An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back.
paper
Cited
Public
- Authors
- Dick, Danielle M
- Year
- 2011
- Journal
- Research in human development
- PMID
- 34385894
- DOI
- 10.1080/15427609.2011.625317
- PMCID
- PMC8356710
There has been a surge of interest in studying gene-environment interaction; however, research in this area faces a number of challenges. Interdisciplinary collaborations are critical at this juncture. This article reviews studies that illustrate how findings across different literatures can be synthesized to characterize how genetic and environmental influences impact developmental pathways. Developmental scientists are poised to make important contributions to studying gene-environment interaction. However, for this potential to be realized developmental-genetic studies must incorporate the most recent advances in genetics, and bridge the current schism that exists between genetic research being conducted in the fields of psychology and genetics.
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| Name | Type |
|---|---|
| additive genetic influences | cohort |
| ADH1B | gene |
| adolescent alcohol use | phenotype |
| adult alcohol dependence | phenotype |
| adult antisocial behavior | phenotype |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| Alcohol Problems | phenotype |
| Alcohol Use | phenotype |
| ALDH2 | gene |
| antisocial personality disorder | phenotype |
| behavior | phenotype |
| behavioral outcomes | phenotype |
| behavior problems | phenotype |
| CDP local | cohort |
| CFTR | gene |
| Child Development Project local | cohort |
| childhood conduct disorder | phenotype |
| CHRM2 | gene |
| COGA sample | cohort |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| Common environmental influences local | phenotype |
| cystic fibrosis | phenotype |
| depression | phenotype |
| deviant peers | phenotype |
| Difficult temperament | phenotype |
| Dominant genetic influences local | phenotype |
| Early adolescent experimentation local | phenotype |
| Electrophysiological measures | phenotype |
| emerging adulthood | cohort |
| endophenotype | phenotype |
| externalizing behavior | phenotype |
| externalizing disorders | phenotype |
| family history of alcoholism | phenotype |
| family history positive | phenotype |
| Finnish twin studies local | cohort |
| frequency of alcohol use | phenotype |
| GABA | phenotype |
| GABRA2 | gene |
| Gene Identification Projects local | cohort |
| genetic factors | cohort |
| geneticists local | cohort |
| Girls age 14 local | cohort |
| GxE interaction local | phenotype |
| GxE Interaction Studies local | cohort |
| heritability | phenotype |
| Human Genome Project | cohort |
| illicit drugs | phenotype |
| International Hapmap Project | cohort |
| K awards local | cohort |
| Late adolescence (ages 16–18) local | cohort |
| Latent genetic influences local | phenotype |
| MAOA | gene |
| Measured genetic influences local | phenotype |
| National Institutes of Health | cohort |
| nicotine | drug |
| nicotine receptor genes local | gene |
| novelty seeking | phenotype |
| Ordinary siblings local | cohort |
| parental monitoring | phenotype |
| peer antisocial behavior local | phenotype |
| peer deviance | phenotype |
| poor parenting local | phenotype |
| psychiatric disorders | phenotype |
| psychiatric traits | phenotype |
| Psychological outcome local | phenotype |
| psychologists | cohort |
| Quantitative drinking measures local | phenotype |
| SLC6A4 | gene |
| smoking behavior | phenotype |
| substances | phenotype |
| substance use | phenotype |
| temperament | phenotype |
| Twin cohort | cohort |
| type 2 diabetes | phenotype |
| unmarried women | phenotype |
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External
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| Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use. | Pasman JA et al. | — | 2019 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| The media and behavioral genetics: Alternatives coexisting with addiction genetics. | Dingel MJ et al. | — | 2015 | → |
| Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. | Weeland J et al. | — | 2015 | → |
| Defining the environment in gene-environment research: lessons from social epidemiology. | Boardman JD et al. | — | 2013 | → |