Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
paper
Cited
Public
- Authors
- Bierut, Laura Jean
- Year
- 2010
- Journal
- Trends in pharmacological sciences
- PMID
- 19896728
- DOI
- 10.1016/j.tips.2009.10.004
- PMCID
- PMC2993565
Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health.
No figures extracted from this document.
1β20 of 26
Next β
| Name | Type |
|---|---|
| African American | cohort |
| African descent populations local | cohort |
| African origin population local | cohort |
| alcohol | phenotype |
| Alcohol Use Disorder | phenotype |
| Asian descent populations local | cohort |
| Asian origin population local | cohort |
| bupropion | drug |
| carcinogen local | drug |
| Carcinogenic agent local | drug |
| cardiovascular disease | phenotype |
| catecholamines | drug |
| Chinese population | cohort |
| chr15 smoking region local | variant |
| CHRNA1 | gene |
| CHRNA10 | gene |
| CHRNA2 | gene |
| Chrna3 | gene |
| Chrna4 | gene |
| CHRNA5 | gene |
| Chrna6 | gene |
| Chrna7 | gene |
| CHRNA9 | gene |
| Chrnb1 | gene |
| Chrnb2 | gene |
| Chrnb3 | gene |
| Chrnb4 | gene |
| CHRND | gene |
| CHRNE local | gene |
| CHRNG | gene |
| Chromosome 15 region local | gene |
| chromosome 15 variant local | variant |
| Chromosome 15 variant local | variant |
| chromosome 15 variants local | variant |
| chronic obstructive pulmonary disease | phenotype |
| cigarettes | phenotype |
| community sample | cohort |
| COPD | phenotype |
| current smoking | phenotype |
| Developing countries local | cohort |
| diabetes | phenotype |
| dopamine | drug |
| early smoking | phenotype |
| European population | cohort |
| genes | gene |
| heavy drinking | phenotype |
| Heavy nicotine dependent smokers local | cohort |
| heavy smoking | phenotype |
| hypertension | phenotype |
| Industrialized countries local | cohort |
| IREB2 | gene |
| Knock-in mouse local | cohort |
| light smokers | phenotype |
| LOC123688 | gene |
| low CHRNA5 expression local | phenotype |
| lung cancer | phenotype |
| lung cancer patients | cohort |
| maternal smoking | phenotype |
| nicotine | drug |
| nicotine dependence | phenotype |
| nicotine dependent cases local | cohort |
| nicotine replacement therapy | drug |
| Nicotinic cholinergic receptor local | drug |
| noradrenaline | drug |
| Pregnant smokers local | cohort |
| Preventable mortality local | phenotype |
| prostate cancer | phenotype |
| PSMA4 | gene |
| rs16969968 | variant |
| smoking | phenotype |
| smoking behavior | phenotype |
| smoking cessation | phenotype |
| smoking quantity | phenotype |
| stroke | phenotype |
| Tobacco-related illnesses local | phenotype |
| tobacco use | phenotype |
| toxins local | drug |
| United States | cohort |
| varenicline | drug |
| Worldwide death toll local | phenotype |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction. | Jiang J et al. | β | 2025 | β |
| Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking. | Bierut L et al. | β | 2023 | β |
| Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence. | Buzzi B et al. | β | 2023 | β |
| Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention. | Volkow ND et al. | β | 2023 | β |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | β | 2022 | β |
| Hedgehog-interacting protein acts in the habenula to regulate nicotine intake. | Caligiuri SPB et al. | β | 2022 | β |
| Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions. | Robinson N et al. | β | 2021 | β |
| Translational Research in Nicotine Addiction. | Fisher ML et al. | β | 2021 | β |
| Association between the ACE-I/D polymorphism and nicotine dependence amongst patients with lung cancer. | Nadalin S et al. | β | 2020 | β |
| Genetic Endowments and Wealth Inequality. | Barth D et al. | β | 2020 | β |
| Association Between rs1051730 and Smoking During Pregnancy in Dutch Women. | Mbarek H et al. | β | 2019 | β |
| Impact of CHRNA5 polymorphisms on the risk of schizophrenia in the Chinese Han population. | Zhan D et al. | β | 2019 | β |
| Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms. | Chaarani B et al. | β | 2019 | β |
| Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial. | McEvoy CT et al. | β | 2019 | β |
| Receptor variants and the development of centrally acting medicationsβ©. | Neale SA et al. | β | 2019 | β |
| Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer. | Santoro A et al. | β | 2019 | β |
| Afferent and efferent connections of the interpeduncular nucleus with special reference to circuits involving the habenula and raphe nuclei. | Lima LB et al. | β | 2017 | β |
| Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons. | Deflorio C et al. | β | 2017 | β |
| "I don't believe it." Acceptance and skepticism of genetic health information among African-American and White smokers. | Waters EA et al. | β | 2017 | β |
| Nicotine enhances alcohol intake and dopaminergic responses through Ξ²2* and Ξ²4* nicotinic acetylcholine receptors. | Tolu S et al. | β | 2017 | β |
| Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies. | Pintarelli G et al. | β | 2017 | β |
| Probing the Allosteric Role of the Ξ±5 Subunit of Ξ±3Ξ²4Ξ±5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands. | Ray C et al. | β | 2017 | β |
| Pulmonary Effects of Maternal Smoking on the Fetus and Child: Effects on Lung Development, Respiratory Morbidities, and Life Long Lung Health. | McEvoy CT et al. | β | 2017 | β |
| Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats. | Han W et al. | β | 2017 | β |
| Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health. | McEvoy CT et al. | β | 2017 | β |
| A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. | Taylor JY et al. | β | 2016 | β |
| Cholinergic Targets in Lung Cancer. | Spindel ER | β | 2016 | β |
| Expression profile of nicotinic acetylcholine receptor subunits in the brain of HIV-1 transgenic rats given chronic nicotine treatment. | Cao J et al. | β | 2016 | β |
| Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. | Buczkowski K et al. | β | 2015 | β |
| Association of substance dependence phenotypes in the COGA sample. | Wetherill L et al. | β | 2015 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. | Chen J et al. | β | 2015 | β |
| Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence. | Tang X et al. | β | 2015 | β |
| Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. | Palmer RH et al. | β | 2015 | β |
| Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes. | Zhong X et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans. | Shorey-Kendrick LE et al. | β | 2015 | β |
| Biomarkers of tobacco smoke exposure. | Mattes W et al. | β | 2014 | β |
| Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. | Wang S et al. | β | 2014 | β |
| Involvement of neuronal Ξ²2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. | Simmons SJ et al. | β | 2014 | β |
| Probing the non-canonical interface for agonist interaction with an Ξ±5 containing nicotinic acetylcholine receptor. | Marotta CB et al. | β | 2014 | β |
| Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. | Korhonen T et al. | β | 2014 | β |
| Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. | Wang S et al. | β | 2014 | β |
| The behavioral economics of substance use disorders: reinforcement pathologies and their repair. | Bickel WK et al. | β | 2014 | β |
| Variation in the Ξ± 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content. | Macqueen DA et al. | β | 2014 | β |
| Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial. | McEvoy CT et al. | β | 2014 | β |
| Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression. | Gallego X et al. | β | 2013 | β |
| Effects of intravenous nicotine on prepulse inhibition in smokers and non-smokers: relationship with familial smoking. | Drobes DJ et al. | β | 2013 | β |
| Genetic matters: thirty years of progress using mouse models in nicotinic research. | Marks MJ | β | 2013 | β |
| Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study. | Meyers JL et al. | β | 2013 | β |
| Role of Ξ±5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice. | Fowler CD et al. | β | 2013 | β |
| Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. | HΓ€llfors J et al. | β | 2013 | β |
| Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder. | Jackson KJ et al. | β | 2013 | β |
| Adult mice voluntarily progress to nicotine dependence in an oral self-selection assay. | Locklear LL et al. | β | 2012 | β |
| Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. | Bousman CA et al. | β | 2012 | β |
| Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women. | Janes AC et al. | β | 2012 | β |
| Common and specific liability to addiction: approaches to association studies of opioid addiction. | Nielsen DA et al. | β | 2012 | β |
| Genome-wide meta-analyses of smoking behaviors in African Americans. | David SP et al. | β | 2012 | β |
| Striatal Ξ±5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. | Exley R et al. | β | 2012 | β |
| The case-only independence assumption: associations between genetic polymorphisms and smoking among controls in two population-based studies. | Hodgson ME et al. | β | 2012 | β |
| The co-occurring use and misuse of cannabis and tobacco: a review. | Agrawal A et al. | β | 2012 | β |
| Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. | Gallego X et al. | β | 2012 | β |
| Twins and the mystery of missing heritability: the contribution of gene-environment interactions. | Kaprio J | β | 2012 | β |
| Advances in the prevention and treatment of lung cancer. | Hodkinson PS et al. | β | 2011 | β |
| Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. | Ware JJ et al. | β | 2011 | β |
| Aversion to nicotine is regulated by the balanced activity of Ξ²4 and Ξ±5 nicotinic receptor subunits in the medial habenula. | Frahm S et al. | β | 2011 | β |
| Linkage analyses of stimulant dependence, craving, and heavy use in American Indians. | Ehlers CL et al. | β | 2011 | β |
| Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer. | Improgo MR et al. | β | 2011 | β |
| Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. | Zhang J et al. | β | 2011 | β |
| Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada. | Conlon MS et al. | β | 2011 | β |
| The German multi-centre study on smoking-related behavior-description of a population-based case-control study. | Lindenberg A et al. | β | 2011 | β |
| Breaking barriers in the genomics and pharmacogenetics of drug addiction. | Ho MK et al. | β | 2010 | β |
| Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. | De Ruyck K et al. | β | 2010 | β |
| The molecular and cellular biology of lung cancer: identifying novel therapeutic strategies. | MacKinnon AC et al. | β | 2010 | β |
| The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. | Improgo MR et al. | β | 2010 | β |
| TTF-1 regulates Ξ±5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium. | Reynolds PR et al. | β | 2010 | β |