Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.
paper
Cited
Public
- Authors
- Lister, Ryan; Pelizzola, Mattia; Kida, Yasuyuki S; Hawkins, R David; Nery, Joseph R; Hon, Gary; Antosiewicz-Bourget, Jessica; O'Malley, Ronan; Castanon, Rosa; Klugman, Sarit; Downes, Michael; Yu, Ruth; Stewart, Ron; Ren, Bing; Thomson, James A; Evans, Ronald M; Ecker, Joseph R
- Year
- 2011
- Journal
- Nature
- PMID
- 21289626
- DOI
- 10.1038/nature09798
- PMCID
- PMC3100360
Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine and studies of disease and development. Somatic cell reprogramming involves epigenomic reconfiguration, conferring iPSCs with characteristics similar to embryonic stem (ES) cells. However, it remains unknown how complete the reestablishment of ES-cell-like DNA methylation patterns is throughout the genome. Here we report the first whole-genome profiles of DNA methylation at single-base resolution in five human iPSC lines, along with methylomes of ES cells, somatic cells, and differentiated iPSCs and ES cells. iPSCs show significant reprogramming variability, including somatic memory and aberrant reprogramming of DNA methylation. iPSCs share megabase-scale differentially methylated regions proximal to centromeres and telomeres that display incomplete reprogramming of non-CG methylation, and differences in CG methylation and histone modifications. Lastly, differentiation of iPSCs into trophoblast cells revealed that errors in reprogramming CG methylation are transmitted at a high frequency, providing an iPSC reprogramming signature that is maintained after differentiation.
Global trends of human iPSC and ES cell DNA methylomesa, Per cent of all cytosines on each strand of the human genome assayed for each sample. b, c, The per cent of all sequencing base calls that were methylated (C, resistant to bisulphite conversion) at covered C bases in the CG (b) and CH contexts (c) (where H = A, C, or T) throughout the genome, minus the bisulphite non-conversion frequency. d, AnnoJ data browser representation of the restoration of non-CG methylation in all iPSC and ES cell lines. e, Dendrogram of the analysed cell lines based on Pearson correlation of mCG or mCH levels in 1-kb windows throughout the genome.
Partially methylated domains become highly methylated on induction of pluripotencya, Total length of PMDs identified in each cell line and overlap of PMDs identified in the four somatic cell types. b, mRNA-Seq RPKM (reads per kilobase of exon per million reads) values for all RefSeq genes outside PMDs, and all RefSeq genes within genomic regions defined as PMDs. For ADS-iPSC and H1 the ADS PMD genomic regions were used as PMDs. P value is from two-tailed Wilcoxon test between ADS PMDs and ADS-iPSC PMDs.
CG-DMRs identified between pluripotent cellsa, Complete linkage hierarchical clustering of mCG density within CG-DMRs identified between all ES cell and iPSC DNA methylomes. Each CG-DMR was profiled over 20 equally sized bins. b, The CG-DMRs for each iPSC line with respect to H1 and H9 ES cells were categorized as having methylation patterns like the progenitor somatic cell line (memory) or iPSC-specific (iDMR). c, Number of iPSC hypomethylated and hypermethyated CG-DMRs aberrant in the indicated number of iPSC lines. d, Number of all CG-DMRs coincident with indicated genomic and genic features. CGI, CG island; TES, transcriptional end site; TSS, transcriptional start site.
Characterization of CG-DMRs in iPSCsa, Normalized mCG levels (lower y-axis) and normalized H3K27me3 ChIP-Seq read density (upper y-axis) over CG-DMRs hypermethylated in all iPSC lines and flanking genomic regions. b, Data browser representation of mRNA, DNA methylation and H3K27me3 density for a CG-DMR identified in all iPSC lines. c, Complete linkage hierarchical clustering of mCG density within the CG-DMRs hypomethylated in both FF-iPSC 19.11 and FF-iPSC 19.11-BMP4 relative to H1, H9 and H1-BMP4 cell lines. Each CG-DMR was profiled over 20 equally sized bins. d, Same as c for hypermethylated CG-DMRs. e, FF-iPSC 19.11 CG-DMR transmission through differentiation to trophoblast cells. CG-DMRs were categorized by methylation state relative to the ES cells (hyper, hypermethylated; hypo, hypomethylated), similarity to somatic progenitor methylation (memory: like progenitor; iDMR: unlike progenitor), and whether the CG-DMR was present in FF-iPSC 19.11 differentiated into trophoblast cells with BMP4 (transmitted) or not (not transmitted).
Failure to restore megabase-scale regions of non-CG methylation is a hallmark of iPSC reprogramminga, Chromosome ideograms and length distribution (inset) of the 22 ADS-iPSC non-CG mega-DMRs. Blue circles and lines indicate location of individual DMRs. Red ellipses indicate the location of centromeres. b, Normalized mCH levels over all non-CG mega-DMRs and flanking genomic regions. c, Lower y-axis as in b for the cell lines indicated. Upper y-axis shows normalized H3K9me3 ChIP-Seq read density throughout the non-CG mega-DMRs and flanking genomic regions. Dashed blue arrows indicate the inverse relationship between mCH and H3K9me3. d, Plot shows normalized mCG levels over the non-CG mega-DMRs and flanking genomic regions. Inset is a data browser representation of DNA methylation where vertical bar height indicates mC level at the 5′ of a non-CG mega-DMR and PMD. e, Normalized mCH levels over a non-CG mega-DMR on chromosome 22 and flanking regions. Top panel shows gene models and ADS-iPSC mCH. f, Comparison of transcript abundance between H1 and ADS-iPSC. Each dot represents a RefSeq gene within the 22 non-CG mega-DMRs. Red dots indicate genes that have a CG-DMR within 2 kb of the transcriptional start site. Blue dots indicate genes that have a CG-DMR within 2 kb of the transcriptional start site, are hypermethylated in all iPSC lines and are associated with loss of H3K27me3. Red dashed lines represent twofold difference. g, The number of genes with a given transcript abundance ratio between H1 and ADS-iPSCs for all RefSeq genes within the non-CG mega-DMRs.
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| Enhanced Ex Vivo Generation of Erythroid Cells from Human Induced Pluripotent Stem Cells in a Simplified Cell Culture System with Low Cytokine Support. | Bernecker C et al. | — | 2019 | → |
| Epigenetic aberrations in human pluripotent stem cells. | Bar S et al. | — | 2019 | → |
| Epigenetic silencing of a multifunctional plant stress regulator. | Zander M et al. | — | 2019 | → |
| Generation of Stable Induced Pluripotent Stem-like Cells from Adult Zebra Fish Fibroblasts. | Peng L et al. | — | 2019 | → |
| Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis. | Ziff OJ et al. | — | 2019 | → |
| HOME: a histogram based machine learning approach for effective identification of differentially methylated regions. | Srivastava A et al. | — | 2019 | → |
| How Does Reprogramming to Pluripotency Affect Genomic Imprinting? | Perrera V et al. | — | 2019 | → |
| Hypomethylation at non-CpG/CpG sites in the promoter of HIF-1α gene combined with enhanced H3K9Ac modification contribute to maintain higher HIF-1α expression in breast cancer. | Li C et al. | — | 2019 | → |
| Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. | Karagiannis P et al. | — | 2019 | → |
| Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors. | Noguchi H et al. | — | 2019 | → |
| iPS-Cell Technology and the Problem of Genetic Instability-Can It Ever Be Safe for Clinical Use? | Attwood SW et al. | — | 2019 | → |
| Lamina Associated Domains and Gene Regulation in Development and Cancer. | Lochs SJA et al. | — | 2019 | → |
| Latest techniques to study DNA methylation. | Gouil Q et al. | — | 2019 | → |
| Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming. | Spyrou J et al. | — | 2019 | → |
| Metabolomic and Transcriptional Analyses Reveal Atmospheric Oxygen During Human Induced Pluripotent Stem Cell Generation Impairs Metabolic Reprogramming. | Spyrou J et al. | — | 2019 | → |
| Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells. | Chen YH et al. | — | 2019 | → |
| Modeling Disease with Human Inducible Pluripotent Stem Cells. | Grandy R et al. | — | 2019 | → |
| New considerations for hiPSC-based models of neuropsychiatric disorders. | Hoffman GE et al. | — | 2019 | → |
| Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells. | Saetersmoen ML et al. | — | 2019 | → |
| Paradoxical association of TET loss of function with genome-wide DNA hypomethylation. | López-Moyado IF et al. | — | 2019 | → |
| Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation. | Brinkman AB et al. | — | 2019 | → |
| Predicting differentiation potential of human pluripotent stem cells: Possibilities and challenges. | Liu LP et al. | — | 2019 | → |
| Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data. | Moumi NA et al. | — | 2019 | → |
| Rapid Multiplexed Reduced Representation Bisulfite Sequencing Library Prep (rRRBS). | Legault LM et al. | — | 2019 | → |
| Role of ten-eleven translocation proteins and 5-hydroxymethylcytosine in hepatocellular carcinoma. | Wang P et al. | — | 2019 | → |
| The impact of transposable element activity on therapeutically relevant human stem cells. | Schumann GG et al. | — | 2019 | → |
| The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia. | Apicella C et al. | — | 2019 | → |
| The Safe and Efficacious Use of Secretome From Fibroblasts and Adipose-derived (but not Bone Marrow-derived) Mesenchymal Stem Cells for Skin Therapeutics. | Maguire G | — | 2019 | → |
| A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains. | Salhab A et al. | — | 2018 | → |
| Actin and myosin II modulate differentiation of pluripotent stem cells. | Boraas LC et al. | — | 2018 | → |
| Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly. | Ravaioli F et al. | — | 2018 | → |
| A Lexicon of DNA Modifications: Their Roles in Embryo Development and the Germline. | Zhu Q et al. | — | 2018 | → |
| Amphioxus functional genomics and the origins of vertebrate gene regulation. | Marlétaz F et al. | — | 2018 | → |
| Biological characterization of human amniotic epithelial cells in a serum-free system and their safety evaluation. | Yang PJ et al. | — | 2018 | → |
| Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells. | Deng J et al. | — | 2018 | → |
| Cell-type-specific brain methylomes profiled via ultralow-input microfluidics. | Ma S et al. | — | 2018 | → |
| Cellular Models: HD Patient-Derived Pluripotent Stem Cells. | Geater C et al. | — | 2018 | → |
| Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA. | Miyagi-Shiohira C et al. | — | 2018 | → |
| Chronic social stress induces DNA methylation changes at an evolutionary conserved intergenic region in chromosome X. | Hing B et al. | — | 2018 | → |
| Comprehensive Whole DNA Methylome Analysis by Integrating MeDIP-seq and MRE-seq. | Xing X et al. | — | 2018 | → |
| Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues. | Chen F et al. | — | 2018 | → |
| Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease. | Kwak KA et al. | — | 2018 | → |
| Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC. | Li J et al. | — | 2018 | → |
| Development and disease in a dish: the epigenetics of neurodevelopmental disorders. | Lewis EM et al. | — | 2018 | → |
| Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors. | Yoon JK et al. | — | 2018 | → |
| Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. | Gilsbach R et al. | — | 2018 | → |
| DNA methylation and de-methylation using hybrid site-targeting proteins. | Lei Y et al. | — | 2018 | → |
| DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium. | Yizhar-Barnea O et al. | — | 2018 | → |
| DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia. | Keller S et al. | — | 2018 | → |
| DNA methylation loss in late-replicating domains is linked to mitotic cell division. | Zhou W et al. | — | 2018 | → |
| Drug screening for human genetic diseases using iPSC models. | Elitt MS et al. | — | 2018 | → |
| Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors. | Nishino K et al. | — | 2018 | → |
| From 1D sequence to 3D chromatin dynamics and cellular functions: a phase separation perspective. | Liu S et al. | — | 2018 | → |
| Generation of human oogonia from induced pluripotent stem cells in vitro. | Yamashiro C et al. | — | 2018 | → |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | — | 2018 | → |
| Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. | Ping W et al. | — | 2018 | → |
| Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality. | González-Nieto D et al. | — | 2018 | → |
| Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association. | Musunuru K et al. | — | 2018 | → |
| Induced Tissue-Specific Stem Cells and Epigenetic Memory in Induced Pluripotent Stem Cells. | Noguchi H et al. | — | 2018 | → |
| Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicating RNA. | Miyagi-Shiohira C et al. | — | 2018 | → |
| In vitro differentiation of human multilineage differentiating stress-enduring (Muse) cells into insulin producing cells. | Fouad AM et al. | — | 2018 | → |
| Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in <i>Arabidopsis</i>. | Zhang Y et al. | — | 2018 | → |
| Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance. | Latchney SE et al. | — | 2018 | → |
| Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining. | Zhang M et al. | — | 2018 | → |
| Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation. | Bartholdy B et al. | — | 2018 | → |
| Mitochondria and the dynamic control of stem cell homeostasis. | Lisowski P et al. | — | 2018 | → |
| On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations. | Wu S et al. | — | 2018 | → |
| Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor. | Tan YT et al. | — | 2018 | → |
| Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures. | Wang L et al. | — | 2018 | → |
| Rules governing the mechanism of epigenetic reprogramming memory. | Luu PL et al. | — | 2018 | → |
| Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing. | Liu JX et al. | — | 2018 | → |
| Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning. | Yu D et al. | — | 2018 | → |
| Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications. | Matoba S et al. | — | 2018 | → |
| Stem Cell Treatment in Retinal Diseases: Recent Developments. | Öner A | — | 2018 | → |
| Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications. | Omole AE et al. | — | 2018 | → |
| The Development of Cancer through the Transient Overexpression of Reprogramming Factors. | Miyagi-Shiohira C et al. | — | 2018 | → |
| The effect of age on stem cell function and utility for therapy. | Narbonne P | — | 2018 | → |
| The Role of microRNAs in Embryonic and Induced Pluripotency. | Beh-Pajooh A et al. | — | 2018 | → |
| The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells. | Mishra S et al. | — | 2018 | → |
| Whole-Genome Bisulfite Sequencing for the Analysis of Genome-Wide DNA Methylation and Hydroxymethylation Patterns at Single-Nucleotide Resolution. | Kernaleguen M et al. | — | 2018 | → |
| Whole-Genome Bisulfite Sequencing Using the Ovation® Ultralow Methyl-Seq Protocol. | Daviaud C et al. | — | 2018 | → |
| Who Will Win: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells for β Cell Replacement and Diabetes Disease Modeling? | Jacobson EF et al. | — | 2018 | → |
| Zinc Fingers, TALEs, and CRISPR Systems: A Comparison of Tools for Epigenome Editing. | Waryah CB et al. | — | 2018 | → |
| Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics. | Panopoulos AD et al. | — | 2017 | → |
| Advances in improving fertility in women through stem cell-based clinical platforms. | Vanni VS et al. | — | 2017 | → |
| Alternative dominance of the parental genomes in hybrid cells generated through the fusion of mouse embryonic stem cells with fibroblasts. | Matveeva NM et al. | — | 2017 | → |
| Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives. | Yang B et al. | — | 2017 | → |
| A smoothed EM-algorithm for DNA methylation profiles from sequencing-based methods in cell lines or for a single cell type. | Lakhal-Chaieb L et al. | — | 2017 | → |
| Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors. | Martínez-Cerdeño V et al. | — | 2017 | → |
| Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity. | Klein M et al. | — | 2017 | → |
| Capturing Human Naïve Pluripotency in the Embryo and in the Dish. | Zimmerlin L et al. | — | 2017 | → |
| Cell-based therapeutic strategies for multiple sclerosis. | Scolding NJ et al. | — | 2017 | → |
| Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells. | Zhao MT et al. | — | 2017 | → |
| Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome. | Okuno H et al. | — | 2017 | → |
| Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. | Cao S et al. | — | 2017 | → |
| Clonal variation of human induced pluripotent stem cells for induction into the germ cell fate. | Yokobayashi S et al. | — | 2017 | → |
| Common genetic variation drives molecular heterogeneity in human iPSCs. | Kilpinen H et al. | — | 2017 | → |
| CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function. | Jang HS et al. | — | 2017 | → |
| Current status in cancer cell reprogramming and its clinical implications. | Izgi K et al. | — | 2017 | → |
| Delayed epidural transplantation of human induced pluripotent stem cell-derived neural progenitors enhances functional recovery after stroke. | Lee IH et al. | — | 2017 | → |
| Differential landscape of non-CpG methylation in embryonic stem cells and neurons caused by DNMT3s. | Lee JH et al. | — | 2017 | → |
| Divergent cytosine DNA methylation patterns in single-cell, soybean root hairs. | Hossain MS et al. | — | 2017 | → |
| DNA methylation: an epigenetic mark of cellular memory. | Kim M et al. | — | 2017 | → |
| DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells. | Zhang L et al. | — | 2017 | → |
| DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes. | Nothjunge S et al. | — | 2017 | → |
| Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells. | Heslop JA et al. | — | 2017 | → |
| Dynamic and rapid changes in the transcriptome and epigenome during germination and in developing rice (Oryza sativa) coleoptiles under anoxia and re-oxygenation. | Narsai R et al. | — | 2017 | → |
| Dynamic DNA methylation reconfiguration during seed development and germination. | Kawakatsu T et al. | — | 2017 | → |
| Dynamic Reorganization of Nucleosome Positioning in Somatic Cells after Transfer into Porcine Enucleated Oocytes. | Tao C et al. | — | 2017 | → |
| Environmental epigenetics in zebrafish. | Cavalieri V et al. | — | 2017 | → |
| Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells. | Akiyama T et al. | — | 2017 | → |
| Epigenetics of cell fate reprogramming and its implications for neurological disorders modelling. | Grzybek M et al. | — | 2017 | → |
| Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. | Ho SM et al. | — | 2017 | → |
| Examining FKBP5 mRNA expression in human iPSC-derived neural cells. | Lieberman R et al. | — | 2017 | → |
| Functional Human Oocytes Generated by Transfer of Polar Body Genomes. | Ma H et al. | — | 2017 | → |
| Generation of a Functional Human Neural Network by NDM29 Overexpression in Neuroblastoma Cancer Cells. | Alloisio S et al. | — | 2017 | → |
| Genome-wide analysis of DNA Methylation profiles on sheep ovaries associated with prolificacy using whole-genome Bisulfite sequencing. | Zhang Y et al. | — | 2017 | → |
| Immunological Issues After Stem Cell-Based β Cell Replacement. | Sordi V et al. | — | 2017 | → |
| Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process. | Turinetto V et al. | — | 2017 | → |
| Influence of donor age on induced pluripotent stem cells. | Lo Sardo V et al. | — | 2017 | → |
| Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs. | Gao S et al. | — | 2017 | → |
| ITIH5 mediates epigenetic reprogramming of breast cancer cells. | Rose M et al. | — | 2017 | → |
| Linking Telomere Regulation to Stem Cell Pluripotency. | Liu L | — | 2017 | → |
| Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. | Zhao MT et al. | — | 2017 | → |
| Myogenic progenitor specification from pluripotent stem cells. | Magli A et al. | — | 2017 | → |
| Nano-MeDIP-seq Methylome Analysis Using Low DNA Concentrations. | Butcher LM et al. | — | 2017 | → |
| Next generation human skin constructs as advanced tools for drug development. | Abaci HE et al. | — | 2017 | → |
| Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts. | Zhang D et al. | — | 2017 | → |
| Optical Trapping Nanometry of Hypermethylated CPG-Island DNA. | Pongor CI et al. | — | 2017 | → |
| P3BSseq: parallel processing pipeline software for automatic analysis of bisulfite sequencing data. | Luu PL et al. | — | 2017 | → |
| Regulatory remodeling in the allo-tetraploid frog Xenopus laevis. | Elurbe DM et al. | — | 2017 | → |
| SPlinted Ligation Adapter Tagging (SPLAT), a novel library preparation method for whole genome bisulphite sequencing. | Raine A et al. | — | 2017 | → |
| Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise. | Duelen R et al. | — | 2017 | → |
| Stem Cell Therapies in Retinal Disorders. | Garg A et al. | — | 2017 | → |
| TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors. | Ancey PB et al. | — | 2017 | → |
| The human-induced pluripotent stem cell initiative-data resources for cellular genetics. | Streeter I et al. | — | 2017 | → |
| The Immunogenicity and Immune Tolerance of Pluripotent Stem Cell Derivatives. | Liu X et al. | — | 2017 | → |
| The sequence preference of DNA methylation variation in mammalians. | Zhang L et al. | — | 2017 | → |
| Variability of human pluripotent stem cell lines. | Ortmann D et al. | — | 2017 | → |
| 10th anniversary of iPS cells: the challenges that lie ahead. | Aoi T | — | 2016 | → |
| Active DNA demethylation at enhancers during the vertebrate phylotypic period. | Bogdanović O et al. | — | 2016 | → |
| Allele-Specific Methylome and Transcriptome Analysis Reveals Widespread Imprinting in the Human Placenta. | Hamada H et al. | — | 2016 | → |
| A maximum-likelihood approach for building cell-type trees by lifting. | Nair NU et al. | — | 2016 | → |
| An integrative analysis of reprogramming in human isogenic system identified a clone selection criterion. | Shutova MV et al. | — | 2016 | → |
| A review of Rett syndrome (RTT) with induced pluripotent stem cells. | Balachandar V et al. | — | 2016 | → |
| Capturing the ephemeral human pluripotent state. | Ávila-González D et al. | — | 2016 | → |
| Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain. | Luo C et al. | — | 2016 | → |
| Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases. | Haston KM et al. | — | 2016 | → |
| CMD kinetics and regenerative medicine. | Anjamrooz SH | — | 2016 | → |
| Computational Tools for Stem Cell Biology. | Bian Q et al. | — | 2016 | → |
| Converting Skin Fibroblasts into Hepatic-like Cells by Transient Programming. | Zhu XQ et al. | — | 2016 | → |
| Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns. | Tost J | — | 2016 | → |
| Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming. | Soufi A et al. | — | 2016 | → |
| Cynomolgus Monkey Induced Pluripotent Stem Cells Generated By Using Allogeneic Genes. | Shimozawa N | — | 2016 | → |
| Cytoskeletal Expression and Remodeling in Pluripotent Stem Cells. | Boraas LC et al. | — | 2016 | → |
| Derivation of integration-free iPSCs from a Klinefelter syndrome patient. | Shimizu T et al. | — | 2016 | → |
| Describing the Stem Cell Potency: The Various Methods of Functional Assessment and <i>In silico</i> Diagnostics. | Singh VK et al. | — | 2016 | → |
| DNA Methylation Signature of Post-injury Neointimal Cells During Vascular Remodeling in the Rat Balloon Injury Model. | Richards J et al. | — | 2016 | → |
| Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate. | Chen IC et al. | — | 2016 | → |
| Editing the epigenome: technologies for programmable transcription and epigenetic modulation. | Thakore PI et al. | — | 2016 | → |
| Effects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells. | Hu S et al. | — | 2016 | → |
| Emerging landscape of cell penetrating peptide in reprogramming and gene editing. | Liu H et al. | — | 2016 | → |
| Epigenetic Determinants of Cancer. | Baylin SB et al. | — | 2016 | → |
| Epigenetic Research in Neuropsychiatric Disorders: the "Tissue Issue". | Bakulski KM et al. | — | 2016 | → |
| Epigenetics of sex determination in mammals. | Tachibana M | — | 2016 | → |
| Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. | Nishizawa M et al. | — | 2016 | → |
| Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions. | Kawakatsu T et al. | — | 2016 | → |
| Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. | Jeffries AR et al. | — | 2016 | → |
| Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins. | Fukusumi H et al. | — | 2016 | → |
| Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants. | Petryszak R et al. | — | 2016 | → |
| Generating hESCs with reduced immunogenicity by disrupting TAP1 or TAPBP. | Cui D et al. | — | 2016 | → |
| Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential. | Kyttälä A et al. | — | 2016 | → |
| Genome engineering tools for building cellular models of disease. | Lin J et al. | — | 2016 | → |
| Genome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing. | Hao Y et al. | — | 2016 | → |
| Glial progenitor cell-based treatment of the childhood leukodystrophies. | Osorio MJ et al. | — | 2016 | → |
| H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes. | Becker JS et al. | — | 2016 | → |
| Human iPSC-derived neurons and lymphoblastoid cells for personalized medicine research in neuropsychiatric disorders. | Gurwitz D | — | 2016 | → |
| Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome. | Darville H et al. | — | 2016 | → |
| Induced Pluripotent Stem Cell as a New Source for Cancer Immunotherapy. | Rami F et al. | — | 2016 | → |
| Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin. | Petrova A et al. | — | 2016 | → |
| Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity. | Tousley A et al. | — | 2016 | → |
| Induced pluripotent stem cells in the inherited cardiomyopathies: From disease mechanisms to novel therapies. | Ross SB et al. | — | 2016 | → |
| iPS Cells-The Triumphs and Tribulations. | Sharma R | — | 2016 | → |
| iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy. | Zhang Y et al. | — | 2016 | → |
| iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System. | Orqueda AJ et al. | — | 2016 | → |
| LMethyR-SVM: Predict Human Enhancers Using Low Methylated Regions based on Weighted Support Vector Machines. | Xu J et al. | — | 2016 | → |
| Mammalian non-CG methylations are conserved and cell-type specific and may have been involved in the evolution of transposon elements. | Guo W et al. | — | 2016 | → |
| Metaboloepigenetic Regulation of Pluripotent Stem Cells. | Harvey AJ et al. | — | 2016 | → |
| Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease. | Yu H et al. | — | 2016 | → |
| Mitochondria in human pluripotent stem cell apoptosis. | TeSlaa T et al. | — | 2016 | → |
| Mitochondria in pluripotent stem cells: stemness regulators and disease targets. | Folmes CD et al. | — | 2016 | → |
| Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells. | Mungenast AE et al. | — | 2016 | → |
| Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. | Lin L et al. | — | 2016 | → |
| Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells. | Butcher LM et al. | — | 2016 | → |
| p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming. | Gong L et al. | — | 2016 | → |
| Pluripotent Stem Cells: Current Understanding and Future Directions. | Romito A et al. | — | 2016 | → |
| Pluripotent stem cells in disease modelling and drug discovery. | Avior Y et al. | — | 2016 | → |
| Pluripotent stem cells: the last 10 years. | Kimbrel EA et al. | — | 2016 | → |
| Promoter methylation regulates the abundance of osa-miR393a in contrasting rice genotypes under salinity stress. | Ganie SA et al. | — | 2016 | → |
| Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells. | Kawser Hossain M et al. | — | 2016 | → |
| Recent progress towards understanding the role of DNA methylation in human placental development. | Bianco-Miotto T et al. | — | 2016 | → |
| Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. | Hysolli E et al. | — | 2016 | → |
| Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. | Klawitter S et al. | — | 2016 | → |
| Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. | King AD et al. | — | 2016 | → |
| Some Ethical Concerns About Human Induced Pluripotent Stem Cells. | Zheng YL | — | 2016 | → |
| Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease. | Hou L et al. | — | 2016 | → |
| Stem Cells in Skeletal Tissue Engineering: Technologies and Models. | Langhans MT et al. | — | 2016 | → |
| Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes. | Liu H et al. | — | 2016 | → |
| Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. | Zimmerlin L et al. | — | 2016 | → |
| The Aberrant DNA Methylation Profile of Human Induced Pluripotent Stem Cells Is Connected to the Reprogramming Process and Is Normalized During In Vitro Culture. | Tesarova L et al. | — | 2016 | → |
| The effects of cytosine methylation on general transcription factors. | Jin J et al. | — | 2016 | → |
| The landscape of DNA methylation amid a perfect storm of autism aetiologies. | Vogel Ciernia A et al. | — | 2016 | → |
| The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. | Youssef AA et al. | — | 2016 | → |
| The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells. | Putnik M et al. | — | 2016 | → |
| Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose. | Saitoh I et al. | — | 2016 | → |
| TopDom: an efficient and deterministic method for identifying topological domains in genomes. | Shin H et al. | — | 2016 | → |
| Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. | van den Hurk M et al. | — | 2016 | → |
| Transgene Reactivation in Induced Pluripotent Stem Cell Derivatives and Reversion to Pluripotency of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells. | Galat V et al. | — | 2016 | → |
| Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells. | Akiyama T et al. | — | 2016 | → |
| Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. | Alves da Silva AF et al. | — | 2016 | → |
| Unique cell-type-specific patterns of DNA methylation in the root meristem. | Kawakatsu T et al. | — | 2016 | → |
| Using human pluripotent stem cells to study Friedreich ataxia cardiomyopathy. | Crombie DE et al. | — | 2016 | → |
| A bibliometric analysis of publications on pluripotent stem cell research. | Lin CL et al. | — | 2015 | → |
| A cautionary note on using binary calls for analysis of DNA methylation. | Prochenka A et al. | — | 2015 | → |
| A comparison of non-integrating reprogramming methods. | Schlaeger TM et al. | — | 2015 | → |
| A developmental framework for induced pluripotency. | Takahashi K et al. | — | 2015 | → |
| Advances in reprogramming-based study of neurologic disorders. | Nityanandam A et al. | — | 2015 | → |
| An alternative pluripotent state confers interspecies chimaeric competency. | Wu J et al. | — | 2015 | → |
| Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases. | Payne NL et al. | — | 2015 | → |
| Ballgown bridges the gap between transcriptome assembly and expression analysis. | Frazee AC et al. | — | 2015 | → |
| Cell replacement therapy for central nervous system diseases. | Tso D et al. | — | 2015 | → |
| Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration. | Orack JC et al. | — | 2015 | → |
| Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. | Karakikes I et al. | — | 2015 | → |
| Detection of differentially methylated regions from bisulfite-seq data by hidden Markov models incorporating genome-wide methylation level distributions. | Saito Y et al. | — | 2015 | → |
| Development of stem cell-based therapy for Parkinson's disease. | Han F et al. | — | 2015 | → |
| Diabetes treatment: A rapid review of the current and future scope of stem cell research. | Sheik Abdulazeez S | — | 2015 | → |
| Dissecting the role of aberrant DNA methylation in human leukaemia. | Amabile G et al. | — | 2015 | → |
| DNA Demethylation Dynamics in the Human Prenatal Germline. | Gkountela S et al. | — | 2015 | → |
| DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. | Kubo N et al. | — | 2015 | → |
| DNA methylation and hydroxymethylation in stem cells. | Cheng Y et al. | — | 2015 | → |
| DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights. | Gómez S et al. | — | 2015 | → |
| DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control. | Kretzmer H et al. | — | 2015 | → |
| Dynamic transcriptional and epigenomic reprogramming from pediatric nasal epithelial cells to induced pluripotent stem cells. | Ji H et al. | — | 2015 | → |
| Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells. | Kang X et al. | — | 2015 | → |
| Embryonic transcription is controlled by maternally defined chromatin state. | Hontelez S et al. | — | 2015 | → |
| Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. | Kabadi AM et al. | — | 2015 | → |
| Epigenetic mechanisms of induced pluripotency. | Gładych M et al. | — | 2015 | → |
| Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. | Lee ST et al. | — | 2015 | → |
| Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health. | Stuppia L et al. | — | 2015 | → |
| Epigenetic States of nephron progenitors and epithelial differentiation. | Adli M et al. | — | 2015 | → |
| Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells. | Zhang Y et al. | — | 2015 | → |
| Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin. | Dorn I et al. | — | 2015 | → |
| Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation. | Lefler S et al. | — | 2015 | → |
| From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases. | Bukovsky A | — | 2015 | → |
| From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease. | Ho SM et al. | — | 2015 | → |
| Gene delivery in tissue engineering and regenerative medicine. | Fang YL et al. | — | 2015 | → |
| Generating a self-organizing kidney from pluripotent cells. | Little MH et al. | — | 2015 | → |
| Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. | Wang J et al. | — | 2015 | → |
| Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer. | Qin Y et al. | — | 2015 | → |
| Generation of induced pluripotent stem cells without genetic defects by small molecules. | Park HS et al. | — | 2015 | → |
| Generation of Isogenic Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System. | Grobarczyk B et al. | — | 2015 | → |
| Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer. | Jadhav RR et al. | — | 2015 | → |
| Global DNA methylation profiling technologies and the ovarian cancer methylome. | Tang J et al. | — | 2015 | → |
| Hierarchical clustering of breast cancer methylomes revealed differentially methylated and expressed breast cancer genes. | Lin IH et al. | — | 2015 | → |
| Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-<i>κ</i>B pathway. | Layman WS et al. | — | 2015 | → |
| HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications. | Karabekian Z et al. | — | 2015 | → |
| HMPL: A Pipeline for Identifying Hemimethylation Patterns by Comparing Two Samples. | Sun S et al. | — | 2015 | → |
| Human body epigenome maps reveal noncanonical DNA methylation variation. | Schultz MD et al. | — | 2015 | → |
| Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. | Wang L et al. | — | 2015 | → |
| Induced Pluripotency and Epigenetic Reprogramming. | Hochedlinger K et al. | — | 2015 | → |
| Induced pluripotent stem cells are induced pluripotent stem cell-like cells. | Song L et al. | — | 2015 | → |
| Induced pluripotent stem cells: Mechanisms, achievements and perspectives in farm animals. | Kumar D et al. | — | 2015 | → |
| Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection. | Noguchi H et al. | — | 2015 | → |
| Insensitivity of Human iPS Cells-Derived Mesenchymal Stem Cells to Interferon-γ-induced HLA Expression Potentiates Repair Efficiency of Hind Limb Ischemia in Immune Humanized NOD Scid Gamma Mice. | Sun YQ et al. | — | 2015 | → |
| Intranasal delivery of stem cells as therapy for central nervous system disease. | Li YH et al. | — | 2015 | → |
| Isolation of Reprogramming Intermediates During Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts. | Nefzger CM et al. | — | 2015 | → |
| Maternal histone variants and their chaperones promote paternal genome activation and boost somatic cell reprogramming. | Yang P et al. | — | 2015 | → |
| Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. | Xiao J et al. | — | 2015 | → |
| MethylC-seq library preparation for base-resolution whole-genome bisulfite sequencing. | Urich MA et al. | — | 2015 | → |
| methylPipe and compEpiTools: a suite of R packages for the integrative analysis of epigenomics data. | Kishore K et al. | — | 2015 | → |
| Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny. | Lee W et al. | — | 2015 | → |
| Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells. | Yanovsky-Dagan S et al. | — | 2015 | → |
| Multiple sclerosis: getting personal with induced pluripotent stem cells. | Di Ruscio A et al. | — | 2015 | → |
| Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling. | Yap MS et al. | — | 2015 | → |
| Neuroepigenomics: Resources, Obstacles, and Opportunities. | Satterlee JS et al. | — | 2015 | → |
| Non-CG Methylation in the Human Genome. | He Y et al. | — | 2015 | → |
| Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State. | Pells S et al. | — | 2015 | → |
| Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing. | Duan J | — | 2015 | → |
| Pluripotent Stem Cells and Skeletal Regeneration--Promise and Potential. | Wu JY | — | 2015 | → |
| Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements. | Zhang W et al. | — | 2015 | → |
| Prediction of promoters and enhancers using multiple DNA methylation-associated features. | Hwang W et al. | — | 2015 | → |
| Present and future challenges of induced pluripotent stem cells. | Ohnuki M et al. | — | 2015 | → |
| Progress and challenges in generating functional hematopoietic stem/progenitor cells from human pluripotent stem cells. | Liu S et al. | — | 2015 | → |
| Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives. | Awe JP et al. | — | 2015 | → |
| Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells. | Makarev E et al. | — | 2015 | → |
| Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data. | Fortin JP et al. | — | 2015 | → |
| Regulation of drug transporter expression and function in the placenta. | Staud F et al. | — | 2015 | → |
| Regulatory elements in low-methylated regions predict directional change of gene expression. | Hu H et al. | — | 2015 | → |
| Repressors of reprogramming. | Popowski M et al. | — | 2015 | → |
| Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand? | Ebert AD et al. | — | 2015 | → |
| Reprogramming cancer cells: a novel approach for cancer therapy or a tool for disease-modeling? | Yilmazer A et al. | — | 2015 | → |
| Reprogramming of cell fate: epigenetic memory and the erasure of memories past. | Nashun B et al. | — | 2015 | → |
| Reprogramming with Small Molecules instead of Exogenous Transcription Factors. | Lin T et al. | — | 2015 | → |
| Safety of human embryonic stem cells in patients with terminal/incurable conditions- a retrospective analysis. | Shroff G et al. | — | 2015 | → |
| Self-Destruct Genetic Switch to Safeguard iPS Cells. | Ivics Z | — | 2015 | → |
| Spatially Enhanced Differential RNA Methylation Analysis from Affinity-Based Sequencing Data with Hidden Markov Model. | Zhang YC et al. | — | 2015 | → |
| Stem cell reprogramming: basic implications and future perspective for movement disorders. | Brändl B et al. | — | 2015 | → |
| Stem cell therapy: challenges ahead. | Bhagavati S | — | 2015 | → |
| Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. | Jurkowski TP et al. | — | 2015 | → |
| Teratoma formation: a tool for monitoring pluripotency in stem cell research. | Nelakanti RV et al. | — | 2015 | → |
| The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences. | Ren J et al. | — | 2015 | → |
| The control of mitochondrial DNA replication during development and tumorigenesis. | Lee WT et al. | — | 2015 | → |
| The human placental methylome. | Robinson WP et al. | — | 2015 | → |
| THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away. | Khosravi-Maharlooei M et al. | — | 2015 | → |
| The role of DNA methylation in directing the functional organization of the cancer epigenome. | Lay FD et al. | — | 2015 | → |
| Transcription factor-mediated reprogramming: epigenetics and therapeutic potential. | Firas J et al. | — | 2015 | → |
| Transdifferentiation via transcription factors or microRNAs: Current status and perspective. | Wang H et al. | — | 2015 | → |
| Using iPS Cells toward the Understanding of Parkinson's Disease. | Torrent R et al. | — | 2015 | → |
| Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency. | Druzhkov P et al. | — | 2015 | → |
| Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. | Shimamoto A et al. | — | 2015 | → |
| Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains. | Jensen TJ et al. | — | 2015 | → |
| Whole-genome DNA methylation profiling with nucleotide resolution. | Hsieh TF | — | 2015 | → |
| Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors. | Planello AC et al. | — | 2014 | → |
| Abnormalities in human pluripotent cells due to reprogramming mechanisms. | Ma H et al. | — | 2014 | → |
| A classification approach for DNA methylation profiling with bisulfite next-generation sequencing data. | Cheng L et al. | — | 2014 | → |
| A Comparative View on Human Somatic Cell Sources for iPSC Generation. | Raab S et al. | — | 2014 | → |
| Advances in the profiling of DNA modifications: cytosine methylation and beyond. | Plongthongkum N et al. | — | 2014 | → |
| A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. | Oh DY et al. | — | 2014 | → |
| A highly efficient method for generation of therapeutic quality human pluripotent stem cells by using naive induced pluripotent stem cells nucleus for nuclear transfer. | Sanal MG | — | 2014 | → |
| Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma. | Marcinkiewicz KM et al. | — | 2014 | → |
| Analysis of interactions between the epigenome and structural mutability of the genome using Genboree Workbench tools. | Coarfa C et al. | — | 2014 | → |
| An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator. | Lee DS et al. | — | 2014 | → |
| A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells. | Huang K et al. | — | 2014 | → |
| Applying "gold standards" to in-vitro-derived germ cells. | Handel MA et al. | — | 2014 | → |
| Assembly of telomeric chromatin to create ALTernative endings. | O'Sullivan RJ et al. | — | 2014 | → |
| Biological and medical applications of a brain-on-a-chip. | Pamies D et al. | — | 2014 | → |
| Bisulfighter: accurate detection of methylated cytosines and differentially methylated regions. | Saito Y et al. | — | 2014 | → |
| Cancer-like epigenetic derangements of human pluripotent stem cells and their impact on applications in regeneration and repair. | Huo JS et al. | — | 2014 | → |
| Cells derived from iPSC can be immunogenic - yes or no? | Cao J et al. | — | 2014 | → |
| Characterizing the strand-specific distribution of non-CpG methylation in human pluripotent cells. | Guo W et al. | — | 2014 | → |
| Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors. | Johannesson B et al. | — | 2014 | → |
| Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin. | Mallon BS et al. | — | 2014 | → |
| Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes. | Hulot JS et al. | — | 2014 | → |
| Continuous passages accelerate the reprogramming of mouse induced pluripotent stem cells. | Shan ZY et al. | — | 2014 | → |
| Deciphering the heterogeneity in DNA methylation patterns during stem cell differentiation and reprogramming. | Shao X et al. | — | 2014 | → |
| Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. | Hovestadt V et al. | — | 2014 | → |
| Dedifferentiation and reprogramming: origins of cancer stem cells. | Friedmann-Morvinski D et al. | — | 2014 | → |
| Defining differentially methylated regions specific for the acquisition of pluripotency and maintenance in human pluripotent stem cells via microarray. | He W et al. | — | 2014 | → |
| Demystifying the U.S. Food and Drug Administration: I. Understanding agency structure and function. | Levi B et al. | — | 2014 | → |
| Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: effects of CREB pathway inhibition. | Pistollato F et al. | — | 2014 | → |
| Disease-in-a-dish: the contribution of patient-specific induced pluripotent stem cell technology to regenerative rehabilitation. | Mack DL et al. | — | 2014 | → |
| Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. | Guo JU et al. | — | 2014 | → |
| DNA sequence explains seemingly disordered methylation levels in partially methylated domains of Mammalian genomes. | Gaidatzis D et al. | — | 2014 | → |
| Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential. | Ohnuki M et al. | — | 2014 | → |
| Ectopic expression of reprogramming factors enhances the development of cloned porcine embryos. | Song Z et al. | — | 2014 | → |
| Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. | Sanchez-Freire V et al. | — | 2014 | → |
| Effects of negative stressors on DNA methylation in the brain: implications for mood and anxiety disorders. | Hing B et al. | — | 2014 | → |
| Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. | Northcott PA et al. | — | 2014 | → |
| Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: evidence and implications. | Firas J et al. | — | 2014 | → |
| Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast. | Cambuli F et al. | — | 2014 | → |
| Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration. | Layman WS et al. | — | 2014 | → |
| Epigenetic regulation of pluripotency and differentiation. | Boland MJ et al. | — | 2014 | → |
| Epigenetics: relevance and implications for public health. | Rozek LS et al. | — | 2014 | → |
| Exploring regulatory elements in low-methylated regions for gene expression prediction. | Hu H et al. | — | 2014 | → |
| Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: a first step toward a clinical-grade cell source. | Boreström C et al. | — | 2014 | → |
| Fourier transform infrared microspectroscopy reveals unique phenotypes for human embryonic and induced pluripotent stem cell lines and their progeny. | Cao J et al. | — | 2014 | → |
| Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy. | Navarro S et al. | — | 2014 | → |
| Genetic background drives transcriptional variation in human induced pluripotent stem cells. | Rouhani F et al. | — | 2014 | → |
| Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways. | Yu W et al. | — | 2014 | → |
| Great expectations: autism spectrum disorder and induced pluripotent stem cell technologies. | Liu EY et al. | — | 2014 | → |
| Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential. | Ishii T | — | 2014 | → |
| Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. | Yamada M et al. | — | 2014 | → |
| Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools. | Acimovic I et al. | — | 2014 | → |
| Human pluripotent stem cell-derived retinal pigmented epithelium in retinal treatment: from bench to bedside. | Parvini M et al. | — | 2014 | → |
| Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges. | Lalit PA et al. | — | 2014 | → |
| Induced pluripotent stem (iPS) cells: a new source for cell-based therapeutics? | de Lázaro I et al. | — | 2014 | → |
| Integrated analysis of DNA methylation and RNA transcriptome during in vitro differentiation of human pluripotent stem cells into retinal pigment epithelial cells. | Liu Z et al. | — | 2014 | → |
| Integrating DNA methylation dynamics into a framework for understanding epigenetic codes. | Szulwach KE et al. | — | 2014 | → |
| Intergenerational genomic DNA methylation patterns in mouse hybrid strains. | Orozco LD et al. | — | 2014 | → |
| iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls. | Prilutsky D et al. | — | 2014 | → |
| iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes. | Martinez-Fernandez A et al. | — | 2014 | → |
| Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells. | Dai R et al. | — | 2014 | → |
| Mechanisms for enhancing cellular reprogramming. | Soufi A | — | 2014 | → |
| Methylated DNA is over-represented in whole-genome bisulfite sequencing data. | Ji L et al. | — | 2014 | → |
| Methylation and transcripts expression at the imprinted GNAS locus in human embryonic and induced pluripotent stem cells and their derivatives. | Grybek V et al. | — | 2014 | → |
| Methylome, transcriptome, and PPAR(γ) cistrome analyses reveal two epigenetic transitions in fat cells. | Takada H et al. | — | 2014 | → |
| Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis. | Jiang P et al. | — | 2014 | → |
| Mouse SCNT ESCs have lower somatic mutation load than syngeneic iPSCs. | Li Z et al. | — | 2014 | → |
| Multiscale representation of genomic signals. | Knijnenburg TA et al. | — | 2014 | → |
| Mutation frequency dynamics in HPRT locus in culture-adapted human embryonic stem cells and induced pluripotent stem cells correspond to their differentiated counterparts. | Krutá M et al. | — | 2014 | → |
| Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons. | Qi SD et al. | — | 2014 | → |
| Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons. | Qi SD et al. | — | 2014 | → |
| Opportunities and Limitations of Modelling Alzheimer's Disease with Induced Pluripotent Stem Cells. | Ovchinnikov DA et al. | — | 2014 | → |
| Perspective for special Gurdon issue for differentiation: can cell fusion inform nuclear reprogramming? | Burns D et al. | — | 2014 | → |
| Pluripotent stem cells in regenerative medicine: challenges and recent progress. | Tabar V et al. | — | 2014 | → |
| Potential and limitation of HLA-based banking of human pluripotent stem cells for cell therapy. | de Rham C et al. | — | 2014 | → |
| Preclinical studies for induced pluripotent stem cell-based therapeutics. | Harding J et al. | — | 2014 | → |
| Protocol for serial cultivation of epithelial cells without enzymes or chemical compounds. | Ye D et al. | — | 2014 | → |
| Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery. | Kiris E et al. | — | 2014 | → |
| Renal cells from spermatogonial germline stem cells protect against kidney injury. | De Chiara L et al. | — | 2014 | → |
| Reprogramming antitumor immunity. | Crompton JG et al. | — | 2014 | → |
| Reprogramming approaches in cardiovascular regeneration. | Dal-Pra S et al. | — | 2014 | → |
| RNA polymerase III transcriptomes in human embryonic stem cells and induced pluripotent stem cells, and relationships with pluripotency transcription factors. | Alla RK et al. | — | 2014 | → |
| RNA-Seq technology and its application in fish transcriptomics. | Qian X et al. | — | 2014 | → |
| Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells. | Huang K et al. | — | 2014 | → |
| Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets. | Hall E et al. | — | 2014 | → |
| Skin fibroblasts from patients with type 1 diabetes (T1D) can be chemically transdifferentiated into insulin-expressing clusters: a transgene-free approach. | Pereyra-Bonnet F et al. | — | 2014 | → |
| Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation. | Faravelli I et al. | — | 2014 | → |
| Strategies for Oral Mucosal Repair by Engineering 3D Tissues with Pluripotent Stem Cells. | Hewitt KJ et al. | — | 2014 | → |
| Study of cell differentiation by phylogenetic analysis using histone modification data. | Nair NU et al. | — | 2014 | → |
| Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum. | Fink KD et al. | — | 2014 | → |
| The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. | Buganim Y et al. | — | 2014 | → |
| The epigenome in pluripotency and differentiation. | Thiagarajan RD et al. | — | 2014 | → |
| The evidence for functional non-CpG methylation in mammalian cells. | Patil V et al. | — | 2014 | → |
| The polycomb protein Ezh2 impacts on induced pluripotent stem cell generation. | Ding X et al. | — | 2014 | → |
| The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies. | Scheiner ZS et al. | — | 2014 | → |
| Transcriptional and epigenetic regulation of T-helper lineage specification. | Tripathi SK et al. | — | 2014 | → |
| Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2). | Tanaka Y et al. | — | 2014 | → |
| Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. | de Almeida PE et al. | — | 2014 | → |
| Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy. | Crompton JG et al. | — | 2014 | → |
| Understanding the roadmaps to induced pluripotency. | Liu K et al. | — | 2014 | → |
| Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity. | Khrapunov S et al. | — | 2014 | → |
| Use of pluripotent stem cells for reproductive medicine: are we there yet? | Duggal G et al. | — | 2014 | → |
| X Chromosome of female cells shows dynamic changes in status during human somatic cell reprogramming. | Kim KY et al. | — | 2014 | → |
| Aging is associated with highly defined epigenetic changes in the human epidermis. | Raddatz G et al. | — | 2013 | → |
| Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. | Ruiz S et al. | — | 2013 | → |
| A new route to human embryonic stem cells. | Trounson A et al. | — | 2013 | → |
| A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells. | Moad M et al. | — | 2013 | → |
| Application of epigenome-modifying small molecules in induced pluripotent stem cells. | Lu J et al. | — | 2013 | → |
| A quantitative system for discriminating induced pluripotent stem cells, embryonic stem cells and somatic cells. | Wang A et al. | — | 2013 | → |
| Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. | Malouf GG et al. | — | 2013 | → |
| Breaking through an epigenetic wall: re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors. | Juárez-Moreno K et al. | — | 2013 | → |
| Browsing (Epi)genomes: a guide to data resources and epigenome browsers for stem cell researchers. | Karnik R et al. | — | 2013 | → |
| Building a microphysiological skin model from induced pluripotent stem cells. | Guo Z et al. | — | 2013 | → |
| Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. | Timp W et al. | — | 2013 | → |
| Cardiac regeneration: current therapies-future concepts. | Doppler SA et al. | — | 2013 | → |
| Cellular reprogramming and cancer development. | Semi K et al. | — | 2013 | → |
| Cellular reprogramming of human peripheral blood cells. | Zhang XB | — | 2013 | → |
| Cellular reprogramming to reset epigenetic signatures. | Hewitt KJ et al. | — | 2013 | → |
| Characterization of cultured epithelial cells using a novel technique not requiring enzymatic digestion for subculturing. | Peramo A et al. | — | 2013 | → |
| Chromatin dynamics during cellular reprogramming. | Apostolou E et al. | — | 2013 | → |
| Chromatin modulators as facilitating factors in cellular reprogramming. | Luna-Zurita L et al. | — | 2013 | → |
| Clinical grade iPS cells: need for versatile small molecules and optimal cell sources. | Wu YL et al. | — | 2013 | → |
| Comparative analysis of targeted differentiation of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSC lines. | Toivonen S et al. | — | 2013 | → |
| Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. | Briggs JA et al. | — | 2013 | → |
| Concise review: the dynamics of induced pluripotency and its behavior captured in gene network motifs. | Muraro MJ et al. | — | 2013 | → |
| CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data. | Su J et al. | — | 2013 | → |
| Delivery of reprogramming factors into fibroblasts for generation of non-genetic induced pluripotent stem cells using a cationic bolaamphiphile as a non-viral vector. | Khan M et al. | — | 2013 | → |
| Differential analysis of gene regulation at transcript resolution with RNA-seq. | Trapnell C et al. | — | 2013 | → |
| Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells. | Koyanagi-Aoi M et al. | — | 2013 | → |
| Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. | Rowland TJ et al. | — | 2013 | → |
| Disclosing the crosstalk among DNA methylation, transcription factors, and histone marks in human pluripotent cells through discovery of DNA methylation motifs. | Luu PL et al. | — | 2013 | → |
| Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes. | Vanderkraats ND et al. | — | 2013 | → |
| Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells. | Xu XH et al. | — | 2013 | → |
| Disease modelling using induced pluripotent stem cells: status and prospects. | Pomp O et al. | — | 2013 | → |
| DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. | Kaaij LT et al. | — | 2013 | → |
| DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. | Heyn H et al. | — | 2013 | → |
| Dynamic association of NUP98 with the human genome. | Liang Y et al. | — | 2013 | → |
| Dynamic regulation of epigenomic landscapes during hematopoiesis. | Abraham BJ et al. | — | 2013 | → |
| Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells. | Offen N et al. | — | 2013 | → |
| Effects of the in vitro manipulation of stem cells: epigenetic mechanisms as mediators of induced metabolic fluctuations. | Paldi A | — | 2013 | → |
| Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells. | Park TS et al. | — | 2013 | → |
| Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors. | Su RJ et al. | — | 2013 | → |
| Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. | Liang G et al. | — | 2013 | → |
| Epigenetic abnormalities in cancer find a "home on the range". | Easwaran H et al. | — | 2013 | → |
| Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea. | Layman WS et al. | — | 2013 | → |
| Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. | Hon GC et al. | — | 2013 | → |
| Epigenetic memory in the context of nuclear reprogramming and cancer. | Halley-Stott RP et al. | — | 2013 | → |
| "Epigenetic memory" phenomenon in induced pluripotent stem cells. | Vaskova EA et al. | — | 2013 | → |
| Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells. | Wang H et al. | — | 2013 | → |
| Epigenetics of reprogramming to induced pluripotency. | Papp B et al. | — | 2013 | → |
| Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population. | Schmitz RJ et al. | — | 2013 | → |
| Epigenomic analysis of multilineage differentiation of human embryonic stem cells. | Xie W et al. | — | 2013 | → |
| GBSA: a comprehensive software for analysing whole genome bisulfite sequencing data. | Benoukraf T et al. | — | 2013 | → |
| Generation of human epidermis-derived mesenchymal stem cell-like pluripotent cells (hEMSCPCs). | Huang B et al. | — | 2013 | → |
| Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies. | Goyal A et al. | — | 2013 | → |
| Genetic and epigenetic instability in human pluripotent stem cells. | Nguyen HT et al. | — | 2013 | → |
| Genetic and epigenetic variations in iPSCs: potential causes and implications for application. | Liang G et al. | — | 2013 | → |
| Genome editing of human pluripotent stem cells to generate human cellular disease models. | Musunuru K | — | 2013 | → |
| Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. | Alisch RS et al. | — | 2013 | → |
| Genome-wide chromatin state transitions associated with developmental and environmental cues. | Zhu J et al. | — | 2013 | → |
| Global epigenomic reconfiguration during mammalian brain development. | Lister R et al. | — | 2013 | → |
| Global indiscriminate methylation in cell-specific gene promoters following reprogramming into human induced pluripotent stem cells. | Nissenbaum J et al. | — | 2013 | → |
| Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts. | Koh S et al. | — | 2013 | → |
| Higher methylation in genomic DNA indicates incomplete reprogramming in induced pluripotent stem cells. | Zhou W et al. | — | 2013 | → |
| High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. | Sun Z et al. | — | 2013 | → |
| How can ethics relate to science? The case of stem cell research. | Carvalho AS et al. | — | 2013 | → |
| How has the study of the human placenta aided our understanding of partially methylated genes? | Schroeder DI et al. | — | 2013 | → |
| Human pluripotent stem cells: an emerging model in developmental biology. | Zhu Z et al. | — | 2013 | → |
| Human pluripotent stem cells for modelling human liver diseases and cell therapy. | Dianat N et al. | — | 2013 | → |
| Human stem cell-based three-dimensional microtissues for advanced cardiac cell therapies. | Emmert MY et al. | — | 2013 | → |
| Identification of active regulatory regions from DNA methylation data. | Burger L et al. | — | 2013 | → |
| Identification of novel imprinted differentially methylated regions by global analysis of human-parthenogenetic-induced pluripotent stem cells. | Stelzer Y et al. | — | 2013 | → |
| Identification of unsafe human induced pluripotent stem cell lines using a robust surrogate assay for pluripotency. | Polanco JC et al. | — | 2013 | → |
| Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. | Su H et al. | — | 2013 | → |
| Immunoreactivity of Pluripotent Markers SSEA-5 and L1CAM in Human Tumors, Teratomas, and Induced Pluripotent Stem Cells. | Cassidy L et al. | — | 2013 | → |
| Induced neural stem cells (iNSCs) in neurodegenerative diseases. | Hermann A et al. | — | 2013 | → |
| Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. | Shao K et al. | — | 2013 | → |
| Induced pluripotent stem cells are sensitive to DNA damage. | Zhang M et al. | — | 2013 | → |
| Induced pluripotent stem cells in reproductive medicine. | Teramura T et al. | — | 2013 | → |
| Inducing translation. | Garber K | — | 2013 | → |
| Instability in X chromosome inactivation patterns in AMD: a new risk factor? | Vladan B et al. | — | 2013 | → |
| Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. | Thatava T et al. | — | 2013 | → |
| Investigation of Rett syndrome using pluripotent stem cells. | Dajani R et al. | — | 2013 | → |
| In vivo cell reprogramming towards pluripotency by virus-free overexpression of defined factors. | Yilmazer A et al. | — | 2013 | → |
| In vivo reprogramming of adult somatic cells to pluripotency by overexpression of Yamanaka factors. | Yilmazer A et al. | — | 2013 | → |
| Mechanisms and models of somatic cell reprogramming. | Buganim Y et al. | — | 2013 | → |
| Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review. | Gurzu S et al. | — | 2013 | → |
| Methods for cancer epigenome analysis. | Nagarajan RP et al. | — | 2013 | → |
| MethyQA: a pipeline for bisulfite-treated methylation sequencing quality assessment. | Sun S et al. | — | 2013 | → |
| Micro- and nanofluidic technologies for epigenetic profiling. | Matsuoka T et al. | — | 2013 | → |
| Modeling stem cell induction processes. | Grácio F et al. | — | 2013 | → |
| Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. | Shirane K et al. | — | 2013 | → |
| Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells. | Honda A et al. | — | 2013 | → |
| -Oh no! hiPSCs misplace their 5hmCs. | Lowry WE | — | 2013 | → |
| Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. | Sandoe J et al. | — | 2013 | → |
| Origins and implications of pluripotent stem cell variability and heterogeneity. | Cahan P et al. | — | 2013 | → |
| Personal genomes, quantitative dynamic omics and personalized medicine. | Mias GI et al. | — | 2013 | → |
| Perspectives of international human epigenome consortium. | Bae JB | — | 2013 | → |
| Pluripotent stem cells and gene therapy. | Simara P et al. | — | 2013 | → |
| Pluripotent stem cells for Parkinson's disease: progress and challenges. | Zeng X et al. | — | 2013 | → |
| Potential for pharmacological manipulation of human embryonic stem cells. | Atkinson SP et al. | — | 2013 | → |
| Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases. | Gao A et al. | — | 2013 | → |
| Predicting the molecular complexity of sequencing libraries. | Daley T et al. | — | 2013 | → |
| Probing DNA shape and methylation state on a genomic scale with DNase I. | Lazarovici A et al. | — | 2013 | → |
| Programmes and prospects for ovotechnology. | Gosden RG | — | 2013 | → |
| Progress in stem cell therapy for major human neurological disorders. | Martínez-Morales PL et al. | — | 2013 | → |
| Prospects of Stem Cells for Retinal Diseases. | Ng TK et al. | — | 2013 | → |
| Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. | Bender S et al. | — | 2013 | → |
| Reprogramming cells for brain repair. | Guarino AT et al. | — | 2013 | → |
| Reprogramming resistant genes: in-depth comparison of gene expressions among iPS, ES, and somatic cells. | Polouliakh N | — | 2013 | → |
| Resetting epigenetic signatures to induce somatic cell reprogramming. | Lluis F et al. | — | 2013 | → |
| Return of results in translational iPS cell research: considerations for donor informed consent. | Lomax GP et al. | — | 2013 | → |
| Sequential addition of reprogramming factors improves efficiency. | Gaeta X et al. | — | 2013 | → |
| Site-specific methylated reporter constructs for functional analysis of DNA methylation. | Han W et al. | — | 2013 | → |
| Small molecules affect human dental pulp stem cell properties via multiple signaling pathways. | Al-Habib M et al. | — | 2013 | → |
| Standardization of human stem cell pluripotency using bioinformatics. | Nestor MW et al. | — | 2013 | → |
| Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration. | Melville H et al. | — | 2013 | → |
| Stem cells in pediatric cardiology. | Patel P et al. | — | 2013 | → |
| Stem cell systems and regeneration in planaria. | Rink JC | — | 2013 | → |
| Stem cell therapy: an exercise in patience and prudence. | Lin HT et al. | — | 2013 | → |
| Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology. | Jadczyk T et al. | — | 2013 | → |
| Steps toward safe cell therapy using induced pluripotent stem cells. | Okano H et al. | — | 2013 | → |
| Stress cycles in stem cells/iPSCs development: implications for tissue repair. | Grafi G | — | 2013 | → |
| Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. | Wang T et al. | — | 2013 | → |
| Technological overview of iPS induction from human adult somatic cells. | Bayart E et al. | — | 2013 | → |
| Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming. | Zhang X et al. | — | 2013 | → |
| TGF-β family signaling in stem cells. | Sakaki-Yumoto M et al. | — | 2013 | → |
| The ageing haematopoietic stem cell compartment. | Geiger H et al. | — | 2013 | → |
| The cellular memory disc of reprogrammed cells. | Anjamrooz SH | — | 2013 | → |
| The evolving field of induced pluripotency: recent progress and future challenges. | Sommer CA et al. | — | 2013 | → |
| The future of epigenetic therapy in solid tumours--lessons from the past. | Azad N et al. | — | 2013 | → |
| The human placenta methylome. | Schroeder DI et al. | — | 2013 | → |
| The non-coding road towards cardiac regeneration. | Hudson JE et al. | — | 2013 | → |
| The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. | Woodruff G et al. | — | 2013 | → |
| The promise and challenges of stem cell-based therapies for skeletal diseases: stem cell applications in skeletal medicine: potential, cell sources and characteristics, and challenges of clinical translation. | Diederichs S et al. | — | 2013 | → |
| Therapeutic potential of human-induced pluripotent stem cell-derived endothelial cells in a bleomycin-induced scleroderma mouse model. | Azhdari M et al. | — | 2013 | → |
| The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation. | Wang Q et al. | — | 2013 | → |
| Tissue engineering and regenerative medicine: recent innovations and the transition to translation. | Fisher MB et al. | — | 2013 | → |
| Toward pluripotency by reprogramming: mechanisms and application. | Wang T et al. | — | 2013 | → |
| Transcription and replication result in distinct epigenetic marks following repression of early gene expression. | Kallestad L et al. | — | 2013 | → |
| Trophoblast differentiation of human embryonic stem cells. | Tiruthani K et al. | — | 2013 | → |
| Understanding impediments to cellular conversion to pluripotency by assessing the earliest events in ectopic transcription factor binding to the genome. | Soufi A et al. | — | 2013 | → |
| Urine as a source of stem cells. | Benda C et al. | — | 2013 | → |
| Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules. | Blancafort P et al. | — | 2013 | → |
| Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. | Jiang J et al. | — | 2013 | → |
| μ-eLCR: a microfabricated device for electrochemical detection of DNA base changes in breast cancer cell lines. | Wee EJ et al. | — | 2013 | → |
| A cell surfaceome map for immunophenotyping and sorting pluripotent stem cells. | Gundry RL et al. | — | 2012 | → |
| A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies. | Grønbæk K et al. | — | 2012 | → |
| Adipose tissue stem cells: the great WAT hope. | Cawthorn WP et al. | — | 2012 | → |
| Aging in the mouse and perspectives of rejuvenation through induced pluripotent stem cells (iPSCs). | Isobe K et al. | — | 2012 | → |
| Alzheimer's disease in a dish: promises and challenges of human stem cell models. | Young JE et al. | — | 2012 | → |
| Amplification-free whole-genome bisulfite sequencing by post-bisulfite adaptor tagging. | Miura F et al. | — | 2012 | → |
| A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. | Valamehr B et al. | — | 2012 | → |
| A poor imitation of a natural process: a call to reconsider the iPSC engineering technique. | Zhang Y et al. | — | 2012 | → |
| Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders. | Christian KM et al. | — | 2012 | → |
| Are embryonic stem and induced pluripotent stem cells the same or different? Implications for their potential therapeutic use. | Christodoulou C et al. | — | 2012 | → |
| A review of the role of stem cells in the development and treatment of glioma. | Heywood RM et al. | — | 2012 | → |
| A stochastic model of epigenetic dynamics in somatic cell reprogramming. | Flöttmann M et al. | — | 2012 | → |
| Atypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana. | You W et al. | — | 2012 | → |
| A ZFN/piggyBac step closer to autologous liver cell therapy. | Mattis AN et al. | — | 2012 | → |
| Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. | Young MA et al. | — | 2012 | → |
| Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. | Xie W et al. | — | 2012 | → |
| Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. | Yu M et al. | — | 2012 | → |
| Bioinformatics applied to gene transcription regulation. | Altobelli G | — | 2012 | → |
| Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. | Liu Y et al. | — | 2012 | → |
| BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions. | Hansen KD et al. | — | 2012 | → |
| Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart. | Buccini S et al. | — | 2012 | → |
| Cardiac repair and restoration using human embryonic stem cells. | Bernstein HS | — | 2012 | → |
| Cell-type specific DNA methylation patterns define human breast cellular identity. | Novak P et al. | — | 2012 | → |
| Cellular reprogramming: a small molecule perspective. | Nie B et al. | — | 2012 | → |
| CG methylation. | Vinson C et al. | — | 2012 | → |
| Challenges for the Therapeutic use of Pluripotent Stem Derived Cells. | Forsberg M et al. | — | 2012 | → |
| Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability. | Fu X et al. | — | 2012 | → |
| Characterization of a unique technique for culturing primary adult human epithelial progenitor/"stem cells". | Marcelo CL et al. | — | 2012 | → |
| Chromatin states accurately classify cell differentiation stages. | Larson JL et al. | — | 2012 | → |
| Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome. | Vollmers C et al. | — | 2012 | → |
| Comparison of gene-specific DNA methylation patterns in equine induced pluripotent stem cell lines with cells derived from equine adult and fetal tissues. | Hackett CH et al. | — | 2012 | → |
| Concise review: chromatin and genome organization in reprogramming. | Biran A et al. | — | 2012 | → |
| Concise review: Genomic stability of human induced pluripotent stem cells. | Martins-Taylor K et al. | — | 2012 | → |
| Concise review: Induced pluripotent stem cell-derived mesenchymal stem cells: progress toward safe clinical products. | Jung Y et al. | — | 2012 | → |
| Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma. | Lake BB et al. | — | 2012 | → |
| Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells. | Lee SB et al. | — | 2012 | → |
| Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. | Kobayashi H et al. | — | 2012 | → |
| Deciphering the complexities of human diseases and disorders by coupling induced-pluripotent stem cells and systems genetics. | Chang WY et al. | — | 2012 | → |
| Defective antiviral responses of induced pluripotent stem cells to baculoviral vector transduction. | Chen GY et al. | — | 2012 | → |
| Defining the nature of human pluripotent stem cell progeny. | Patterson M et al. | — | 2012 | → |
| Delineating nuclear reprogramming. | Ooi J et al. | — | 2012 | → |
| Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: from fixation to computation. | Splinter E et al. | — | 2012 | → |
| Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. | Trapnell C et al. | — | 2012 | → |
| Direct cellular reprogramming in Caenorhabditis elegans: facts, models, and promises for regenerative medicine. | Zuryn S et al. | — | 2012 | → |
| Distinct DNA methylomes of newborns and centenarians. | Heyn H et al. | — | 2012 | → |
| DNA methylation profiling in the clinic: applications and challenges. | Heyn H et al. | — | 2012 | → |
| DNA methylome analysis using short bisulfite sequencing data. | Krueger F et al. | — | 2012 | → |
| Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. | Raddatz G et al. | — | 2012 | → |
| Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency? | Lowry WE | — | 2012 | → |
| Editorial: Our top 10 developments in stem cell biology over the last 30 years. | Armstrong L et al. | — | 2012 | → |
| Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin? | Romeo F et al. | — | 2012 | → |
| Emerging stem cell therapies: treatment, safety, and biology. | Sng J et al. | — | 2012 | → |
| Enhancers: emerging roles in cell fate specification. | Ong CT et al. | — | 2012 | → |
| Epigenetic Modulations of Induced Pluripotent Stem Cells: Novel Therapies and Disease Models. | Huang C et al. | — | 2012 | → |
| Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. | Landan G et al. | — | 2012 | → |
| Epigenetics and chromatin dynamics: a review and a paradigm for functional disorders. | Ordog T et al. | — | 2012 | → |
| Epigenetics of pluripotent cells. | Medvedev SP et al. | — | 2012 | → |
| Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. | Kulis M et al. | — | 2012 | → |
| Equally potent? Does cellular reprogramming justify the abandonment of human embryonic stem cells? | Nazor KL et al. | — | 2012 | → |
| Establishment of transgene-free induced pluripotent stem cells reprogrammed from human stem cells of apical papilla for neural differentiation. | Zou XY et al. | — | 2012 | → |
| Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale. | Barrera V et al. | — | 2012 | → |
| Evolution of energy metabolism, stem cells and cancer stem cells: how the warburg and barker hypotheses might be linked. | Trosko JE et al. | — | 2012 | → |
| Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. | Soufi A et al. | — | 2012 | → |
| Fast and sensitive mapping of bisulfite-treated sequencing data. | Otto C et al. | — | 2012 | → |
| Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. | Crider KS et al. | — | 2012 | → |
| From pluripotency to distinct cardiomyocyte subtypes. | David R et al. | — | 2012 | → |
| Generating pluripotent stem cells: differential epigenetic changes during cellular reprogramming. | Tobin SC et al. | — | 2012 | → |
| Generation of human induced pluripotent stem cells from urine samples. | Zhou T et al. | — | 2012 | → |
| Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state. | Nishishita N et al. | — | 2012 | → |
| Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice. | Wang Y et al. | — | 2012 | → |
| Genetics and epigenetics of the skin meet deep sequence. | Cheng JB et al. | — | 2012 | → |
| Genetics, genomics and the power of stem cells to identify novel treatment options in complex diseases. | Broeckel U et al. | — | 2012 | → |
| Genome-scale technology driven advances to research into normal and malignant haematopoiesis. | Göttgens B | — | 2012 | → |
| Genome-wide analysis of DNA methylation and gene expression changes in two Arabidopsis ecotypes and their reciprocal hybrids. | Shen H et al. | — | 2012 | → |
| Genomic landscape of human allele-specific DNA methylation. | Fang F et al. | — | 2012 | → |
| Genomic stability in reprogramming. | Ronen D et al. | — | 2012 | → |
| Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. | Hon GC et al. | — | 2012 | → |
| Hematopoietic, CNS and skeletal muscle stem cells as drug targets: opportunities, progress and challenges. | Billin A | — | 2012 | → |
| Higher copy number variation and diverse X chromosome inactivation in parthenote-derived human embryonic stem cells. | Liu W et al. | — | 2012 | → |
| Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. | Hansson J et al. | — | 2012 | → |
| Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. | Xu H et al. | — | 2012 | → |
| Human amniotic epithelial cells are reprogrammed more efficiently by induced pluripotency than adult fibroblasts. | Easley CA et al. | — | 2012 | → |
| Human induced pluripotent stem cells improve stroke outcome and reduce secondary degeneration in the recipient brain. | Polentes J et al. | — | 2012 | → |
| Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. | Sun YQ et al. | — | 2012 | → |
| Human pluripotent stem cells: applications and challenges in neurological diseases. | Hibaoui Y et al. | — | 2012 | → |
| Human pluripotent stem cells for disease modelling and drug screening. | Maury Y et al. | — | 2012 | → |
| Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. | Ruiz S et al. | — | 2012 | → |
| Impact of retrotransposons in pluripotent stem cells. | Tanaka Y et al. | — | 2012 | → |
| Induced pluripotent stem cells as a disease modeling and drug screening platform. | Ebert AD et al. | — | 2012 | → |
| Induced pluripotent stem cells in cardiovascular research. | Sinnecker D et al. | — | 2012 | → |
| Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles. | Panopoulos AD et al. | — | 2012 | → |
| Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis. | Moraveji SF et al. | — | 2012 | → |
| Introduction: The use of animals models to advance epigenetic science. | Dolinoy DC et al. | — | 2012 | → |
| Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells. | Sugawara T et al. | — | 2012 | → |
| In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. | Arand J et al. | — | 2012 | → |
| Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells. | Knoepfler PS | — | 2012 | → |
| 'Leveling' the playing field for analyses of single-base resolution DNA methylomes. | Schultz MD et al. | — | 2012 | → |
| Library-free methylation sequencing with bisulfite padlock probes. | Diep D et al. | — | 2012 | → |
| Linking genome to epigenome. | Yuan GC | — | 2012 | → |
| Maintaining differentiated cellular identity. | Holmberg J et al. | — | 2012 | → |
| Metabolic programming of insulin action and secretion. | Martin-Gronert MS et al. | — | 2012 | → |
| Methylome analysis using MeDIP-seq with low DNA concentrations. | Taiwo O et al. | — | 2012 | → |
| Modeling psychiatric disorders at the cellular and network levels. | Brennand KJ et al. | — | 2012 | → |
| Modeling psychiatric disorders through reprogramming. | Brennand KJ et al. | — | 2012 | → |
| Molecular mechanisms of induced pluripotency. | Muchkaeva IA et al. | — | 2012 | → |
| New lessons learned from disease modeling with induced pluripotent stem cells. | Onder TT et al. | — | 2012 | → |
| Next generation sequencing in epigenetics: insights and challenges. | Meaburn E et al. | — | 2012 | → |
| Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. | Anderson OS et al. | — | 2012 | → |
| Orchestrating transcriptional control of adult neurogenesis. | Hsieh J | — | 2012 | → |
| Oxidative stress-induced biomarkers for stem cell-based chemical screening. | Yang SR et al. | — | 2012 | → |
| PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation. | Hewitt KJ et al. | — | 2012 | → |
| Pluripotency and its layers of complexity. | Ooi J et al. | — | 2012 | → |
| Pluripotency of induced pluripotent stem cells. | Kang L et al. | — | 2012 | → |
| Pluripotent human stem cells for the treatment of retinal disease. | Rowland TJ et al. | — | 2012 | → |
| Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes. | Rodríguez-Ubreva J et al. | — | 2012 | → |
| Predictive models of gene regulation from high-throughput epigenomics data. | Althammer S et al. | — | 2012 | → |
| Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. | Burridge PW et al. | — | 2012 | → |
| Progress and bottleneck in induced pluripotency. | Zhang ZN et al. | — | 2012 | → |
| Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway. | Chen M et al. | — | 2012 | → |
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| Prospect of induced pluripotent stem cell genetic repair to cure genetic diseases. | Adiwinata Pawitan J | — | 2012 | → |
| Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. | Richter J et al. | — | 2012 | → |
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| Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate. | Mauda-Havakuk M et al. | — | 2011 | → |
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