Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.
paper
Cited
Public
- Authors
- Ciccocioppo, Roberto; Gehlert, Donald R; Ryabinin, Andrey; Kaur, Simranjit; Cippitelli, Andrea; Thorsell, Annika; LΓͺ, Anh D; Hipskind, Philip A; Hamdouchi, Chafiq; Lu, Jianliang; Hembre, Erik J; Cramer, Jeffrey; Song, Min; McKinzie, David; Morin, Michelle; Economidou, Daina; Stopponi, Serena; Cannella, Nazzareno; Braconi, Simone; Kallupi, Marsida; de Guglielmo, Giordano; Massi, Maurizio; George, David T; Gilman, Jody; Hersh, Jacqueline; Tauscher, Johannes T; Hunt, Stephen P; Hommer, Daniel; Heilig, Markus
- Year
- 2009
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 19913192
- DOI
- 10.1016/j.alcohol.2009.08.003
- PMCID
- PMC2804869
This article summarizes the proceedings of a symposium held at the conference on "Alcoholism and Stress: A Framework for Future Treatment Strategies" in Volterra, Italy, May 6-9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol-related behaviors in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin-releasing factor receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory, indicating a role of the urocortin 1 receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropeptide Y receptor system in the modulation of behaviors associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism.
No figures extracted from this document.
β Prev
21β40 of 40
| Name | Type |
|---|---|
| 125I-sauvagine local | drug |
| AA rats | cohort |
| acamprosate | drug |
| ACTH | drug |
| addiction | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol Exposure | phenotype |
| Alcoholic behaviors local | phenotype |
| alcoholism | phenotype |
| alcohol preference | phenotype |
| alcohol-preferring rat lines local | cohort |
| Alcohol seeking | phenotype |
| alcohol self-administration | phenotype |
| alcohol sensitivity | phenotype |
| Alcohol Use | phenotype |
| amygdala | anatomy |
| anxiety | phenotype |
| anxiety-like behavior | phenotype |
| Anxiogenic-like effect local | phenotype |
| anxiolytic effect | phenotype |
| anxious recently detoxified alcoholics local | cohort |
| Behavioral adaptation to stressors local | phenotype |
| Behavioral insensitivity to restraint stress local | phenotype |
| BIIE0246 | drug |
| BLA | anatomy |
| BNST | anatomy |
| BOLD response to negative affective stimuli local | phenotype |
| BOLD response to positive stimuli local | phenotype |
| Brain CRH system dysregulation local | phenotype |
| buprenorphine | drug |
| C57BL/6J | cohort |
| CeA | anatomy |
| central amygdala | anatomy |
| central nervous system | anatomy |
| cerebellum | anatomy |
| c-fos | gene |
| cocaine | phenotype |
| conditioned place preference | phenotype |
| Conditioned reinstatement local | phenotype |
| Conditioned reinstatement of alcohol seeking local | phenotype |
| cortex | anatomy |
| corticotropins local | drug |
| cortisol | drug |
| CP154526 local | drug |
| craving | phenotype |
| CRF | drug |
| CRH | gene |
| CRH antagonist local | drug |
| CRH antagonists local | drug |
| CRHBP | gene |
| CRHR1 | gene |
| CRHR2 | gene |
| DBA/2J | cohort |
| depression | phenotype |
| Depression disorder local | phenotype |
| Detoxified alcoholic inpatients local | cohort |
| disulfiram | drug |
| dorsal raphe nucleus | anatomy |
| drug dependence | phenotype |
| Drugs targeting peptidic systems local | drug |
| Edinger-Westphal nucleus | anatomy |
| Elevated plus-maze local | phenotype |
| ethanol consumption | phenotype |
| ethanol-induced hypothermia | phenotype |
| ethanol preference | phenotype |
| Ethanol responding local | phenotype |
| Ethanol reward local | phenotype |
| ethanol seeking reinstatement local | phenotype |
| excessive alcohol self-administration local | phenotype |
| Excessive alcohol self-administration local | phenotype |
| Fear-linked suppression of behavior local | phenotype |
| Foot shock stress local | drug |
| foot shock stress-induced reinstatement local | phenotype |
| gamma-hydroxybutyrate | drug |
| GR205171 local | drug |
| HAP1 local | cohort |
| HAP2 local | cohort |
| heavy drinking | phenotype |
| high alcohol intake rat lines local | cohort |
| high alcohol preference | phenotype |
| High ethanol preference local | phenotype |
| hippocampus | anatomy |
| Home cage ethanol drinking local | phenotype |
| HPA axis dysregulation | anatomy |
| humans | cohort |
| hypothalamus | anatomy |
| LAP1 local | cohort |
| LAP2 local | cohort |
| lateral septum | anatomy |
| lateral superior olive local | anatomy |
| low alcohol intake rat lines local | cohort |
| low alcohol preference | phenotype |
| LY686017 local | drug |
| Marchigian Sardinian (msP) rat local | cohort |
| Marchigian Sardinian rat local | cohort |
| mice | cohort |
| mood disorders | phenotype |
| msP rats local | cohort |
| MTIP | drug |
| NaΓ―ve animals local | cohort |
| naltrexone | drug |
| Neuropeptidergic system local | drug |
| neuropeptide Y | drug |
| NK1 antagonist local | drug |
| NK1 receptor knockout mice local | cohort |
| N/OFQ | drug |
| N/OFQ receptor agonist local | drug |
| Nondependent rats local | cohort |
| non-preferring rat lines local | cohort |
| NOP receptor local | drug |
| NOP receptor local | gene |
| NPY | gene |
| NPY1R | gene |
| NPY2R | gene |
| NPY4R local | gene |
| NPY5R | gene |
| nucleus accumbens | anatomy |
| ondansetron | drug |
| opioid | drug |
| OPRL1 | cohort |
| overall well-being local | phenotype |
| pain | phenotype |
| perioculomotor Ucn 1-containing area (pIIIu) local | anatomy |
| pIIIu local | anatomy |
| pituitary gland | anatomy |
| PNOC | gene |
| Post-dependent animals local | cohort |
| Postdependent rats local | cohort |
| Post-dependent state local | phenotype |
| R121919 local | drug |
| rats | cohort |
| Rats with a history of dependence local | cohort |
| Rats with a history of ethanol exposure local | cohort |
| relapse | phenotype |
| rodents | cohort |
| saccharin | drug |
| Saccharine local | drug |
| social anxiety | phenotype |
| spinal cord | anatomy |
| spontaneous alcohol craving local | phenotype |
| Sprague-Dawley rats | cohort |
| stress | phenotype |
| stressβalcohol cue induced craving local | phenotype |
| stress and reward brain areas local | anatomy |
| Stress-induced alcohol seeking | phenotype |
| Stress-induced ethanol-seeking local | phenotype |
| Stress-induced reinstatement of ethanol-seeking local | phenotype |
| Stress-regulating peptidic systems local | drug |
| stress response | phenotype |
| subjective well-being | phenotype |
| substance P | drug |
| tachykinins | drug |
| TacR1 | gene |
| topiramate | drug |
| Ucn1 | drug |
| Ucn2 | drug |
| Ucn3 | drug |
| voluntary alcohol consumption | phenotype |
| VTA | anatomy |
| Wildtype littermates local | cohort |
| Wistar rats | cohort |
| Wistars local | cohort |
| Y2-antagonist local | drug |
| Y2-preferring agonist local | drug |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Substance P/Neurokinin-1 receptor signaling exhibits sex-specific regulation of inhibitory transmission in the central amygdala. | Gashi L et al. | β | 2026 | β |
| Alcohol induces concentration-dependent transcriptomic changes in oligodendrocytes. | Bazzi SA et al. | β | 2025 | β |
| "Maladaptive stress-coping behavior in CX<sub>3</sub>CR1-deficient mice: Impact of adolescent stress and alcohol exposure on neuroimmune responses and inflammation". | Medina-Vera D et al. | β | 2025 | β |
| Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice. | Fu Y et al. | β | 2024 | β |
| Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats. | Khom S et al. | β | 2022 | β |
| Genetic deletion or pharmacological blockade of nociceptin/orphanin FQ receptors in the ventral tegmental area attenuates nicotine-motivated behaviour. | Domi A et al. | β | 2022 | β |
| Neuropeptidergic regulation of compulsive ethanol seeking in C. elegans. | Salim C et al. | β | 2022 | β |
| Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, Ξ²-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders. | Haass-Koffler CL et al. | β | 2021 | β |
| Does endogenous cholecystokinin modulate alcohol intake? | Ballaz S et al. | β | 2021 | β |
| Genetically selected alcohol-preferring msP rats to study alcohol use disorder: Anything lost in translation? | Borruto AM et al. | β | 2021 | β |
| Neuropeptide Y Gene Γ Environment Interaction Predicts Resilience and Positive Future Focus. | Gan Y et al. | β | 2019 | β |
| NOP-Related Mechanisms in Substance Use Disorders. | Ciccocioppo R et al. | β | 2019 | β |
| NOP-Targeted Nonpeptide Ligands. | Zaveri NT et al. | β | 2019 | β |
| Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice. | Santos-Rocha JB et al. | β | 2018 | β |
| Influence of stress associated with chronic alcohol exposure on drinking. | Becker HC | β | 2017 | β |
| Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models. | Yardley MM et al. | β | 2017 | β |
| Neurochemical Markers in the Mammalian Brain: Structure, Roles in Synaptic Communication, and Pharmacological Relevance. | Rees CL et al. | β | 2017 | β |
| Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function. | Thorsell A et al. | β | 2016 | β |
| Alcohol and violence: neuropeptidergic modulation of monoamine systems. | Miczek KA et al. | β | 2015 | β |
| Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. | Lang R et al. | β | 2015 | β |
| Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats. | Cippitelli A et al. | β | 2015 | β |
| Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation. | Phillips TJ et al. | β | 2015 | β |
| Social partners prevent alcohol relapse behavior in prairie voles. | Hostetler CM et al. | β | 2014 | β |
| Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. | Zorrilla EP et al. | β | 2013 | β |
| Comparative distribution of central neuropeptide Y (NPY) in the prairie (Microtus ochrogaster) and meadow (M. pennsylvanicus) vole. | Hostetler CM et al. | β | 2013 | β |
| Neuropeptide Y and posttraumatic stress disorder. | Sah R et al. | β | 2013 | β |
| Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats. | Ayanwuyi LO et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G Γ E effects. | Ray LA et al. | β | 2013 | β |
| Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. | Sirohi S et al. | β | 2012 | β |
| Association study of 45 candidate genes in nicotine dependence in Han Chinese. | Wei J et al. | β | 2012 | β |
| Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption. | Becker HC | β | 2012 | β |
| Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. | Cippitelli A et al. | β | 2012 | β |
| The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans. | Kenna GA et al. | β | 2012 | β |
| Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. | Breese GR et al. | β | 2011 | β |
| Does midbrain urocortin 1 matter? A 15-year journey from stress (mal)adaptation to energy metabolism. | Kozicz T et al. | β | 2011 | β |
| Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala. | Lam MP et al. | β | 2011 | β |
| Effects of stress on alcohol drinking: a review of animal studies. | Becker HC et al. | β | 2011 | β |
| Effects of voluntary running in the female mice lateral septum on BDNF and corticotropin-releasing factor receptor 2. | Gustafsson S et al. | β | 2011 | β |
| Elevated serum levels of neuropeptide Y in stress cardiomyopathy. | Szardien S et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Emerging drugs to treat alcoholism. | Soyka M et al. | β | 2010 | β |