 1990, Gilles de la Tourette syndrome is not linked to D2-dopamine receptor	1978653	10.1001/archpsyc.1990.01810230089014	Cited
Gelernter, J. et al., Mol. Psychiatry, 2003, A chromosome 14 risk locus for simple phobia: results from a genomewide linkage scan	12556910	10.1038/sj.mp.4001224	Cited
Gibbons, R.J. et al., Nat. Genet, 2000, Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation	10742099	10.1038/74191	Cited
Gillespie, N.A. et al., Psychol. Med, 2005, The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression	15842033	10.1017/s0033291704002727	Cited
Gottesman, I, Schizophrenia genesis The origins of madness, 1991	—	—	—
Gottesman, I.I. et al., Am. J. Psychiatry, 2003, The endophenotype concept in psychiatry etymology and strategic intentions	12668349	10.1176/appi.ajp.160.4.636	Cited
Green, R.F. et al., Am. J. Obstet. Gynecol, 2007, Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview	17618743	10.1016/j.ajog.2007.02.028	Cited
Grice, D.E. et al., Am. J. Hum. Genet, 1996, Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test	8751866	—	Cited
Guindalini, C. et al., Proc. Natl. Acad. Sci. USA, 2006, A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample	16537431	10.1073/pnas.0504789103	Cited
Hagberg, B. et al., Brain Dev, 1983, Epidemiology of mental retardation--a Swedish survey	6686416	10.1016/s0387-7604(83)80072-2	Cited
Halliday, J. et al., J. Med. Genet, 1986, X linked hydrocephalus: a survey of a 20 year period in Victoria, Australia	3950933	10.1136/jmg.23.1.23	Cited
Hamilton, S.P. et al., Proc. Natl. Acad. Sci. USA, 2003, Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q	12604791	10.1073/pnas.0335669100	Cited
Hanna, G.L. et al., Am. J. Med. Genet, 2002, Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands	12116192	10.1002/ajmg.10519	Cited
Hanna, G.L. et al., Biol. Psychiatry, 2007, Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder	17544380	10.1016/j.biopsych.2007.01.008	Cited
Hannula-Jouppi, K. et al., PLoS Genet, 2005, The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia	16254601	10.1371/journal.pgen.0010050	Cited
Haspolat, S. et al., J. Child Neurol, 2005, Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures	16159520	10.1177/08830738050200070401	Cited
Haverkamp, F. et al., Eur. J. Pediatr, 1999, Congenital hydrocephalus internus and aqueduct stenosis: aetiology and implications for genetic counselling	10378395	10.1007/s004310051123	Cited
Hawke, J.L. et al., Dyslexia, 2006, Genetic influences on reading difficulties in boys and girls the Colorado twin study	16512171	10.1002/dys.301	Cited
Hempelmann, A. et al., Epilepsy Res, 2007, Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy	17215107	10.1016/j.eplepsyres.2006.12.001	Cited
Herran, A. et al., Psychiatry Clin. Neurosci, 1999, Folate levels in psychiatric outpatients	10498238	10.1046/j.1440-1819.1999.00572.x	Cited
Hettema, J.M. et al., Am. J. Psychiatry, 2001, A review and meta-analysis of the genetic epidemiology of anxiety disorders	11578982	10.1176/appi.ajp.158.10.1568	Cited
Hettema, J.M. et al., Mol. Psychiatry, 2006, Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism	16718280	10.1038/sj.mp.4001845	Cited
Hiroi, N. et al., Mol. Psychiatry, 2005, Genetic susceptibility to substance dependence	15583701	10.1038/sj.mp.4001622	Cited
Horowitz, R. et al., Am. J. Med. Genet, 2000, Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study	11054766	—	Cited
Hunnerkopf, R. et al., Neuropsychopharmacology, 2007, Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits	17392738	10.1038/sj.npp.1301383	Cited
Inada, Y. et al., Psychiatry Res, 2003, Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene	12759158	10.1016/s0165-1781(03)00064-7	Cited
Jablensky, A. et al., Br. J. Psychiatry, 1987, Incidence worldwide of schizophrenia	3427300	10.1192/s0007125000216802	Cited
Jin, P. et al., Hum. Mol. Genet, 2000, Understanding the molecular basis of fragile X syndrome	10767313	10.1093/hmg/9.6.901	Cited
Johnson, E.W. et al., Hum. Mol. Genet, 1998, Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest	9384604	10.1093/hmg/7.1.63	Cited
Jonnal, A.H. et al., Am. J. Med. Genet, 2000, Obsessive and compulsive symptoms in a general population sample of female twins	11121183	10.1002/1096-8628(20001204)96:6<791::aid-ajmg19>3.0.co;2-c	Cited
Jorde, L.B. et al., Am. J. Phys. Anthropol, 1983, Epidemiology and genetics of neural tube defects an application of the Utah Genealogical Data Base	6353932	10.1002/ajpa.1330620106	Cited
Kaabi, B. et al., Am. J. Hum. Genet, 2006, Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus	16532386	10.1086/501072	Cited
Kanemoto, K. et al., Ann. Neurol, 2000, Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy	10805326	—	Cited
Kato, T, Psychiatry Clin. Neurosci, 2007, Molecular genetics of bipolar disorder and depression	17239033	10.1111/j.1440-1819.2007.01604.x	Cited
Kay, S.R. et al., Psychiatr. Dev, 1987, The positive-negative dimension in schizophrenia: its validity and significance	2888108	—	Cited
Kendler, K.S. et al., Am. J. Psychiatry, 1991, The genetic epidemiology of bulimia nervosa	1842216	10.1176/ajp.148.12.1627	Cited
Kendler, K.S. et al., Psychol Med, 1997, Stressful life events and genetic liability to major depression genetic control of exposure to the environment?	9153675	10.1017/s0033291797004716	Cited
Kessler, R.C. et al., Arch. Gen. Psychiatry, 1994, Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States.Results from the National Comorbidity Survey	8279933	10.1001/archpsyc.1994.03950010008002	Cited
Kessler, R.C. et al., Arch. Gen. Psychiatry, 1995, Posttraumatic stress disorder in the National Comorbidity Survey	7492257	10.1001/archpsyc.1995.03950240066012	Cited
Kessler, R.C. et al., JAMA, 2003, The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)	12813115	10.1001/jama.289.23.3095	Cited
Kjeldsen, M.J. et al., Epilepsy Res, 2002, Genetic and environmental factors in febrile seizures: a Danish population-based twin study	12350392	10.1016/s0920-1211(02)00121-3	Cited
Klump, K.L. et al., Psychol. Med, 2001, Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample	11352375	10.1017/s0033291701003725	Cited
Koizumi, H. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2004, Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders	15108194	10.1002/ajmg.b.20153	Cited
Kortegaard, L.S. et al., Psychol. Med, 2001, A preliminary population-based twin study of self-reported eating disorder	11232922	10.1017/s0033291701003087	Cited
Kutsche, K. et al., Nat. Genet, 2000, Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation	11017088	10.1038/80002	Cited
Lang, U.E. et al., Psychopharmacology (Berl), 2005, Association of a functional BDNF polymorphism and anxiety-related personality traits	15918078	10.1007/s00213-004-2137-7	Cited
Lappalainen, J. et al., Arch. Gen. Psychiatry, 2002, A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States	12215082	10.1001/archpsyc.59.9.825	Cited
Lauritsen, M.B. et al., Mol. Psychiatry, 2006, A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands	16205737	10.1038/sj.mp.4001754	Cited
Lee, H.J. et al., Depress. Anxiety, 2005, Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder	15965993	10.1002/da.20064	Cited
Lee, J.A. et al., Neuron, 2006, Genomic rearrangements and gene copy-number alterations as a cause of nervous system disorders	17015230	10.1016/j.neuron.2006.09.027	Cited
Lencz, T. et al., Mol. Psychiatry, 2007, Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia	17522711	10.1038/sj.mp.4001983	Cited
Lesch, K.P. et al., Science, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region	8929413	10.1126/science.274.5292.1527	Cited
Lochner, C. et al., Eur. Neuropsychopharmacol, 2004, Gender in obsessive-compulsive disorder: clinical and genetic findings	15013025	10.1016/S0924-977X(03)00063-4	Cited
Maron, E. et al., Psychiatr. Genet, 2005, Association study of 90 candidate gene polymorphisms in panic disorder	15722953	10.1097/00041444-200503000-00004	Cited
Massat, I. et al., Mol. Psychiatry, 2005, Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study	15583702	10.1038/sj.mp.4001615	Cited
McGrath, M. et al., Am. J. Psychiatry, 2004, Association between catechol-O-methyltransferase and phobic anxiety	15337664	10.1176/appi.ajp.161.9.1703	Cited
Meira-Lima, I. et al., Genes Brain Behav, 2004, Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder	15005715	10.1046/j.1601-1848.2003.0042.x	Cited
Meloni, I. et al., Nat. Genet, 2002, FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation	11889465	10.1038/ng857	Cited
Meng, H. et al., Proc. Natl. Acad. Sci. USA, 2005, DCDC2 is associated with reading disability and modulates neuronal development in the brain	16278297	10.1073/pnas.0508591102	Cited
Merienne, K. et al., Nat. Genet, 1999, A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation	10319851	10.1038/8719	Cited
Middeldorp, C.M. et al., Mol. Psychiatry, 2008, Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype	17700576	10.1038/sj.mp.4002061	Cited
Mikolajczyk, E. et al., Neuropsychobiology, 2006, Association of eating disorders with catechol-o-methyltransferase gene functional polymorphism	17028449	10.1159/000096043	Cited
Miyasaka, K. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2004, Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese	15108185	10.1002/ajmg.b.20160	Cited
Miyasaka, K. et al., J. Neural Transm, 2006, Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population	16362631	10.1007/s00702-005-0393-2	Cited
Montes, G. et al., J. Dev. Behav. Pediatr, 2006, Characteristics of school-age children with autism	17041273	10.1097/00004703-200610000-00002	Cited
Mortensen, P.B. et al., N. Engl. J. Med, 1999, Effects of family history and place and season of birth on the risk of schizophrenia	10029644	10.1056/NEJM199902253400803	Cited
Mulley, J. et al., Epilepsia, 2004, Febrile convulsions and genetic susceptibility: role of the neuronal nicotinic acetylcholine receptor alpha 4 subunit	15101840	10.1111/j.0013-9580.2004.62803.x	Cited
Munafo, M. et al., Nicotine Tob. Res, 2004, The genetic basis for smoking behavior: a systematic review and meta-analysis	15370155	10.1080/14622200410001734030	Cited
Munafo, M.R. et al., Mol. Psychiatry, 2007, Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias	17453061	10.1038/sj.mp.4001938	Cited
Muramatsu, T. et al., Biochem. Biophys. Res. Commun, 1995, Dopamine transporter gene polymorphism and alcoholism	7779096	10.1006/bbrc.1995.1773	Cited
Nakamura, K. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2006, Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder	16511838	10.1002/ajmg.b.30211	Cited
Nakayama, J. et al., Hum. Mol. Genet, 2000, Significant evidence for linkage of febrile seizures to chromosome 5q14-q15	10587582	10.1093/hmg/9.1.87	Cited
Nakayama, J. et al., Neurology, 2004, Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18	15557493	10.1212/01.wnl.0000144499.34164.e0	Cited
Nakayama, J. et al., Neurosci. Lett, 2003, Failure to find causal mutations in the GABA(A)-receptor gamma2 subunit (GABRG2) gene in Japanese febrile seizure patients	12759178	10.1016/s0304-3940(03)00338-0	Cited
Nature, 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls	17554300	10.1038/nature05911	Cited
Nemeroff, C.B. et al., J. Psychiatr. Res, 2006, Posttraumatic stress disorder: a state-of-the-science review	16242154	10.1016/j.jpsychires.2005.07.005	Cited
Noble, E.P. et al., Drug Alcohol Depend, 1993, Allelic association of the D2 dopamine receptor gene with cocaine dependence	8261891	10.1016/0376-8716(93)90113-5	Cited
Olsson, M. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2004, Angiotensin-related genes in patients with panic disorder	15108186	10.1002/ajmg.b.20164	Cited
Owen, M.J. et al., Mol. Psychiatry, 1996, Modern molecular genetic approaches to complex traits: implications for psychiatric disorders	9118311	—	Cited
Owen, M.J. et al., Trends Genet, 2005, Schizophrenia genes at last?	16009449	10.1016/j.tig.2005.06.011	Cited
Padmanabhan, R, Congenit. Anom. (Kyoto), 2006, Etiology, pathogenesis and prevention of neural tube defects	16732763	10.1111/j.1741-4520.2006.00104.x	Cited
Pauls, D.L, J. Psychosom. Res, 2003, An update on the genetics of Gilles de la Tourette syndrome	12842226	10.1016/s0022-3999(02)00586-x	Cited
Peiffer, A. et al., Ann. Neurol, 1999, A locus for febrile seizures (FEB3) maps to chromosome 2q23-24	10514109	10.1002/1531-8249(199910)46:4<671::aid-ana20>3.0.co;2-5	Cited
Peng, B. et al., Genetics, 2007, Simulations provide support for the common disease-common variant hypothesis	17151262	10.1534/genetics.106.058164	Cited
Pitkin, R.M, Am. J. Clin. Nutr, 2007, Folate and neural tube defects	17209211	10.1093/ajcn/85.1.285S	Cited
Pritchard, J.K, Am. J. Hum. Genet, 2001, Are rare variants responsible for susceptibility to complex diseases?	11404818	10.1086/321272	Cited
Rasheed, A. et al., Toxicol.Appl. Pharmacol, 1997, Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome?	9194424	10.1006/taap.1997.8152	Cited
Redon, R. et al., Nature, 2006, Global variation in copy number in the human genome	17122850	10.1038/nature05329	Cited
Reich, D.E. et al., Trends Genet, 2001, On the allelic spectrum of human disease	11525833	10.1016/s0168-9525(01)02410-6	Cited
Reik, W. et al., Development, 1993, Adult phenotype in the mouse can be affected by epigenetic events in the early embryo	8187648	10.1242/dev.119.3.933	Cited
Ribases, M. et al., Hum. Mol. Genet, 2004, Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations	15115760	10.1093/hmg/ddh137	Cited
Rideout W.M., 3rd et al., Science, 2001, Nuclear cloning and epigenetic reprogramming of the genome	11498580	10.1126/science.1063206	Cited
Risch, N, Am. J. Hum. Genet, 1990, Linkage strategies for genetically complex traits I. Multilocus models	2301392	—	Cited
Risch, N. et al., Science, 1996, The future of genetic studies of complex human diseases	8801636	10.1126/science.273.5281.1516	Cited
Risch, N.J, Nature, 2000, Searching for genetic determinants in the new millennium	10866211	10.1038/35015718	Cited
Robertson, M.M, J.Psychosom. Res, 2003, Diagnosing Tourette syndrome: is it a common disorder?	12842225	10.1016/s0022-3999(02)00580-9	Cited
Ross, C.A. et al., Neuron, 2006, Neurobiology of schizophrenia	17015232	10.1016/j.neuron.2006.09.015	Cited
Rothe, C. et al., Int. J. Neuropsychopharmacol, 2004, Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia	14984628	10.1017/S1461145703004061	Cited
Rowe, D.C. et al., Behav. Genet, 1998, The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children	9670597	10.1023/a:1021427314941	Cited
Samuels, J. et al., Am. J. Psychiatry, 2007, Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study	17329475	10.1176/ajp.2007.164.3.493	Cited
Schinka, J.A. et al., Mol. Psychiatry, 2004, A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety	14966478	10.1038/sj.mp.4001405	Cited
Schroeder, S.R, Environ. Health Perspect, 2000, Mental retardation and developmental disabilities influenced by environmental neurotoxic insults	10852834	10.1289/ehp.00108s3395	Cited
Schumacher, J. et al., Biol. Psychiatry, 2005, Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression	16005437	10.1016/j.biopsych.2005.04.006	Cited
Sebat, J. et al., Science, 2007, Strong association of de novo copy number mutations with autism	17363630	10.1126/science.1138659	Cited
Sen, S. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2004, Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits	15108187	10.1002/ajmg.b.20158	Cited
Shaywitz, S.E. et al., Jama, 1990, Prevalence of reading disability in boys and girls Results of the Connecticut Longitudinal Study	2376893	—	Cited
Shugart, Y.Y. et al., Mol. Psychiatry, 2006, Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q	16755275	10.1038/sj.mp.4001847	Cited
Slager, S.L. et al., Genet. Epidemiol, 2000, Effect of allelic heterogeneity on the power of the transmission disequilibrium test	10642427	10.1002/(SICI)1098-2272(200002)18:2<143::AID-GEPI4>3.0.CO;2-5	Cited
Smoller, J.W. et al., Am. J. Med. Genet. C Semin. Med. Genet, 2003, Family, twin, and adoption studies of bipolar disorder	14601036	10.1002/ajmg.c.20013	Cited
Steinlein, O. et al., Am. J. Med. Genet, 1997, Possible association of a silent polymorphism in the neuronal nicotinic acetylcholine receptor subunit alpha4 with common idiopathic generalized epilepsies	9259383	10.1002/(sici)1096-8628(19970725)74:4<445::aid-ajmg18>3.0.co;2-i	Cited
Stoll, C. et al., Eur. J. Epidemiol, 1992, An epidemiologic study of environmental and genetic factors in congenital hydrocephalus	1294384	10.1007/BF00145322	Cited
Stromme, P. et al., Nat. Genet, 2002, Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy	11889467	10.1038/ng862	Cited
Sullivan, P.F. et al., Nicotine Tob. Res, 1999, The genetic epidemiology of smoking	11768187	10.1080/14622299050011811	Cited
Surtees, P.G. et al., J. Psychiatr. Res, 2007, No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults	16497333	10.1016/j.jpsychires.2006.01.004	Cited
Szatmari, P. et al., Nat. Genet, 2007, Mapping autism risk loci using genetic linkage and chromosomal rearrangements	17322880	10.1038/ng1985	Cited
Tadic, A. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2003, Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression	12555227	10.1002/ajmg.b.10013	Cited
Taipale, M. et al., Proc. Natl. Acad. Sci. USA, 2003, A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain	12954984	10.1073/pnas.1833911100	Cited
Tarnok, Z. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2007, Dopaminergic candidate genes in Tourette syndrome: Association between tic severity and 3' UTR polymorphism of the dopamine transporter gene	17508355	10.1002/ajmg.b.30517	Cited
Thoeringer, C.K. et al., J. Psychiatr. Res, 2007, Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks	16904689	10.1016/j.jpsychires.2006.06.001	Cited
Thorgeirsson, T.E. et al., Am. J. Hum. Genet, 2003, Anxiety with panic disorder linked to chromosome 9q in Iceland	12679899	10.1086/375141	Cited
Tiihonen, J. et al., Mol. Psychiatry, 1999, Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism	10395222	10.1038/sj.mp.4000509	Cited
Tilgen, N. et al., Neurosci. Lett, 2002, Association analysis between the human interleukin 1beta (-511) gene polymorphism and susceptibility to febrile convulsions	12431777	10.1016/s0304-3940(02)01069-8	Cited
Timberlake, D.S. et al., Health Psychol, 2006, An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health	16569110	10.1037/0278-6133.25.2.190	Cited
Tkachev, D. et al., Lancet, 2003, Oligodendrocyte dysfunction in schizophrenia and bipolar disorder	13678875	10.1016/S0140-6736(03)14289-4	Cited
Torrey, E.F. et al., Schizophr. Res, 1996, Birth seasonality in bipolar disorder, schizophrenia, schizoaffective disorder and stillbirths	8885042	10.1016/0920-9964(96)00022-9	Cited
Torrey, E.F. et al., Schizophr. Res, 1997, Seasonality of births in schizophrenia and bipolar disorder: a review of the literature	9428062	10.1016/s0920-9964(97)00092-3	Cited
Tremolizzo, L. et al., Proc. Natl. Acad. Sci. USA, 2002, An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability	12481028	10.1073/pnas.262658999	Cited
True, W.R. et al., Arch. Gen. Psychiatry, 1993, twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms	8466386	10.1001/archpsyc.1993.01820160019002	Cited
Tsai, F.J. et al., Arch. Pediatr. Adolesc. Med, 2002, Polymorphisms for interleukin 1 beta exon 5 and interleukin 1 receptor antagonist in Taiwanese children with febrile convulsions	12038885	10.1001/archpedi.156.6.545	Cited
van der Linden, I.J. et al., J. Mol. Med, 2006, The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida	17024475	10.1007/s00109-006-0093-x	Cited
Weaver, I.C. et al., Nat. Neurosci, 2004, Epigenetic programming by maternal behavior	15220929	10.1038/nn1276	Cited
Westberg, L. et al., Neuropsychopharmacology, 2002, Association between a polymorphism of the 5-HT2C receptor and weight loss in teenage girls	12007749	10.1016/S0893-133X(01)00417-1	Cited
Whitehead, A.S. et al., Qjm, 1995, A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects	8542260	—	Cited
Willems, P.J, Am. J. Med. Genet, 1988, Heterogeneity in familial hydrocephalus	3232710	10.1002/ajmg.1320310229	Cited
Wolffe, A.P. et al., Science, 1999, Epigenetics: regulation through repression	10521337	10.1126/science.286.5439.481	Cited
Wollstein, A. et al., Nucleic Acids Res, 2007, Efficacy assessment of SNP sets for genome-wide disease association studies	17726055	10.1093/nar/gkm621	Cited
Xu, G.L. et al., Nature, 1999, Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene	10647011	10.1038/46052	Cited
Xu, K. et al., Arch. Gen. Psychiatry, 2004, Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations	15184239	10.1001/archpsyc.61.6.597	Cited
Yang, M.S. et al., Int. J. Dev. Neurosci, 2007, A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence	17236739	10.1016/j.ijdevneu.2006.12.002	Cited
Yearwood, E.L. et al., Arch. Psychiatr. Nurs, 2007, Immigrant youth at risk for disorders of mood: recognizing complex dynamics	17556109	10.1016/j.apnu.2007.02.006	Cited
Yinan, M. et al., Neurosci. Lett, 2004, Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population	15342122	10.1016/j.neulet.2004.06.054	Cited
Yoon, D.Y. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2007, Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3)	17171650	10.1002/ajmg.b.30466	Cited
Zemni, R. et al., Nat. Genet, 2000, new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation	10655063	10.1038/72829	Cited
Zhang, H. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2006, Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence	16649215	10.1002/ajmg.b.30332	Cited
Zhang, J. et al., J. Neurol, 2006, Genetics of human hydrocephalus	16773266	10.1007/s00415-006-0245-5	Cited
Zhu, H. et al., BMC Med. Genet, 2007, Association between CFL1 gene polymorphisms and spina bifida risk in a California population	17352815	10.1186/1471-2350-8-12	Cited
Zhu, H. et al., Mol. Genet. Metab, 2004, Promoter haplotype combinations for the human PDGFRA gene are associated with risk of neural tube defects	14741194	10.1016/j.ymgme.2003.11.003	Cited
Zhu, H. et al., Mol. Genet. Metab, 2006, A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida	16256389	10.1016/j.ymgme.2005.09.008	Cited

In this knowledge base

Title	Year	PMID
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	2019	30087005

External

Title	Authors	Journal	Year	Link
Cumulative environmental exposures adversely impact social behaviour and are associated with dysregulation of genes and proteins involved in epigenetic, ribosomal, and immune regulation in male mice.	Bucknor MC et al.	—	2026	→
Limitations and opportunities in multi-omics integration for neurodevelopmental, neurodegenerative and psychiatric disorders: A systematic review.	Behrens LMP et al.	—	2026	→
A peripheral irritant motor response (PIMR) assay to identify chemical-induced locomotor deficits in larval zebrafish (Danio rerio).	McAtee D et al.	—	2025	→
GLUT1 and Cerebral Glucose Hypometabolism in Human Focal Cortical Dysplasia Is Associated with Hypermethylation of Key Glucose Regulatory Genes.	Ghosh C et al.	—	2025	→
Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice.	Dudas A et al.	—	2025	→
Parents' perspectives on conversations about prognosis and an assessment of prognostic information available online: A mixed-methods study.	Gokoolparsadh A et al.	—	2025	→
Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.	Al-Beltagi M et al.	—	2025	→
A Comprehensive Review on Current Insights Into Epileptic Encephalopathy: Pathogenesis and Therapeutic Strategies.	Patil R et al.	—	2024	→
Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model.	Hsieh CC et al.	—	2024	→
An examination of the association between infant non-nutritive suck and developmental outcomes at 12 months.	Martens A et al.	—	2024	→
A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0.	Locubiche S et al.	—	2024	→
Bisphenol A (BPA) and neurological disorders: An overview.	Hyun SA et al.	—	2024	→
Case Report: Intellectual disability and borderline intellectual functioning in two sisters with a 12p11.22 loss.	Choi H et al.	—	2024	→
Exploring hub genes and crucial pathways linked to oxidative stress in bipolar disorder depressive episodes through bioinformatics analysis.	Wu S et al.	—	2024	→
Neuropsychological profile in a child with Buschke-Ollendorff syndrome: A case report	Covuccia M et al.	—	2024	—
Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems.	Rokach M et al.	—	2024	→
The early life exposome and autism risk: a role for the maternal microbiome?	Di Gesù CM et al.	—	2024	→
Tactile sensory processing as a precursor of executive attention: Toward early detection of attention impairments and neurodevelopmental disorders.	Anquetil M et al.	—	2023	→
Epidemiological Profile of Children with Neurodevelopmental Disorders in a Diagnostic Center in Southern Puerto Rico, 2006-2017.	Pacheco M et al.	—	2022	→
Identifying Boys With Autism Spectrum Disorder Based on Whole-Brain Resting-State Interregional Functional Connections Using a Boruta-Based Support Vector Machine Approach.	Zhao L et al.	—	2022	→
Integrated Analysis of miRNA and mRNA Expression Profiles Reveals the Molecular Mechanism of Posttraumatic Stress Disorder and Therapeutic Drugs.	Gan C et al.	—	2022	→
Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan.	Perfilyeva A et al.	—	2022	→
Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update.	Asgharian P et al.	—	2022	→
Role of melatonin in autism spectrum disorders in a male murine transgenic model: Study in the prefrontal cortex.	Borsani E et al.	—	2022	→
The Crosstalk Between Neurons and Glia in Methamphetamine-Induced Neuroinflammation.	Shi S et al.	—	2022	→
Association of maternal diabetes with neurodevelopmental disorders: autism spectrum disorders, attention-deficit/hyperactivity disorder and intellectual disability.	Chen S et al.	—	2021	→
Co-Design of a Neurodevelopment Assessment Scale: A Study Protocol.	Masi A et al.	—	2021	→
Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia.	Mike JK et al.	—	2021	→
Exposure to 3'Sialyllactose-Poor Milk during Lactation Impairs Cognitive Capabilities in Adulthood.	Pisa E et al.	—	2021	→
Novel frameshift mutation in PURA gene causes severe encephalopathy of unclear cause.	Spangenberg L et al.	—	2021	→
Pituitary stalk interruption syndrome.	Voutetakis A	—	2021	→
Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle.	Bonnycastle K et al.	—	2021	→
Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.	Siemann JK et al.	—	2021	→
SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants.	Figueiredo CP et al.	—	2021	→
A Bibliometric Insight of Genetic Factors in ASD: Emerging Trends and New Developments.	Wang K et al.	—	2020	→
A Pilot Randomized Control Trial With the Probiotic Strain <i>Lactobacillus rhamnosus</i> GG (LGG) in ADHD: Children and Adolescents Report Better Health-Related Quality of Life.	Kumperscak HG et al.	—	2020	→
Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology.	Cheroni C et al.	—	2020	→
CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.	Xu Q et al.	—	2020	→
Increased RNA editing in maternal immune activation model of neurodevelopmental disease.	Tsivion-Visbord H et al.	—	2020	→
Reproducible differentiation and characterization of neurons from mouse embryonic stem cells.	Saxena S et al.	—	2020	→
Right Place at the Right Time: How Changes in Protocadherins Affect Synaptic Connections Contributing to the Etiology of Neurodevelopmental Disorders.	Mancini M et al.	—	2020	→
Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes.	Ilan Y	—	2020	→
Zebrafish as a Model of Neurodevelopmental Disorders.	de Abreu MS et al.	—	2020	→
Artificial intelligence for precision medicine in neurodevelopmental disorders.	Uddin M et al.	—	2019	→
Contemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders.	Seo DO et al.	—	2019	→
Management of Self-injurious Behaviors in Children with Neurodevelopmental Disorders: A Pharmacotherapy Overview.	Sabus A et al.	—	2019	→
Neuronal migration in the CNS during development and disease: insights from <i>in vivo</i> and <i>in vitro</i> models.	Buchsbaum IY et al.	—	2019	→
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	Scarnati MS et al.	—	2019	→
Developmental trajectories of children with Down syndrome by socio-economic status: the case of Latin America.	Arango PS et al.	—	2018	→
Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II.	Dixit AB et al.	—	2018	→
Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.	Fisher NM et al.	—	2018	→
Mother-newborn separation at birth in hospitals: A possible risk for neurodevelopmental disorders?	Császár-Nagy N et al.	—	2018	→
Opportunities for an enhanced integration of neuroscience and genomics.	Moore AA et al.	—	2018	→
Optimizing an eHealth insomnia intervention for children with neurodevelopmental disorders: a Delphi study.	Ali N et al.	—	2018	→
Reanalysis of exome sequencing data of intellectual disability samples: Yields and benefits.	Al-Nabhani M et al.	—	2018	→
Understanding Neurodevelopmental Disorders: The Promise of Regulatory Variation in the 3'UTRome.	Wanke KA et al.	—	2018	→
E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration.	Upadhyay A et al.	—	2017	→
Environmental Pollutants and Neurodevelopment: Review of Benefits From Closure of a Coal-Burning Power Plant in Tongliang, China.	Kalia V et al.	—	2017	→
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders.	Neniskyte U et al.	—	2017	→
Gut microbiota and attention deficit hyperactivity disorder: new perspectives for a challenging condition.	Cenit MC et al.	—	2017	→
Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during <i>in-Vitro</i> Human Embryonic Cortical Neurogenesis.	Parween S et al.	—	2017	→
Influence of gut microbiota on neuropsychiatric disorders.	Cenit MC et al.	—	2017	→
Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring.	Banik A et al.	—	2017	→
Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.	Philippat C et al.	—	2017	→
Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children.	Levy RJ et al.	—	2016	→
Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review.	Blackmer AB et al.	—	2016	→
Oxytocin reversed MK-801-induced social interaction and aggression deficits in zebrafish.	Zimmermann FF et al.	—	2016	→
RNA-binding proteins, neural development and the addictions.	Bryant CD et al.	—	2016	→
Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders.	Schubert D et al.	—	2015	→
The impact of obstetric mode of delivery on childhood behavior.	Al Khalaf SY et al.	—	2015	→
An inside job: how endosomal Na(+)/H(+) exchangers link to autism and neurological disease.	Kondapalli KC et al.	—	2014	→
Modeling neurodevelopmental disorders using human pluripotent stem cells.	Telias M et al.	—	2014	→
Novel homozygous DEAF1 variant suspected in causing white matter disease, intellectual disability, and microcephaly.	Faqeih EA et al.	—	2014	→
Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.	Hashimoto-Torii K et al.	—	2014	→
Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins.	Li J et al.	—	2013	→
A review on genetics of sleep disorders.	Bidaki R et al.	—	2012	→
Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.	Zain MA et al.	—	2012	→
Signals controlling rest and reactivation of T helper memory lymphocytes in bone marrow.	Tokoyoda K et al.	—	2012	→
Molecular cytogenetics and cytogenomics of brain diseases.	Iourov IY et al.	—	2008	→