Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration.
paper
Cited
Public
- Authors
- Di Lorenzo, Giorgio; Daverio, Andrea; Ferrentino, Fabiola; Santarnecchi, Emiliano; Ciabattini, Fabio; Monaco, Leonardo; Lisi, Giulia; Barone, Ylenia; Di Lorenzo, Cherubino; Niolu, Cinzia; Seri, Stefano; Siracusano, Alberto
- Year
- 2015
- Journal
- Frontiers in human neuroscience
- PMID
- 25999835
- DOI
- 10.3389/fnhum.2015.00234
- PMCID
- PMC4419718
Despite the increasing body of evidence supporting the hypothesis of schizophrenia as a disconnection syndrome, studies of resting-state EEG Source Functional Connectivity (EEG-SFC) in people affected by schizophrenia are sparse. The aim of the present study was to investigate resting-state EEG-SFC in 77 stable, medicated patients with schizophrenia (SCZ) compared to 78 healthy volunteers (HV). In order to study the effect of illness duration, SCZ were divided in those with a short duration of disease (SDD; n = 25) and those with a long duration of disease (LDD; n = 52). Resting-state EEG recordings in eyes closed condition were analyzed and lagged phase synchronization (LPS) indices were calculated for each ROI pair in the source-space EEG data. In delta and theta bands, SCZ had greater EEG-SFC than HV; a higher theta band connectivity in frontal regions was observed in LDD compared with SDD. In the alpha band, SCZ showed lower frontal EEG-SFC compared with HV whereas no differences were found between LDD and SDD. In the beta1 band, SCZ had greater EEG-SFC compared with HVs and in the beta2 band, LDD presented lower frontal and parieto-temporal EEG-SFC compared with HV. In the gamma band, SDD had greater connectivity values compared with LDD and HV. This study suggests that resting state brain network connectivity is abnormally organized in schizophrenia, with different patterns for the different EEG frequency components and that EEG can be a powerful tool to further elucidate the complexity of such disordered connectivity.
Resting-state EEG SFC results of the four comparisons in the six bands. The red color indicates an increase of LPS (functional connectivity) indices and the blue a decrease. The thicker is the line the bigger is the difference. HV, Healthy Volunteers; SCZ, people affected by schizophrenia; LDD, people affected by schizophrenia with Long Duration of Disease; SDD, people affected by schizophrenia with Short Duration of Disease.
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| 40 | Limitations | Some limitations in the current study must be considered. The pharmacological therapy could be a⦠|
| 41 | Conclusions | Our study reports for the first time differences in resting-state EEG-SFC functional connectivity⦠|
| 42 | Conclusions | Globally, our findings could be interpreted either as the expression of long-term changes in⦠|
| 43 | Conclusions β Conflict of interest statement | The authors declare that the research was conducted in the absence of any commercial or financialβ¦ |
| 44 | Figure 1 | Resting-state EEG SFC results of the four comparisons in the six bands. The red color indicates an⦠|
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In this knowledge base
External
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| Modeling Brain Functional Connectivity Patterns during an Isometric Arm Force Exertion Task at Different Levels of Perceived Exertion: A Graph Theoretical Approach. | Ismail L et al. | β | 2022 | β |
| The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research. | Ippolito G et al. | β | 2022 | β |
| Advanced Signal Processing Methods for Characterization of Schizophrenia. | Masychev K et al. | β | 2021 | β |
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| Comparative analysis of default mode networks in major psychiatric disorders using resting-state EEG. | Choi KM et al. | β | 2021 | β |
| Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis. | YΓΌksel M et al. | β | 2021 | β |
| DelIrium VULnerability in GEriatrics (DIVULGE) study: a protocol for a prospective observational study of electroencephalogram associations with incident postoperative delirium. | Boord MS et al. | β | 2021 | β |
| Delta resting-state functional connectivity in the cognitive control network as a prognostic factor for maintaining abstinence: An eLORETA preliminary study. | Januszko P et al. | β | 2021 | β |
| Disorganization of Oscillatory Activity in Animal Models of Schizophrenia. | Speers LJ et al. | β | 2021 | β |
| Distinct alterations in resting-state electroencephalogram during eyes closed and eyes open and between morning and evening are present in first-episode psychosis patients. | Zhang Y et al. | β | 2021 | β |
| Do NMDA-R antagonists re-create patterns of spontaneous gamma-band activity in schizophrenia? A systematic review and perspective. | Bianciardi B et al. | β | 2021 | β |
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| Reconfiguration of Ξ±mplitude driven dominant coupling modes (DoCM) mediated by Ξ±-band in adolescents with schizophrenia spectrum disorders. | Dimitriadis SI | β | 2021 | β |
| Resting-state functional EEG connectivity in salience and default mode networks and their relationship to dissociative symptoms during NMDA receptor antagonism. | de la Salle S et al. | β | 2021 | β |
| Schizophrenia Classification Using Resting State EEG Functional Connectivity: Source Level Outperforms Sensor Level. | Azizi S et al. | β | 2021 | β |
| Special Report on the Impact of the COVID-19 Pandemic on Clinical EEG and Research and Consensus Recommendations for the Safe Use of EEG. | Campanella S et al. | β | 2021 | β |
| The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences. | Meyers JL et al. | β | 2021 | β |
| Alterations in sleep, sleep spindle, and EEG power in mGluR5 knockout mice. | Aguilar DD et al. | β | 2020 | β |
| Altered Cortical Functional Networks in Patients With Schizophrenia and Bipolar Disorder: A Resting-State Electroencephalographic Study. | Kim S et al. | β | 2020 | β |
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| Reduced parietal alpha power and psychotic symptoms: Test-retest reliability of resting-state magnetoencephalography in schizophrenia and healthy controls. | Candelaria-Cook FT et al. | β | 2020 | β |
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| Electroconvulsive Therapy Modulates Resting-State EEG Oscillatory Pattern and Phase Synchronization in Nodes of the Default Mode Network in Patients With Depressive Disorder. | Takamiya A et al. | β | 2019 | β |
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| Is resting state frontal alpha connectivity asymmetry a useful index to assess depressive symptoms? A preliminary investigation in a sample of university students. | Imperatori C et al. | β | 2019 | β |
| Quantitative and Qualitative Comparison of EEG-Based Neural Network Organization in Two Schizophrenia Groups Differing in the Duration of Illness and Disease Burden: Graph Analysis With Application of the Minimum Spanning Tree. | Jonak K et al. | β | 2019 | β |
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