Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

paper Cited Public

Authors: Heinz, Sven; Benner, Christopher; Spann, Nathanael; Bertolino, Eric; Lin, Yin C; Laslo, Peter; Cheng, Jason X; Murre, Cornelis; Singh, Harinder; Glass, Christopher K
Year: 2010
Journal: Molecular cell
PMID: 20513432
DOI: 10.1016/j.molcel.2010.05.004
PMCID: PMC2898526

#	Section	Preview
0	Introduction	The development of complex multicellular organisms involves hierarchically organized progenitor…
1	Introduction	Several mechanisms have been proposed to explain this phenomenon, including protein-protein…
2	Introduction	The mammalian hematopoietic system represents a well-characterized model for the analysis of the…
3	Introduction	2007), while E2A, EBF1, Pax5 and Oct-2 play important roles in the development and function of B…
4	Introduction	To address the question of how lineage-determining transcription factors bind to genomic regions in…
5	Distinct PU.1 binding programs in macrophages and B cells	We initially performed chromatin immunoprecipitation-coupled deep sequencing (ChIP-Seq) (Barski et…
6	Distinct PU.1 binding programs in macrophages and B cells	Scatter plots of the tag counts around genomic peak coordinates enable comparative visualization of…
7	Distinct PU.1 binding programs in macrophages and B cells	To examine the relationship of PU.1 binding sites and gene expression patterns, we performed…
8	Distinct PU.1 binding programs in macrophages and B cells	mix of cell type-specific and commonly bound PU.1 peaks (e.g., Figure 1B, peak position (b)). The…
9	PU.1 binds in the vicinity of other lineage-determining transcription factors	To gain insight into possible sequence determinants of the distinct PU.1 binding patterns observed…
10	PU.1 binds in the vicinity of other lineage-determining transcription factors	In addition to the ETS motifs, common promoter-proximal PU.1-bound regions were highly enriched for…
11	PU.1 binds in the vicinity of other lineage-determining transcription factors	In striking contrast, macrophage-specific and B cell-specific PU.1-bound regions were significantly…
12	PU.1 binds in the vicinity of other lineage-determining transcription factors	To confirm that the PU.1-co-enriched motifs were occupied by the associated cell type-restricted…
13	PU.1 binds in the vicinity of other lineage-determining transcription factors	1% macrophage-specific (4× PU.1 tag difference) (Figure S2D). C/EBP and Oct-2 binding sites…
14	Combinatorial interplay delineates stage-specific cistromes	The observation that PU. 1 binding occurred in the vicinity of motifs bound by lineage-restricted…
15	Combinatorial interplay delineates stage-specific cistromes	the appearance of PU.1 sites at new genomic positions that were not occupied by PU.1 in the previous…
16	Combinatorial interplay delineates stage-specific cistromes	To directly test if the binding of PU.1 to B lineage-specific sites is dependent on E2A, we…
17	Combinatorial interplay delineates stage-specific cistromes	To conversely investigate whether PU.1 itself can also promote binding of one of its…
18	Combinatorial interplay delineates stage-specific cistromes	We next evaluated the consequences of PU.1 activity on C/EBPβ binding in PU.1−/−cells stably…
19	PU.1 induces sequential nucleosome remodelling and histone H3K4 monomethylation	Recent studies have demonstrated that lineage-determining transcription factors preferentially…

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GLIS3, a novel regulator of eicosanoid gene expression and metabolism in normal kidney and polycystic kidney disease.	Srivastava C et al.	—	2026	→
Glucocorticoid-dependence and independence of the circadian liver transcriptome.	Maidstone RJ et al.	—	2026	→
GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer.	Müller J et al.	—	2026	→
GNL3 Orchestrates AR Transcriptional Programs to Drive Castration-Resistant Prostate Cancer and Immune Evasion.	Zhang C et al.	—	2026	→
Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization.	Zaratiana C et al.	—	2026	→
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.	Nitsch S et al.	—	2026	→
Haplotype-Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine.	Peng Y et al.	—	2026	→
Hfq modulates system-wide regulatory networks controlling biocontrol property in <i>Lysobacter enzymogenes</i>.	Cheng X et al.	—	2026	→
HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.	Naas S et al.	—	2026	→
High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq.	Shen Q et al.	—	2026	→
Histone H3.3 phosphorylation facilitates H3K9me3-heterochromatin formation during retrotransposon silencing and X-chromosome inactivation via H3.3K27me3-CBX7-KAP1 axis.	Chen J et al.	—	2026	→
Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling.	Feierman ER et al.	—	2026	→
hnRNPM cooperates with BCAS2 to modulate alternative splicing during oocyte development.	Zhou S et al.	—	2026	→
HP1β and H3K9me3 Regulate Olfactory Receptor Choice and Transcriptional Identity.	Escamilla-Del-Arenal M et al.	—	2026	→
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State.	Tsutsui Y et al.	—	2026	→
Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells.	Shtolz N et al.	—	2026	→
Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.	Xie S et al.	—	2026	→
Identification of novel DNA sequence motifs that modulate transcription in T cells.	Knoetze N et al.	—	2026	→
iFish: a comprehensive multi-omics database for fish genetics, transcriptional regulation, and epigenetic research.	Liu R et al.	—	2026	→
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself.	Gorin A et al.	—	2026	→
IFNγ shapes macrophage inflammatory responses by STAT1 isoform-specific epigenetic and transcriptional mechanisms.	Akagha MJ et al.	—	2026	→
IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms.	Heemskerk KM et al.	—	2026	→
Image-based epigenetic profiling with deep learning and high-speed super-resolution microscopy.	Wang Y et al.	—	2026	→
Immune activation of primary human macrophages is suppressed by the coordinated action of <i>Yersinia</i> effectors.	Bekere I et al.	—	2026	→
Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network.	Yi M et al.	—	2026	→
Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection.	Garcia-Moreno M et al.	—	2026	→
Induction of Yin Yang 1 (YY1) overexpression in mature adipocytes promotes dysfunctional adipose tissue and systemic insulin resistance in mice.	Pedersen L et al.	—	2026	→
Influence of DNA methylation and chromatin accessibility on regulation of gene expression during <i>Trichomonas vaginalis-</i>host cell interaction.	Muñoz D et al.	—	2026	→
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.	Lewis AC et al.	—	2026	→
Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages.	Verwaerde S et al.	—	2026	→
INO80 regulates promoter-associated R-loops to coordinate transcription and maintain genome stability in embryonic stem cells.	Lim H et al.	—	2026	→
Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato.	Tamiru-Oli M et al.	—	2026	→
Integrated analysis of ATAC-seq and RNA-seq reveals the TCP-ARF molecular module related to pathogenic process of phytoplasma infection in Paulownia fortunei.	Huang S et al.	—	2026	→
Integrated chromatin and transcriptomic profiling reveals sex-specific mechanisms of gene regulation in hepatic nutrient responses.	Zhang Z et al.	—	2026	→
Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer.	Preston-Alp S et al.	—	2026	→
Integrating natural and engineered genetic variations to decode regulatory influence on blood traits.	Tardaguila M et al.	—	2026	→
Integration of bulk RNA-seq pipeline metrics for assessing low-quality samples.	Hamilton S et al.	—	2026	→
Integrative analysis of CUT&Tag-seq and RNA-seq reveals widespread H3K27ac upregulation associated with the activation of muscle-growth-related transcriptional programs in broiler breast muscle.	Cai G et al.	—	2026	→
Integrative analysis of quantitative trait loci of alternative polyadenylation and GWAS highlights key regulators of milk production and immune traits in Holstein.	Tao X et al.	—	2026	→
Integrative epigenomic and transcriptomic profiling reveals organ-specific and coordinated cold stress responses in the brain and gill of Nile tilapia.	Li X et al.	—	2026	→
Integrative multi-omic and phenotypic analysis of open raceway pond production of Monoraphidium minutum 26B-AM reveals distinct stress signatures for scale-up and infection.	Kepesidis G et al.	—	2026	→
Integrative profiling of transcriptome and H3K27ac modification reveals changes associated with BCG-induced trained immunity in bovine immune cells.	Samuel BER et al.	—	2026	→
Interlocked transcription factor feedback loops maintain and restore adult touch sensation.	Marques F et al.	—	2026	→
Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m<sup>6</sup>A regulation.	Lin Y et al.	—	2026	→
Interspecies hybridization as a route of accessory chromosome origin in fungal pathogens.	Fagundes WC et al.	—	2026	→
In vitro mimicking of humanized cardiogenesis under porcine condition.	Li J et al.	—	2026	→
JMJD2 regulates enhancer-promoter interactions via biomolecular condensate formation.	Jiang S et al.	—	2026	→
KDM4A promotes NEPC progression through regulation of MYC expression.	Mak CSL et al.	—	2026	→
Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice.	Bergo V et al.	—	2026	→
Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells.	Holmlund H et al.	—	2026	→
Lf2 is a knotted homeobox regulator that modulates leaflet number in soybean.	Clark CB et al.	—	2026	→
LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture.	Lee M et al.	—	2026	→
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation.	Zhou Y et al.	—	2026	→
Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits.	Alkhawaja AA et al.	—	2026	→
Long-term intermittent estradiol exposure induces epithelial-mesenchymal transition-like plasticity in MCF10A cells.	Sakiyama K et al.	—	2026	→
<i>Candida auris</i> metabolism and growth preferences in physiologically relevant skin-like conditions.	Nicklas JP et al.	—	2026	→
<i>EPB41L4A-AS1</i> long noncoding RNA acts in both <i>cis</i>- and <i>trans</i>-acting transcriptional regulation and controls nucleolar biology.	Monziani A et al.	—	2026	→
<i>ROBO2</i> Variants Associated With Atrial Septal Defect Define a Novel Regulatory Element.	Kim SW et al.	—	2026	→
MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.	Vanneste D et al.	—	2026	→
Manipulation of Alternative Splicing of <i>IKZF1</i> Elicits Distinct Gene Regulatory Responses in T Cells.	Pastor L et al.	—	2026	→
Massively parallel reporter assay for mapping gene-specific regulatory regions at single-nucleotide resolution.	Tulloch AJ et al.	—	2026	→
Matrix-bound nanovesicles as epigenetic modulators of myeloid cells.	Capella-Monsonís H et al.	—	2026	→
Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells.	Aarts MT et al.	—	2026	→
Mechanistic Insights Into NFIX-Mediated DNA Recognition and Transcriptional Regulation in Skeletal Muscle.	Zhu C et al.	—	2026	→
MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2.	Iida K et al.	—	2026	→
Metabolomic remodeling and genetic regulation in potato tubers during domestication.	Zhang Z et al.	—	2026	→
Methionine and choline deficiency rewires transcriptional programs to recapitulate molecular features of human MASH.	You W et al.	—	2026	→
Method for ATAC Sequencing Data Analysis for Understanding Chromatin Biology in Legumes.	Singh S et al.	—	2026	→
Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels.	DeMeulenaere KE et al.	—	2026	→
Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response.	Kapetanovic R et al.	—	2026	→
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.	Burr SP et al.	—	2026	→
M<sup>5</sup>C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance.	Liu J et al.	—	2026	→
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia.	Hartmann M et al.	—	2026	→
Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV).	Nguyen N et al.	—	2026	→
MRG15 decline in aged/injured MuSCs hinders regeneration via differentiation defects.	Li Z et al.	—	2026	→
mTOR inhibition promotes ATRA-induced cancer cell differentiation by overcoming a metabolic hyperactive state.	Zhang L et al.	—	2026	→
Multimodal bHLH-PAS DNA binding controls specificity and drives obesity.	Bersten DC et al.	—	2026	→
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.	Smith GR et al.	—	2026	→
Multiomics Analysis of Arboviral Capsid Targets in Mosquitoes Reveals a Proviral Function of the Chromatin-Remodeling Brahma Complex.	Flory C et al.	—	2026	→
Multi-omics analysis of somatic mutants reveals TCP7 allelically regulates multiple carotenogenic genes in citrus.	Wang X et al.	—	2026	→
Multiple modes of transcriptional regulation by the nuclear hormone receptor RARγ in human squamous cell carcinoma.	Hoxie HR et al.	—	2026	→
Multi-region m<sup>6</sup>A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci.	Shafik AM et al.	—	2026	→
Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.	Chen S et al.	—	2026	→
MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription.	Kalyan Sundaram R et al.	—	2026	→
NAD<sup>+</sup> sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis.	Stokes MS et al.	—	2026	→
Nanog mediated control of TBX3-GATA6 circuitry in primitive endoderm differentiation of mESCs.	Wu H et al.	—	2026	→
Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos.	Hu Y et al.	—	2026	→
Neural stem cell quiescence is actively maintained by the epigenome.	Malkowska A et al.	—	2026	→
Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization.	Valnegri P et al.	—	2026	→
Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis.	Shammas G et al.	—	2026	→
Next-Generation Sequencing Analysis of 8-Oxo-7,8-dihydroguanine in Human Mitochondrial DNA.	Zheng X et al.	—	2026	→
NF-κB is a central regulator of hypoxia-induced gene expression.	Shakir D et al.	—	2026	→
Nuclear receptor coregulator interactions: beyond the switch.	Cassim Bawa FN et al.	—	2026	→
NyxBind: enhancing deep neural representations for transcription factor binding site prediction via contrastive learning.	Yang X et al.	—	2026	→
Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition.	Reyes J et al.	—	2026	→
Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer.	Zhong Z et al.	—	2026	→
Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.	Wang K et al.	—	2026	→
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance.	Arai M et al.	—	2026	→
Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging.	Lu Z et al.	—	2026	→
OsCLSY4 modulates epigenomic patterns and grain size in rice.	Zhang R et al.	—	2026	→
OsDof1 enhances rice (Oryza sativa L.) lodging resistance through suppression of tryptophan-dependent auxin biosynthesis.	Hu W et al.	—	2026	→
OTX2 controls chromatin accessibility to direct somatic versus germline differentiation.	Barbieri E et al.	—	2026	→
p53 increases phospholipid headgroup scavenging in senescence.	Yashinskie JJ et al.	—	2026	→
Patient-derived lung organoids from bronchoalveolar lavage capture epithelial heterogeneity and disease biology in bronchopulmonary dysplasia.	Sonti S et al.	—	2026	→
PCLIPtools: a robust framework for identifying RNA-protein interaction sites from PAR-CLIP experiments.	Polash AH et al.	—	2026	→
Perinatal BPAF Exposure Reprograms Offspring's Immune-Metabolic Axis: A Multi-Omics Investigation of Intergenerational Hepatotoxicity.	Bai S et al.	—	2026	→
Photoclick chemistry led to the identification of HELLS as a helicase for DNA G-quadruplexes.	Gao Z et al.	—	2026	→
Plasma proteome adaptations during feminizing gender-affirming hormone therapy.	Nguyen NNL et al.	—	2026	→
Predictive prioritization of enhancers associated with pancreatic disease risk.	Wang L et al.	—	2026	→
Prevalence of N6-methyladenosine (m6A) in mycoplasma mRNA:Epitranscriptomic regulation in minimal genomes.	Zhang S et al.	—	2026	→
Prevention of Cholestatic Liver Disease Through BCL6-FXR Enterohepatic Crosstalk.	Fruzyna E et al.	—	2026	→
PRMT1 Inhibition Targets BNC1-Dependent Proliferation in Squamous Cell Carcinoma.	Boudra R et al.	—	2026	→
Profiling active RNA polymerase II transcription start sites from total RNA by capped small RNA sequencing (csRNA-seq).	Meyer MK et al.	—	2026	→
Profiling the epigenomic landscape of late embryonic and adult mouse hind limb muscles.	Queeno SR et al.	—	2026	→
Protocadherin 20 Is a POU Class 2 Homeobox 3 Target Gene Required for Proper Tuft Cell Microvillus Organization.	Ankenbauer KE et al.	—	2026	→
Protocols for Chromatin Immunoprecipitation Sequencing and qPCR to Investigate Pytohormone-Responsive Transcriptional Regulation in Plants.	Aksoy E et al.	—	2026	→
PTPN2 deficiency amplifies inflammatory signalling and impairs functional maturation of human stem cell-derived islets.	Vandenbempt V et al.	—	2026	→
PU.1 aggravates hepatic sinusoidal obstruction syndrome by upregulating PTBP1 and activating the Wnt/β-catenin pathway.	Yang L et al.	—	2026	→
RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF-β signaling.	Rodrigues-Junior DM et al.	—	2026	→
RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions.	Lee H et al.	—	2026	→
Rebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasia.	Zhang Y et al.	—	2026	→
Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction.	Yu XX et al.	—	2026	→
Recruitment of transcriptional effectors by Cas9 creates <i>cis</i>-regulatory elements and demonstrates distance-dependent transcriptional regulation.	Boulos J et al.	—	2026	→
Regulatory role for tumor suppressor REST on estrogen receptor (ESR1) expression and leiomyoma pathophysiology.	Bird SG et al.	—	2026	→
Relationship among Toll-like receptors, β2 adrenergic receptor, and mitogen-activated protein kinases in regulating Il1b transcription.	de Melo FM et al.	—	2026	→
Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling.	Botman M et al.	—	2026	→
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function.	Nadarajah CJ et al.	—	2026	→
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis.	Hu X et al.	—	2026	→
RM2Target v2.0: an updated database for the target genes of writers, erasers, and readers of RNA modifications.	Bao X et al.	—	2026	→
RMzyme: regulations of RNA-modifying enzymes in humans.	Luo R et al.	—	2026	→
RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis.	Kim HY et al.	—	2026	→
Rumen microbiome biogeography and ventral epithelial architecture in three ruminant species.	Sang J et al.	—	2026	→
scBrainScope: cross-species multidimensional brain atlas.	Qin S et al.	—	2026	→
scVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants.	Yu ZM et al.	—	2026	→
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE.	Lazzarotto CR et al.	—	2026	→
Serum Response Factor (SRF) promotes actin cytoskeletal organization in adipocytes to support adaptive hypertrophic expansion and tissue remodeling during obesity in mice.	So J et al.	—	2026	→
Sex Differences in Brain Cell Type-Specific Chromatin Accessibility in Schizophrenia.	Ma Y et al.	—	2026	→
Sex effects on gene expression across the human cerebral cortex at cell type resolution.	DeCasien AR et al.	—	2026	→
Sex-specific nonlinear DNA methylation aging trajectories reveal biomarkers of cancer risk and inflammation.	Grolaux R et al.	—	2026	→
Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging.	Amaral ML et al.	—	2026	→
Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function.	Chen G et al.	—	2026	→
Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality.	Palmer CR et al.	—	2026	→
Single-cell spatiotemporal dissection of the human maternal-fetal interface.	Wang C et al.	—	2026	→
Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs.	Kabbe M et al.	—	2026	→
Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation.	Deng X et al.	—	2026	→
Single-Nucleus Multi-Omics Reveals Hypoxia-Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma.	You C et al.	—	2026	→
Skin Epidermal Progenitor Maintenance by the SRCAP-H2A.Z Axis Downstream to Extracellular Signal-Regulated Kinase and mTOR Signaling.	Droll SH et al.	—	2026	→
Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.	Zhang H et al.	—	2026	→
SOX2 phosphorylation during mitosis limits genomic damage.	Williams CAC et al.	—	2026	→
SRSF3-TRIM28-MDC1 prevents DNA damage caused by R-loops in fatty liver disease in mice.	Wu P et al.	—	2026	→
Stage- and cluster-specific regulation of chondrogenic gene programs by Sox9 in mouse embryonic limb buds.	Sega M et al.	—	2026	→
STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.	Lee HK et al.	—	2026	→
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes.	Grassmann S et al.	—	2026	→
Stepwise selection of Tof11/12 and GmRVE1 facilitates soybean adaptation to high-latitude regions.	Cheng Q et al.	—	2026	→
Synthetic super-enhancers enable precision viral immunotherapy.	Koeber U et al.	—	2026	→
Systematic transcriptome analysis reveals the function of alternative promoters in hematopoietic lineages.	Zhang T et al.	—	2026	→
Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype.	Heavican-Foral TB et al.	—	2026	→
Tfam-mediated metabolic perturbation in RORγt<sup>+</sup> lymphocytes impacts intestinal tissue homeostasis and promotes GATA3<sup>+</sup>RORγt<sup>+</sup> innate lymphoid cells.	Sun N et al.	—	2026	→
TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells.	Ali MM et al.	—	2026	→
The bladder cancer m<sup>6</sup>A landscape is defined by global methylation dilution and focal 3'-UTR hypermethylation.	Koch J et al.	—	2026	→
The brain neurovascular epigenome and its association with dementia.	Ziegler KC et al.	—	2026	→
The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4.	Jiang Y et al.	—	2026	→
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements.	Koulle A et al.	—	2026	→
The Epigenetic Battleground: Host Chromatin at the Core of Infection.	Machado FC et al.	—	2026	→
The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.	Kittane S et al.	—	2026	→
The nuclear cap-binding complex safeguards stress-resistant protein synthesis and proliferation of stem cells.	Oh S et al.	—	2026	→
The response to kidney injury is epigenetically regulated through the activation of bivalent genes.	Tickman BI et al.	—	2026	→
The RNA-binding protein HuR modulates the expression of the disease-linked <i>CCL2</i> rs1024611G-rs13900T haplotype.	Akhtar F et al.	—	2026	→
The RNA-binding protein Squid regulates embryonic midgut development via Axin alternative splicing in Bombyx mori.	Tong C et al.	—	2026	→
The striatal heterogeneous nuclear ribonucleoprotein H1 mRNA targetome associated with methamphetamine administration and behavior.	Ruan QT et al.	—	2026	→
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling.	Todorov-Völgyi K et al.	—	2026	→
The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors.	Ji JH et al.	—	2026	→
The Transcription Factor DDIT3 Regulates Macrophage Function by Inhibiting KLF10 to Attenuate ALI/ARDS Inflammation.	Sun M et al.	—	2026	→
The transcription factor TaWRKY58 coordinates growth and drought sensitivity in wheat by repressing TaLRR and TaBCS1.	Zhang Y et al.	—	2026	→
The Tumor-to-Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma.	Wu C et al.	—	2026	→
Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila.	Maziak N et al.	—	2026	→
Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids.	Zhu B et al.	—	2026	→
Time-course ATAC-seq and RNA-seq analysis of porcine synovium-derived mesenchymal stem cells under in vitro osteogenic induction.	Li S et al.	—	2026	→
Total RNA and MicroRNA Transcriptomic Responses of Human Retinal Müller Glial Cells to Infection with <i>Toxoplasma gondii</i> Tachyzoites.	Rochet E et al.	—	2026	→
TOX drives CD4<sup>+</sup> T<sub>H</sub>1 effector function, antitumor immunity and autoimmune pathology.	Naizir B et al.	—	2026	→
Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro.	Jamil AJM et al.	—	2026	→
Transcription factor NFYA directs male meiotic entry by regulating accessible chromatin at meiotic promoters in mice.	Säflund M et al.	—	2026	→
Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.	Wang Z et al.	—	2026	→
Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding.	Paldi F et al.	—	2026	→
Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity.	Cheon Y et al.	—	2026	→
Two distinct chromatin modules regulate proinflammatory gene expression.	Seufert I et al.	—	2026	→
Unannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states.	Zhou X et al.	—	2026	→
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.	Sun X et al.	—	2026	→
Wheat TaSPL13-2B Improves Floret Fertility and Enhances Grain Number per Spikelet Through Jasmonic Acid Signalling Pathway.	Li L et al.	—	2026	→
WNT inhibition activates interferon stimulated gene expression by alleviating epigenetic repression of endogenous retroviruses.	Williams CM et al.	—	2026	→
YAP Induces a Prorenewal Metabolic State in Cardiomyocytes.	Liu L et al.	—	2026	→
YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers.	Seol T et al.	—	2026	→
YAP-TEAD regulates the super-enhancer network to control early surface ectoderm commitment.	Wang Z et al.	—	2026	→
YTHDC1-Mediated m<sup>6</sup>A Modification of MAGI3 mRNA Regulates Proliferation and Differentiation of Myoblasts.	Chen Q et al.	—	2026	→
ZC3H13 Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation.	Monteagudo-García Ó et al.	—	2026	→
ZNF787 recognizes the core sequence of MIR element to regulate gene expression.	Liao L et al.	—	2026	→
3D enhancer architecture coordinated by CTCF determines immune-related gene expression patterns via RNA polymerase II pause-release in CD4+ T cells.	Lee EC et al.	—	2025	→
3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion.	Si C et al.	—	2025	→
5-hydroxymethylcytosine analysis reveals stable epigenomic changes in tumor tissue that enable cancer detection in cell-free DNA.	Xue Y et al.	—	2025	→
A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction effects.	Fu B et al.	—	2025	→
A cell and transcriptome atlas of human arterial vasculature.	Zhao Q et al.	—	2025	→
A combined genomic arrhythmia propensity score delineates cumulative risk.	Monroe TO et al.	—	2025	→
A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells.	Li H et al.	—	2025	→
A conserved differentiation programme facilitates inhibitory neuron production in the developing mouse and human cerebellum.	Christensen JB et al.	—	2025	→
A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization.	Huang Y et al.	—	2025	→
A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS.	Nuyttens L et al.	—	2025	→
ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice.	Zhang Y et al.	—	2025	→
Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.	Tsolova AO et al.	—	2025	→
ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer.	Yang HJ et al.	—	2025	→
Adenovirus maturation establishes the transcription competent packaging of its genome.	Baumgartl C et al.	—	2025	→
A de novo-originated gene drives rose scent diversification.	Li Y et al.	—	2025	→
Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA.	Zeng T et al.	—	2025	→
Adrenergic signaling coordinates distant and local responses to amputation in axolotl.	Payzin-Dogru D et al.	—	2025	→
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation.	Wang M et al.	—	2025	→
A fungal chromatin remodeler drives transcription by establishing an open chromatin architecture and activated histone environment.	Xu M et al.	—	2025	→
Age- and cell-type-specific effects of histone variant H2BE in the brain.	Louzon S et al.	—	2025	→
A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling.	Rahimov F et al.	—	2025	→
A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression.	Almaghrabi R et al.	—	2025	→
ALDH18A1 has carcinogenic functions and regulates alternative splicing events of DNA repair-related genes in esophageal carcinoma cells.	Yongkang W et al.	—	2025	→
A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq.	Gaynor-Gillett SC et al.	—	2025	→
A molecular circuit regulates fate plasticity in emerging and adult AT2 cells.	Sawhney AS et al.	—	2025	→
An activating <i>Stat1</i> mutant disrupts normal STAT4 innate lymphocyte programs during viral infection.	Philips RL et al.	—	2025	→
Analysis of histone modification interplay reveals two distinct domains in facultative heterochromatin in Pyricularia oryzae.	Dang TA et al.	—	2025	→
Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organization.	Tamon L et al.	—	2025	→
Analysis of Non-Coding RNAs and N6-Methyladenosine-Modified Genes in Response to flg22 in Grape Immunity.	Duan R et al.	—	2025	→
Analysis of the three-dimensional genome of exhausted CD8<sup>+</sup> T cells reveals a critical role of IRF8 in their differentiation and functions in cancer.	Li R et al.	—	2025	→
Analyzing the relationship of RNA and DNA methylation with gene expression.	Xie S et al.	—	2025	→
Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity.	Henriques-Oliveira L et al.	—	2025	→
Androgen receptor-mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells.	Hiltunen J et al.	—	2025	→
Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations.	Kraft M et al.	—	2025	→
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma.	Fraire CR et al.	—	2025	→
An Isoform-Specific RUNX1C-BTG2 Axis Governs AML Quiescence and Chemoresistance.	Han C et al.	—	2025	→
An organoid library unveils subtype-specific IGF-1 dependency via a YAP-AP1 axis in human small cell lung cancer.	Fukushima T et al.	—	2025	→
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells.	Sturmlechner I et al.	—	2025	→
Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish.	Lin Q et al.	—	2025	→
A PRDM16-CtBP1/2 complex interacts with HDAC1/2 to regulate transcriptional programs of neurogenesis and guide cortical neuron migration.	Warren S et al.	—	2025	→
A programmed decline in ribosome levels governs human early neurodevelopment.	Ni C et al.	—	2025	→
Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression.	Wang Q et al.	—	2025	→
A role for pH dynamics regulating transcription factor DNA-binding selectivity.	Kisor KP et al.	—	2025	→
A role for the transcriptional coregulator RIP140 in the control of muscle endurance fitness.	Pruzinsky E et al.	—	2025	→
A scheduler for rhythmic gene expression.	Gaidatzis D et al.	—	2025	→
A spatially organized <i>Cd24a</i><sup>+</sup>/<i>Pax9</i><sup>+</sup> stem cell core governs postnatal tooth establishment.	Shan C et al.	—	2025	→
Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy.	Wu SPS et al.	—	2025	→
A STAT3/integrin axis accelerates pancreatic cancer initiation and progression.	Campos AD et al.	—	2025	→
A systematic review and functional <i>in-silico</i> analysis of genes and variants associated with amyotrophic lateral sclerosis.	Arreola-Aldape CA et al.	—	2025	→
ATAC-seq in Emerging Model Organisms: Challenges and Strategies.	Erdoğan DE et al.	—	2025	→
ATOH8 is crucial for the differentiation of human trophoblast stem cells into extravillous trophoblasts.	Salamah J et al.	—	2025	→
A Transcription Factor-based Framework for Monitoring Stress Status in Oysters: Applications in Conservation and Restoration.	Wang ST et al.	—	2025	→
ATRX Promotes Transcription Initiation of HSV-1 Immediate Early Genes During Early Lytic Infection.	Dunn LEM et al.	—	2025	→
Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism.	Li M et al.	—	2025	→
Automated high-throughput profiling of single-cell total transcriptome with scComplete-seq.	Dinçaslan FB et al.	—	2025	→
BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells.	Ma J et al.	—	2025	→
BACH2 drives the development and function of group 2 innate lymphoid cells.	Liu G et al.	—	2025	→
Baf60c in skeletal muscle regulates adipose tissue thermogenesis via Musclin-mediated endocrine signaling.	Han S et al.	—	2025	→
BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1.	Monziani A et al.	—	2025	→
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma.	Shinozaki T et al.	—	2025	→
Base editing of trinucleotide repeats that cause Huntington's disease and Friedreich's ataxia reduces somatic repeat expansions in patient cells and in mice.	Matuszek Z et al.	—	2025	→
BCLAF1 restrains stress responses in hematopoietic stem cells to support expansion and repopulation.	Crowley SJ et al.	—	2025	→
Benchmarking transcription factor binding site prediction models: a comparative analysis on synthetic and biological data.	Tognon M et al.	—	2025	→
BINDER achieves accurate identification of hierarchical TADs by comprehensively characterizing consensus TAD boundaries.	Liu Y et al.	—	2025	→
Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice.	Li S et al.	—	2025	→
BIT: Bayesian Identification of Transcriptional regulators from epigenomics-based query region sets.	Lu Z et al.	—	2025	→
Bivalent chromatin instructs lineage specification during hematopoiesis.	Yagi M et al.	—	2025	→
BLIMP1 negatively regulates IL-2 signaling in T cells.	Roy S et al.	—	2025	→
Blocking nuclear receptor Nr4a3 unlocks the senescence barrier to promote direct cardiac reprogramming.	Liu M et al.	—	2025	→
BMAL1 and ARNT enable circadian HIF2α responses in clear cell renal cell carcinoma.	Mello RM et al.	—	2025	→
BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells.	Gallardo A et al.	—	2025	→
Brain DNA Methylation Atlas of App<sup>NL-G-F</sup> Alzheimer's Disease Model Mice Across Age and Region Reveals Choline-Induced Resilience.	Krunic A et al.	—	2025	→
Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function.	Folkerts J et al.	—	2025	→
Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes.	Spencer M et al.	—	2025	→
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia.	Ducharme JB et al.	—	2025	→
CANTAC-seq analysis reveals E2f1 and Otx1 coordinate zygotic genome activation in Xenopus tropicalis.	Cui H et al.	—	2025	→
Cardiomyocyte YAP represses myocardial inflammation and fibrosis and restrains MEF2-regulated gene expression.	Ninh VK et al.	—	2025	→
CBFβ-SMMHC-driven leukemogenesis requires enhanced RUNX1-DNA binding affinity in mice.	Zhen T et al.	—	2025	→
CD206+ macrophages facilitate wound healing through interactions with Gpnmb<sup>hi</sup> fibroblasts.	Honda A et al.	—	2025	→
C/EBPα activates <i>Irf8</i> expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development.	Chen J et al.	—	2025	→
Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations.	Menezes NA et al.	—	2025	→
Cell Cycle Arrest of a ‘Zippering’ Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders	Qu T et al.	—	2025	—
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors.	Bernadskaya YY et al.	—	2025	→
Cell-free DNA-based inference of the activities of 370 + transcription factors mirrors their activities in tumors.	Tamaki R et al.	—	2025	→
Cell type- and factor-specific nonsense-mediated RNA decay.	Tan K et al.	—	2025	→
Cell type-specific functions of the PBAF chromatin-remodeling complex in neuronal diversification.	Osuma A et al.	—	2025	→
Cellular and molecular mechanisms of seahorse male pregnancy.	Liu Y et al.	—	2025	→
CFTR Gene Regulation in Human Pancreatic Duct, Bile Duct and Sweat Gland Epithelial Cells.	Umrigar A et al.	—	2025	→
Changes in gene expression levels caused by H3K9me3/H3K9ac modifications are associated with BmCPV infection in <i>Bombyx mori</i>.	Qiu Q et al.	—	2025	→
Changes of methylation at enhancers appear to be essential for HIV infection progression.	Taryma-Leśniak O et al.	—	2025	→
Characterization of the Chromatin Accessibility in the Hearts of Mice With Lipopolysaccharide (LPS)-Induced Sepsis.	Xu HJ et al.	—	2025	→
Characterization of Ultra-Short plasma Cell-Free DNA in maternal blood and its preliminary potential as a screening marker for preeclampsia.	Liu W et al.	—	2025	→
Charting the regulatory landscape of TP53 on transposable elements in cancer.	Qu X et al.	—	2025	→
ChromActivity: integrative epigenomic and functional characterization assay based annotation of regulatory activity across diverse human cell types.	Dincer TU et al.	—	2025	→
Chromatin accessibility analysis reveals functional cis-regulatory regions related to fruit development and domestication in tomato.	Cheng YJ et al.	—	2025	→
Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis.	Prat A et al.	—	2025	→
Chromatin accessibility and transcriptomic profiles of sheep pituitary function associated with fecundity.	Li S et al.	—	2025	→
Chromatin accessibility dynamics and transcriptional regulatory networks underlying the primary nitrogen response in rice roots.	Li W et al.	—	2025	→
Chromatin accessibility in stem cells unveils progressive transcriptional alterations in myelodysplastic syndrome.	Oshima M et al.	—	2025	→
Chromatin accessibility landscape of a parasitic nematode during embryogenesis.	Lu H et al.	—	2025	→
Chromatin accessibility of circulating CD8⁺ T cells differentiates disease severity in IgA nephropathy.	Kim G et al.	—	2025	→
Chromatin and transcriptional dynamics underlying the immune-modulatory effects of vitamin D<sub>3</sub> in vivo.	Rybiński M et al.	—	2025	→
Chromatin-dependent motif syntax defines differentiation trajectories.	Durdu S et al.	—	2025	→
Chromatin dynamics and transcriptional regulation of heat stress in an ectothermic fish.	Huang S et al.	—	2025	→
Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte development.	Tingvall-Gustafsson J et al.	—	2025	→
Chromatin looping-based CRISPR screen identifies TLK2 as chromatin loop formation regulator in cancer stemness plasticity.	Wang Z et al.	—	2025	→
Chromatin loops are an ancestral hallmark of the animal regulatory genome.	Kim IV et al.	—	2025	→
Chromatin remodeling and H3K4me3 depletion regulate germline specification from pluripotency.	Wang S et al.	—	2025	→
Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion.	Samareh P et al.	—	2025	→
Chronic circadian misalignment accelerates sarcopenia progression in mice.	Seya T et al.	—	2025	→
Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant.	McNamara ME et al.	—	2025	→
Cistromic insight into the association of retinoid X receptor with MyoD and CTCF in proliferating myoblasts.	Clément JT et al.	—	2025	→
Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration.	Hou J et al.	—	2025	→
CmVNI2-CmMYB3 module regulates flavonol biosynthesis in response to low temperature in chrysanthemum flower.	Jiang T et al.	—	2025	→
Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression.	Ye X et al.	—	2025	→
Cohesin Loading Factor NIPBL Is Essential for MYCN Expression and MYCN-Driven Oncogenic Transcription in Neuroblastoma.	Kang JY et al.	—	2025	→
Cohesin stabilization at promoters and enhancers by common transcription factors and chromatin regulators.	Bryan AF et al.	—	2025	→
Cohesin supercoils DNA during loop extrusion.	Davidson IF et al.	—	2025	→
Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer.	Olsen SN et al.	—	2025	→
Comparative analysis of DREB gene family in buckwheat: the role of FtDREB02 in the delphinidin biosynthesis and drought stress response.	Wang J et al.	—	2025	→
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development.	Schindler M et al.	—	2025	→
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation.	Zhou Z et al.	—	2025	→
Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia.	Geng T et al.	—	2025	→
Comprehensive resource for transcription readthrough events in healthy human tissues.	Mei Y et al.	—	2025	→
Computational Analyses and Challenges of Single-cell ATAC-seq.	Wang C et al.	—	2025	→
Concerted Actions of FoxO1 and PPARα in Hepatic Gene Expression and Metabolic Adaptation.	Kitamoto T et al.	—	2025	→
Conservation of cis-regulatory codes over half a billion years of evolution.	Ogawa Y et al.	—	2025	→
Contrasting roles of KMT2C and KMT2D in breast cancer.	Tinsley E et al.	—	2025	→
Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing.	Polletti S et al.	—	2025	→
Cooperative control of neuron-specific repressive chromatin states by intellectual-disability-linked KDM1A and KDM5C demethylases.	Martín-González AM et al.	—	2025	→
Coordinated action of multiple active histone modifications shapes the zygotic genome activation in teleost embryos.	Fukushima HS et al.	—	2025	→
Coordinated gene expression within sustained STAT3-associated chromatin conformations contributes to hepatocellular carcinoma progression.	Jang S et al.	—	2025	→
Coordinated histone methylation loss and MYC activation promote translational capacity under amino acid restriction.	Cheng C et al.	—	2025	→
Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction.	Wang F et al.	—	2025	→
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues.	Cheng QX et al.	—	2025	→
Cortisol-Induced Chromatin Remodeling and Gene Expression in Skeletal Muscle of Rainbow Trout: Integrative ATAC-Seq and RNA-Seq Analysis.	Zuloaga R et al.	—	2025	→
Cotton <i>STARD</i> Gene Family: Characterization, Evolution, and Expression Profiles During Salt Stress.	Cui R et al.	—	2025	→
CpG methylation changes associated with hyperglycemia in type 1 diabetes occur at angiogenic glomerular and retinal gene loci.	Shao X et al.	—	2025	→
CRAMP1 drives linker histone expression to enable Polycomb repression.	Matthews RE et al.	—	2025	→
Creb5 controls its own expression and directly induces the joint interzone regulatory program.	Zhang CH et al.	—	2025	→
Cross-platform motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factors.	Vorontsov IE et al.	—	2025	→
C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation.	Strickland BA et al.	—	2025	→
CUT&Tag overcomes biases of ChIP and establishes chromatin patterns for repetitive genomic loci.	Park BJ et al.	—	2025	→
Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability.	Wang X et al.	—	2025	→
Deciphering Complex Interactions Between LTR Retrotransposons and Three Papaver Species Using LTR_Stream.	Xu T et al.	—	2025	→
Deciphering Haplotype-level Chromosome Conformation Alteration in Down Syndrome by Haplotype-resolved Multi-omics Analysis.	Wu C et al.	—	2025	→
Deciphering meiotic chromatin organization by SYCP3.	Guo S et al.	—	2025	→
Deciphering plasmid replication dynamics: a computational approach to predict ColE1-like plasmid copy number.	Saban R et al.	—	2025	→
Deciphering RNA modification and post-transcriptional regulation with NetRNApan.	Xu H et al.	—	2025	→
Deciphering the role of cis-regulatory elements and TFAP2C in the activation of zygotic Sox2 expression in mouse preimplantation embryos.	Kim J et al.	—	2025	→
Deciphering the role of histone modifications in memory and exhausted CD8 T cells.	Huang H et al.	—	2025	→
Decoding cancer heterogeneity through super-enhancer landscapes: from subtype discovery to therapeutic opportunity.	Cai S et al.	—	2025	→
Decoding cell-class specific roles of non-coding variants in human retina.	VandenBosch LS et al.	—	2025	→
Decoding human cardiovascular development and disease through single-cell transcriptomic and epigenomic profiling.	Dunkenberger L et al.	—	2025	→
Decoding the germline genetic architecture of prostate cancer at a single cell resolution.	Wang C et al.	—	2025	→
Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection.	Santosa EK et al.	—	2025	→
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer.	Hibshman PS et al.	—	2025	→
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis.	Lee Y et al.	—	2025	→
Defining transcription factor nucleosome binding with Pioneer-seq.	Tsompana M et al.	—	2025	→
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming.	Zhao T et al.	—	2025	→
Dictionary based approaches for studying intrinsic DNA shape in transcription factor recognition.	Kalsan M et al.	—	2025	→
Diet-induced obesity induces oxidative stress and enhances H3K4me3 levels, driving nonresolving inflammation and myelopoiesis in hematopoietic stem and progenitor cells.	Takahashi K et al.	—	2025	→
Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells.	Foo CZ et al.	—	2025	→
Differential Control of Growth and Identity by HNF4α Isoforms in Pancreatic Ductal Adenocarcinoma.	Fang P et al.	—	2025	→
Differential Transcriptional Activity of ΔNp63β Is Encoded by an Isoform-Specific C-Terminus.	McCann AA et al.	—	2025	→
DiffHiChIP: Identifying differential chromatin contacts from HiChIP data.	Bhattacharyya S et al.	—	2025	→
Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant.	Lemée MV et al.	—	2025	→
Dissecting pre- to post-implantation transition of DNA methylome-transcriptome dynamics in early mammalian development.	Zhu Q et al.	—	2025	→
Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure.	Gill R et al.	—	2025	→
Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition.	Wei J et al.	—	2025	→
Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging.	Chia JJ et al.	—	2025	→
Divergent combinations of enhancers encode spatial gene expression.	Hong D et al.	—	2025	→
Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity.	Eyunni S et al.	—	2025	→
DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.	Beumer N et al.	—	2025	→
DNA Methylation Concurrence, Independent of DNA Methylation Ratios, Is Associated with Chromatin Accessibility and 3D Genome Architecture.	Zhang G et al.	—	2025	→
DNA methylation insulates genic regions from CTCF loops near nuclear speckles.	Roseman SA et al.	—	2025	→
DNA methylation mediates the immunosuppressive tumour microenvironment in metastatic endometrial clear cell carcinoma.	Jia H et al.	—	2025	→
DNA methylomes undergo distinct waves of remodeling during thymic T cell development and do not acquire a proliferation-induced imprint.	Hamm F et al.	—	2025	→
DNA methyltransferase 1 modulates mitochondrial function through bridging m<sup>5</sup>C RNA methylation.	Wang J et al.	—	2025	→
DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons.	Sugo N et al.	—	2025	→
DNA/RNA hybrid profiling in autistic patients: A focus on mRNA and non-coding RNA variations.	Kianmehr L et al.	—	2025	→
DNMT3A-dependent DNA methylation shapes the endothelial enhancer landscape.	Gehrs S et al.	—	2025	→
Dominant-negative effects of Weaver syndrome-associated EZH2 variants.	Deevy O et al.	—	2025	→
Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease.	Gong T et al.	—	2025	→
Dual mechanism of inflammation sensing by the hematopoietic progenitor genome.	Tran VL et al.	—	2025	→
Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules.	Wang L et al.	—	2025	→
Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border.	Hamrud E et al.	—	2025	→
Dynamic m<sup>6</sup>A RNA methylation correlates with ethylene-induced petal senescence and may modulate antioxidant and metabolic pathways in carnation (Dianthus caryophyllus L.).	Wang H et al.	—	2025	→
Dynamic regulation and embryo-endosperm crosstalk revealed by whole transcriptome profiling of wheat seed development.	Guo X et al.	—	2025	→
Dynamics of chromatin accessibility governing Gd-IgA1 synthesis in B cells associated with IgA nephropathy.	Gan Y et al.	—	2025	→
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation.	Maestri D et al.	—	2025	→
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour.	Rocks D et al.	—	2025	→
Elementary 3D organization of active and silenced E. coli genome.	Gavrilov AA et al.	—	2025	→
Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation.	Yin L et al.	—	2025	→
Elucidating the chromatin-driven transcription regulatory networks response to Streptococcus agalactiae infection under low temperature in Nile tilapia.	Huang S et al.	—	2025	→
Elucidating the landscape of genome-wide chromatin interaction sites of the lncRNA TUG1 in bovine cell lines and liver tissue.	Weikard R et al.	—	2025	→
Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.	Gupta A et al.	—	2025	→
Endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans.	Traba SA et al.	—	2025	→
Endometrial aging is accompanied by H3K27ac and PGR loss.	Wang Y et al.	—	2025	→
Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease.	Dou Y et al.	—	2025	→
Engineered Endosymbionts that Modulate Primary Macrophage Function and Attenuate Tumor Growth by Shifting the Tumor Microenvironment.	Madsen CS et al.	—	2025	→
Engraftment and persistence of <i>HBB</i> base-edited hematopoietic stem cells in nonhuman primates.	Radtke S et al.	—	2025	→
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.	Ee LS et al.	—	2025	→
Enhancing R-loop prediction with high-throughput sequencing data.	Vanhaeren T et al.	—	2025	→
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA.	Cingaram PKR et al.	—	2025	→
Enlarged PML-nuclear bodies trigger conflicting cell cycle signal-mediated cytotoxicity in leukemia cells.	Baba T et al.	—	2025	→
Eomesodermin in conjunction with the BAF complex promotes expansion and invasion of the trophectoderm lineage.	Bisia AM et al.	—	2025	→
Epigenetic and transcriptional programming of murine eosinophils in the esophagus.	Felton JM et al.	—	2025	→
Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin.	Cashman TJ et al.	—	2025	→
Epigenetic mechanisms linking atherosclerosis to ischemic stroke: insights from DNA methylation and transcriptome integration.	Ding B et al.	—	2025	→
Epigenetic-mediated positive feedback loop facilitates the progression of lung adenocarcinoma.	Cheng Y et al.	—	2025	→
Epigenetic modifications in the murine liver upon depletion of transcriptional coregulator host cell factor 1.	Kaushal S et al.	—	2025	→
Epigenetic modulation of odontoblast differentiation: implications for regenerative endodontics.	Zhang Q et al.	—	2025	→
Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks.	Todd CD et al.	—	2025	→
Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence.	Tran LN et al.	—	2025	→
Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression.	Caggiano C et al.	—	2025	→
Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC.	Zamuner FT et al.	—	2025	→
Epigenetic regulation of TIMP-3 expression in human macrophages via physiological and pharmacological modification of histone3 lysine27 (H3K27).	Yıldırım-Buharalıoğlu G et al.	—	2025	→
Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons.	Cuvertino S et al.	—	2025	→
Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci.	Weldy CS et al.	—	2025	→
Epithelial transcription factor Elf3 mediates host immune responses to microbiota and protects against aerocystitis in zebrafish.	Davis BR et al.	—	2025	→
Essential roles of CTCF binding sites at TAD boundaries in modulating chromatin interactions and transcriptional regulation at the <i>Ifng</i> locus.	Muto K et al.	—	2025	→
Establishing the super-enhancer landscape in chicken adipose tissue.	Mu F et al.	—	2025	→
Establishment of bovine extraembryonic endoderm stem cells enables efficient blastoid formation.	Ming H et al.	—	2025	→
Ethylene response factors ERF.B2 and ERF.B5 synergically regulate ascorbic acid biosynthesis at multiple sites in tomato.	Chen W et al.	—	2025	→
Evidence that abscisic acid mediates gene activation under dehydrating conditions in pearl millet.	Qazi M et al.	—	2025	→
Extracellular vesicles derived from pro-inflammatory M1 macrophages induce an inflammatory and invasive phenotype in melanoma cells.	Mäki-Mantila K et al.	—	2025	→
Extrachromosomal circular DNA expressing miRNA promotes ovarian cancer progression.	Wu N et al.	—	2025	→
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription.	Taghbalout A et al.	—	2025	→
Fibroblast mechanoperception instructs pulmonary developmental and pattern specification gene expression programs.	Miller AE et al.	—	2025	→
Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation.	Zhang H et al.	—	2025	→
Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus.	Hendrickson CL et al.	—	2025	→
Foxn3 is required to suppress aberrant ciliogenesis in nonphotoreceptor retinal neurons.	Liu S et al.	—	2025	→
Fragment dispersity index analysis of cfDNA fragments reveals chromatin accessibility and enables early cancer detection.	Wang Y et al.	—	2025	→
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia.	Huang H et al.	—	2025	→
Functional genetic elements of a butterfly mimicry supergene.	VanKuren NW et al.	—	2025	→
Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma.	Sharma S et al.	—	2025	→
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia.	Kaltenecker D et al.	—	2025	→
G9a controls plasma cell differentiation through FOXO1 and ETS1 binding site regulatory networks.	George-Alexander LMM et al.	—	2025	→
GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia.	Alikarami F et al.	—	2025	→
Gene regulatory dynamics during craniofacial development in a carnivorous marsupial.	Cook LE et al.	—	2025	→
Gene-regulatory programs that specify age-related differences during thymocyte development.	Ganapathi Sankaran D et al.	—	2025	→
Genetic disruption of the baculum compromises the ability of male mice to copulate.	Ghione CR et al.	—	2025	→
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism.	Zhou D et al.	—	2025	→
Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury.	Abe Y et al.	—	2025	→
Genome assembly of two allotetraploid cotton germplasms reveals mechanisms of somatic embryogenesis and enables precise genome editing.	Xu Z et al.	—	2025	→
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression.	Kohwi Y et al.	—	2025	→
Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer.	Li H et al.	—	2025	→
Genome-Wide Analysis of bZIP Transcription Factor Family and Its Expression in Graft Healing of Soapberry (<i>Sapindus mukorossi</i> Gaertn.).	Chen N et al.	—	2025	→
Genome-wide demethylation and targeted remethylation during metamorphosis in the jewel wasp Nasonia vitripennis.	Thomas CL et al.	—	2025	→
Genome-wide identification of the H3K27ac signals reveals key thermogenic cis-regulatory elements of brown adipose tissues in Oryctolagus cuniculus.	Du K et al.	—	2025	→
Genome-wide mapping of RNA-protein associations through sequencing.	Qi Z et al.	—	2025	→
Genomic analysis of glaucoma pathogenesis due to gmds mutation in zebrafish.	Ameen MT et al.	—	2025	→
Genomic and chromosomal architectures underlying fertility maintenance in the testes of intergeneric homoploid hybrids.	Ren L et al.	—	2025	→
Genomic and DNA methylomic factors associated with the efficacy of oral medroxyprogesterone acetate on endometrial neoplastic disease.	Sugiyama Y et al.	—	2025	→
Gfi1 controls the formation of effector-like CD8<sup>+</sup> T cells during chronic infection and cancer.	Ojo OA et al.	—	2025	→
Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling.	Yang C et al.	—	2025	→
GmSop20 Functions as a Key Coordinator of the Oil-To-Protein Ratio in Soybean Seeds.	Zheng H et al.	—	2025	→
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells.	Robinson J et al.	—	2025	→
Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration.	Van Dijck E et al.	—	2025	→
Graft-seq precisely maps RNA modifications via site-specific chemical grafting strategy.	Li T et al.	—	2025	→
Growth of human regulatory CD4<sup>+</sup> T cells is more tightly controlled than effector T cells due to distinctive molecular programming.	Moro A et al.	—	2025	→
Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements.	Levy G et al.	—	2025	→
H2A.Z is essential for oocyte maturation and fertility in female mouse.	Xu Q et al.	—	2025	→
H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes.	Mei H et al.	—	2025	→
H3K4me2 distinguishes a distinct class of enhancers during the maternal-to-zygotic transition.	Hurton MD et al.	—	2025	→
H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells.	Cooke EW et al.	—	2025	→
HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs.	Kulkarni K et al.	—	2025	→
Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping.	Fink EE et al.	—	2025	→
Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers ApoB-Containing Lipoproteins in Mice.	Helsley RN et al.	—	2025	→
Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms.	Makris K et al.	—	2025	→
Hepatocyte metabolic adaptations during pregnancy and lactation.	Yang L et al.	—	2025	→
HIF1α-PHD1-FOXA1 Axis Orchestrates Hypoxic Reprogramming and Androgen Signaling Suppression in Prostate Cancer.	Liang L et al.	—	2025	→
Highly accurate prophage island detection with PIDE.	Gao H et al.	—	2025	→
Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing.	Tallan A et al.	—	2025	→
High-quality reference genome and population analysis of allotetraploid Elymus sibiricus provide insight into genome origin and environmental adaptations to the Qinghai-Tibetan Plateau.	Li X et al.	—	2025	→
High resolution diel transcriptomes of autotetraploid potato reveal expression and sequence conservation among rhythmic genes.	Feke A et al.	—	2025	→
Histone deacetylase complex 1 facilitates hypocotyl elongation by attenuating acetylation and transcription via a PIF4-dependent process.	Fang W et al.	—	2025	→
Histone H3K4 demethyltransferase VvJMJ14 promotes H<sub>2</sub>O<sub>2</sub> inducing fruit ripening in grape.	Zuo DD et al.	—	2025	→
HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells.	Quan L et al.	—	2025	→
H<sup>3</sup>NGST: a fully automated, web-based platform for end-to-end ChIP-seq analysis.	Heo HH et al.	—	2025	→
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes.	Bernardo E et al.	—	2025	→
Hominoid-specific transposable elements reshaped neural crest migration in craniofacial development.	Deelen L et al.	—	2025	→
HOXA5-driven transcriptional program in lung development.	Frenette B et al.	—	2025	→
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity.	Sayeed K et al.	—	2025	→
Human genetic variation determines 24-hour rhythmic gene expression and disease risk.	Chen Y et al.	—	2025	→
Human monocyte inflammation in patients with Lp(a) or atherosclerotic cardiovascular disease is not accompanied by changes in chromatin accessibility in circulating classical monocytes.	Kempkes RWM et al.	—	2025	→
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.	Sanchez-Garcia MA et al.	—	2025	→
IceQream: Quantitative chromosome accessibility analysis using physical TF models.	Bercovich A et al.	—	2025	→
Identification and functional characterization of JrbZIP40 in walnut reveals its role in salt and drought stress tolerance in transgenic Arabidopsis seedlings.	Wei J et al.	—	2025	→
IGF2BP3-mediated m<sup>6</sup>A modification of RASGRF1 promoting joint injury in rheumatoid arthritis.	Geng Q et al.	—	2025	→
IGF2BP3 Modulates mRNA Splicing and Stability to Promote Trophoblast Progression via Interaction with PDE3A and Suppression by miR-196a-5p in Preeclampsia.	Li C et al.	—	2025	→
Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia.	Angelino E et al.	—	2025	→
Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis.	Matsuda S et al.	—	2025	→
Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells.	Jaber-Hijazi F et al.	—	2025	→
Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming.	Zhao W et al.	—	2025	→
Induction of the zinc finger transcription factor GATA2 promotes kidney inflammation-related gene expression.	Takai J et al.	—	2025	→
Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy.	Hirade K et al.	—	2025	→
Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.	Cai Y et al.	—	2025	→
Inhibition of the Transcription Factor PU.1 Suppresses Tumor Growth in Mice by Promoting the Recruitment of Cytotoxic Lymphocytes Through the CXCL9-CXCR3 Axis.	Sleapnicov N et al.	—	2025	→
Injury-induced Clusterin<sup>+</sup> cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages.	Fan L et al.	—	2025	→
Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation.	Jiang C et al.	—	2025	→
Integrated analysis of differential intra-chromosomal community interactions: A study of breast cancer.	Yao Z et al.	—	2025	→
Integrated genomic analysis and CRISPRi implicates <i>EGFR</i> in Alzheimer's disease risk.	Leung YY et al.	—	2025	→
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis.	Park B et al.	—	2025	→
Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation.	Traxler P et al.	—	2025	→
Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation.	Liu C et al.	—	2025	→
Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle.	Chen Q et al.	—	2025	→
Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer.	Du H et al.	—	2025	→
Integrative analysis of RNA binding proteins identifies DDX55 as a novel regulator of 3'UTR isoform diversity.	Gazzara MR et al.	—	2025	→
Integrative characterization of MYC RNA-binding function.	Li S et al.	—	2025	→
Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan Pigs.	Lai D et al.	—	2025	→
Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis.	Eskandarian Boroujeni M et al.	—	2025	→
Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer.	Dayanc B et al.	—	2025	→
Integrative RNA-seq and CLIP-seq analysis reveals <i>hnRNP-F</i> regulation of <i>TNFα/NFκB</i> signaling in high-glucose conditions.	Wang L et al.	—	2025	→
Integrative transcriptomic analysis reveals alternative splicing complexity and transcriptomic diversity in porcine placentas across altitudes.	Li CY et al.	—	2025	→
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development.	Edupuganti RR et al.	—	2025	→
Interplay of the Genetic Variants and Allele Specific Methylation in the Context of a Single Human Genome Study.	Voronina MD et al.	—	2025	→
Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins.	Beyer JN et al.	—	2025	→
Intragenic viral silencer element regulates HTLV-1 latency via RUNX complex recruitment.	Sugata K et al.	—	2025	→
Ints7 deficiency activates DNA damage response to elicit resurgence of endogenous retrovirus MERVL and anastasis of embryonic stem cells.	Shen Y et al.	—	2025	→
Investigation of methylation profiles in Silver-Russell syndrome to explore episignatures.	Hara-Isono K et al.	—	2025	→
In vivo transition in chromatin accessibility during differentiation of deep-layer excitatory neurons in the neocortex.	Sakai S et al.	—	2025	→
IRF4 Promotes Immune Evasion and Shapes the Tumor Microenvironment in Follicular Lymphoma.	Dasari S et al.	—	2025	→
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.	Bjune JI et al.	—	2025	→
Isoform characterization of m<sup>6</sup>A in single cells identifies its role in RNA surveillance.	Ren Z et al.	—	2025	→
Jpx RNA controls Xist induction through spatial reorganization of the mouse X-inactivation center.	Oh HJ et al.	—	2025	→
Jund orchestrates <i>cis</i>-regulatory element dynamics to facilitate endothelial-to-hematopoietic transition.	Guo J et al.	—	2025	→
JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium.	Khader N et al.	—	2025	→
KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2.	Cunniff PJ et al.	—	2025	→
KLF feedback loops in innate immunity.	Salmon JM et al.	—	2025	→
Knockdown of USF1 and USF2 drives prolonged changes in the gene expression response of M12-5B3 cells to DNA damage.	Bellingham-Johnstun KS et al.	—	2025	→
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation.	Cheung MY et al.	—	2025	→
KnowYourCG: Facilitating base-level sparse methylome interpretation.	Goldberg DC et al.	—	2025	→
Lactate regulates cell differentiation of erythroid progenitor cells via histone lactylation modification.	Yang Q et al.	—	2025	→
Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle.	Jabre S et al.	—	2025	→
Landscape and m<sup>6</sup>A post-transcriptional regulation of soybean proteome.	Yang Q et al.	—	2025	→
Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing.	Sun R et al.	—	2025	→
Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation.	Tian SZ et al.	—	2025	→
LARP4-mediated hypertranslation drives T cell dysfunction in tumors.	Liu Y et al.	—	2025	→
Late gene regulation by the alternative sigma factors of <i>Chlamydia trachomatis</i>.	Rizvi SMA et al.	—	2025	→
Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis.	Seasock MJ et al.	—	2025	→
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness.	Pawar AS et al.	—	2025	→
LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs.	Wu L et al.	—	2025	→
Ligand-specific regulation of a binary enhancer code dictating cellular senescence.	Suter T et al.	—	2025	→
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development.	Adami A et al.	—	2025	→
Lineage trajectories and fate determinants of postnatal neural stem cells and ependymal cells in the developing ventricular zone.	Zheng J et al.	—	2025	→
Linker histones enhance robustness in diurnal transcription dynamics.	Rutowicz K et al.	—	2025	→
Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity.	Yagyu H et al.	—	2025	→
Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes.	Farhangdoost N et al.	—	2025	→
LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2.	Kiriakopulos K et al.	—	2025	→
Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing.	Quinones-Valdez G et al.	—	2025	→
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory.	Ziogas A et al.	—	2025	→
Low dose IFNγ remodels enhancer landscape to potentiate mesenchymal stromal cell activation.	Lin J et al.	—	2025	→
<i>CARINH</i>, an Interferon-Induced LncRNA in Cancer and Inflammation.	Gourvest M et al.	—	2025	→
<i>k</i>-mer manifold approximation and projection for visualizing DNA sequences.	Fu C et al.	—	2025	→
<i>LIN28B</i> hypomethylation drives oncogenic signaling and stratifies poor prognosis in juvenile myelomonocytic leukemia.	Lai J et al.	—	2025	→
Luminal hormone-responsive cells tune the regenerative remodeling of mammary glands in large mammals.	Li Y et al.	—	2025	→
Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation.	Staehle HF et al.	—	2025	→
m6A modification is incorporated into bacterial mRNA without specific functional benefit.	Szydlo K et al.	—	2025	→
Machine-guided cell-fate engineering.	Appleton E et al.	—	2025	→
Machine learning-augmented m6A-Seq analysis without a reference genome.	Yang J et al.	—	2025	→
Macrophages with different origins proliferate <i>ex vivo</i> and do not lose their core intrinsic features.	Habash SA et al.	—	2025	→
Many transcription factor families have evolutionarily conserved binding motifs in plants.	Zenker S et al.	—	2025	→
Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow.	Wit N et al.	—	2025	→
Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants.	Shook MS et al.	—	2025	→
Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity.	Kosicki M et al.	—	2025	→
Maternal factor OTX2 regulates human embryonic genome activation and early development.	Wang Q et al.	—	2025	→
Mathematical modeling suggests 14-3-3 proteins modulate RAF paradoxical activation.	Mendiratta G et al.	—	2025	→
Mechanical confinement governs phenotypic plasticity in melanoma.	Hunter MV et al.	—	2025	→
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome.	Wang SE et al.	—	2025	→
Mechanism of parent-of-origin effects revealed by multi-omic data in euro-chinese hybrid pigs.	Li C et al.	—	2025	→
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness.	Cosgrove BD et al.	—	2025	→
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types.	Moore JR et al.	—	2025	→
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors.	Lu C et al.	—	2025	→
Meta-analysis reveals transcription factors and DNA binding domain variants associated with congenital heart defect and orofacial cleft.	Jeong R et al.	—	2025	→
Methylation aberrations and genomic instability synergistically drive the evolution of intrahepatic cholangiocarcinoma.	Li G et al.	—	2025	→
Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity.	Daman AW et al.	—	2025	→
MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma.	Dias D et al.	—	2025	→
Mitigating Cell Cycle Effects in Multi-Omics Data: Solutions and Analytical Frameworks.	Nie R et al.	—	2025	→
Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis.	Du H et al.	—	2025	→
Modeling combinatorial regulation from single-cell multi-omics provides regulatory units underpinning cell type landscape using cRegulon.	Feng Z et al.	—	2025	→
Modeling post-gastrula development via bidirectional pluripotent stem cells.	Liu K et al.	—	2025	→
Modeling the vertebrate regulatory sequence landscape by UUATAC-seq and deep learning.	Han X et al.	—	2025	→
Modelling arrhythmogenic cardiomyopathy fattyfibro pathology with PKP2-deficient epicardial cells derived from human iPSCs.	Falana SL et al.	—	2025	→
Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing.	Valcárcel G et al.	—	2025	→
Modulation of glucocorticoid receptor function under iron overload.	Zhu W et al.	—	2025	→
Molecular architecture of mesoderm cells across early to middle stage of human embryo development at single-cell resolution.	Zhang W et al.	—	2025	→
Molecular basis of NFIB-mediated regulation of oncogenic transcription.	Zhu C et al.	—	2025	→
Molecular Determinants of the Human Retinal Pigment Epithelium Cell Fate and Potential Pharmacogenomic Targets for Precision Medicine.	Zibetti C	—	2025	→
Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones.	Carrington JT et al.	—	2025	→
Motif-based models accurately predict cell type-specific distal regulatory elements.	Cornejo-Páramo P et al.	—	2025	→
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.	Rajabli F et al.	—	2025	→
Multi-dimensional annotation of porcine variants using genomic and epigenomic features in pigs.	Yin H et al.	—	2025	→
Multi-dimensional epigenomic dynamics converge on H3K4-mediated regulation of low-CO<sub>2</sub> adaptation in Nannochloropsis oceanica.	Gong Y et al.	—	2025	→
Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation.	Pérez-Posada A et al.	—	2025	→
Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells.	Du C et al.	—	2025	→
Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential.	Cheng CCY et al.	—	2025	→
Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells.	Zeng A et al.	—	2025	→
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength.	Wang YX et al.	—	2025	→
Multi-omics analyses integration reveals a novel TRF2-miR-181a-5p-S100A10 regulatory axis in colon cancer.	Dinami R et al.	—	2025	→
Multi-omics analysis of early reperfused ischemic heart reveals ERRβ/γ activation protects against acute myocardial infarction injury.	Gao Y et al.	—	2025	→
Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.	Li Y et al.	—	2025	→
Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus.	Zhang J et al.	—	2025	→
Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-kB binding.	Wang L et al.	—	2025	→
Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.	Aguilar RR et al.	—	2025	→
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.	Mahat DB et al.	—	2025	→
Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state.	Rominger MC et al.	—	2025	→
Mutation of SMARCA4 Induces Cancer Cell-Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy.	Wang Y et al.	—	2025	→
MYADM Activates RhoA-Mediated Ameboid Migration to Drive Metastasis.	Tsai YT et al.	—	2025	→
MYC drives left-handed Z-DNA formation to shape gene expression.	Wan X et al.	—	2025	→
MYC Regulates a DNA Repair Gene Expression Program in Small Cell Carcinoma of the Ovary, Hypercalcemic Type.	Evans JR et al.	—	2025	→
Myogenic enhancer snatching promotes adipogenic differentiation during epigenetic reprogramming mediated by lineage-specific transcription factors.	Hu M et al.	—	2025	→
Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification.	Jiang R et al.	—	2025	→
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells.	Zhu X et al.	—	2025	→
NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors.	Hill C et al.	—	2025	→
NANOG governs cell metabolism and redox homeostasis in human naïve embryonic stem cells.	Shao M et al.	—	2025	→
NASP implication in the androgen receptor associated with castration resistance in prostate cancer.	Feng Y et al.	—	2025	→
Nat10 maintains the homeostasis of pluripotent and 2-cell-like states in mouse embryonic stem cells through mRNA cytidine acetylation.	Feng G et al.	—	2025	→
Natural variants of <i>AGL80.5</i> and <i>FPA.3</i> contribute to bud break timing in poplar by controlling auxin biosynthesis.	Li L et al.	—	2025	→
NDF/GLYR1 Promotes RNA Polymerase II Processivity via Pol II Binding and Nucleosome Destabilization.	Li Z et al.	—	2025	→
Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers.	Demurtas M et al.	—	2025	→
Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.	Wu Y et al.	—	2025	→
NF1-depleted ER<sup>+</sup> breast cancers are differentially sensitive to CDK4/6 inhibitors.	Zheng ZY et al.	—	2025	→
NLRP3 proteins translocation into nuclei mediates SV40 T-antigen-induced corneal epithelial cell immortalization.	Xu J et al.	—	2025	→
Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma.	Aloisi S et al.	—	2025	→
Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodeling.	Yoo M et al.	—	2025	→
Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells.	Ferrero G et al.	—	2025	→
Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus.	Traunmüller L et al.	—	2025	→
Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus.	Anirudhan J et al.	—	2025	→
NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice.	Park S et al.	—	2025	→
NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants.	Ma X et al.	—	2025	→
Nuclear 2'-<i>O</i>-methylation regulates RNA splicing through its binding protein FUBP1.	Gao B et al.	—	2025	→
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.	Zhang H et al.	—	2025	→
Nuclear-lamin-guided plastic positioning and folding of the human genome.	Wang Z et al.	—	2025	→
Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.	Chen X et al.	—	2025	→
Nucleolar FRG2 lncRNAs inhibit rRNA transcription and cytoplasmic translation, linking FSHD to dysregulation of muscle-specific protein synthesis.	Salsi V et al.	—	2025	→
Nucleosome dynamics render heterochromatin accessible in living human cells.	Prajapati HK et al.	—	2025	→
OCT-2 Is Associated With Pro-Metastatic Epigenomic Properties of Triple-Negative Breast Cancer Cells.	Ogikubo K et al.	—	2025	→
O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis.	Ahmed O et al.	—	2025	→
OoAREB1 from Oxytropis ochrocephala binds to the promoters of stress-responsive genes to enhance their expression and improve drought tolerance.	Han XM et al.	—	2025	→
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma.	Fort G et al.	—	2025	→
Organ-level gene-regulatory networks inferred from transcriptomic data reveal context-specific regulation and highlight novel regulators of ripening and ABA-mediated responses in tomato.	Fernández JD et al.	—	2025	→
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm.	Vasileva E et al.	—	2025	→
OsNTL2 confers rice osmotic stress resilience through coordinated transcriptional regulation of the ASC-GSH redox cycle and cell wall biosynthesis.	Zhou H et al.	—	2025	→
Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder.	Zhao X et al.	—	2025	→
p53 reveals principles of chromatin remodeling and enhancer activation.	Fischer M et al.	—	2025	→
PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription.	Love L et al.	—	2025	→
Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase.	Trebino MA et al.	—	2025	→
Pathway-level convergence: an underexplored aspect of convergent evolution.	Hoitinga PK et al.	—	2025	→
PB-DiffHiC: a statistical framework for detecting differential chromatin interactions from high resolution pseudo-bulk Hi-C data.	Zhou Y et al.	—	2025	→
PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.	Mok CH et al.	—	2025	→
Phase-separated NDF-FACT condensates facilitate transcription elongation on chromatin.	Li Z et al.	—	2025	→
Phenotypic heterogeneity and plasticity in colorectal cancer metastasis.	Ogden S et al.	—	2025	→
Phylostratigraphic analysis revealed that ancient ohnologue PtoWRKY53 innovated a vascular transcription regulatory network in Populus.	Huang W et al.	—	2025	→
PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence.	Wang J et al.	—	2025	→
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment.	Chen D et al.	—	2025	→
Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling.	Orlando KA et al.	—	2025	→
PKL mediates H3K4me2 modification and spatial gene congregation in chromatin regulation.	Song M et al.	—	2025	→
POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis.	Zhang T et al.	—	2025	→
Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment.	Parmar A et al.	—	2025	→
Positional distribution of transcription factor binding sites in the human genome.	Yu CP et al.	—	2025	→
POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population.	Benoit CR et al.	—	2025	→
PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts.	Guo Q et al.	—	2025	→
PRC1-Mediated H2Aub Loop Formation and Function in Arabidopsis.	Luo L et al.	—	2025	→
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation.	He L et al.	—	2025	→
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses.	Guichard V et al.	—	2025	→
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming.	Lu JY et al.	—	2025	→
Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma.	Huang C et al.	—	2025	→
Profiling of RUVBL2-Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer.	Xue R et al.	—	2025	→
Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination.	Keshavarzian T et al.	—	2025	→
Protocol for transcriptomic and epigenomic analysis of JAK inhibitor sensitivity in IFN-γ-primed human macrophages using ATAC-seq and RNA-seq.	Kwon G et al.	—	2025	→
RACK7 senses and fine-tunes enhancer activity.	Dong L et al.	—	2025	→
Range extender mediates long-distance enhancer activity.	Bower G et al.	—	2025	→
RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity.	Singh S et al.	—	2025	→
RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing.	Wu T et al.	—	2025	→
Reactivation of an embryonic cardiac neural crest transcriptional profile during zebrafish heart regeneration.	Dhillon-Richardson RM et al.	—	2025	→
Read-level DNA methylation deconvolution enhances circulating tumor DNA detection.	Qi T et al.	—	2025	→
Recurrent integration of domestic cat hepatitis B virus DNA near feline CCNE1 supports an oncogenic role in hepatocellular carcinoma in cats.	Cavasin JP et al.	—	2025	→
Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt.	Miluzio A et al.	—	2025	→
Regulation of inflammatory responses by pH-dependent transcriptional condensates.	Wu Z et al.	—	2025	→
Regulation of ribosomal gene expression and senescence by a PML-mTOR-RONIN nuclear complex in triple-negative breast cancer.	Medkour Y et al.	—	2025	→
Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement.	Walker MWG et al.	—	2025	→
Repeat-element RNAs integrate a neuronal growth circuit.	Zahavi EE et al.	—	2025	→
Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice.	Chen YN et al.	—	2025	→
Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction.	Shi C et al.	—	2025	→
Requirements for establishment and epigenetic stability of mammalian heterochromatin.	Tatarakis A et al.	—	2025	→
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer's disease.	Ardura-Fabregat A et al.	—	2025	→
Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes.	Byun S et al.	—	2025	→
REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate.	Sahinyan K et al.	—	2025	→
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci.	Mimoso CA et al.	—	2025	→
Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation.	Leesang TE et al.	—	2025	→
Retinoic Acid-Regulated Epigenetic Marks Identify <i>Alx1</i> as a Direct Target Gene Required for Optic Cup Formation.	Berenguer M et al.	—	2025	→
Retrograde signals control dynamic changes to the chromatin state at photosynthesis-associated loci.	Quevedo M et al.	—	2025	→
Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome.	Hu B et al.	—	2025	→
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation.	Tan B et al.	—	2025	→
Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity.	Sun SJ et al.	—	2025	→
Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules.	Bond MJ et al.	—	2025	→
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo.	Kucinski J et al.	—	2025	→
Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22.	Fan W et al.	—	2025	→
Ribosome dysregulation and intervention in age-related infertility.	Li J et al.	—	2025	→
RNA-interactome capture identifies SRSF3 as a key protein for herpesviral gene expression.	Vogt C et al.	—	2025	→
RNA m<sup>6</sup>A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors.	Dong S et al.	—	2025	→
SATB1 is a key regulator of quiescence in stem-like CD8<sup>+</sup> T cells.	Lin S et al.	—	2025	→
Scalable screening of ternary-code DNA methylation dynamics associated with human traits.	Goldberg DC et al.	—	2025	→
scRegulate: single-cell regulatory-embedded variational inference of transcription factor activity from gene expression.	Zandigohar M et al.	—	2025	→
Second-order threat conditioning in the amygdala-posterior piriform cortex network.	Sepahvand T et al.	—	2025	→
SEgene identifies links between super enhancers and gene expression across cell types.	Shinkai N et al.	—	2025	→
Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma.	Iyer AR et al.	—	2025	→
SEPAR enables spatial metagene discovery and associated molecular pattern characterization in spatial transcriptomics and multi-omics datasets.	Zhang L et al.	—	2025	→
Sequence and parent-of-origin dependent m<sup>6</sup>A contribute to allele-specific gene expression.	Zhang Y et al.	—	2025	→
Sex-biased transcriptome in in vitro produced bovine early embryos.	Shi M et al.	—	2025	→
Sex-dimorphic gene regulation in murine macrophages across niches.	McGill CJ et al.	—	2025	→
Sex-specific expression and function of TRIM28 during mouse primordial germ differentiation.	DiRusso JA et al.	—	2025	→
Sex-specific transcriptome dynamics of <i>Anopheles gambiae</i> during embryonic development.	Kalita AI et al.	—	2025	→
Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation.	Tang PC et al.	—	2025	→
SF3B6 promotes the oncogenic phenotypes of MDA-MB-231 cells by extensively interacting with and regulating transcripts expression and alternative splicing.	Yuan C et al.	—	2025	→
Shoring up the base: The development and regulation of cortical sclerenchyma in grass nodal roots.	McCahill IW et al.	—	2025	→
Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains.	Xiang Y et al.	—	2025	→
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue.	Chen ZJ et al.	—	2025	→
Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression.	Melton R et al.	—	2025	→
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate.	Zhao X et al.	—	2025	→
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience.	Liu Z et al.	—	2025	→
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression.	Chawla A et al.	—	2025	→
Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures.	Xia M et al.	—	2025	→
Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies.	Loh LS et al.	—	2025	→
SlALKBH9B is involved in drought-induced flower drop by regulating ethylene production.	Cai Y et al.	—	2025	→
SlWRKY14 integrates carotenoid and flavonoid biosynthetic pathways to regulate coloration and quality of tomato fruits.	Li Y et al.	—	2025	→
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.	Tsanov KM et al.	—	2025	→
SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages.	Efthymiadou A et al.	—	2025	→
Spatial joint profiling of DNA methylome and transcriptome in tissues.	Lee CN et al.	—	2025	→
Spatial patterning of the epigenome during vertebrate gastrulation.	Azambuja AP et al.	—	2025	→
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development.	Sun Y et al.	—	2025	→
Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in <i>Aspergillus</i>.	Moon H et al.	—	2025	→
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias.	Venkatasubramanian M et al.	—	2025	→
SPT6 regulates H3K14Ac deposition in mouse embryonic stem cells.	Zhang D et al.	—	2025	→
SRSF10 regulates oligodendrocyte differentiation during mouse central nervous system development by modulating pre-mRNA splicing.	Mu Y et al.	—	2025	→
Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection.	Plajer V et al.	—	2025	→
Stage-specific requirement for METTL3-dependent m<sup>6</sup>A epitranscriptomic regulation during myogenesis.	Tan YY et al.	—	2025	→
Stepwise neofunctionalization of the NF-κB family member Rel during vertebrate evolution.	Daly AE et al.	—	2025	→
Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA.	Zhu C et al.	—	2025	→
Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3.	Alpsoy A et al.	—	2025	→
Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells.	Kaiser AM et al.	—	2025	→
Subtype-specific RNA sequencing using micro-dissection revealed extracellular matrix alterations as key factors in lung adenocarcinoma invasion.	Yuan C et al.	—	2025	→
Super-Enhancer-Mediated DLX5 Activation Defines Regulatory Mechanisms in Human Embryonic Stem Cell-Derived Osteoblasts.	Fujita S et al.	—	2025	→
SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity.	Chatterjee P et al.	—	2025	→
SWI/SNF complexes govern ontology-specific transcription factor function in MYC-subtype atypical teratoid rhabdoid tumor.	Nesvick CL et al.	—	2025	→
SWI/SNF Functions as a Gatekeeper of Enhancer Chromatin Access to Control Progression of Mesenchymal Triple-Negative Breast Cancer.	Møldrup RIJ et al.	—	2025	→
Synaptic activity causes minute-scale changes in BAF complex composition and function.	Gourisankar S et al.	—	2025	→
TAC-C uncovers open chromatin interaction in crops and SPL-mediated photosynthesis regulation.	Kang J et al.	—	2025	→
TAF1 is required for fetal but not adult hematopoiesis in mice.	Liu F et al.	—	2025	→
Targeted long-read methylation analysis using hybridization capture suitable for clinical specimens.	Kunigo K et al.	—	2025	→
Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis.	Dian M et al.	—	2025	→
Targeting FOXA1 and FOXA2 disrupts the lineage-specific oncogenic output program in prostate cancer.	Formaggio N et al.	—	2025	→
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer.	Luo J et al.	—	2025	→
Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype.	Lou S et al.	—	2025	→
Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18::SSX fusion oncoproteins and impairs sarcomagenesis.	Iyer R et al.	—	2025	→
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis.	Tu C et al.	—	2025	→
Tbx1 stabilizes differentiation of the cardiopharyngeal mesoderm and drives morphogenesis in the pharyngeal apparatus.	Lanzetta O et al.	—	2025	→
TBX3 advances the developmental chromatin landscape toward the hepatic fate.	Stephan TL et al.	—	2025	→
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference.	Dorme M et al.	—	2025	→
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice.	Bright AR et al.	—	2025	→
Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification.	Guerin LN et al.	—	2025	→
Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression.	Luo CH et al.	—	2025	→
The 3D genome of plasma cells in multiple myeloma.	Zhang K et al.	—	2025	→
The ALX4 dimer structure provides insight into how disease alleles impact function.	Cain B et al.	—	2025	→
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.	Murphy KB et al.	—	2025	→
The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes.	Zhao Q et al.	—	2025	→
The Condensin II complex regulates essential gene expression programs during erythropoiesis.	Abid D et al.	—	2025	→
The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells.	Fang J et al.	—	2025	→
The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1<sup>+</sup>CD8<sup>+</sup> T cells.	Humblin E et al.	—	2025	→
The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion.	Chen Y et al.	—	2025	→
The epigenetic circle: feedback loops in the maintenance of cellular memory.	Tomljanović M et al.	—	2025	→
The Fire Ant Social Chromosome Exerts a Major Influence on Genome Regulation.	Jones BM et al.	—	2025	→
The genomic origin of the unique chaetognath body plan.	Piovani L et al.	—	2025	→
The GR-LEDGF/p75-HSP27 Axis Contributes to Cross-Resistance Between Enzalutamide and Docetaxel in Prostate Cancer.	Ochoa PT et al.	—	2025	→
The histone variant H3.14 is an early player in the abiotic stress response of Arabidopsis.	Nunez-Vazquez R et al.	—	2025	→
The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons.	Sun MA et al.	—	2025	→
The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer.	Xie W et al.	—	2025	→
The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed.	Fang S et al.	—	2025	→
The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity.	Li W et al.	—	2025	→
The METTL3-PGR-WNT4 axis is critical for human endometrial stromal cell decidualization.	Hong YQ et al.	—	2025	→
The METTL3-YTHDC1 axis mediates architectural RNA m<sup>6</sup>A modification to modulate the integrity of chromatin TADs in MLLr + AML genome.	Fu R et al.	—	2025	→
The MpANT-Auxin Loop Modulates Marchantia polymorpha Development.	Melissa DÁ et al.	—	2025	→
The myoblast methylome: multiple types of associations with chromatin and transcription.	Sen S et al.	—	2025	→
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development.	Girdhar K et al.	—	2025	→
The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.	Hayashi A et al.	—	2025	→
The Non-Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism.	Maiorino T et al.	—	2025	→
The NuRD component CHD3 promotes BMP signalling during cranial neural crest cell specification.	Mitchell ZH et al.	—	2025	→
The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome.	Jeon S et al.	—	2025	→
The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic Cancer.	Bowman CL et al.	—	2025	→
Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC.	Xue W et al.	—	2025	→
The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing, and irreversibility of the G1/S transition.	Nagasato-Ichikawa A et al.	—	2025	→
The RNA m<sup>6</sup>A landscape during human oocyte-to-embryo transition.	Li Y et al.	—	2025	→
The significance of chromosome conformation capture in 3D genome architecture comprehension.	Cetin S et al.	—	2025	→
The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer.	Akano I et al.	—	2025	→
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8<sup>+</sup> T cells.	Murphy MK et al.	—	2025	→
The transcription factor BATF pioneers the differentiation program of effector CD8<sup>+</sup> T cells through the interaction with IRF4.	Fujisawa S et al.	—	2025	→
The transcription factor BnaWRKY75 enhances resistance to the necrotrophic pathogen Sclerotinia sclerotiorum by promoting salicylic acid biosynthesis in oilseed rape.	Liu D et al.	—	2025	→
The transcription factor IID subunit Taf13 is dispensable for TATA binding protein promoter recruitment and RNA polymerase II transcription.	Martianov I et al.	—	2025	→
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors.	Léger J et al.	—	2025	→
Tissue-Specific Chromatin Accessibility Regions and Transcription Factor Binding Sites in Pig Brain and Endocrine Tissues.	Ponsuksili S et al.	—	2025	→
Tissue-specific isoform usage and gene expression revealed through RNA-seq and ATAC-seq in developing cattle.	Khilji SF et al.	—	2025	→
TOC1 phosphorylation disproportionally enhances chromatin binding at rhythmic gene promoters.	Yan J et al.	—	2025	→
Topologically associating domains and the evolution of three-dimensional genome architecture in rice.	Kurbidaeva A et al.	—	2025	→
TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis.	Liu Q et al.	—	2025	→
Transcriptional and chromatin accessibility landscapes of hematopoiesis in a mouse model of breast cancer.	Fan C et al.	—	2025	→
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.	Troester S et al.	—	2025	→
Transcriptional control of C. elegans male tail tip morphogenesis by DMD-3.	Fernandez P et al.	—	2025	→
Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization.	Shanel G et al.	—	2025	→
Transcriptional Regulation of Macrophage Specification and Function.	Vanneste D et al.	—	2025	→
Transcriptional regulator SATB1 limits CD8<sup>+</sup> T cell population expansion and effector differentiation in chronic infection and cancer.	Heyden L et al.	—	2025	→
Transcription factors instruct DNA methylation patterns in plant reproductive tissues.	Xu G et al.	—	2025	→
Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis.	Mukherjee D et al.	—	2025	→
Transcriptome analysis reveals PTBP1 as a key regulator of circRNA biogenesis.	Wang M et al.	—	2025	→
Transcriptome profiling of peripheral blood mononuclear cells from highly susceptible adult cattle infected with a virulent strain of Babesia bovis.	Capelli-Peixoto J et al.	—	2025	→
Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to <i>Campylobacter jejuni</i> inoculation.	Zhao Y et al.	—	2025	→
Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia.	Farhangdoost N et al.	—	2025	→
Transcriptomic signatures of rare variant impacts across sex and the X chromosome.	Ungar RA et al.	—	2025	→
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations.	Hou Y et al.	—	2025	→
Transient gene melting governs the timing of oligodendrocyte maturation.	Allan KC et al.	—	2025	→
Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages.	Babarinde IA et al.	—	2025	→
Triclosan inhibits human trophoblast cell migration via TCF12-mediated RASSF8 regulation.	Dong G et al.	—	2025	→
TRIM35, a novel DNA-binding protein, epigenetically modifies H3 to promote HSPA6 transcription and suppress breast cancer progression.	Jing X et al.	—	2025	→
U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation.	Kim G et al.	—	2025	→
Ume6 protein complexes connect morphogenesis, adherence and hypoxic genes to shape Candida albicans biofilm architecture.	Do E et al.	—	2025	→
UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.	Cai G et al.	—	2025	→
Uncovering hidden enhancers through unbiased in vivo testing.	Mannion BJ et al.	—	2025	→
Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes.	Petersen RM et al.	—	2025	→
Uncovering the multi-layer cis-regulatory landscape of rice via integrative nascent RNA analysis.	Goliasse M et al.	—	2025	→
Understanding the regulatory grammar of sepsis-causing Staphylococcus aureus bacteria using contexualised DNA language models.	Chen T et al.	—	2025	→
Unlocking the Puzzle of Mammalian Transfection: The Role of the RNA-sensing-Mediated Interferon Response in the Cellular Defense Against Foreign DNA Intrusion.	Li X et al.	—	2025	→
Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function.	Rittenhouse NL et al.	—	2025	→
Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments.	Thompson MD et al.	—	2025	→
Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions.	Zhang Z et al.	—	2025	→
Upregulation of long non-coding RNA SNHG11 promotes apoptosis and its molecular mechanisms in human osteosarcoma U2OS cells.	Dai Z et al.	—	2025	→
Variation in Genome Architecture and Epigenetic Modification Across the Microsporidia Phylogeny.	Angst P et al.	—	2025	→
Vimentin network dysregulation mediates neurite deficits in <i>SNCA</i> duplication Parkinson's patient-derived midbrain neurons.	Schneider Y et al.	—	2025	→
Vitamin D and lipopolysaccharide jointly induce a distinct epigenetic and transcriptional program in human monocytes.	Jankowski M et al.	—	2025	→
WDR5 serves in co-activation and influences genome targeting of KLF3.	Yang L et al.	—	2025	→
Whole genome DNA methylation profiles define Meniere's disease subclusters.	Patil V et al.	—	2025	→
Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features.	Lin B et al.	—	2025	→
Wnt signaling activation induces CTCF binding and loop formation at <i>cis</i>-regulatory elements of target genes.	Nordin A et al.	—	2025	→
WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern.	Malkmus J et al.	—	2025	→
YAP regulates transcriptional programs for layer-specific periosteal expansion during fracture repair.	Nijsure MP et al.	—	2025	→
YTHDF2 alleviates the radioresistance of rectal cancer cells by targeting methylated MYC.	Fang Y et al.	—	2025	→
Zinc eluted from glassware is a risk factor for embryo development in human and animal assisted reproduction†.	Yao T et al.	—	2025	→
ZmMYB92 modulates secondary wall cellulose synthesis in maize.	Zhang X et al.	—	2025	→
β-catenin functions as a molecular adapter for disordered cBAF interactions.	Chan YS et al.	—	2025	→