Social cognition as an RDoC domain.
paper
Cited
Public
- Authors
- Gur, Ruben C; Gur, Raquel E
- Year
- 2016
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 26607670
- DOI
- 10.1002/ajmg.b.32394
- PMCID
- PMC4843508
While the bulk of research into neural substrates of behavior and psychopathology has focused on cognitive, memory and executive functions, there has been a recent surge of interest in emotion processing and social cognition, manifested in designating Social Cognition as a major RDoC domain. We describe the origins of this field's influence on cognitive neuroscience and highlight the most salient findings leading to the characterization of the "social brain" and the establishments of parameters that quantify normative and aberrant behaviors. Such parameters of behavior and neurobiology are required for a potentially successful RDoC construct, especially if heritability is established, because of the need to link with genomic systems. We proceed to illustrate how a social cognition measure can be used within the RDoC framework by presenting a task of facial emotion identification. We show that performance is sensitive to normative individual differences related to age and sex and to deficits associated with schizophrenia and other psychotic disorders. Neuroimaging studies with this task demonstrate that it recruits limbic and frontal regulatory activation in healthy samples as well as abnormalities in psychiatric populations. Evidence for its heritability was documented in genomic family studies and in patients with the 22q11.2 deletion syndrome. Measures that meet such criteria can help build translational bridges between cellular molecular mechanisms and behavior that elucidate aberrations related to psychopathology. Such links will transcend current diagnostic classifications and ultimately lead to a mechanistically based diagnostic nomenclature. Establishing such bridges will provide the elements necessary for early detection and scientifically grounded intervention.
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| 19 reports local | cohort |
| 22q11.2 deletion | variant |
| 22q11DS local | cohort |
| 22q11DS cohort local | cohort |
| 91 patients local | cohort |
| Abnormal amygdala activation local | phenotype |
| accuracy | phenotype |
| Affect discrimination local | phenotype |
| Affect Discrimination local | phenotype |
| Affective deficits local | phenotype |
| affiliate behavior local | phenotype |
| Affiliative behavior | phenotype |
| age | phenotype |
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| aggression | phenotype |
| Ambiguous Intentions Hostility Questionnaire local | phenotype |
| amygdala | anatomy |
| amygdala overactivation local | phenotype |
| animal models | cohort |
| Anosodysaphorie local | phenotype |
| Anosognosie local | phenotype |
| anterior cingulate cortex | anatomy |
| anti-social behavior local | phenotype |
| anxiety | phenotype |
| arousal | phenotype |
| attention | phenotype |
| Attenuated Psychosis Syndrome local | phenotype |
| autism spectrum disorders | phenotype |
| Awareness of Social Inferences Test local | phenotype |
| Babinski cohort local | cohort |
| behavioral abnormalities of emotion processing local | phenotype |
| Behavioral emotion identification deficits local | phenotype |
| Bell Lysaker Emotion Recognition Task local | phenotype |
| benzodiazepines | drug |
| bipolar disorder | phenotype |
| Bipolar-Schizophrenia Network on Intermediate Phenotypes local | cohort |
| Brain Systems Implicated in Social Cognition local | anatomy |
| case-control sample | cohort |
| case reports local | cohort |
| cerebral hemispheres | anatomy |
| Clinical high risk (CHR) local | cohort |
| clinical high risk (CHR) youths local | cohort |
| Clinically psychosis-prone subjects local | cohort |
| clinical population | cohort |
| cognition | phenotype |
| cognitive measures | phenotype |
| cognitive symptoms | phenotype |
| common variants | cohort |
| Computerized Neurocognitive Battery (CNB) local | cohort |
| Cortico-limbic system local | anatomy |
| cortico-striatal pathways local | anatomy |
| deception local | phenotype |
| delusions | phenotype |
| depression | phenotype |
| deteriorating social functioning local | phenotype |
| developmental stage | phenotype |
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| docile behavior local | phenotype |
| dorsolateral prefrontal cortex | anatomy |
| dysphoria | phenotype |
| Electrophysiological measures | phenotype |
| Elevated amygdala activity local | phenotype |
| Emotion | phenotype |
| emotional lability local | phenotype |
| emotion identification | phenotype |
| Emotion identification accuracy local | phenotype |
| emotion identification deficit local | phenotype |
| Emotion identification deficits local | phenotype |
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| Emotion identification speed local | phenotype |
| Emotion Identification Test local | phenotype |
| Emotion intensity differentiation local | phenotype |
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| endophenotype | phenotype |
| ER40 local | phenotype |
| euphoria | phenotype |
| euphoric mood change local | phenotype |
| Facial affect perception local | phenotype |
| Facial affect perception deficit local | phenotype |
| facial emotion identification local | phenotype |
| Facial Emotion Identification local | phenotype |
| Facial emotion processing local | phenotype |
| families | cohort |
| family members | cohort |
| fear conditioning | phenotype |
| first-degree relatives | cohort |
| first-episode psychosis local | phenotype |
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| First-episode subjects local | cohort |
| First-generation antipsychotics local | drug |
| flat affect local | phenotype |
| frontal control systems local | anatomy |
| frontal cortex | anatomy |
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| fusiform gyrus | anatomy |
| gelastic epilepsy local | phenotype |
| genetic factors | cohort |
| hallucinations | phenotype |
| healthy controls | cohort |
| Healthy people local | cohort |
| healthy populations local | cohort |
| high-risk subjects | cohort |
| Hinting Task local | phenotype |
| hippocampal regions local | anatomy |
| Hughlings-Jackson cohort local | cohort |
| Implicit bias local | phenotype |
| Implicit Bias local | phenotype |
| Independent family study of African-Americans local | cohort |
| individuals at risk for schizophrenia local | cohort |
| insula | anatomy |
| intellectual disability | phenotype |
| intensity/arousal local | phenotype |
| jocularity local | phenotype |
| Klüver-Bucy syndrome local | phenotype |
| language | phenotype |
| lateral orbitofrontal cortex | anatomy |
| left hemispheric lesion local | anatomy |
| left-sided foci local | anatomy |
| left-sided lesions local | anatomy |
| Left side of the face local | anatomy |
| limbic regions | anatomy |
| limbic system | anatomy |
| memory | phenotype |
| mood disorders | phenotype |
| Mood induction local | phenotype |
| mood regulation | phenotype |
| moral judgment local | phenotype |
| Multiplex multigenerational family study of schizophrenia local | cohort |
| negative symptoms | phenotype |
| negative valence | phenotype |
| Neuroleptic naïve patients local | cohort |
| neuropsychiatric disorders | phenotype |
| Normal amygdala activation local | phenotype |
| Optimized early intervention program local | cohort |
| orbitofrontal cortex | anatomy |
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| pathological crying local | phenotype |
| pathological laughing local | phenotype |
| Philadelphia Neurodevelopmental Cohort | cohort |
| Pinkham et al 2015 local | cohort |
| PNC sample local | cohort |
| positive affect | phenotype |
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| prefrontal cortex | anatomy |
| Prodrome local | phenotype |
| prosodic disturbance local | phenotype |
| psychiatric disorders | phenotype |
| Psychiatric Genomics Consortium | cohort |
| Psychiatric Symptomatology local | phenotype |
| psychopathology | phenotype |
| psychosis | phenotype |
| RDoC | cohort |
| Reading the Mind in the Eyes Task local | phenotype |
| Reduced amygdala activation local | phenotype |
| Reduced prefrontal-amygdala functional connectivity local | phenotype |
| Relationships Across Domains local | phenotype |
| response to baby schema local | phenotype |
| retrospective study of 119 cases local | cohort |
| reward valuation local | phenotype |
| right frontal cortex | anatomy |
| right hemispherectomy local | anatomy |
| right hemispheric lesion local | anatomy |
| right-sided damage local | anatomy |
| risk taking | phenotype |
| rodents | cohort |
| running speed | phenotype |
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| schizophrenia | phenotype |
| Second-generation antipsychotics local | drug |
| sex | phenotype |
| sexual attraction local | phenotype |
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| social approach | phenotype |
| social avoidance | phenotype |
| social behavior | phenotype |
| social cognition | phenotype |
| Social Cognition and Functioning (SCAF) study local | cohort |
| Social cognition measures local | phenotype |
| Social Cognition Tests local | phenotype |
| Social disengagement local | phenotype |
| Social-emotional deficits local | phenotype |
| social functioning | phenotype |
| Spatial processing local | phenotype |
| Stimulus salience local | phenotype |
| Subjective ratings local | phenotype |
| Temporolimbic local | anatomy |
| Third independent family sample local | cohort |
| Threat perception local | phenotype |
| Threat-related signals local | phenotype |
| Trustworthiness Task local | phenotype |
| uncontrollable emotional outbursts local | phenotype |
| ventral pallidum | anatomy |
| ventral prefrontal cortex | anatomy |
| ventral striatum | anatomy |
| ventromedial prefrontal cortex | anatomy |
| Ventromedial prefrontal cortex-amygdala connectivity local | anatomy |
| verbal memory | phenotype |
| working memory | phenotype |
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