MAGMA: generalized gene-set analysis of GWAS data.
paper
Cited
Public
- Authors
- de Leeuw, Christiaan A; Mooij, Joris M; Heskes, Tom; Posthuma, Danielle
- Year
- 2015
- Journal
- PLoS computational biology
- PMID
- 25885710
- DOI
- 10.1371/journal.pcbi.1004219
- PMCID
- PMC4401657
By aggregating data for complex traits in a biologically meaningful way, gene and gene-set analysis constitute a valuable addition to single-marker analysis. However, although various methods for gene and gene-set analysis currently exist, they generally suffer from a number of issues. Statistical power for most methods is strongly affected by linkage disequilibrium between markers, multi-marker associations are often hard to detect, and the reliance on permutation to compute p-values tends to make the analysis computationally very expensive. To address these issues we have developed MAGMA, a novel tool for gene and gene-set analysis. The gene analysis is based on a multiple regression model, to provide better statistical performance. The gene-set analysis is built as a separate layer around the gene analysis for additional flexibility. This gene-set analysis also uses a regression structure to allow generalization to analysis of continuous properties of genes and simultaneous analysis of multiple gene sets and other gene properties. Simulations and an analysis of Crohn's Disease data are used to evaluate the performance of MAGMA and to compare it to a number of other gene and gene-set analysis tools. The results show that MAGMA has significantly more power than other tools for both the gene and the gene-set analysis, identifying more genes and gene sets associated with Crohn's Disease while maintaining a correct type 1 error rate. Moreover, the MAGMA analysis of the Crohn's Disease data was found to be considerably faster as well.
Comparison of gene analysis results for different test-statistics.Gene -log10 p-values from the CD data gene analysis in MAGMA for three different gene test-statistics, comparing analyses using (A) the mean Ο 2 statistic with the top Ο 2 statistic, (B) the mean Ο 2 statistic and the PC regression model and (C) the top Ο 2 statistic and the PC regression model. P-values below 10β8 are truncated to 10β8 (grey points) to preserve the visibility of the other points.
Comparison of self-contained gene-set analysis results.Gene setβlog10 p-values from the CD data self-contained gene-set analysis for MAGMA and PLINK. Panel (A) shows the PLINK-avg (no pruning) results compared with the MAGMA-main analysis, panel (B) the PLINK-prune results compared with the MAGMA-main analysis and (C) the two PLINK analyses compared to each other. P-values below 10β8 are truncated to 10β8 (grey points) to preserve the visibility of the other points.
Comparison of competitive gene-set analysis results.Gene set -log10 p-values from the CD data competitive gene-set analysis for MAGMA, ALIGATOR, INRICH and MAGENTA. Results for ALIGATOR and INRICH are shown for each for the SNP p-value cutoff that yielded the highest observed power (0.01 and 0.0001 respectively), MAGENTA at the advised 5th percentile cutoff. P-values for gene sets not evaluated by one of the methods are shown in grey. The shown correlations are for the -log10 p-values for gene-sets evaluated by both methods.
Comparison of competitive gene-set analysis results at different SNP cut-offs.Comparison of gene set -log10 p-values from the CD data competitive gene-set analysis at different SNP p-value cut-offs for ALIGATOR (top row), INRICH (middle row) and MAGENTA (bottom row). The highest cut-off on the horizontal axis is compared to each of the lower cut-offs. P-values for gene sets not evaluated at the lower cut-off are shown in grey. The shown correlations are for the -log10 p-values for gene-sets evaluated at both cut-offs. Horizontal and vertical grey dotted lines demarcate the p = 0.05 nominal significance threshold.
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| The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology. | Moberget T et al. | β | 2026 | β |
| The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study. | Armstrong RA et al. | β | 2026 | β |
| The genetic architecture of reproductive subtypes of depression in females. | Crestol A et al. | β | 2026 | β |
| The genetic landscape of human functional brain connectivity. | Maciel BA et al. | β | 2026 | β |
| The genetics of cannabis lifetime use. | Bright U et al. | β | 2026 | β |
| The polygenic, omnigenic and stratagenic models of complex disease risk. | GarcΓa-GonzΓ‘lez J et al. | β | 2026 | β |
| The shared genetic architecture underlying the autoimmune and cardiovascular disease: a multivariate genome-wide analysis. | Zhang J et al. | β | 2026 | β |
| Toward Trustworthy Multi-View Representation With Fine-Grained Explainability Embeddings. | Zhang J et al. | β | 2026 | β |
| Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery. | Zhang CY et al. | β | 2026 | β |
| Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders. | Werwath KE et al. | β | 2026 | β |
| Transcriptome-wide association study identifies key genes in Graves' ophthalmopathy. | Yuan J et al. | β | 2026 | β |
| Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo. | Fernandez Garcia M et al. | β | 2026 | β |
| Transcriptomic integration nominates FOXN2 as a candidate schizophrenia risk gene. | Yu L et al. | β | 2026 | β |
| Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries. | Khan Y et al. | β | 2026 | β |
| Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation. | Yi S et al. | β | 2026 | β |
| Uncovering pleiotropic loci linking keratoconus and allergic diseases through integrative genomic analyses. | Li G et al. | β | 2026 | β |
| Unraveling the genetic interplay and therapeutic potentials between major depressive disorder and metabolic syndrome: multi-ancestry and multi-trait genome-wide association analyses. | Feng Y et al. | β | 2026 | β |
| Unraveling the genetic interplay between sleep disorders and Alzheimer's disease: From shared genes to potential therapeutic targets. | Gao X et al. | β | 2026 | β |
| Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study. | Lin YJ et al. | β | 2026 | β |
| Unveiling novel susceptibility genes for kidney stone disease by a cross-tissue transcriptome-wide association study. | Sun X | β | 2026 | β |
| Unveiling the hidden genetic conundrum linking pulmonary diseases and neuropsychiatric disorders: Novel insights from advanced omics-based analyses of the lung-brain axis. | Ding S et al. | β | 2026 | β |
| 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma. | Saarentaus EC et al. | β | 2025 | β |
| A Bayesian Model for Paired Data in Genome-Wide Association Studies with Application to Breast Cancer. | Bu Y et al. | β | 2025 | β |
| Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data. | Costanzo MC et al. | β | 2025 | β |
| A contextual genomic perspective on physical activity and its relationship to health, well being and illness. | Galimberti M et al. | β | 2025 | β |
| A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration. | Yang H et al. | β | 2025 | β |
| A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration. | Zhang L et al. | β | 2025 | β |
| A cross-tissue transcriptome-wide association study identifies new key genes in ischemic stroke. | Song Z et al. | β | 2025 | β |
| A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia. | Wang L et al. | β | 2025 | β |
| A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia. | Li L et al. | β | 2025 | β |
| A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function. | Zhu X et al. | β | 2025 | β |
| A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort. | Liu M et al. | β | 2025 | β |
| Advances and Challenges in Depression Marker Research. | Jin W et al. | β | 2025 | β |
| A genetic common factor underlying self-reported math ability and highest math class taken. | Giannelis A et al. | β | 2025 | β |
| A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders. | Smeland OB et al. | β | 2025 | β |
| A genome-wide association study for lifetime estrogen exposure identifies novel loci and polygenic signals in East Asian postmenopausal women. | Yuk M et al. | β | 2025 | β |
| A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity. | Beyene MB et al. | β | 2025 | β |
| A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival. | Dutta D et al. | β | 2025 | β |
| A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration. | Oh K et al. | β | 2025 | β |
| A genome-wide association study identifies genetic variants associated with hip pain in the UK Biobank cohort (Nβ=β221,127). | Pan Q et al. | β | 2025 | β |
| A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells. | Wang TM et al. | β | 2025 | β |
| A Genome-Wide Association Study of Anti-MΓΌllerian Hormone (AMH) Levels in Samoan Women. | Erdogan-Yildirim Z et al. | β | 2025 | β |
| A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions. | Mhatre S et al. | β | 2025 | β |
| A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort. | Treccani M et al. | β | 2025 | β |
| A genome-wide association study of high-sensitivity C-reactive protein in a large Korean population highlights its genetic relationship with cholesterol metabolism. | Oh K et al. | β | 2025 | β |
| A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases. | You D et al. | β | 2025 | β |
| A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders. | Antonatos C et al. | β | 2025 | β |
| Aggregating dependent signals with heavy-tailed combination tests. | Gui L et al. | β | 2025 | β |
| A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth. | Pathare ADS et al. | β | 2025 | β |
| Alzheimer's disease transcriptional landscape in ex vivo human microglia. | Kosoy R et al. | β | 2025 | β |
| A meta-analysis of genome-wide studies of resilience in the German population. | Herrera-Rivero M et al. | β | 2025 | β |
| Amino Acid Stress Response Genes Contribute to a 25-Fold Increased Risk of L-Asparaginase-Induced Hypersensitivity. | Anderson SJ et al. | β | 2025 | β |
| A Module-Level Polygenic Risk Score-Based NetWAS Framework for Identifying AD Genetic Modules Mediated by Amygdala: An ADNI Study. | Luo H et al. | β | 2025 | β |
| A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci. | Ihejirika SA et al. | β | 2025 | β |
| A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking. | Rosoff DB et al. | β | 2025 | β |
| A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer. | Shi J et al. | β | 2025 | β |
| A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation. | Breusegem SY et al. | β | 2025 | β |
| A Multitrait Analysis of Genome-Wide Association Study Reveals the Shared Genetic Architecture Between Inflammatory Bowel Disease and Ankylosing Spondylitis. | Li H et al. | β | 2025 | β |
| Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder. | Ivanov SM et al. | β | 2025 | β |
| A review of post-GWAS studies in schizophrenia. | Maserrat S et al. | β | 2025 | β |
| ARFID InitiativE Sweden (ARIES): study protocol for a large-scale genetic and registry-linked cohort study on avoidant/restrictive food intake disorder. | Hog L et al. | β | 2025 | β |
| A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex. | Dufournet A et al. | β | 2025 | β |
| A set of downregulated pleiotropic genes are possible multi-omics biomarkers underlying the irritable bowel syndrome-non-alcoholic fatty liver disease comorbidity. | Hong J et al. | β | 2025 | β |
| A single-cell genomic atlas for the effects of chronic ethanol exposure in the mouse dorsal striatum. | Wildermuth E et al. | β | 2025 | β |
| A splicing-based multitissue association study of joint transcriptomes identified susceptibility genes for osteoarthritis. | Zhang L et al. | β | 2025 | β |
| Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia. | Prohens L et al. | β | 2025 | β |
| Association of ZNF608 Polymorphisms With House Dust Mite-Induced Allergic Rhinitis. | Li H et al. | β | 2025 | β |
| Associations between common genetic variants and income provide insights about the socio-economic health gradient. | Kweon H et al. | β | 2025 | β |
| Associations between RetNet gene polymorphisms and the efficacy of orthokeratology for myopia control: a retrospective clinical study. | Xia R et al. | β | 2025 | β |
| Associations of plasma sex-related hormone and protein levels and alcohol dependence. | Ho AM et al. | β | 2025 | β |
| A statistical physics approach to integrating multi-omics data for disease-module detection. | Wang XW et al. | β | 2025 | β |
| A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. | Baune BT et al. | β | 2025 | β |
| A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis. | Hu B et al. | β | 2025 | β |
| A systematic review of GWAS on CMR imaging traits: genetic insights into cardiovascular structure, function, and diseases. | Lakda S et al. | β | 2025 | β |
| Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles. | Shan X et al. | β | 2025 | β |
| A unified framework for identification of cell-type-specific spatially variable genes in spatial transcriptomic studies. | Wang Z et al. | β | 2025 | β |
| BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis. | Anterasian C et al. | β | 2025 | β |
| Beyond the Standard GWAS-A Guide for Plant Biologists. | Clauw P et al. | β | 2025 | β |
| Beyond volume: Unraveling the genetics of human brain geometry. | Primus SA et al. | β | 2025 | β |
| Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health. | Jia RY et al. | β | 2025 | β |
| Blood Pressure Genetics in Han Taiwanese With Cross-Trait Analysis in East Asians: Insights Into Comorbidities, All-Cause Mortality, and Cardiovascular Mortality. | Lin YJ et al. | β | 2025 | β |
| Brain connectivity and transcriptomic similarity inform abnormal morphometric similarity patterns in first-episode, treatment-naΓ―ve major depressive disorder. | Xue K et al. | β | 2025 | β |
| Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics. | MULTI Consortium et al. | β | 2025 | β |
| Brain region and cell type-specific DNA methylation profiles in association with ADHD. | Meijer M et al. | β | 2025 | β |
| Bridging sleep with psychiatric disorders through genetics. | Zimmerman AJ et al. | β | 2025 | β |
| Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans. | Wallis NJ et al. | β | 2025 | β |
| Causal relationship between tinnitus and 8 psychiatric phenotypes: a Mendelian randomization study. | Guo T et al. | β | 2025 | β |
| Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex. | Franklin A et al. | β | 2025 | β |
| Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus. | Zillich L et al. | β | 2025 | β |
| Characterizing somatic mutations in ovarian cancer germline risk regions. | Lai PH et al. | β | 2025 | β |
| Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study. | Konzok J et al. | β | 2025 | β |
| Chromatin accessibility during human first-trimester neurodevelopment. | Mannens CCA et al. | β | 2025 | β |
| Chromatin state origins of uterine leiomyoma. | RΓ€isΓ€nen M et al. | β | 2025 | β |
| Chromosome X-wide common variant association study in autism spectrum disorder. | Mendes M et al. | β | 2025 | β |
| Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study. | GΓΌler M et al. | β | 2025 | β |
| Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD. | Zhong Y et al. | β | 2025 | β |
| Common genetic variation influencing the human lung imaging phenotypes. | Zhu M et al. | β | 2025 | β |
| Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. | Lee DSM et al. | β | 2025 | β |
| Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine. | Niu Y et al. | β | 2025 | β |
| Comprehensive Genome-Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases. | Jiang Y et al. | β | 2025 | β |
| Comprehensive genomic insights into the genetic causality and comorbidity in urological cancers. | Zhang X et al. | β | 2025 | β |
| Comprehensive Multi-omics Analysis of Regulatory Variants for Body Weight in Cattle. | Niu ηηΎ€η Q et al. | β | 2025 | β |
| Comprehensive snRNA-Seq Datasets of Human and Mouse Podocytopathy Integrated with GWAS of Microalbuminuria. | Qing J et al. | β | 2025 | β |
| Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis. | Qiao J et al. | β | 2025 | β |
| Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates. | van Alten S et al. | β | 2025 | β |
| Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression. | Li Y et al. | β | 2025 | β |
| Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis. | Luo Y et al. | β | 2025 | β |
| Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation. | Yuan S et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide analysis reveals novel insights into thyroid cancer etiology. | Zhu Y et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association and Mendelian randomization identify RALB as a susceptibility gene for breast hypertrophy. | Gu J et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates. | Liu Y et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association studies identify genetic susceptibility genes for prostate cancer. | Hua J et al. | β | 2025 | β |
| Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG. | Chen J et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes. | Yan F et al. | β | 2025 | β |
| Cross-Trait Genome-Wide Association Study Identifies Shared Genetic Risk Loci Between COPD and Five Autoimmune Diseases. | Wen H et al. | β | 2025 | β |
| Deciphering genetic susceptibility to clear cell renal cell carcinoma. | Mandelia M et al. | β | 2025 | β |
| Deciphering the shared genetic architecture between bipolar disorder and body mass index. | Ma H et al. | β | 2025 | β |
| Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density. | Zhou J et al. | β | 2025 | β |
| Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank. | Westerman KE et al. | β | 2025 | β |
| Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank. | Xu W et al. | β | 2025 | β |
| Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia. | Zhou J et al. | β | 2025 | β |
| Deep representation learning of electrocardiogram reveals biological insights in cardiac phenotypes and cardiovascular diseases. | Yeung MW et al. | β | 2025 | β |
| Diet as a source of the non-direct genetic effects in metabolic traits: evidence from a family-based GWAS study. | Xiao H et al. | β | 2025 | β |
| Disentangling associations between complex traits and cell types with seismic. | Lai Q et al. | β | 2025 | β |
| Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases. | Yamamoto Y et al. | β | 2025 | β |
| Dissecting Schizophrenia Biology Using Pleiotropy With Cognitive Genomics. | Bhattacharyya U et al. | β | 2025 | β |
| Dissecting the Cellular Heterogeneity Underlying Liver Diseases Through the Integration of GWASs and Single-Cell RNA Sequencing. | Zhou M et al. | β | 2025 | β |
| Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study. | Shao H et al. | β | 2025 | β |
| Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease. | Trenkwalder T et al. | β | 2025 | β |
| DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition. | Abentung A et al. | β | 2025 | β |
| Drug repurposing candidates for amyotrophic lateral sclerosis using common and rare genetic variants. | Gerring ZF et al. | β | 2025 | β |
| Early establishment and life course stability of sex biases in the human brain transcriptome. | Benoit-Pilven C et al. | β | 2025 | β |
| Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences. | Beeche C et al. | β | 2025 | β |
| Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients. | Kang L et al. | β | 2025 | β |
| Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank. | Richards AL et al. | β | 2025 | β |
| Elucidating shared genetic association between female body mass index and preeclampsia. | Yang F et al. | β | 2025 | β |
| Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study. | Sun F et al. | β | 2025 | β |
| EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis. | Wang L et al. | β | 2025 | β |
| Epigenome-wide DNA methylation profiling reveals risk genes for migraine and its subtypes. | Liu M et al. | β | 2025 | β |
| Evaluating the causal effect of circulating proteome on the risk of Juvenile idiopathic arthritis: an omics pipeline study. | Wu X et al. | β | 2025 | β |
| Exome sequencing identifies protein-coding variants associated with loneliness and social isolation. | Wang YX et al. | β | 2025 | β |
| Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach. | Prapiadou S et al. | β | 2025 | β |
| Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis. | Qi B et al. | β | 2025 | β |
| Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses. | Yin Y et al. | β | 2025 | β |
| Exploring the early drivers of pain in Parkinson's disease. | Liu S et al. | β | 2025 | β |
| Exploring the genetic components and multi-omics sources of inflammatory bowel disease from the perspective of autoimmune disorders. | Wang Z et al. | β | 2025 | β |
| Exploring the genetic influence on hair cortisol concentration: Genetic association of rs11621961 on SERPINA6/1 locus in the 2004 Pelotas Birth Cohort (Brazil). | Camerini L et al. | β | 2025 | β |
| Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders. | Song Q et al. | β | 2025 | β |
| Exploring the omnigenic architecture of selected complex traits. | Ratajczak F et al. | β | 2025 | β |
| Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis. | Wang L et al. | β | 2025 | β |
| FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries. | Wonkam A et al. | β | 2025 | β |
| From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap. | Tripathi U et al. | β | 2025 | β |
| From single nucleotide variations to genes: identifying the genetic links between sleep and psychiatric disorders. | Jia N et al. | β | 2025 | β |
| From variants to mechanisms: Neurogenomics in the post-GWAS era. | Margolis MP et al. | β | 2025 | β |
| Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis. | ChiΓ±as M et al. | β | 2025 | β |
| Functional genomics of human skeletal development and the patterning of height heritability. | Richard D et al. | β | 2025 | β |
| Functional variant at 19q13.3 confers nonsyndromic cleft palate susceptibility by regulating <i>HIF3A</i>. | Lou S et al. | β | 2025 | β |
| Gene and pathway analysis of genome-wide genetic associations of bladder cancer. | Shi M et al. | β | 2025 | β |
| Gene-based Hardy-Weinberg equilibrium test using genotype count data: application to six types of cancers. | Nishino J et al. | β | 2025 | β |
| Gene expression differences associated with alcohol use disorder in human brain. | Willis C et al. | β | 2025 | β |
| Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19. | Monistrol-Mula A et al. | β | 2025 | β |
| Genetic Analysis and Predictive Modeling of COVID-19 Severity in a Hospital-Based Patient Cohort. | Alloza-Moral I et al. | β | 2025 | β |
| Genetic Analysis of Retinal Cell Types in Neuropsychiatric Disorders. | Boudriot E et al. | β | 2025 | β |
| Genetic and immune regulatory links between inflammatory bowel disease and breast cancer involving the JAK STAT PD L1 axis. | Zeng L et al. | β | 2025 | β |
| Genetic and metabolomic pathways linking frailty, chronic kidney disease, and kidney failure: a Mendelian randomization and multi-omics analysis. | Chen Y et al. | β | 2025 | β |
| Genetic approach uncovering the pathways between childhood maltreatment and suicide attempt. | Qu D et al. | β | 2025 | β |
| Genetic architecture and mechanisms shared between kidney and ureteral stones, cardiovascular diseases, and metabolic syndrome: A comprehensive GWAS analysis. | Hua Y et al. | β | 2025 | β |
| Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk. | Wu Z et al. | β | 2025 | β |
| Genetic Architecture of Cerebral White Matter Hyperintensities in Diverse Hispanic/Latino Adults. | Fornage M et al. | β | 2025 | β |
| Genetic architecture of gastric adenocarcinoma in West Asia. | Latifi-Navid S et al. | β | 2025 | β |
| Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders. | Kondo R et al. | β | 2025 | β |
| Genetic Comorbidity of Psoriasis and Four Cardiovascular Diseases: Uncovering Shared Mechanisms and Potential Therapeutic Targets. | Li X et al. | β | 2025 | β |
| Genetic correlation and causation of craniofacial microsomia with 33 diseases in Asian populations: insights from large-scale genome-wide cross-trait analysis. | Luo P et al. | β | 2025 | β |
| Genetic Determinants of Leukocyte Count in Nonsyndromic Cleft Lip With or Without Cleft Palate Among Asians. | Xing C et al. | β | 2025 | β |
| Genetic determinants of proteomic aging. | MΓΆrseburg A et al. | β | 2025 | β |
| Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes. | McGrail C et al. | β | 2025 | β |
| Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma. | Xu Y et al. | β | 2025 | β |
| Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes. | Wang Q et al. | β | 2025 | β |
| Genetic Insights Into the Interplay Between Aging and Kidney Health. | Wang Y et al. | β | 2025 | β |
| Genetic insights into the therapeutic potential of hydrogen sulfide. | Brady JJR et al. | β | 2025 | β |
| Genetic Links between Gastrointestinal Disorders and Kidney Stone Disease: Insights from a Genome-Wide Cross-Trait Analysis. | Wang Y et al. | β | 2025 | β |
| Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults. | Ceja Z et al. | β | 2025 | β |
| Genetic markers of early response to lurasidone in acute schizophrenia. | Yoshikawa A et al. | β | 2025 | β |
| Genetic Markers of Postmortem Brain Iron. | Cornelis MC et al. | β | 2025 | β |
| Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease highlight shared and tissue-specific effects. | Genetic Modifiers of Huntingtonβs Disease (GeM-HD) Consortium | β | 2025 | β |
| Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design. | Li X et al. | β | 2025 | β |
| Genetic overlap between multi-site chronic pain and cognition: a large-scale genome-wide cross-trait analysis. | Chen Y et al. | β | 2025 | β |
| Genetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis. | Lin W et al. | β | 2025 | β |
| Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations. | Jiang X et al. | β | 2025 | β |
| Genetic proxies for clinical traits are associated with increased risk of severe COVID-19. | Chaddock NJM et al. | β | 2025 | β |
| Genetic relationship between epilepsy and mental disorders: A comprehensive GWAS analysis. | Abudusalamu R et al. | β | 2025 | β |
| Genetic relationship between SjΓΆgren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis. | Zhou Y et al. | β | 2025 | β |
| Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma. | Jin H et al. | β | 2025 | β |
| Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. | Askarova A et al. | β | 2025 | β |
| Genetic Studies Through the Lens of Gene Networks. | Subirana-GranΓ©s M et al. | β | 2025 | β |
| Genetic, Transcriptomic, and Epigenomic Insights into SjΓΆgren's Disease: An Integrative Network Investigation and Immune Diseases Comparison. | Enduru N et al. | β | 2025 | β |
| Genetic variants associated with chronic postsurgical pain: evidence from the China Surgery and Anaesthesia Cohort study. | Song J et al. | β | 2025 | β |
| GeneticΒ variantsΒ associatedΒ withΒ metabolic dysfunction-associatedΒ fattyΒ liverΒ diseasesΒ inΒ aΒ KoreanΒ population. | Park JH et al. | β | 2025 | β |
| Genetic variants predisposing to an increased risk of kidney stone disease. | Lovegrove CE et al. | β | 2025 | β |
| Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder. | Zhao Y et al. | β | 2025 | β |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | β | 2025 | β |
| Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health. | Jawinski P et al. | β | 2025 | β |
| Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population. | Enzan N et al. | β | 2025 | β |
| Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression. | Shorter JR et al. | β | 2025 | β |
| Genome-Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical Cancer. | Beckhaus T et al. | β | 2025 | β |
| Genome-wide association analysis of composite sleep health scores in 413,904 individuals. | Goodman MO et al. | β | 2025 | β |
| Genome-wide association and DNA methylation analyses of SSRI treatment response in major depressive disorder. | Lyu N et al. | β | 2025 | β |
| Genome-wide association for sarcoidosis identifies novel risk loci and genetic heritability in African and European ancestries: a meta-analysis from the Finngen, Million Veteran Program, UK Biobank, and Biobank Japan datasets. | Ricci A et al. | β | 2025 | β |
| Genome-wide association meta-analyses of drug-resistant epilepsy. | Leu C et al. | β | 2025 | β |
| Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry. | Gui A et al. | β | 2025 | β |
| Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. | van der Laan CM et al. | β | 2025 | β |
| Genome-wide association studies are enriched for interacting genes. | Nguyen PT et al. | β | 2025 | β |
| Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans. | Sherva R et al. | β | 2025 | β |
| Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study. | Deng WQ et al. | β | 2025 | β |
| Genome-wide association study and genomic selection for growth-related traits in Eastern oyster (Crassostrea virginica). | MarΓn-Nahuelpi R et al. | β | 2025 | β |
| Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology. | Larsson SC et al. | β | 2025 | β |
| Genome-wide association study and polygenic risk prediction of hypothyroidism. | Rand SA et al. | β | 2025 | β |
| Genome-Wide Association Study Identifies a Locus at 17p13 to Be Associated With Intestinal Malrotation. | Gaitanidis A et al. | β | 2025 | β |
| Genome-wide association study identifies <i>ABCG1</i> as a susceptibility locus for tick-borne encephalitis. | Gampawar PG et al. | β | 2025 | β |
| Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders. | Strom NI et al. | β | 2025 | β |
| Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. | Henry A et al. | β | 2025 | β |
| Genome-wide association study of chlamydia reinfection in African American women. | Tiwari HK et al. | β | 2025 | β |
| Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics. | Andersson NW et al. | β | 2025 | β |
| Genome-wide association study provides insights into the genetic basis of Lewy body dementia. | Zhu P et al. | β | 2025 | β |
| Genome-wide association study unravels mechanisms of brain glymphatic activity. | Huang SY et al. | β | 2025 | β |
| Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype. | Krause S et al. | β | 2025 | β |
| Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum. | Bu L et al. | β | 2025 | β |
| Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources. | Pilalis E et al. | β | 2025 | β |
| Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density. | Lei B et al. | β | 2025 | β |
| Genome-wide interaction study of physical activity and genetic susceptibility on colorectal cancer using UK biobank data. | Cho S et al. | β | 2025 | β |
| Genomic correlation, shared loci, and causal link between obesity and diabetic microvascular complications: A genome-wide pleiotropic analysis. | Zhang W et al. | β | 2025 | β |
| Genomic data-driven framework for drug target discovery in atrial fibrillation. | Tao Y et al. | β | 2025 | β |
| Genomic determinants of biological age estimated by deep learning applied to retinal images. | Huang Y et al. | β | 2025 | β |
| Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth. | Ambalavanan N et al. | β | 2025 | β |
| Genomic insights into young stock survival in Danish Jersey cattle: A breed-specific QTL on chromosome 10 and its regulatory potential. | Bai Z et al. | β | 2025 | β |
| Genomics of schizophrenia, bipolar disorder and major depressive disorder. | Owen MJ et al. | β | 2025 | β |
| Genomics yields biological and phenotypic insights into bipolar disorder. | O'Connell KS et al. | β | 2025 | β |
| Global and Sex-Stratified Genome-Wide Association Study of Long COVID Based on Patient-Driven Symptom Recall. | Polo-Alonso S et al. | β | 2025 | β |
| GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases. | Li X et al. | β | 2025 | β |
| GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis. | Yuan S et al. | β | 2025 | β |
| GWAS meta-analysis identifies five susceptibility loci for endometrial cancer. | Ramachandran D et al. | β | 2025 | β |
| GWAS study of myelosuppression among NSCLC patients receiving platinum-based combination chemotherapy. | Huang H et al. | β | 2025 | β |
| Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy. | Wu Z et al. | β | 2025 | β |
| Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks. | Graham AC et al. | β | 2025 | β |
| Identification and catalog of viral transcriptional regulators in human diseases. | Citu C et al. | β | 2025 | β |
| Identification of biomarkers for endometriosis based on summary-data-based Mendelian randomization and machine learning. | Xie Z et al. | β | 2025 | β |
| Identification of candidate susceptibility genes for cutaneous malignant melanoma through integrated multi-method analysis. | Zhou P et al. | β | 2025 | β |
| Identification of pathogenic cell types and shared genetic loci and genes for Alzheimer's disease and inflammatory bowel disease. | Zhang J et al. | β | 2025 | β |
| Identification of potential therapeutic targets for problematic alcohol use using multi-omics data. | Lee DJ et al. | β | 2025 | β |
| Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder. | Icick R et al. | β | 2025 | β |
| Identifying Alzheimer's disease-related pathways based on whole-genome sequencing data. | Wang Y et al. | β | 2025 | β |
| Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases. | Stratford JK et al. | β | 2025 | β |
| Identifying genes and traits associated with pre-eclampsia using summary statistics. | Zhu W et al. | β | 2025 | β |
| Identifying genetic overlaps in obesity and metabolic disorders unlocking unique and shared mechanistic insights. | Fu L et al. | β | 2025 | β |
| Identifying genetic variants for brain connectivity using Ball Covariance Ranking and Aggregation. | Dai W et al. | β | 2025 | β |
| Identifying Myeloid-Derived Suppressor Cells and Lipocalin-2 as Therapeutic Targets for Intervertebral Disc Degeneration. | Zhang C et al. | β | 2025 | β |
| Identifying Therapeutic Targets for Amyotrophic Lateral Sclerosis Through Modeling of Multi-Omics Data. | Blaudin de ThΓ© FX et al. | β | 2025 | β |
| IL-18 receptor axis in allergic conjunctivitis: a multi-omics study. | Yuan L et al. | β | 2025 | β |
| Immune-Developmental Processes Contribute to Schizophrenia Risk: Insights From a Genetic Overlap Study With Height. | Romero C et al. | β | 2025 | β |
| Improving Machine Learning Prediction of ADHD Using Gene Set Polygenic Risk Scores and Risk Scores From Genetically Correlated Phenotypes. | Barnett EJ et al. | β | 2025 | β |
| Insights Into Chronic Low Back Pain Etiology: Population-Based Genome-Wide Association Study Identifies 18 Risk Loci. | Martinsen AE et al. | β | 2025 | β |
| Integrated analysis for drug repositioning in migraine using genetic evidence and claims database. | Inokuchi S et al. | β | 2025 | β |
| Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease. | Pan L et al. | β | 2025 | β |
| Integrated Genomic Approaches to Elucidate the Genetic Basis of Brugada Syndrome in Taiwanese Patients. | Goswami C et al. | β | 2025 | β |
| Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia. | Fu W et al. | β | 2025 | β |
| Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders. | Ding H et al. | β | 2025 | β |
| Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology. | Davis CN et al. | β | 2025 | β |
| Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs. | Xu Z et al. | β | 2025 | β |
| Integrating microbial GWAS and single-cell transcriptomics reveals associations between host cell populations and the gut microbiome. | Li J et al. | β | 2025 | β |
| Integrating Proteomics and GWAS to Identify Key Tissues and Genes Underlying Human Complex Diseases. | Xue C et al. | β | 2025 | β |
| Integration of transcriptome-wide association study and gene-based association analysis identifies candidate genes for Hodgkin lymphoma. | Jia WH et al. | β | 2025 | β |
| Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling. | Sagulkoo P et al. | β | 2025 | β |
| Integrative gene and isoform co-expression networks reveal regulatory rewiring in stress-related psychiatric disorders. | Rehawi G et al. | β | 2025 | β |
| Integrative genetics and multiomics analysis reveal mechanisms and therapeutic targets in vitiligo highlighting JAK STAT pathway regulation of CTSS. | Dong ZY et al. | β | 2025 | β |
| Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential. | Chen H et al. | β | 2025 | β |
| Integrative multi-omics analysis deciphers the regulatory mechanisms of egg weight traits in chickens. | Ding J et al. | β | 2025 | β |
| Integrative multi-omics analysis identifies TGFA as a novel glioma susceptibility gene and therapeutic target. | Jiang R et al. | β | 2025 | β |
| Integrative multi-omics data from early development to identify the genes and cell types underlying attention-deficit/hyperactivity disorder. | Jiao S et al. | β | 2025 | β |
| Investigating associations between JAK inhibition and venous thromboembolism by systematic mining of large-scale datasets. | Haysen SR et al. | β | 2025 | β |
| Investigating the causal and genetic relationship between migraine and Parkinson's disease. | Deng MG et al. | β | 2025 | β |
| Investigating the common genetic basis between inflammatory bowel disease and metabolic syndrome through genomic structural equation modeling. | Shen P et al. | β | 2025 | β |
| Investigating the shared genetic architecture between adiposity measures and obesity-related cancers. | Wang S et al. | β | 2025 | β |
| Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer. | Li Z et al. | β | 2025 | β |
| Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis. | Yuan L et al. | β | 2025 | β |
| Investigating the shared genetic architecture between post-traumatic stress disorder and neurodegenerative diseases: a large-scale genomewide cross-trait analysis. | Shi Y et al. | β | 2025 | β |
| IPGCA: A Comprehensive Single Cell Atlas of 1Β 074Β 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross-Species Conservation. | Yu P et al. | β | 2025 | β |
| iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia. | Chang MH et al. | β | 2025 | β |
| Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes. | Zhu Z et al. | β | 2025 | β |
| Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes. | Abedi M et al. | β | 2025 | β |
| Large-scale audiometric phenotyping identifies distinct genes and pathways involved in hearing loss subtypes. | Ahmed S et al. | β | 2025 | β |
| Large-scale composite hypothesis testing procedure for omics data analyses. | De Walsche A et al. | β | 2025 | β |
| Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy. | Tadros R et al. | β | 2025 | β |
| Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation. | Zhu Z et al. | β | 2025 | β |
| LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes. | Hof JP et al. | β | 2025 | β |
| Leveraging Alzheimer's Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma. | Tolosa-Tort P et al. | β | 2025 | β |
| Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA. | Abdellaoui A et al. | β | 2025 | β |
| Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response. | Bukhari Z et al. | β | 2025 | β |
| Linking Genome-Wide Association Studies to Pharmacological Treatments for Psychiatric Disorders. | Arnatkeviciute A et al. | β | 2025 | β |
| Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts. | Tiozon RN et al. | β | 2025 | β |
| Liver Enzyme Genetics and Health Conditions in East Asians: Genetic Architecture and Causal Insights. | Lin YJ et al. | β | 2025 | β |
| Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease. | Ray NR et al. | β | 2025 | β |
| Local genetic sex differences in quantitative traits. | Uffelmann E et al. | β | 2025 | β |
| Longitudinal characterization of impulsivity phenotypes boosts signal for genomic correlates and heritability. | Deng WQ et al. | β | 2025 | β |
| <i>CARINH</i>, an Interferon-Induced LncRNA in Cancer and Inflammation. | Gourvest M et al. | β | 2025 | β |
| M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits. | Ochoa S et al. | β | 2025 | β |
| Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins. | Wang G et al. | β | 2025 | β |
| Mapping the cellular etiology of schizophrenia and complex brain phenotypes. | Duncan LE et al. | β | 2025 | β |
| Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies. | Fominykh V et al. | β | 2025 | β |
| Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans. | Romero Villela PN et al. | β | 2025 | β |
| Mendelian Randomization Reveals Causalities Between DNA Methylation and Schizophrenia. | Wang D et al. | β | 2025 | β |
| Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity. | Villaplana-Velasco A et al. | β | 2025 | β |
| Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. | Roselli C et al. | β | 2025 | β |
| Meta-Analysis of Transcriptomic Studies of Blood and Six Brain Regions Identifies a Consensus of 15 Cross-Tissue Mechanisms in Alzheimer's Disease and Suggests an Origin of Cross-Study Heterogeneity. | Hou J et al. | β | 2025 | β |
| Meta-evolutionary exome analysis identifies novel type 2 diabetes mellitus genes in the UK Biobank and all of us. | Wilhelm K et al. | β | 2025 | β |
| Microfluidic and Computational Tools for Neurodegeneration Studies. | Gomez K et al. | β | 2025 | β |
| Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses. | Jin C et al. | β | 2025 | β |
| Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases. | Ma K et al. | β | 2025 | β |
| Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress. | Hu X et al. | β | 2025 | β |
| MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses. | Xing A et al. | β | 2025 | β |
| MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. | van der Graaf A et al. | β | 2025 | β |
| Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. | Johnson EC et al. | β | 2025 | β |
| Multi-ancestry genome-wide association analyses of polycystic ovary syndrome. | Zhao H et al. | β | 2025 | β |
| Multi-ancestry genome-wide association meta-analysis identifies candidate genes for computed tomography-based carcass composition traits in pigs. | Han H et al. | β | 2025 | β |
| Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis. | Zhang M et al. | β | 2025 | β |
| Multi-ancestry investigation of the genomics of erectile dysfunction. | Bright U et al. | β | 2025 | β |
| Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain. | Stanaway IB et al. | β | 2025 | β |
| Multi-domain rule-based phenotyping algorithms enable improved GWAS signal. | Newbury A et al. | β | 2025 | β |
| Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy. | Jiang S et al. | β | 2025 | β |
| Multi-omics Analysis of Energy Metabolism Pathways Across Major Psychiatric Disorders. | Zou S et al. | β | 2025 | β |
| Multi-omics and comprehensive multi-trait analysis identify shared genetic etiology of heart failure and related cancers. | Shui W et al. | β | 2025 | β |
| Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle. | Zhang T et al. | β | 2025 | β |
| Multiomic single-cell profiling identifies critical regulators of postnatal brain. | Clarence T et al. | β | 2025 | β |
| Multi-omics integration reveals Chr1 associated QTL mediating backfat thickness in pigs. | Yu N et al. | β | 2025 | β |
| Multi-phase, multi-ethnic GWAS uncovers putative loci in predisposition to elite sprint and power performance, health and disease. | Wang G et al. | β | 2025 | β |
| Multi-trait association analysis reveals shared genetic architecture between lung cancer and cardiometabolic diseases. | Lyu Q et al. | β | 2025 | β |
| Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities. | Chen H et al. | β | 2025 | β |
| Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery. | Mountford HS et al. | β | 2025 | β |
| Mutual-assistance learning for trustworthy biomarker discovery and disease prediction. | Zhang J et al. | β | 2025 | β |
| Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses. | Ivie JJ et al. | β | 2025 | β |
| Network-based drug repurposing for psychiatric disorders using single-cell genomics. | Gupta C et al. | β | 2025 | β |
| Neural networks reveal novel gene signatures in Parkinson disease from single-nuclei transcriptomes. | Fiorini MR et al. | β | 2025 | β |
| Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. | Wen J et al. | β | 2025 | β |
| Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle. | Jin Y et al. | β | 2025 | β |
| New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways. | O'Connell KS et al. | β | 2025 | β |
| New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma. | Wang Y et al. | β | 2025 | β |
| New insights into thiopurine toxicity: The contribution of rare XDH variants to myelotoxicity. | Tejera-PΓ©rez H et al. | β | 2025 | β |
| Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese. | Zhou D et al. | β | 2025 | β |
| Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways. | Bradley J et al. | β | 2025 | β |
| Novel insight into the gene etiology of ulcerative colitis gained from transcriptome association study and single-cell sequence analysis. | Ren D et al. | β | 2025 | β |
| Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts. | Liu J et al. | β | 2025 | β |
| Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease. | Phillips JM et al. | β | 2025 | β |
| Novel susceptibility genes for sleep apnea revealed by a cross-tissue transcriptome-wide association study. | Meng L et al. | β | 2025 | β |
| Paradoxical regulation of IGF2 in promoting lipid metabolism in adipose tissues. | Zhou C et al. | β | 2025 | β |
| PARK7 is a Key Regulator of Oxidative Stress - Related Breast Cancer Risk: A Multi-Omics Study. | Wang T et al. | β | 2025 | β |
| Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder. | Sharew NT et al. | β | 2025 | β |
| Pharmacogenetic study of antipsychotic-induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study. | Wong KC et al. | β | 2025 | β |
| Plasma circulating microRNAs and symptoms of depression: Results from a population-based study. | Kuilman MM et al. | β | 2025 | β |
| Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers. | van der Meer D et al. | β | 2025 | β |
| Pleiotropy in Multitrait Genome-Wide Association Studies: Approaches and Insights From Schizophrenia-Cognition Analyses. | Lee CH | β | 2025 | β |
| Polygenic enrichment analysis in multi-omics levels identifies cell/tissue specific associations with schizophrenia based on single-cell RNA sequencing data. | Cheng B et al. | β | 2025 | β |
| Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank. | Akimova ET et al. | β | 2025 | β |
| Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis. | Antonatos C et al. | β | 2025 | β |
| Prioritizing effector genes at trait-associated loci using multimodal evidence. | Schipper M et al. | β | 2025 | β |
| Prioritizing Parkinson's disease risk genes in genome-wide association loci. | Lange LM et al. | β | 2025 | β |
| Protocol for genetic analysis of population-scale ultra-low-depth sequencing data. | Zeng J et al. | β | 2025 | β |
| Realizing the promise of genome-wide association studies for effector gene prediction. | Costanzo MC et al. | β | 2025 | β |
| Recent Advances in Experimental Functional Characterization of GWAS Candidate Genes in Osteoporosis. | MalavaΕ‘iΔ P et al. | β | 2025 | β |
| Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction. | Chen L et al. | β | 2025 | β |
| Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location. | Wills C et al. | β | 2025 | β |
| Rethinking GWAS: how lessons from genetic screens and artificial intelligence could reveal biological mechanisms. | Hazelett DJ | β | 2025 | β |
| Role of ferroptosis-related IREB2 in the shared genetic etiology between smoking and facial aging: Insights from large-scale genome-wide cross-trait analysis. | Cai X et al. | β | 2025 | β |
| rs762855 single nucleotide polymorphism modulates the risk for diffuse-type gastric cancer in females: a genome-wide association study in the Korean population. | Park K et al. | β | 2025 | β |
| Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links. | Zhang K et al. | β | 2025 | β |
| sc2GWAS: a comprehensive platform linking single cell and GWAS traits of human. | Yin M et al. | β | 2025 | β |
| SC-VAR: a computational tool for interpreting polygenic disease risks using single-cell epigenomic data. | Zhao G et al. | β | 2025 | β |
| Sequence-based genome-wide association study reveals host genomic regions and candidate genes influencing the fecal microbiota of Holstein cows. | Brulin L et al. | β | 2025 | β |
| Sex-stratified genome-wide association meta-analysis of major depressive disorder. | Thomas JT et al. | β | 2025 | β |
| Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus. | Guo X et al. | β | 2025 | β |
| Shared genetic architecture and causal relationship between frailty and schizophrenia. | Deng MG et al. | β | 2025 | β |
| Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases. | Lazanas P et al. | β | 2025 | β |
| Shared genetic architecture between grip strength and cognitive function: insights from large-scale genome-wide cross-trait analysis. | Liu H et al. | β | 2025 | β |
| Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis. | Li G et al. | β | 2025 | β |
| Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis. | Bai W et al. | β | 2025 | β |
| Shared genetic architecture contributes to risk of major cardiovascular diseases. | Qiao J et al. | β | 2025 | β |
| Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes. | Liu W et al. | β | 2025 | β |
| Shared Genetic Architecture of Obstructive Sleep Apnea and Neck Pain: A Large-Scale Genome-Wide Association Study. | Yang F et al. | β | 2025 | β |
| Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets. | Dou C et al. | β | 2025 | β |
| Shared genetic associations between CHA<sub>2</sub>DS<sub>2</sub>-VASc score and cardio-embolic stroke: Insights from mendelian randomization based bioinformatics analysis. | Yuan K et al. | β | 2025 | β |
| Shared Genetic Links Between Birth Weight and Developmental-Behavioral Disorders. | Sun R et al. | β | 2025 | β |
| Shared genetics of lung cancer and type 2 diabetes: a large-scale genome-wide cross-trait analysis. | Wang Z et al. | β | 2025 | β |
| Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer. | Cheng Y et al. | β | 2025 | β |
| Single-Cell Mapping of Genetic Risk Across Ten Respiratory Diseases. | Zhou M et al. | β | 2025 | β |
| Single-cell multiomic analysis unveils the immune landscape dynamics of graves' ophthalmopathy. | Ke S et al. | β | 2025 | β |
| Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology. | Gaur P et al. | β | 2025 | β |
| Spatially resolved mapping of cells associated with human complex traits. | Song L et al. | β | 2025 | β |
| Spatiotemporal dynamics of RERE in schizophrenia pathogenesis: insights from multi-omics and single-cell sequencing. | Shen J et al. | β | 2025 | β |
| Structural framework to address variant-gene relationship in primary open-angle glaucoma. | Singh N et al. | β | 2025 | β |
| Susceptibility genes for allergic conjunctivitis revealed by cross-tissue transcriptome-wide association study. | Xu Q et al. | β | 2025 | β |
| Susceptibility to childhood asthma modified by the interactive effects of polycyclic aromatic hydrocarbons exposure and genetic polymorphisms of the aryl hydrocarbon receptor signaling pathway: functional analysis based on lipid metabolism. | Tao X et al. | β | 2025 | β |
| Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases. | Ma Y et al. | β | 2025 | β |
| The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease. | Murphy KB et al. | β | 2025 | β |
| The brief resilience scale: a genome-wide association study in the UK Biobank. | Cornelis MC et al. | β | 2025 | β |
| The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia. | Toikumo S et al. | β | 2025 | β |
| The crucial role of immune factors in susceptibility to SARS-CoV-2 infection and severity of COVID-19. | Yu XH et al. | β | 2025 | β |
| The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach. | Papassotiropoulos A et al. | β | 2025 | β |
| The emergence of genetic variants linked to brain and cognitive traits in human evolution. | Libedinsky I et al. | β | 2025 | β |
| The genetic architecture of cervical length is shared with spontaneous preterm birth risk. | Wolf HM et al. | β | 2025 | β |
| The Genetic Architecture of the Human Corpus Callosum and its Subregions. | Bhatt RR et al. | β | 2025 | β |
| The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis. | Tong Y et al. | β | 2025 | β |
| The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases. | Konieczny MJ et al. | β | 2025 | β |
| The health impacts and genetic architecture of food liking in cardio-metabolic diseases. | Jiang W et al. | β | 2025 | β |
| The hidden genetic and microbial networks connecting neuropsychiatric and digestive disorders. | Xiong J et al. | β | 2025 | β |
| The impact of common and rare genetic variants on bradyarrhythmia development. | Weng LC et al. | β | 2025 | β |
| The integration of genome-wide and transcriptome-wide association studies in neurodegenerative diseases: opportunities, challenges, and current methodological innovations. | Gu SC et al. | β | 2025 | β |
| The Intersection of Genetics and Neuroimaging: A Systematic Review of Imaging Genetics in Neurological Disease for Personalized Treatment. | Mashhour MA et al. | β | 2025 | β |
| The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources. | Dilliott AA et al. | β | 2025 | β |
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| The role of inflammation in the development of tic symptoms in subjects with ADHD. | Takahashi N et al. | β | 2025 | β |
| The role of the brain-bone axis in skeletal degenerative diseases and psychiatric disorders, A genome-wide pleiotropic analysis. | Gao S et al. | β | 2025 | β |
| The shared genetic architecture and evolution of human language and musical rhythm. | AlagΓΆz G et al. | β | 2025 | β |
| The shared genetic etiology of autoimmune disorders and interstitial lung disease: insights from large-scale genome-wide cross-trait analysis. | Zhou F et al. | β | 2025 | β |
| The Utility of Genome-Wide Association Studies in Inherited Arrhythmias and Cardiomyopathies. | Dababneh S et al. | β | 2025 | β |
| The X chromosome's influences on the human brain. | Jiang Z et al. | β | 2025 | β |
| TidyGWAS: a scalable approach for standardized cleaning of genome-wide association study summary statistics. | Harder A et al. | β | 2025 | β |
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| Transcriptomic divergence of network hubs in the prenatal human brain. | Oldham S et al. | β | 2025 | β |
| Transcriptomic Insights into Gas6-Induced Placental Dysfunction: Gene Targets for Preeclampsia Therapy. | Jackson M et al. | β | 2025 | β |
| TRAPT: a multi-stage fused deep learning framework for predicting transcriptional regulators based on large-scale epigenomic data. | Zhang G et al. | β | 2025 | β |
| Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling. | Foote IF et al. | β | 2025 | β |
| Unraveling the genetic link: causal effects and PRS predictions of adiposity-related health conditions in East Asian individuals. | Lin YJ et al. | β | 2025 | β |
| Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845Β 492 individuals: a diagnostic study. | Huang W et al. | β | 2025 | β |
| Unraveling the shared genetic foundations of neurodevelopmental and psychiatric disorders: Insights from comprehensive genome-wide analyses. | Maimaiti A et al. | β | 2025 | β |
| Unsupervised feature extraction using deep learning empowers discovery of genetic determinants of the electrocardiogram. | Sieliwonczyk E et al. | β | 2025 | β |
| Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders. | Liwayiding A et al. | β | 2025 | β |
| Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery. | Wei S et al. | β | 2025 | β |
| Unveiling novel susceptibility genes and drug targets for basal cell carcinoma by a cross-tissue transcriptome-wide association study. | Sun H et al. | β | 2025 | β |
| Unveiling the genetic pleiotropy between anxiety disorders and autoimmune diseases: insights from large-scale genome-wide cross-trait analysis. | Lin H et al. | β | 2025 | β |
| Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study. | Xu J et al. | β | 2025 | β |
| Using genomic context informed genotype data and within-model ancestry adjustment to classify type 2 diabetes. | Barnett EJ et al. | β | 2025 | β |
| Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study. | Mokhtari A et al. | β | 2025 | β |
| Utilising genomic association data for causal inference in anorexia nervosa. | Adams DM et al. | β | 2025 | β |
| White matter microstructure in mid- to late adulthood is influenced by pathway-stratified polygenic risk for Alzheimer's disease. | Harrison JR et al. | β | 2025 | β |
| Whole-exome sequencing reveals sex difference in the genetic architecture of high myopia. | Liu X et al. | β | 2025 | β |
| Whole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of Ξ²-thalassemia. | Wang X et al. | β | 2025 | β |
| X-chromosome-wide association study for Alzheimer's disease. | Le Borgne J et al. | β | 2025 | β |
| Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation. | Zheng S et al. | β | 2024 | β |
| Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study. | Tissink EP et al. | β | 2024 | β |
| Accelerated biological aging as a potential risk factor for rheumatoid arthritis. | Dan YL et al. | β | 2024 | β |
| Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders. | GonzΓ‘lez-PeΓ±as J et al. | β | 2024 | β |
| Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies. | Wang S et al. | β | 2024 | β |
| A comprehensive framework for trans-ancestry pathway analysis using GWAS summary data from diverse populations. | Fu S et al. | β | 2024 | β |
| A concerted neuron-astrocyte program declines in ageing and schizophrenia. | Ling E et al. | β | 2024 | β |
| A cross-tissue transcriptome-wide association study identifies new susceptibility genes for frailty. | Lin D et al. | β | 2024 | β |
| A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis. | Hu X et al. | β | 2024 | β |
| A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD. | Chen G et al. | β | 2024 | β |
| A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine. | Gui J et al. | β | 2024 | β |
| Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis. | Misicka E et al. | β | 2024 | β |
| Advancing crop improvement through GWAS and beyond in mung bean. | Ahmed SR et al. | β | 2024 | β |
| A genome-wide association meta-analysis of all-cause and vascular dementia. | Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium | β | 2024 | β |
| A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort. | Chen SP et al. | β | 2024 | β |
| A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children. | Lin YP et al. | β | 2024 | β |
| A genome-wide Association study of the Count of Codeine prescriptions. | Song W et al. | β | 2024 | β |
| A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing. | Bhatt IS et al. | β | 2024 | β |
| A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. | Gupta P et al. | β | 2024 | β |
| A genome-wide meta-analysis of palmoplantar pustulosis implicates T<sub>H</sub>2 responses and cigarette smoking in disease pathogenesis. | Hernandez-Cordero A et al. | β | 2024 | β |
| A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait. | Abbondanza F et al. | β | 2024 | β |
| A high-dimensional omnibus test for set-based association analysis. | Yang H et al. | β | 2024 | β |
| Alzheimer's disease as a causal risk factor for diabetic retinopathy: a Mendelian randomization study. | Ouyang F et al. | β | 2024 | β |
| Alzheimer's disease rewires gene coexpression networks coupling different brain regions. | Mitra S et al. | β | 2024 | β |
| A multi-ancestry genetic study of pain intensity in 598,339 veterans. | Toikumo S et al. | β | 2024 | β |
| A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping. | Dong P et al. | β | 2024 | β |
| Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior. | Sullivan KA et al. | β | 2024 | β |
| Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes. | Giel AS et al. | β | 2024 | β |
| Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline. | Wiegrebe S et al. | β | 2024 | β |
| An approach to identify gene-environment interactions and reveal new biological insight in complex traits. | Zhu X et al. | β | 2024 | β |
| An emerging multi-omic understanding of the genetics of opioid addiction. | Johnson EO et al. | β | 2024 | β |
| A New Method for Conditional Gene-Based Analysis Effectively Accounts for the Regional Polygenic Background. | Svishcheva GR et al. | β | 2024 | β |
| An integrative framework to prioritize genes in more than 500 loci associated with body mass index. | Hemerich D et al. | β | 2024 | β |
| An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn's disease with defective antimicrobial activity. | Aschenbrenner D et al. | β | 2024 | β |
| A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors. | Jia X et al. | β | 2024 | β |
| A novel method for multiple phenotype association studies based on genotype and phenotype network. | Cao X et al. | β | 2024 | β |
| A protein risk score for all-cause and respiratory-specific mortality in non-Hispanic white and African American individuals who smoke. | Moll M et al. | β | 2024 | β |
| A sex-stratified analysis of the genetic architecture of human brain anatomy. | Shafee R et al. | β | 2024 | β |
| A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease. | Tsartsalis S et al. | β | 2024 | β |
| A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens. | Reiner BC et al. | β | 2024 | β |
| A spatiotemporal proteomic map of human adipogenesis. | Klingelhuber F et al. | β | 2024 | β |
| Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality. | Yu XH et al. | β | 2024 | β |
| Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality. | Rong GW et al. | β | 2024 | β |
| Association of common genetic variants with chronic axonal polyneuropathy in the general population: a genome-wide association study. | Taams NE et al. | β | 2024 | β |
| Association of Metabolic Diseases and Moderate Fat Intake with Myocardial Infarction Risk. | Zhou J et al. | β | 2024 | β |
| Autoimmune diseases and cardiovascular risk: Mendelian randomization analysis for the impact of 19 autoimmune diseases on 14 cardiovascular conditions. | Bao Y et al. | β | 2024 | β |
| Canadian COVID-19 host genetics cohort replicates known severity associations. | Garg E et al. | β | 2024 | β |
| Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer. | Sun X et al. | β | 2024 | β |
| Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study. | Liang Y et al. | β | 2024 | β |
| Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics. | Mi Z et al. | β | 2024 | β |
| Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population. | Simmonds E et al. | β | 2024 | β |
| Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation. | van der Meer D et al. | β | 2024 | β |
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| Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes. | Li M et al. | β | 2024 | β |
| Combining genetic and single-cell expression data reveals cell types and novel candidate genes for orofacial clefting. | Siewert A et al. | β | 2024 | β |
| Common polygenic variation in the early medication change (EMC) cohort affects disorder risk, but not the antidepressant treatment response. | MΓΌller S et al. | β | 2024 | β |
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| Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia. | Dear R et al. | β | 2024 | β |
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| Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics. | Rexach JE et al. | β | 2024 | β |
| Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis. | Zou M et al. | β | 2024 | β |
| Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain. | Vogel JW et al. | β | 2024 | β |
| Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan. | Chen HL et al. | β | 2024 | β |
| Disentangling the genetic overlap between ischemic stroke and obesity. | Yang R et al. | β | 2024 | β |
| Dissecting shared genetic architecture between depression and body mass index. | Zhang H et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies. | Enduru N et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between anti-MΓΌllerian hormone and age at menopause based on genome-wide association study. | Long P et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between endometriosis and polycystic ovary syndrome. | Tan H et al. | β | 2024 | β |
| Distinct genetic liability profiles define clinically relevant patient strata across common diseases. | Trastulla L et al. | β | 2024 | β |
| Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo. | Sportelli L et al. | β | 2024 | β |
| Drivers of genomic differentiation landscapes in populations of disparate ecological and geographical settings within mainland Apis cerana. | Dong J et al. | β | 2024 | β |
| Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants. | Rahman MS et al. | β | 2024 | β |
| Effect of Passaging on Bovine Chondrocyte Gene Expression and Engineered Cartilage Production. | Lindberg ED et al. | β | 2024 | β |
| Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer. | Tang M et al. | β | 2024 | β |
| Epidemiologic and genetic associations between primary biliary cholangitis and extrahepatic rheumatic diseases. | Qian Q et al. | β | 2024 | β |
| Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity. | Townsend HA et al. | β | 2024 | β |
| Evaluation of Bayesian Linear Regression derived gene set test methods. | Bai Z et al. | β | 2024 | β |
| Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases. | Gholipourshahraki T et al. | β | 2024 | β |
| Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety. | Zhang X et al. | β | 2024 | β |
| Evidence that variation in root anatomy contributes to local adaptation in Mexican native maize. | McLaughlin CM et al. | β | 2024 | β |
| Exploring the causal effect of placental physiology in susceptibility to mental and addictive disorders: a Mendelian randomization study. | JΓ‘come-Ferrer P et al. | β | 2024 | β |
| Exploring the Common Genetic Underpinnings of Chronic Pulmonary Disease and Esophageal Carcinoma Susceptibility. | Zhang D et al. | β | 2024 | β |
| Exploring the interconnected between type 2 diabetes mellitus and nonalcoholic fatty liver disease: Genetic correlation and Mendelian randomization analysis. | Ni W et al. | β | 2024 | β |
| Exploring the Shared Genetic Architecture Between Obstructive Sleep Apnea and Body Mass Index. | Zhou P et al. | β | 2024 | β |
| Exploring the shared genetic basis of major depressive disorder and frailty. | Fu W et al. | β | 2024 | β |
| Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry. | Ray NR et al. | β | 2024 | β |
| Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample. | Krug A et al. | β | 2024 | β |
| From genetic associations to genes: methods, applications, and challenges. | Qi T et al. | β | 2024 | β |
| From GWASs toward Mechanistic Understanding with Case Studies in Dermatogenetics. | Shen S et al. | β | 2024 | β |
| Functional and regulatory diversification of Period genes responsible for circadian rhythm in vertebrates. | Kwak JS et al. | β | 2024 | β |
| Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study. | Ren S et al. | β | 2024 | β |
| Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study. | Shi R et al. | β | 2024 | β |
| Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes. | Du Z et al. | β | 2024 | β |
| Genetic associations of protein-coding variants in venous thromboembolism. | He XY et al. | β | 2024 | β |
| Genetic basis of right and left ventricular heart shape. | Burns R et al. | β | 2024 | β |
| Genetic drivers and cellular selection of female mosaic X chromosome loss. | Liu A et al. | β | 2024 | β |
| Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors. | Savage JE et al. | β | 2024 | β |
| Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia. | Cameron D et al. | β | 2024 | β |
| Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia. | Tume CE et al. | β | 2024 | β |
| Genetic interactions and pleiotropy in metabolic diseases: Insights from a comprehensive GWAS analysis. | Shen J et al. | β | 2024 | β |
| Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity. | Chen Y et al. | β | 2024 | β |
| Genetic overlap between major depressive disorder and obstructive sleep apnea. | Lin F et al. | β | 2024 | β |
| Genetic risk factors underlying white matter hyperintensities and cortical atrophy. | Patel Y et al. | β | 2024 | β |
| Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci. | Lori A et al. | β | 2024 | β |
| Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. | Francis M et al. | β | 2024 | β |
| Genome-Wide Analysis of Exertional Rhabdomyolysis in Sickle Cell Trait Positive African Americans. | Ren M et al. | β | 2024 | β |
| Genome-Wide and Exome-Wide Association Study Identifies Genetic Underpinning of Comorbidity between Myocardial Infarction and Severe Mental Disorders. | Jiang B et al. | β | 2024 | β |
| Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. | Nievergelt CM et al. | β | 2024 | β |
| Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease. | Ramachandran D et al. | β | 2024 | β |
| Genome-wide association analysis and admixture mapping in a Puerto Rican cohort supports an Alzheimer disease risk locus on chromosome 12. | Akgun B et al. | β | 2024 | β |
| Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women. | Cai Y et al. | β | 2024 | β |
| Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage. | Westergaard D et al. | β | 2024 | β |
| Genome-wide association meta-analysis identifies two novel loci associated with dental caries. | Nogawa S et al. | β | 2024 | β |
| Genome-wide association neural networks identify genes linked to family history of Alzheimer's disease. | Ghose U et al. | β | 2024 | β |
| Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer. | Laskar RS et al. | β | 2024 | β |
| Genome-wide association studies for pelvic organ prolapse in the Japanese population. | Matsunami M et al. | β | 2024 | β |
| Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration. | Ahmad S et al. | β | 2024 | β |
| Genome-wide association study of cardiometabolic multimorbidity in the UK Biobank. | Zhao C et al. | β | 2024 | β |
| Genome wide association study of clinical duration and age at onset of sporadic CJD. | Hummerich H et al. | β | 2024 | β |
| Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study. | Tebeka S et al. | β | 2024 | β |
| Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population. | Strom NI et al. | β | 2024 | β |
| Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations. | Gelernter J et al. | β | 2024 | β |
| Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors. | Olofsson IA et al. | β | 2024 | β |
| Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. | Jurgens SJ et al. | β | 2024 | β |
| Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders. | Adewuyi EO et al. | β | 2024 | β |
| Genome-wide determinants of mortality and motor progression in Parkinson's disease. | Tan MMX et al. | β | 2024 | β |
| Genome-Wide Gene-Environment Interaction Analysis Identifies Novel Candidate Variants for Growth Traits in Beef Cattle. | Deng T et al. | β | 2024 | β |
| Genome-wide investigation of exogenous female hormones, genetic variation, and venous thromboembolism risk. | Hasser EK et al. | β | 2024 | β |
| Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction. | Schormair B et al. | β | 2024 | β |
| Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. | Salo V et al. | β | 2024 | β |
| Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome. | AkΓ§imen F et al. | β | 2024 | β |
| Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. | GarcΓa-MarΓn LM et al. | β | 2024 | β |
| Genomic network analysis characterizes genetic architecture and identifies trait-specific biology | Thorp JG et al. | β | 2024 | β |
| GLP-1-directed NMDA receptor antagonism for obesity treatment. | Petersen J et al. | β | 2024 | β |
| GOAT: efficient and robust identification of gene set enrichment. | Koopmans F | β | 2024 | β |
| Gut-bone axis research: unveiling the impact of gut microbiota on postmenopausal osteoporosis and osteoclasts through Mendelian randomization. | Xiao H et al. | β | 2024 | β |
| GWAS breakthroughs: mapping the journey from one locus to 393 significant coronary artery disease associations. | Aherrahrou R et al. | β | 2024 | β |
| GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma. | Huang Y et al. | β | 2024 | β |
| GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. | Shade LMP et al. | β | 2024 | β |
| Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction. | Pain O et al. | β | 2024 | β |
| Hemochromatosis neural archetype reveals iron disruption in motor circuits. | Loughnan R et al. | β | 2024 | β |
| Heritability and genetic contribution analysis of structural-functional coupling in human brain. | Dai W et al. | β | 2024 | β |
| Identification and correction for collider bias in a genome-wide association study of diabetes-related heart failure. | Sun YV et al. | β | 2024 | β |
| Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1. | Jung J et al. | β | 2024 | β |
| Identification of genetic variants associated with clinical features of sickle cell disease. | Tsukahara K et al. | β | 2024 | β |
| Identification of rare disease genes as drivers of common diseases through tissue-specific gene regulatory networks. | Bakker OB et al. | β | 2024 | β |
| Identifying Common Genetic Etiologies Between Inflammatory Bowel Disease and Related Immune-Mediated Diseases. | Liu X et al. | β | 2024 | β |
| Identifying potential drug targets for varicose veins through integration of GWAS and eQTL summary data. | Cui Y et al. | β | 2024 | β |
| Illuminating Shared Genetic Associations Between Oesophageal Carcinoma and Pulmonary Carcinoma Risk. | Zhang D et al. | β | 2024 | β |
| Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness. | Amelink JS et al. | β | 2024 | β |
| Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters. | Bonk S et al. | β | 2024 | β |
| Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets. | Frei O et al. | β | 2024 | β |
| Improved polygenic risk prediction in migraine-first patients. | Torok D et al. | β | 2024 | β |
| Inflammatory bowel disease and osteoporosis: Common genetic effects, pleiotropy, and causality. | Hu YQ et al. | β | 2024 | β |
| Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. | Ghouse J et al. | β | 2024 | β |
| Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation. | ThΓ©riault S et al. | β | 2024 | β |
| Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. | Hong J et al. | β | 2024 | β |
| Interpretable multimodal machine learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy. | Nguyen PBH et al. | β | 2024 | β |
| Investigating causality and shared genetic architecture between body mass index and cognitive function: a genome-wide cross-trait analysis and bi-directional Mendelian randomization study. | Chen M et al. | β | 2024 | β |
| Investigating the Bidirectional Association of Rheumatoid Arthritis and Thyroid Function: A Methodologic Assessment of Mendelian Randomization. | Tan Y et al. | β | 2024 | β |
| Investigating the genetic relationship of intracranial and subcortical brain volumes with depression and other psychiatric disorders. | GarcΓa-MarΓn LM et al. | β | 2024 | β |
| Investigating the shared genetic architecture between attention-deficit/hyperactivity disorder and risk taking behavior: A large-scale genomewide cross-trait analysis. | Chen Y et al. | β | 2024 | β |
| Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function. | Zhang S et al. | β | 2024 | β |
| Investigating the shared genetic architecture of osteoarthritis and frailty: a genome-wide cross-trait analysis. | Guo H et al. | β | 2024 | β |
| Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation. | Shen J et al. | β | 2024 | β |
| Joint testing of rare variant burden scores using non-negative least squares. | Ziyatdinov A et al. | β | 2024 | β |
| Machine learning integrative approaches to advance computational immunology. | Curion F et al. | β | 2024 | β |
| Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. | Dearden L et al. | β | 2024 | β |
| Mechanism of electroconvulsive therapy in schizophrenia: a bioinformatics analysis study of RNA-seq data. | Wang T et al. | β | 2024 | β |
| Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance. | Cai Z et al. | β | 2024 | β |
| Microglial function interacts with the environment to affect sex-specific depression risk. | Fitzgerald E et al. | β | 2024 | β |
| Mining single-cell data for cell type-disease associations. | Chen KG et al. | β | 2024 | β |
| Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases. | Ruisch IH et al. | β | 2024 | β |
| Molecular signatures of cortical expansion in the human foetal brain. | Ball G et al. | β | 2024 | β |
| Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. | Toikumo S et al. | β | 2024 | β |
| Multiome-wide Association Studies: Novel Approaches for Understanding Diseases. | Shao M et al. | β | 2024 | β |
| Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder. | Zillich E et al. | β | 2024 | β |
| Multi-trait analysis reveals risk loci for heart failure and the shared genetic etiology with blood lipids, blood pressure, and blood glucose. | Zhu Y et al. | β | 2024 | β |
| Multivariate genomic analysis of 5βmillion people elucidates the genetic architecture of shared components of the metabolic syndrome. | Park S et al. | β | 2024 | β |
| Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology. | Kumar P et al. | β | 2024 | β |
| Navigating the omics era of lipid metabolism. | Henne WM | β | 2024 | β |
| Network-based analysis predicts interacting genetic modifiers from a meta-mapping study of spike-wave discharge in mice. | Lara MK et al. | β | 2024 | β |
| Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease. | Shantaraman A et al. | β | 2024 | β |
| Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk. | Borcuk C et al. | β | 2024 | β |
| Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. | Yang BZ et al. | β | 2024 | β |
| Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. | Andrade-Brito DE et al. | β | 2024 | β |
| Novel Insights Into the Causal Effects and Shared Genetics Between Body Fat and Parkinson Disease. | Zhao Q et al. | β | 2024 | β |
| Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities. | Zhu H et al. | β | 2024 | β |
| Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations. | Han X et al. | β | 2024 | β |
| Novel risk loci for COVID-19 hospitalization among admixed American populations. | Diz-de Almeida S et al. | β | 2024 | β |
| Olanzapine enhances early brain maturation through activation of the NODAL/FOXH1 axis. | Teng Z et al. | β | 2024 | β |
| Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine. | Eszlari N et al. | β | 2024 | β |
| Omics Approaches to Investigate the Pathogenesis of Suicide. | Boldrini M et al. | β | 2024 | β |
| Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease. | Jamialahmadi O et al. | β | 2024 | β |
| Pathway enrichment in genome-wide analysis of longitudinal Alzheimer's disease biomarker endophenotypes. | Rosewood TJ et al. | β | 2024 | β |
| Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study. | Clarelli F et al. | β | 2024 | β |
| Pharmacological Approaches to Hearing Loss. | Cederroth CR et al. | β | 2024 | β |
| Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies. | Moll M et al. | β | 2024 | β |
| Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition. | Yang X et al. | β | 2024 | β |
| Potential drug targets for osteoporosis identified: A Mendelian randomization study. | Zhao G et al. | β | 2024 | β |
| Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis. | Katsoula G et al. | β | 2024 | β |
| Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure. | Ganji-Arjenaki M et al. | β | 2024 | β |
| Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries. | Pybus AF et al. | β | 2024 | β |
| Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank. | Elmore AR et al. | β | 2024 | β |
| Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. | Zhao Y et al. | β | 2024 | β |
| Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson's disease. | Doostparast Torshizi A et al. | β | 2024 | β |
| Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions. | Gao Y et al. | β | 2024 | β |
| Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics. | Dall'Aglio L et al. | β | 2024 | β |
| Rare and common variants associated with alcohol consumption identify a conserved molecular network. | Leger BS et al. | β | 2024 | β |
| Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction. | Savage JE et al. | β | 2024 | β |
| Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma. | Alpen K et al. | β | 2024 | β |
| Regulatory elements in <i>SEM1-DLX5-DLX6</i> (7q21.3) locus contribute to genetic control of coronal nonsyndromic craniosynostosis and bone density-related traits. | Nicoletti P et al. | β | 2024 | β |
| Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma. | Djeddi S et al. | β | 2024 | β |
| Risk Factors for Intracerebral Hemorrhage: Genome-Wide Association Study and Mendelian Randomization Analyses. | Larsson SC et al. | β | 2024 | β |
| Schizophrenia polygenic risk scores, clinical variables and genetic pathways as predictors of phenotypic traits of bipolar I disorder. | Grigoroiu-Serbanescu M et al. | β | 2024 | β |
| Seedling root system adaptation to water availability during maize domestication and global expansion. | Yu P et al. | β | 2024 | β |
| Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus. | Benjamin KJM et al. | β | 2024 | β |
| Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. | Bosworth ML et al. | β | 2024 | β |
| Sex-specific genetic architecture of blood pressure. | Yang ML et al. | β | 2024 | β |
| Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke. | CΓ‘rcel-MΓ‘rquez J et al. | β | 2024 | β |
| Shared and Unique Genetic Links between Neuroticism and Gastrointestinal Tract Diseases. | Tian Y et al. | β | 2024 | β |
| Shared genetic aetiology of respiratory diseases: a genome-wide multitraits association analysis. | Chen Z et al. | β | 2024 | β |
| Shared genetic architecture and causal relationship between liver and heart disease. | Fang Z et al. | β | 2024 | β |
| Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis. | Yu X et al. | β | 2024 | β |
| Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis. | Liu X et al. | β | 2024 | β |
| Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases. | Gong T et al. | β | 2024 | β |
| Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis. | Chen Z et al. | β | 2024 | β |
| Shared genetic correlations between kidney diseases and sepsis. | Zhang T et al. | β | 2024 | β |
| Shared genetic links between hypothyroidism and psychiatric disorders: evidence from a comprehensive genetic analysis. | Zhou J et al. | β | 2024 | β |
| Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease. | Di H et al. | β | 2024 | β |
| Shared Genetic Links Between Sleep, Neurodevelopmental and Neuropsychiatric Conditions: A Genome-Wide and Pathway-Based Polygenic Score Analysis. | Fahey L et al. | β | 2024 | β |
| Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates. | Lalagkas PN et al. | β | 2024 | β |
| Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders. | Xiu Z et al. | β | 2024 | β |
| Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD. | Pineda SS et al. | β | 2024 | β |
| Single cell dual-omic atlas of the human developing retina. | Zuo Z et al. | β | 2024 | β |
| Single-cell multi-cohort dissection of the schizophrenia transcriptome. | Ruzicka WB et al. | β | 2024 | β |
| Single-cell multiomics analysis reveals cell/tissue-specific associations in bipolar disorder. | Wei W et al. | β | 2024 | β |
| Single-cell multiregion dissection of Alzheimer's disease. | Mathys H et al. | β | 2024 | β |
| Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease. | Su Y et al. | β | 2024 | β |
| Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease. | Wang Q et al. | β | 2024 | β |
| Single-Nucleus RNA-Seq Characterizes the Cell Types Along the Neuronal Lineage in the Adult Human Subependymal Zone and Reveals Reduced Oligodendrocyte Progenitor Abundance with Age. | Puvogel S et al. | β | 2024 | β |
| Spatial multiomic landscape of the human placenta at molecular resolution. | Ounadjela JR et al. | β | 2024 | β |
| Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma. | Yasumizu Y et al. | β | 2024 | β |
| Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population. | Vanneste M et al. | β | 2024 | β |
| Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk. | Law PJ et al. | β | 2024 | β |
| Systematic Review and Phenome-Wide Scans of Genetic Associations with Vascular Cognitive Impairment. | Diany R et al. | β | 2024 | β |
| Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population. | Kumar S et al. | β | 2024 | β |
| Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood. | Daskalakis NP et al. | β | 2024 | β |
| The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models. | MacDonald HJ et al. | β | 2024 | β |
| The genetic architecture of biological age in nine human organ systems. | Wen J et al. | β | 2024 | β |
| The genetic architecture of youth anxiety: a study protocol. | McAusland L et al. | β | 2024 | β |
| The genetic landscape of basal ganglia and implications for common brain disorders. | Bahrami S et al. | β | 2024 | β |
| The goldmine of GWAS summary statistics: a systematic review of methods and tools. | Kontou PI et al. | β | 2024 | β |
| The immune cells have complex causal regulation effects on cancers. | Li M et al. | β | 2024 | β |
| The neocortical infrastructure for language involves region-specific patterns of laminar gene expression. | Wong MMK et al. | β | 2024 | β |
| The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease. | O'Brien CL et al. | β | 2024 | β |
| The shared genetic etiology of antisocial behavior and psychiatric disorders: Insights from pleiotropy and causality analysis. | Wang S et al. | β | 2024 | β |
| The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ERβ+βbreast cancer but not ER- breast cancer. | Bi K et al. | β | 2024 | β |
| The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function. | Jiang W et al. | β | 2024 | β |
| Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer. | Peruchet-Noray L et al. | β | 2024 | β |
| Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration. | Guvenek A et al. | β | 2024 | β |
| Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson's disease. | Dehestani M et al. | β | 2024 | β |
| Uncovering genetic loci and biological pathways associated with age-related cataracts through GWAS meta-analysis. | Diaz-Torres S et al. | β | 2024 | β |
| Uncovering novel regulatory variants in carbohydrate metabolism: a comprehensive multi-omics study of glycemic traits in the Indian population. | Nair JM et al. | β | 2024 | β |
| Understanding the genetic complexity of puberty timing across the allele frequency spectrum. | Kentistou KA et al. | β | 2024 | β |
| Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories. | Gezsi A et al. | β | 2024 | β |
| Unlocking the genetic basis of vitamin E content in sweet corn kernels: Expanding breeding targets through genome-wide association studies. | Li K et al. | β | 2024 | β |
| Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders. | Abar L et al. | β | 2024 | β |
| Unveiling Gene Interactions in Alzheimer's Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach. | Sanders KL et al. | β | 2024 | β |
| Unveiling the Mechanism of Retinoic Acid Therapy for Cutaneous Warts: Insights from Multi-Omics Integration. | Dong ZY et al. | β | 2024 | β |
| Valid inference for machine learning-assisted genome-wide association studies. | Miao J et al. | β | 2024 | β |
| X-linked genetic associations in sporadic thoracic aortic dissection. | Musfee FI et al. | β | 2024 | β |