Neuroimmune signaling in alcohol use disorder.
paper
Cited
Public
- Authors
- Erickson, Emma K; Grantham, Emily K; Warden, Anna S; Harris, R A
- Year
- 2019
- Journal
- Pharmacology, biochemistry, and behavior
- PMID
- 30590091
- DOI
- 10.1016/j.pbb.2018.12.007
- PMCID
- PMC6946054
Alcohol use disorder (AUD) is a widespread disease with limited treatment options. Targeting the neuroimmune system is a new avenue for developing or repurposing effective pharmacotherapies. Alcohol modulates innate immune signaling in different cell types in the brain by altering gene expression and the molecular pathways that regulate neuroinflammation. Chronic alcohol abuse may cause an imbalance in neuroimmune function, resulting in prolonged perturbations in brain function. Likewise, manipulating the neuroimmune system may change alcohol-related behaviors. Psychiatric disorders that are comorbid with AUD, such as post-traumatic stress disorder, major depressive disorder, and other substance use disorders, may also have underlying neuroimmune mechanisms; current evidence suggests that convergent immune pathways may be involved in AUD and in these comorbid disorders. In this review, we provide an overview of major neuroimmune cell-types and pathways involved in mediating alcohol behaviors, discuss potential mechanisms of alcohol-induced neuroimmune activation, and present recent clinical evidence for candidate immune-related drugs to treat AUD.
Microglia-specific consequences of alcohol-induced neuroinflammation. Alcohol exposure generates a proinflammatory environment in brain, resulting in up-regulation of immune ligands such as cytokines and chemokines. This results in activation of immune receptors on microglia, persistent transcriptome changes, structural plasticity, and the production of several inflammatory mediators that can alter neuronal function.
Astrocyte-specific consequences of alcohol-induced neuroinflammation. Alcohol exposure generates a proinflammatory environment in brain, resulting in up-regulation of immune ligands such as cytokines and chemokines. This results in activation of immune receptors on astrocytes, leading to transcriptome changes which contribute to the modulation of several astrocyte functions, including glutamate homeostasis, calcium signaling, gap junction communication, structural plasticity, and the production of inflammatory mediators, which can alter neuronal function in various ways.
Potential neuroimmune-mediated mechanisms that underlie associations between psychiatric diseases including alcohol use disorder (AUD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD). AUD, MDD, and PTSD are frequently comorbid. Environmental and biological factors that can influence and lead to neuroinflammation are associated with all three disorders. Sustained neuroimmune imbalance can lead to physiological consequences that drive behavioural phenotypes associated with psychiatric disease. Altered behavior may enhance further risk for neuroinflammation, resulting in a persistent cycle that leaves patients vulnerable to additional psychiatric disorders. Pharmacotherapies that target neuroinflammation are possible treatment options for comorbid psychiatric diseases with common neuroimmune elements.
| # | Section | Preview |
|---|---|---|
| 60 | Clinical studies of immune modulators for alcohol use disorder | The only drug currently FDA-approved for AUD treatment with potential to target the neuroimmune⦠|
| 61 | Clinical studies of immune modulators for alcohol use disorder | More recent studies have investigated the potential for the neuroimmune modulator ibudilast in⦠|
| 62 | Clinical studies of immune modulators for alcohol use disorder | feasibility concerns (ClinicalTrials.gov identifier: NCT01631630). Several other clinical studies⦠|
| 63 | Convergent neuroimmune mechanisms for other drugs of abuse | Alcohol is often co-abused with illicit drugs (Soyka, 2015; Witkiewitz and Vowles, 2018) that⦠|
| 64 | Convergent neuroimmune mechanisms for other drugs of abuse | Chronic use of methamphetamine is associated with microglial activation in humans as visualized⦠|
| 65 | Convergent neuroimmune mechanisms for other drugs of abuse | Much research has been devoted to the role of TLR4 and associated signaling cascades in mediating⦠|
| 66 | Convergent neuroimmune mechanisms for other drugs of abuse | cocaine-induced dopamine release. In addition, (+)-naloxone does not reduce methamphetamine craving⦠|
| 67 | Convergent neuroimmune mechanisms for other drugs of abuse | As we discussed for alcohol action, other TLRs and immune receptors are likely important for opioid-β¦ |
| 68 | Convergent neuroimmune mechanisms for other drugs of abuse | As discussed for alcohol, several preclinical studies have demonstrated that dysregulation of⦠|
| 69 | Convergent neuroimmune mechanisms for other drugs of abuse | requires intravenous administration and has poor brain penetrability, limiting its potential⦠|
| 70 | Convergent neuroimmune mechanisms for other drugs of abuse | As discussed with alcohol drinking, administering anti-inflammatory drugs, such as ibudilast, PDE-4β¦ |
| 71 | Convergent neuroimmune mechanisms for other drugs of abuse | ibudilast reduces the subjective effects (Worley et al., 2016). A phase II clinical trial of⦠|
| 72 | Convergent neuroimmune mechanisms for other drugs of abuse | of which have also been shown to reduce alcohol consumption or craving, are being actively⦠|
| 73 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Post-traumatic stress disorder and alcohol use disorder | Post-traumatic stress disorder (PTSD) is an anxiety-like disorder that may develop after exposure toβ¦ |
| 74 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Post-traumatic stress disorder and alcohol use disorder | Lifetime trauma, particularly early life adversity, is a major risk factor for development of PTSDβ¦ |
| 75 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Post-traumatic stress disorder and alcohol use disorder | cytokine expression, and the presence of psychiatric symptoms is a significant predictor ofβ¦ |
| 76 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Post-traumatic stress disorder and alcohol use disorder | in post-mortem brains of human alcoholics. These findings support a role for immune signaling in theβ¦ |
| 77 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Post-traumatic stress disorder and alcohol use disorder | Immune-targeted compounds offer a new approach to treat individuals with PTSD and PTSD/AUD.β¦ |
| 78 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Major depressive disorder and alcohol use disorder | Major depressive disorder (MDD) is another psychiatric illness sharing a high comorbidity with AUD.β¦ |
| 79 | Comorbidity of Post-traumatic stress disorder or major depressive disorder with alcohol use disorder and immune signaling β Major depressive disorder and alcohol use disorder | Like individuals with AUD, patients with MDD have higher levels of pro-inflammatory cytokines andβ¦ |
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| Aal-AabodaM, AlhaddadH, OsowikF, NauliSM, SariY, 2015 Effects of (R)-(β)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats. J. Neurosci. Res. 93, 930β937. 10.1002/jnr.23554.25601490PMC4397131 | β | β | β |
| AbbasiS-H, HosseiniF, ModabberniaA, AshrafiM, AkhondzadehS, 2012 Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study. J. Affect. Disord. 141, 308β314. 10.1016/j.jad.2012.03.033.22516310 | β | β | β |
| AbulseoudOA, CamsariUM, RubyCL, KasasbehA, ChoiS, ChoiDS, 2014 Attenuation of ethanol withdrawal by ceftriaxone-induced upregulation of glutamate transporter EAAT2. Neuropsychopharmacology 39, 1674β1684. 10.1038/npp.2014.14.24452391PMC4023140 | β | β | β |
| AdedayoAD, AderinolaAA, AdekilekunTA, OlaoluOO, OlanikeAM, OlayemiIK, 2018 Morphine-alcohol treatment impairs cognitive functions and increases neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats. Anat. Cell Biol. 51, 41β51. 10.5115/acb.2018.51.1.41.29644109PMC5890016 | β | β | β |
| AdermarkL, LovingerDM, 2006 Ethanol effects on electrophysiological properties of astrocytes in striatal brain slices. Neuropharmacology 51, 1099β1108. 10.1016/j.neuropharm.2006.05.035.16938316 | β | β | β |
| AdermarkL, OlssonT, HanssonE, 2004 Ethanol acutely decreases astroglial gap junction permeability in primary cultures from defined brain regions. Neurochem. Int. 45, 971β978. 10.1016/j.neuint.2004.06.007.15337295 | β | β | β |
| AgrawalA, TillmanR, GruczaRA, NelsonEC, McCutcheonVV, FewL, ConnerKR, LynskeyMT, DickDM, EdenbergHJ, HesselbrockVM, KramerJR, KupermanS, NurnbergerJI, SchuckitMA, PorjeszB, BucholzKK, 2017 Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. J. Affect. Disord. 213, 96β104. 10.1016/j.jad.2016.12.060.28213124PMC5434702 | β | β | β |
| AgrawalRG, HewetsonA, GeorgeCM, SyapinPJ, BergesonSE, 2011 Minocycline reduces ethanol drinking. Brain Behav. Immun. 25, S165βS169. 10.1016/j.bbi.2011.03.002.21397005PMC3098317 | β | β | β |
| AgrawalRG, OwenJA, LevinPS, HewetsonA, BermanAE, FranklinSR, , 2014 Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking. Alcohol. Clin. Exp. Res. 38 (2), 428β437. 10.1111/acer.12288.24125126PMC3924867 | β | β | β |
| Alfonso-LoechesS, Pascual-LucasM, BlancoAM, Sanchez-VeraI, GuerriC, 2010 Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J. Neurosci. 30, 8285β8295. 10.1523/JNEUROSCI.0976-10.2010.20554880PMC6634595 | β | β | β |
| Alfonso-LoechesS, PascualM, GuerriC, 2013 Gender differences in alcohol-induced neurotoxicity and brain damage. Toxicology 311, 27β34. 10.1016/j.tox.2013.03.001.23500890 | β | β | β |
| Alfonso-LoechesS, UreΓ±a-PeraltaJR, Morillo-BarguesMJ, Oliver-De La CruzJ, GuerriC, 2014 Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. Front. Cell. Neurosci. 8, 10.3389/fncel.2014.00216.PMC411802625136295 | β | β | β |
| AlhaddadH, DasSC, SariY, 2014 Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats. Psychopharmacology 231 (20), 4049β4057. 10.1007/s00213-014-3545-y.24687412PMC4176549 | β | β | β |
| AlhamoruniA, WrightKL, LarvinM, OβSullivanSE, 2012 Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability. Br. J. Pharmacol. 165, 2598β2610. 10.1111/j.1476-5381.2011.01589.x.21745190PMC3423254 | β | β | β |
| AllamanI, FiumelliH, MagistrettiPJ, MartinJ-L, 2011 Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes. Psychopharmacology 216, 75β84. 10.1007/s00213-011-2190-y.21301813 | β | β | β |
| AlshehriFS, AlthobaitiYS, SariY, 2017 Effects of administered ethanol and methamphetamine on glial glutamate transporters in rat striatum and hippocampus. J. Mol. Neurosci. 61, 343β350. 10.1007/s12031-016-0859-8.27888396PMC5346045 | β | β | β |
| AlthobaitiYS, AlshehriFS, AlmalkiAH, SariY, 2016 Effects of ceftriaxone on glial glutamate transporters in Wistar rats administered sequential ethanol and methamphetamine. Front. Neurosci. 10, 427 10.3389/fnins.2016.00427.27713684PMC5031687 | β | β | β |
| AsatryanL, OstrovskayaO, LieuD, DaviesDL, 2017 Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells. Neuropharmacology. 10.1016/j.neuropharm.2017.09.030.PMC649293428943285 | β | β | β |
| AschnerM, MutkusLA, AllenJW, 2001 Amino acid uptake and release in primary astrocyte cultures exposed to ethanol. Ann. N. Y. Acad. Sci. 939, 23β27.1146277510.1111/j.1749-6632.2001.tb03607.x | β | β | β |
| AsquithM, PasalaS, EngelmannF, HaberthurK, MeyerC, ParkB, GrantKA, MessaoudiI, 2014 Chronic ethanol consumption modulates growth factor release, mucosal cytokine production, and microRNA expression in nonhuman primates. Alcohol. Clin. Exp. Res. 38, 980β993. 10.1111/acer.12325.24329418PMC3984381 | β | β | β |
| AvilaDV, MyersSA, ZhangJ, KharebavaG, McClainCJ, KimH-Y, WhittemoreSR, GobejishviliL, BarveS, 2017 Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology 125, 376β385. 10.1016/j.neuropharm.2017.08.011.28807677PMC5797427 | β | β | β |
| Ayers-RinglerJR, JiaY-F, QiuY-Y, ChoiD-S, 2016 Role of astrocytic glutamate transporter in alcohol use disorder. World J. Psychiatry 6, 31β42. 10.5498/wjp.v6.i1.31.27014596PMC4804266 | β | β | β |
| BachtellRK, JonesJD, HeinzerlingKG, BeardsleyPM, ComerSD, 2017 Glial and neuroinflammatory targets for treating substance use disorders. Drug Alcohol Depend. 180, 156β170. 10.1016/j.drugalcdep.2017.08.003.28892721PMC5790191 | β | β | β |
| BajoM, MadambaSG, RobertoM, BlednovYA, SagiVN, RobertsE, RiceKC, HarrisRA, SigginsGR, 2014 Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala. Brain Behav. Immun. 40, 191β202. 10.1016/j.bbi.2014.03.007.24675033PMC4126651 | β | β | β |
| BajoM, MontgomerySE, CatesLN, NadavT, DelucchiAM, ChengK, YinH, CrawfordEF, RobertsAJ, RobertoM, 2016 Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent mice. Alcohol Alcohol. 51, 541β548. 10.1093/alcalc/agw026.27151970PMC5004745 | β | β | β |
| BajoM, VarodayanFP, MadambaSG, RobertAJ, CasalLM, OleataCS, SigginsGR, RobertoM, 2015 IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala. Front. Pharmacol. 6, 49 10.3389/fphar.2015.00049.25852553PMC4365713 | β | β | β |
| BakerDG, NievergeltCM, OβConnorDT, 2012 Biomarkers of PTSD: neuropeptides and immune signaling. Neuropharmacology 62, 663β673. 10.1016/j.neuropharm.2011.02.027.21392516 | β | β | β |
| BalaS, CsakT, KodysK, CatalanoD, AmbadeA, FuriI, LoweP, ChoY, Iracheta-VellveA, SzaboG, 2017 Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease. J. Leukoc. Biol. 102, 487β498. 10.1189/jlb.3A0716-310R.28584078PMC6608073 | β | β | β |
| BalaS, MarcosM, GattuA, CatalanoD, SzaboG, 2014 Acute binge drinking in-creases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One 9, e96864 10.1371/journal.pone.0096864.24828436PMC4020790 | β | β | β |
| BanasrM, DumanRS, 2008 Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors. Biol. Psychiatry 64, 863β870. 10.1016/j.biopsych.2008.06.008.18639237PMC2709733 | β | β | β |
| BanksWA, 2005 Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr. Pharm. Des. 11, 973β984.1577724810.2174/1381612053381684 | β | β | β |
| BanksWA, 2015 The blood-brain barrier in neuroimmunology: tales of separation and assimilation. Brain Behav. Immun. 44, 1β8. 10.1016/j.bbi.2014.08.007.25172555PMC4275374 | β | β | β |
| BanksWA, EricksonMA, 2010 The blood-brain barrier and immune function and dysfunction. Neurobiol. Dis. 37, 26β32. 10.1016/j.nbd.2009.07.031.19664708 | β | β | β |
| BarnesJ, MondelliV, ParianteCM, 2017 Genetic contributions of inflammation to depression. Neuropsychopharmacology 42, 81β98. 10.1038/npp.2016.169.27555379PMC5143493 | β | β | β |
| BarrT, SureshchandraS, RueggerP, ZhangJ, MaW, BornemanJ, GrantK, MessaoudiI, 2018 Concurrent gut transcriptome and microbiota profiling following chronic ethanol consumption in nonhuman primates. Gut Microbes 31, 1β19. 10.1080/19490976.2018.1441663.PMC621965329517944 | β | β | β |
| BarsonJR, KaratayevO, ChangG-Q, JohnsonDF, BocarslyME, HoebelBG, LeibowitzSF, 2009 Positive relationship between dietary fat, ethanol intake, triglycerides, and hypothalamic peptides: counteraction by lipid-lowering drugs.Alcohol 43, 433β441. 10.1016/j.alcohol.2009.07.003.19801273PMC2758659 | β | β | β |
| BartonEA, BakerC, LeasureJL, 2017 Investigation of sex differences in the microglial response to binge ethanol and exercise. Brain Sci. 7, 139 10.3390/brainsci7100139.PMC566406629064447 | β | β | β |
| Baxter-PotterLN, HenricksAM, BergerAL, BieniaszKV, LugoJM, McLaughlinRJ, 2017 Alcohol vapor exposure differentially impacts mesocorticolimbic cytokine expression in a sex-, region-, and duration-specific manner. Neuroscience 346, 238β246. 10.1016/j.neuroscience.2017.01.015.28131626 | β | β | β |
| BeattieMC, ReguyalCS, PorcuP, DaunaisJB, GrantKA, MorrowAL, 2018 Neuroactive steroid (3Ξ±,5Ξ±)3-hydroxypregnan-20-one (3Ξ±,5Ξ±-THP) and pro-inflammatory cytokine MCP-1 levels in hippocampus CA1 are correlated with voluntary ethanol consumption in cynomolgus monkey. Alcohol. Clin. Exp. Res. 42, 12β20. 10.1111/acer.13545.29112774PMC5750072 | β | β | β |
| BeckerHC, RonD, 2014 Animal models of excessive alcohol consumption: recent advances and future challenges. Alcohol 48, 205β208. 10.1016/j.alcohol.2014.04.001.24811154PMC5081257 | β | β | β |
| Beitner-JohnsonD, GuitartX, NestlerEJ, 1993 Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area. J. Neurochem. 61, 1766β1773.822899210.1111/j.1471-4159.1993.tb09814.x | β | β | β |
| BellRL, LopezMF, CuiC, EgliM, JohnsonKW, FranklinKM, BeckerHC, 2013 Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addict. Biol. 20, 38β42. 10.1111/adb.12106.24215262PMC4017009 | β | β | β |
| BhardwajSS, ChalasaniN, 2007 Lipid-lowering agents that cause drug-induced hepatotoxicity. Clin. Liver Dis. 11, 597β613. vii. 10.1016/j.cld.2007.06.010.17723922PMC2048990 | β | β | β |
| BhattacharyaA, 2018 Recent advances in CNS P2X7 physiology and pharmacology: focus on neuropsychiatric disorders. Front. Pharmacol. 9, 30 10.3389/fphar.2018.00030.29449810PMC5799703 | β | β | β |
| BhattacharyaA, WangQ, AoH, ShoblockJR, LordB, AluisioL, FraserI, NepomucenoD, NeffRA, WeltyN, LovenbergTW, BonaventureP, WickendenAD, LetavicMA, 2013 Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br. J. Pharmacol. 170, 624β640. 10.1111/bph.12314.23889535PMC3792000 | β | β | β |
| BjarnasonI, PetersTJ, WiseRJ, 1984 The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1, 179β182.614133210.1016/s0140-6736(84)92109-3 | β | β | β |
| BlancoAM, PascualM, VallesSL, GuerriC, 2004 Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B. Neuroreport 15, 681β685.1509447510.1097/00001756-200403220-00021 | β | β | β |
| BlancoAM, VallesSL, PascualM, GuerriC, 2005 Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J. Immunol. 175, 6893β6899.1627234810.4049/jimmunol.175.10.6893 | β | β | β |
| BlankT, PrinzM, 2017 Type I interferon pathway in CNS homeostasis and neurological disorders. Glia 65, 1397β1406. 10.1002/glia.23154.28519900 | β | β | β |
| BlednovYA, BenavidezJM, BlackM, FergusonLB, SchoenhardGL, GoateAM, EdenbergHJ, WetherillL, HesselbrockV, ForoudT, HarrisAdron R., 2014a Peroxisome proliferator-activated receptors Ξ±and Ξ³are linked with alcohol consumption in mice and withdrawal and dependence in humans. Alcohol. Clin. Exp. Res. 39, 136β145. 10.1111/acer.12610.25516156PMC4308472 | β | β | β |
| BlednovYA, BenavidezJM, BlackM, HarrisRA, 2014b Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front. Neurosci. 8, 1696 10.3389/fnins.2014.00129.PMC403433924904269 | β | β | β |
| BlednovYA, BenavidezJM, BlackM, MayfieldJ, HarrisRA, 2015 Role of in-terleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiaze-pines. Neuropharmacology 95, 309β320. 10.1016/j.neuropharm.2015.03.015.25839897PMC4465986 | β | β | β |
| BlednovYA, BenavidezJM, GeilC, PerraS, MorikawaH, HarrisRA, 2011 Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav. Immun. 25, S92βS105. 10.1016/j.bbi.2011.01.008.21266194PMC3098320 | β | β | β |
| BlednovYA, BergesonSE, WalkerD, FerreiraVMM, KuzielWA, HarrisRA, 2005 Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav. Brain Res. 165, 110β125. 10.1016/j.bbr.2005.06.026.16105698PMC3040067 | β | β | β |
| BlednovYA, BlackM, BenavidezJM, StamatakisEE, HarrisRA, 2016a PPAR agonists: I. Role of receptor subunits in alcohol consumption in male and female mice. Alcohol. Clin. Exp. Res. 40, 553β562. 10.1111/acer.12976.26857685PMC4775296 | β | β | β |
| BlednovYA, BlackM, BenavidezJM, StamatakisEE, HarrisRA, 2016b PPAR agonists: II. Fenofibrate and tesaglitazar alter behaviors related to voluntary alcohol consumption. Alcohol. Clin. Exp. Res. 40, 563β571. 10.1111/acer.12972.26857541PMC4775356 | β | β | β |
| BlednovYA, BlackM, ChernisJ, Da CostaA, MayfieldJ, HarrisRA, 2017Ethanol consumption in mice lacking CD14, TLR2, TLR4, or MyD88. Alcohol. Clin.Exp. Res. 41, 516β530. 10.1111/acer.13316.28146272PMC5332291 | β | β | β |
| BlednovYA, Da CostaAJ, HarrisRA, MessingRO, 2018a Apremilast alters behavioral responses to ethanol in mice: II. Increased sedation, intoxication and reduced acute functional tolerance. Alcohol. Clin. Exp. Res. 10.1111/acer.13615.PMC591632729469954 | β | β | β |
| BlednovYA, Da CostaAJ, TarboxT, PonomarevaO, MessingRO, HarrisRA, 2018b Apremilast alters behavioral responses to ethanol in mice: I. Reduced ethanol consumption and preference. Alcohol. Clin. Exp. Res. 10.1111/acer.13616.PMC591591229469962 | β | β | β |
| BlednovYA, PonomarevI, GeilC, BergesonS, KoobGF, HarrisRA, 2012 Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict. Biol. 17, 108β120. 10.1111/j.1369-1600.2010.00284.x.21309947PMC3117922 | β | β | β |
| BrayJG, ReyesKC, RobertsAJ, GruolDL, 2018 Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol. Neuropharmacology. 10.1016/j.neuropharm.2018.02.031.PMC597512329499275 | β | β | β |
| BrayJG, ReyesKC, RobertsAJ, RansohoffRM, GruolDL, 2013 Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression. Neuropharmacology 67, 115β125. 10.1016/j.neuropharm.2012.11.007.23164616PMC3595200 | β | β | β |
| BrayJG, RobertsAJ, GruolDL, 2017 Transgenic mice with increased astrocyte expression of CCL2 show altered behavioral effects of alcohol. Neuroscience 354, 88β100. 10.1016/j.neuroscience.2017.04.009.28431906PMC5529144 | β | β | β |
| BreenMS, MaihoferAX, GlattSJ, TyleeDS, ChandlerSD, TsuangMT, RisbroughVB, BakerDG, OβConnorDT, NievergeltCM, WoelkCH, 2015 Gene networks specific for innate immunity define post-traumatic stress disorder. Mol. Psychiatry 20, 1538β1545. 10.1038/mp.2015.9.25754082PMC4565790 | β | β | β |
| BriΓ¨reFN, RohdeP, SeeleyJR, KleinD, LewinsohnPM, 2014 Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr. Psychiatry 55, 526β533. 10.1016/j.comppsych.2013.10.007.24246605PMC4131538 | β | β | β |
| BrownKT, LevisSC, OβNeillCE, NorthcuttAL, FabisiakTJ, WatkinsLR, BachtellRK, 2017 Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking. Brain Behav. Immun. 10.1016/j.bbi.2017.08.012.PMC625225228813640 | β | β | β |
| BullC, FreitasKCC, ZouS, PolandRS, SyedWA, UrbanDJ, MinterSC, SheltonKL, HauserKF, NegusSS, KnappPE, BowersMS, 2014 Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence. Neuropsychopharmacology 39, 2835β2845. 10.1038/npp.2014.135.24903651PMC4200494 | β | β | β |
| BullC, SyedWA, MinterSC, BowersMS, 2015 Differential response of glial fibrillary acidic protein-positive astrocytes in the rat prefrontal cortex following ethanol self-administration. Alcohol. Clin. Exp. Res. 39, 650β658. 10.1111/acer.12683.25833026PMC4384186 | β | β | β |
| BurmaNE, BoninRP, Leduc-PessahH, BaimelC, CairncrossZF, MousseauM, ShankaraJV, StemkowskiPL, BaimoukhametovaD, BainsJS, AntleMC, ZamponiGW, CahillCM, BorglandSL, De KoninckY, TrangT, 2017 Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents. Nat. Med. 23, 355β360. 10.1038/nm.4281.28134928 | β | β | β |
| CanalsI, GinistyA, QuistE, TimmermanR, FritzeJ, MiskinyteG, MonniE, HansenMG, HidalgoI, BryderD, BengzonJ, AhleniusH, 2018 Rapid and efficient induction of functional astrocytes from human pluripotent stem cells. Nat. Methods 15, 693β696. 10.1038/s41592-018-0103-2.30127505 | β | β | β |
| CaoX, LiL-P, WangQ, WuQ, HuH-H, ZhangM, FangY-Y, ZhangJ, LiS-J, XiongW-C, YanH-C, GaoY-B, LiuJ-H, LiX-W, SunL-R, ZengY-N, ZhuX-H, GaoT-M, 2013 Astrocyte-derived ATP modulates depressive-like behaviors. Nat. Med. 19, 773β777. 10.1038/nm.3162.23644515 | β | β | β |
| CapuronL, DantzerR, 2003 Cytokines and depression: the need for a new paradigm. Brain Behav. Immun. 17, 119β124. 10.1016/S0889-1591(02)00078-8.12615197 | β | β | β |
| CatlinMC, GuizzettiM, CostaLG, 2000 Effect of ethanol on muscarinic receptor-induced calcium responses in astroglia. J. Neurosci. Res. 60, 345β355. 10.1002/(SICI)1097-4547(20000501)60:3<345::AID-JNR9>3.0.CO;2-6.10797537 | β | β | β |
| ChaiH, Diaz-CastroB, ShigetomiE, MonteE, OcteauJC, YuX, CohnW, RajendranPS, VondriskaTM, WhiteleggeJP, CoppolaG, KhakhBS, 2017 Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence. Neuron. 10.1016/j.neuron.2017.06.029.PMC581131228712653 | β | β | β |
| ChastainLG, SarkarDK, 2014 Role of microglia in regulation of ethanol neurotoxic action. Int. Rev. Neurobiol. 118, 81β103. 10.1016/B978-0-12-801284-0.00004-X.25175862 | β | β | β |
| ChenH, HeD, LasekAW, 2017a Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression. Genes Brain Behav. 16, 699β708. 10.1111/gbb.12384.28398003PMC5595638 | β | β | β |
| ChenJ-X, HuangK-M, LiuM, JiangJ-X, LiuJ-P, ZhangY-X, YangC, XinW-J, ZhangX-Q, 2017b Activation of TLR4/STAT3 signaling in VTA contributes to the acquisition and maintenance of morphine-induced conditioned place preference. Behav. Brain Res. 335, 151β157. 10.1016/j.bbr.2017.08.022.28827130 | β | β | β |
| ChenZ, JalabiW, HuW, ParkH-J, GaleJT, KiddGJ, BernatowiczR, GossmanZC, ChenJT, DuttaR, TrappBD, 2014 Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat. Commun. 5, 420 10.1038/ncomms5486.PMC410901525047355 | β | β | β |
| ChigurupatiS, DhanarajSA, BalakumarP, 2015 A step ahead of PPARΞ³ full agonists to PPARΞ³ partial agonists: therapeutic perspectives in the management of diabetic insulin resistance. Eur. J. Pharmacol. 755, 50β57. 10.1016/j.ejphar.2015.02.043.25748601 | β | β | β |
| ChoiD-S, CasciniM-G, MailliardW, YoungH, ParedesP, McMahonT, DiamondI, BonciA, MessingRO, 2004 The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat. Neurosci. 7, 855β861. 10.1038/nn1288.15258586 | β | β | β |
| CippitelliA, DomiE, UbaldiM, DouglasJC, LiHW, DemopulosG, GaitanarisG, RobertoM, DrewPD, KaneCJM, CiccocioppoR, 2017 Protection against alcohol-induced neuronal and cognitive damage by the PPARΞ³ receptor agonist pioglitazone. Brain Behav. Immun. 64, 320β329. 10.1016/j.bbi.2017.02.001.28167117PMC5482782 | β | β | β |
| ClarkeT-K, AdamsMJ, DaviesG, HowardDM, HallLS, PadmanabhanS, MurrayAD, SmithBH, CampbellA, HaywardC, PorteousDJ, DearyIJ, McIntoshAM, 2017 Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK biobank (N = 112 117). Mol. Psychiatry 22, 1376β1384. 10.1038/mp.2017.153.28937693PMC5622124 | β | β | β |
| ColemanLG, ZouJ, CrewsFT, 2017 Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. J. Neuroinflammation 14, 22 10.1186/s12974-017-0799-4.28118842PMC5264311 | β | β | β |
| CollinsMA, NeafseyEJ, 2016 Alcohol, excitotoxicity and adult brain damage: an experimentally unproven chain-of-events. Front. Mol. Neurosci. 9, 8 10.3389/fnmol.2016.00008.26903800PMC4748059 | β | β | β |
| CookRT, 1998 Alcohol abuse, alcoholism, and damage to the immune systemβa review. Alcohol. Clin. Exp. Res. 22, 1927β1942.9884135 | β | β | β |
| CooperZD, JohnsonKW, PavlicovaM, GlassA, VosburgSK, SullivanMA, ManubayJM, MartinezDM, JonesJD, SacconePA, ComerSD, 2016 The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. Addict. Biol. 21, 895β903. 10.1111/adb.12261.25975386PMC4644513 | β | β | β |
| CooperZD, JohnsonKW, VosburgSK, SullivanMA, ManubayJ, MartinezD, JonesJD, SacconePA, ComerSD, 2017 Effects of ibudilast on oxycodone-induced analgesia and subjective effects in opioid-dependent volunteers. Drug Alcohol Depend. 178, 340β347. 10.1016/j.drugalcdep.2017.04.029.28688296 | β | β | β |
| CrewsFT, 2012 Immune function genes, genetics, and the neurobiology of addiction. Alcohol Res. 34, 355β361.2313405210.35946/arcr.v34.3.11PMC3860409 | β | β | β |
| CrewsFT, QinL, SheedyD, VetrenoRP, ZouJ, 2013 High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol. Psychiatry 73, 602β612. 10.1016/j.biopsych.2012.09.030.23206318PMC3602398 | β | β | β |
| CrewsFT, SarkarDK, QinL, ZouJ, BoyadjievaN, VetrenoRP, 2015 Neuroimmune function and the consequences of alcohol exposure. Alcohol Res. 37 (331β41β344β51).10.35946/arcr.v37.2.15PMC459062726695754 | β | β | β |
| CrewsFT, VetrenoRP, 2015 Mechanisms of neuroimmune gene induction in alcoholism. Psychopharmacology 233, 1543β1557. 10.1007/s00213-015-3906-1.25787746PMC4828484 | β | β | β |
| CrewsFT, WalterTJ, ColemanLG, VetrenoRP, 2017 Toll-like receptor signaling and stages of addiction. Psychopharmacology 234, 1483β1498. 10.1007/s00213-017-4560-6.28210782PMC5420377 | β | β | β |
| CrewsFT, ZouJ, QinL, 2011 Induction of innate immune genes in brain create the neurobiology of addiction. Brain Behav. Immun. 25 (Suppl. 1), S4βS12. 10.1016/j.bbi.2011.03.003.21402143PMC3552373 | β | β | β |
| CservenkaA, BrumbackT, 2017 The burden of binge and heavy drinking on the brain: effects on adolescent and Young adult neural structure and function. Front. Psychol. 8, 1111 10.3389/fpsyg.2017.01111.28713313PMC5491846 | β | β | β |
| CuiC, ShurtleffD, HarrisRA, 2014 Neuroimmune mechanisms of alcohol and drug addiction. Int. Rev. Neurobiol. 118, 1β12. 10.1016/B978-0-12-801284-0.00001-4.25175859PMC4804710 | β | β | β |
| CullenKM, HallidayGM, 1994 Chronic alcoholics have substantial glial pathology in the forebrain and diencephalon. Alcohol Alcohol. Suppl. 2, 253β257.8974344 | β | β | β |
| CummingsJR, TomiyamaAJ, RayLA, 2018 Does the neuroimmune modulator Ibudilast alter food craving? Results in a sample with alcohol use disorder. J. Addict. Med. 12, 410β417. 10.1097/ADM.0000000000000416.29794557PMC6167170 | β | β | β |
| DantzerR, 2006 Cytokine, sickness behavior, and depression. Neurol. Clin. 24, 441β460. 10.1016/j.ncl.2006.03.003.16877117PMC2909644 | β | β | β |
| DantzerR, 2018 Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol. Rev. 98, 477β504. 10.1152/physrev.00039.2016.29351513PMC5866360 | β | β | β |
| DasSC, YamamotoBK, HristovAM, SariY, 2015 Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats. Neuropharmacology 97, 67β74. 10.1016/j.neuropharm.2015.05.009.26002627PMC4537362 | β | β | β |
| DavisL, UezatoA, NewellJM, FrazierE, 2008 Major depression and comorbid substance use disorders. Curr. Opin. Psychiatry 21, 14β18. 10.1097/YCO.0b013e3282f32408.18281835 | β | β | β |
| De BiaseLM, SchuebelKE, FusfeldZH, JairK, HawesIA, CimbroR, ZhangH-Y, LiuQ-R, ShenH, XiZ-X, GoldmanD, BonciA, 2017 Local cues establish and maintain region-specific phenotypes of basal ganglia microglia. Neuron 95, 341β356.e6. 10.1016/j.neuron.2017.06.020.28689984PMC5754189 | β | β | β |
| de GuglielmoG, KallupiM, ScuppaG, DemopulosG, GaitanarisG, CiccocioppoR, 2017 Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents. Psychopharmacology 234, 223β234. 10.1007/s00213-016-4452-1.27714428 | β | β | β |
| de la MonteSM, KrilJJ, 2014 Human alcohol-related neuropathology. Acta Neuropathol. 127, 71β90. 10.1007/s00401-013-1233-3.24370929PMC4532397 | β | β | β |
| de TimaryP, StΓ€rkelP, DelzenneNM, LeclercqS, 2017 A role for the peripheral immune system in the development of alcohol use disorders? Neuropharmacology 122, 148β160.10.1016/j.neuropharm.2017.04.013.28400259 | β | β | β |
| DuailibiMS, CordeiroQ, BrietzkeE, RibeiroM, LaRoweS, BerkM, TrevizolAP, 2017 N-acetylcysteine in the treatment of craving in substance use disorders: systematic review and meta-analysis. Am. J. Addict. 26, 660β666. 10.1111/ajad.12620.28898494 | β | β | β |
| DworkinER, WanklynS, StasiewiczPR, CoffeySF, 2018 PTSD symptom presentation among people with alcohol and drug use disorders: comparisons by substance of abuse. Addict. Behav. 76, 188β194. 10.1016/j.addbeh.2017.08.019.28846939PMC5614876 | β | β | β |
| EdenbergHJ, XueiX, WetherillLF, BierutL, BucholzK, DickDM, HesselbrockV, KupermanS, PorjeszB, SchuckitMA, TischfieldJA, AlmasyLA, NurnbergerJI, ForoudT, 2008 Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence. Hum. Mol. Genet. 17, 963β970. 10.1093/hmg/ddm368.18079108 | β | β | β |
| El-HageN, WuG, AmbatiJ, Bruce-KellerAJ, KnappPE, HauserKF, 2006 CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates. J. Neuroimmunol. 178, 9β16. 10.1016/j.jneuroim.2006.05.027.PMC431070316831471 | β | β | β |
| EricksonEK, FarrisSP, BlednovYA, MayfieldRD, HarrisRA, 2018 Astrocyte-specific transcriptome responses to chronic ethanol consumption. Pharm. J. 18, 942 10.1038/s41397-017-0012-2.PMC603369729305589 | β | β | β |
| ErtaM, QuintanaA, HidalgoJ, 2012 Interleukin-6, a major cytokine in the central nervous system. Int. J. Biol. Sci. 8, 1254β1266. 10.7150/ijbs.4679.23136554PMC3491449 | β | β | β |
| EtiΓ©vantA, OosterhofC, BΓ©tryC, AbrialE, Novo-PerezM, RoveraR, ScarnaH, DevaderC, MazellaJ, WegenerG, SΓ‘nchezC, Dkhissi-BenyahyaO, GronfierC, CoizetV, BeaulieuJM, BlierP, LucasG, HaddjeriN, 2015 Astroglial control of the antidepressant-like effects of prefrontal cortex deep brain stimulation. EBioMedicine 2, 898β908. 10.1016/j.ebiom.2015.06.023.26425697PMC4563138 | β | β | β |
| EvrardSG, Duhalde-VegaM, TagliaferroP, MirochnicS, CaltanaLR, BruscoA, 2006 A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. Exp. Neurol. 200, 438β459. 10.1016/j.expneurol.2006.03.001.16631170 | β | β | β |
| EzquerF, MoralesP, QuintanillaME, SantapauD, Lespay-RebolledoC, EzquerM, Herrera-MarschitzM, IsraelY, 2018 Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking. Sci. Rep. 8, 4325 10.1038/s41598-018-22750-7.29567966PMC5864829 | β | β | β |
| FantoniER, Dal BenD, FalzoniS, Di VirgilioF, LovestoneS, GeeA, 2017 Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel18F-labelled PET tracer targeting P2X7. EJNMMI Res. 7, 31 10.1186/s13550-017-0275-2.28374288PMC5378566 | β | β | β |
| FederA, ParidesMK, MurroughJW, PerezAM, MorganJE, SaxenaS, KirkwoodK, RotAan Het M., LapidusKAB, WanL-B, IosifescuD, CharneyDS, 2014 Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiat. 71, 681β688. 10.1001/jamapsychiatry.2014.62.24740528 | β | β | β |
| FelgerJC, LiZ, HaroonE, WoolwineBJ, JungMY, HuX, MillerAH, 2015 Inflammation is associated with decreased functional connectivity within cortices-triatal reward circuitry in depression. Mol. Psychiatry 21, 1358β1365. 10.1038/mp.2015.168.26552591PMC4862934 | β | β | β |
| FergusonLB, MostD, BlednovYA, HarrisRA, 2014 PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption. Neuropharmacology 86, 397β407. 10.1016/j.neuropharm.2014.06.024.25036611PMC4188800 | β | β | β |
| FernandesNC, SriramU, GofmanL, CennaJM, RamirezSH, PotulaR, 2016Methamphetamine alters microglial immune function through P2X7R signaling. J. Neuroinflammation 13, 91 10.1186/s12974-016-0553-3.27117066PMC4847215 | β | β | β |
| Fernandez-LizarbeS, MontesinosJ, GuerriC, 2013 Ethanol induces TLR4/TLR2 as-sociation, triggering an inflammatory response in microglial cells. J. Neurochem. 126, 261β273. 10.1111/jnc.12276.23600947 | β | β | β |
| Fernandez-LizarbeS, PascualM, GuerriC, 2009 Critical role of TLR4 response in the activation of microglia induced by ethanol. J. Immunol. 183, 4733β4744. 10.4049/jimmunol.0803590.19752239 | β | β | β |
| FerrierL, BerardF, DebrauwerL, ChaboC, LangellaP, BuenoL, FioramontiJ, 2006 Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents. Am. J. Pathol. 168, 1148β1154. 10.2353/ajpath.2006.050617.16565490PMC1606551 | β | β | β |
| FerriniF, De KoninckY, 2013 Microglia control neuronal network excitability via BDNF signalling. Neural Plast. 2013 10.1155/2013/429815.429815-11.PMC378062524089642 | β | β | β |
| FranklinKM, HauserSR, LasekAW, McClintickJ, DingZ-M, McBrideWJ, BellRL, 2015 Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4). Psychopharmacology 232, 2251β2262. 10.1007/s00213-014-3852-3.25585681PMC4465875 | β | β | β |
| FrankMG, AdhikaryS, SobeskyJL, WeberMD, WatkinsLR, MaierSF, 2016 The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain Behav. Immun. 51, 99β108. 10.1016/j.bbi.2015.08.001.26254235PMC5652313 | β | β | β |
| FrankMG, BarattaMV, SprungerDB, WatkinsLR, MaierSF, 2007 Microgliaserve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav. Immun. 21, 47β59. 10.1016/j.bbi.2006.03.005.16647243 | β | β | β |
| FriendDM, KeefeKA, 2013 Glial reactivity in resistance to methamphetamine-induced neurotoxicity. J. Neurochem. 125, 566β574. 10.1111/jnc.12201.23414433PMC3637419 | β | β | β |
| FujioM, NakagawaT, SekiyaY, OzawaT, SuzukiY, MinamiM, SatohM, KanekoS, 2005 Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats. Eur. J. Neurosci. 22, 2744β2754. 10.1111/j.1460-9568.2005.04467.x.16324108 | β | β | β |
| GajbhiyeSV, TripathiRK, PetareAU, PoteyAV, ShankarA, 2018 Minocycline in alcohol withdrawal induced anxiety and alcohol relapse in rats. Curr. Clin. Pharmacol. 13 10.2174/1574884713666180228110310.29493462 | β | β | β |
| GarcΓa-MarchenaN, AraosPF, BarriosV, SΓ‘nchez-MarΓnL, ChowenJA, PedrazM, Castilla-OrtegaE, Romero-SanchizP, PonceG, GavitoAL, DecaraJ, SilvaD, TorrensM, ArgenteJ, RubioG, SerranoA, de FonsecaFR, PavΓ³nFJ, 2017 Plasma chemokines in patients with alcohol use disorders: association of CCL11 (Eotaxin-1) with psychiatric comorbidity. Front. Psych. 7, 1 10.3389/fpsyt.2016.00214.PMC524232728149283 | β | β | β |
| GemmaC, BachstetterAD, 2013 The role of microglia in adult hippocampal neurogenesis. Front. Cell. Neurosci. 7, 229 10.3389/fncel.2013.00229.24319411PMC3837350 | β | β | β |
| GirardM, MalauzatD, NubukpoP, 2017 Serum inflammatory molecules and markers of neuronal damage in alcohol-dependent subjects after withdrawal. World J. Biol. Psychiatry 5, 1β15. 10.1080/15622975.2017.1349338.28669319 | β | β | β |
| GlausJ, von KΓ€nelR, LasserreAM, StrippoliMPF, VandeleurCL, CastelaoE, Gholam-RezaeeM, MarangoniC, WagnerEYN, Marques-VidalP, WaeberG, VollenweiderP, PreisigM, MerikangasKR, 2017 Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study. Psychol.Med. 46, 1β13. 10.1017/S0033291717002744.28929992 | β | β | β |
| GoldsteinRZ, VolkowND, 2011 Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat. Rev. Neurosci. 12, 652β669. 10.1038/nrn3119.22011681PMC3462342 | β | β | β |
| GongM-F, WenR-T, XuY, PanJ-C, FeiN, ZhouY-M, XuJ-P, LiangJ-H, ZhangH-T, 2017 Attenuation of ethanol abstinence-induced anxiety-and depres-sive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. Psychopharmacology 234, 3143β3151. 10.1016/j.bbi.2017.02.017.28748375 | β | β | β |
| GonzΓ‘lezA, ParienteJA, SalidoGM, 2007 Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes. Brain Res. 1178, 28β37. 10.1016/j.brainres.2007.08.040.17888892 | β | β | β |
| GonΓ§alvesJ, LeitΓ£oRA, Higuera-MatasA, AssisMA, CoriaSM, Fontes-RibeiroC, AmbrosioE, SilvaAP, 2017 Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown. Brain Behav. Immun. 62, 306β317. 10.1016/j.bbi.2017.02.017.28237710 | β | β | β |
| GracePM, StrandKA, GalerEL, UrbanDJ, WangX, BarattaMV, FabisiakTJ, AndersonND, ChengK, GreeneLI, BerkelhammerD, ZhangY, EllisAL, YinHH, CampeauS, RiceKC, RothBL, MaierSF, WatkinsLR, 2016 Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc. Natl. Acad. Sci. U. S. A. 113, E3441βE3450. 10.1073/pnas.1602070113.27247388PMC4914184 | β | β | β |
| GruolDL, VoK, BrayJG, RobertsAJ, 2014 CCL2-ethanol interactions and hip-pocampal synaptic protein expression in a transgenic mouse model. Front. Integr. Neurosci. 8, 29 10.3389/fnint.2014.00029.24772072PMC3983522 | β | β | β |
| GualA, HeY, TorupL, van den BrinkW, MannK, 2013 A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence. Eur. Neuropsychopharmacol. 23, 1432β1442. 10.1016/j.euroneuro.2013.02.006.23562264 | β | β | β |
| GuardadoP, OliveraA, RuschHL, RoyM, MartinC, LejbmanN, LeeH, GillJM, 2016 Altered gene expression of the innate immune, neuroendocrine, and nuclear factor-kappa B (NF-ΞΊB) systems is associated with posttraumatic stress disorder in military personnel. J. Anxiety Disord. 38, 9β20. 10.1016/j.janxdis.2015.12.004.26751122 | β | β | β |
| GuyonA, SkrzydelskiD, De GiryI, RovΓ¨reC, ConductierG, TrocelloJM, DaugΓ©V, KitabgiP, RostΓ¨neW, NahonJL, MΓ©lik ParsadaniantzS, 2009 Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release. Neuroscience 162, 1072β1080. 10.1016/j.neuroscience.2009.05.048.19477239 | β | β | β |
| HabbasS, SantelloM, BeckerD, StubbeH, ZappiaG, LiaudetN, KlausFR, KolliasG, FontanaA, PryceCR, SuterT, VolterraA, 2015 Neuroinflammatory TNFΞ± impairs memory via astrocyte signaling. Cell 163, 1730β1741. 10.1016/j.cell.2015.11.023.26686654 | β | β | β |
| Habibi-AslB, VaezH, NajafiM, BidaghiA, GhanbarzadehS, 2014 Attenuation of morphine-induced dependence and tolerance by ceftriaxone and amitriptyline in mice. Acta Anaesthesiol. Taiwanica 52, 163β168. 10.1016/j.aat.2014.11.001.25557842 | β | β | β |
| HabibN, Avraham-DavidiI, BasuA, BurksT, ShekharK, HofreeM, ChoudhurySR, AguetF, GelfandE, ArdlieK, WeitzDA, Rozenblatt-RosenO, ZhangF, RegevA, 2017 Massively parallel single-nucleus RNA-seq with DroNc-seq. Nat. Methods 14, 955β958. 10.1038/nmeth.4407.28846088PMC5623139 | β | β | β |
| HaileCN, KostenTA, 2017 The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats. Neuropharmacology 116, 364β370. 10.1016/j.neuropharm.2017.01.007.28088358PMC5385150 | β | β | β |
| HakamiAY, SariY, 2017 Ξ²-Lactamase inhibitor, clavulanic acid, attenuates ethanol intake and increases glial glutamate transporters expression in alcohol preferring rats. Neurosci. Lett. 657, 140β145. 10.1016/j.neulet.2017.08.013.28826758PMC5604845 | β | β | β |
| HanB, OlfsonM, MojtabaiR, 2017 Depression care among depressed adults with and without comorbid substance use disorders in the United States. Depress. Anxiety 34, 291β300. 10.1002/da.22592.28152244 | β | β | β |
| HarperKM, KnappDJ, ParkMA, BreeseGR, 2018 Differential effects of single versus repeated minocycline administration-lack of significant interaction with chronic alcohol history. Pharmacol. Biochem. Behav. 168, 33β42. 10.1016/j.pbb.2018.03.007.29572015 | β | β | β |
| HarrisRA, BajoM, BellRL, BlednovYA, VarodayanFP, TruittJM, de GuglielmoG, LasekAW, LogripML, VendruscoloLF, RobertsAJ, RobertsE, GeorgeO, MayfieldJ, BilliarTR, HackamDJ, MayfieldRD, KoobGF, RobertoM, HomanicsGE, 2017 Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. J. Neurosci. 37, 1139β1155. 10.1523/JNEUROSCI.2002-16.2016.27986929PMC5296793 | β | β | β |
| HarryGJ, KraftAD, 2008 Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment. Expert Opin. Drug Metab. Toxicol. 4, 1265β1277. 10.1517/17425255.4.10.1265.18798697PMC2658618 | β | β | β |
| HeadM, GoodwinL, DebellF, GreenbergN, WesselyS, FearNT, 2016 Posttraumatic stress disorder and alcohol misuse: comorbidity in UK military personnel. Soc. Psychiatry Psychiatr. Epidemiol. 51, 1171β1180. 10.1007/s00127-016-1177-8.26864534PMC4977328 | β | β | β |
| HeJ, CrewsFT, 2008 Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp. Neurol. 210, 349β358. 10.1016/j.expneurol.2007.11.017.18190912PMC2346541 | β | β | β |
| HernandezRV, PuroAC, ManosJC, Huitron-ResendizS, ReyesKC, LiuK, VoK, RobertsAJ, GruolDL, 2016 Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function. Neuropharmacology 103, 27β43. 10.1016/j.neuropharm.2015.12.015.26707655PMC4755829 | β | β | β |
| HilesSA, BakerAL, de MalmancheT, AttiaJ, 2012 A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity. Brain Behav. Immun. 26, 1180β1188. 10.1016/j.bbi.2012.06.001.22687336 | β | β | β |
| HillmerAT, SandiegoCM, HannestadJ, AngaritaGA, KumarA, McGovernEM, HuangY, OβConnorKC, CarsonRE, OβMalleySS, CosgroveKP, 2017 In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence. Mol. Psychiatry 118, 381 10.1038/mp.2017.10.PMC557366028242869 | β | β | β |
| HolleranKM, WilsonHH, FetterlyTL, BluettRJ, CentanniSW, GilfarbRA, RoccoLER, PatelS, WinderDG, 2016 Ketamine and MAG lipase inhibitor-dependent reversal of evolving depressive-like behavior during forced abstinence from alcohol drinking. Neuropsychopharmacology 41, 2062β2071. 10.1038/npp.2016.3.26751284PMC4908652 | β | β | β |
| HutchinsonMR, NorthcuttAL, ChaoLW, KearneyJJ, ZhangY, BerkelhammerDL, LoramLC, RozeskeRR, BlandST, MaierSF, GleesonTT, WatkinsLR, 2008a Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav. Immun. 22, 1248β1256. 10.1016/j.bbi.2008.07.008.18706994PMC2783326 | β | β | β |
| HutchinsonMR, NorthcuttAL, HiranitaT, WangX, LewisSS, ThomasJ, van SteegK, KopajticTA, LoramLC, SfregolaC, GalerE, MilesNE, BlandST, AmatJ, RozeskeRR, MaslanikT, ChapmanTR, StrandKA, FleshnerM, BachtellRK, SomogyiAA, YinH, KatzJL, RiceKC, MaierSF, WatkinsLR, 2012 Opioid activation of toll-like receptor 4 contributes to drug reinforcement. J. Neurosci. 32, 11187β11200. 10.1523/JNEUROSCI.0684-12.2012.22895704PMC3454463 | β | β | β |
| HutchinsonMR, ShavitY, GracePM, RiceKC, MaierSF, WatkinsLR, 2011 Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol. Rev. 63, 772β810. 10.1124/pr.110.004135.21752874PMC3141878 | β | β | β |
| HutchinsonMR, ZhangY, BrownK, CoatsBD, ShridharM, SholarPW, PatelSJ, CrysdaleNY, HarrisonJA, MaierSF, RiceKC, WatkinsLR, 2008b Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur. J. Neurosci. 28, 20β29. 10.1111/j.1460-9568.2008.06321.x.18662331PMC2588470 | β | β | β |
| HutchinsonMR, ZhangY, ShridharM, EvansJH, BuchananMM, ZhaoTX, SlivkaPF, CoatsBD, RezvaniN, WieselerJ, HughesTS, LandgrafKE, ChanS, FongS, PhippsS, FalkeJJ, LeinwandLA, MaierSF, YinH, RiceKC, WatkinsLR, 2010 Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav. Immun. 24, 83β95. 10.1016/j.bbi.2009.08.004.19679181PMC2788078 | β | β | β |
| HuW, LuT, ChenA, HuangY, HansenR, ChandlerLJ, ZhangH-T, 2011 Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology 218 (2), 331β339. 10.1007/s00213-011-2290-8.21509503PMC4210373 | β | β | β |
| JabarisSSL, SumathyH, GirishR, NarayananS, SugumarM, BabuSaravana C., ThanikachalamS, ThanikachalamM, 2015 Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system. Brain Res. 1622, 279β291. 10.1016/j.brainres.2015.07.003.26168894 | β | β | β |
| JacobsenJHW, Buisman-PijlmanFT, MustafaS, RiceKC, HutchinsonMR, 2018a Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology 128, 460β473. 10.1016/j.neuropharm.2017.09.028.28947376PMC7387100 | β | β | β |
| JacobsenJHW, Buisman-PijlmanFTA, MustafaS, RiceKC, HutchinsonMR, 2018b The efficacy of (+)-naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain Behav. Immun. 67, 181β193. 10.1016/j.bbi.2017.08.021.28864261PMC7387101 | β | β | β |
| JaramilloAA, RandallPA, StewartS, FortinoB, Van VoorhiesK, BesheerJ, 2018 Functional role for cortical-striatal circuitry in modulating alcohol self-administration. Neuropharmacology 130, 42β53. 10.1016/j.neuropharm.2017.11.035.29183687PMC5891728 | β | β | β |
| JohnCS, SmithKL, Vanβt VeerA, GompfHS, CarlezonWA, CohenBM, ΓngΓΌrD, Bechtholt-GompfAJ, 2012 Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia. Neuropsychopharmacology 37, 2467β2475. 10.1038/npp.2012.105.22739467PMC3442341 | β | β | β |
| JonesJD, SullivanMA, ManubayJM, MogaliS, MetzVE, CiccocioppoR, ComerSD, 2016 The effects of pioglitazone, a PPARΞ³ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users. Physiol. Behav. 159, 33β39. 10.1016/j.physbeh.2015.10.006.26455893PMC5444321 | β | β | β |
| JuneHL, LiuJ, WarnockKT, BellKA, BalanI, BollinoD, PucheA, AurelianL, 2015 CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration. Neuropsychopharmacology 40, 1549β1559. 10.1038/npp.2015.4.25567426PMC4397415 | β | β | β |
| KalkNJ, GuoQ, OwenD, CherianR, ErritzoeD, GilmourA, RibeiroAS, McGonigleJ, WaldmanA, MatthewsP, CavanaghJ, McInnesI, DarK, GunnR, RabinerEA, Lingford-HughesAR, 2017 Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. Transl. Psychiatry 7, e996 10.1038/tp.2016.264.28072413PMC5545729 | β | β | β |
| KaneCynthia J.M., PhelanKD, DouglasJC, WagonerG, JohnsonJW, XuJ, PhelanPS, DrewPD, 2014 Effects of Ethanol on Immune Response in the Brain: Region Specific Changes in Adolescent versus Adult Mice.10.1111/acer.12244PMC387225224033454 | β | β | β |
| KappelmannN, LewisG, DantzerR, JonesPB, KhandakerGM, 2016 Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol. Psychiatry 33, 664 10.1038/mp.2016.167.PMC579489627752078 | β | β | β |
| KarahanianE, QuintanillaME, FernandezK, IsraelY, 2014 Fenofibrateβa lipid-lowering drugβreduces voluntary alcohol drinking in rats. Alcohol 48, 665β670. 10.1016/j.alcohol.2014.08.004.25241056 | β | β | β |
| KarlssonC, SchankJR, RehmanF, StojakovicA, BjΓΆrkK, BarbierE, SolomonM, TapocikJ, EngblomD, ThorsellA, HeiligM, 2017 Proinflammatory signaling regulates voluntary alcohol intake and stress-induced consumption after exposure to social defeat stress in mice. Addict. Biol. 22, 1279β1288. 10.1111/adb.12416.27273552 | β | β | β |
| KarlssonR-M, AdermarkL, MolanderA, Perreau-LenzS, SingleyE, SolomonM, HolmesA, TanakaK, LovingerDM, SpanagelR, HeiligM, 2012 Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology 63, 181β189. 10.1016/j.neuropharm.2012.01.027.22342743PMC3372600 | β | β | β |
| KarwadMA, MacphersonT, WangB, TheophilidouE, SarmadS, BarrettDA, LarvinM, WrightKL, LundJN, OβSullivanSE, 2017 Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARΞ±. FASEB J. 31, 469β481. 10.1096/fj.201500132.27623929 | β | β | β |
| KashimaDT, GrueterBA, 2017 Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc. Natl. Acad. Sci. U. S. A. 5, 201705974 10.1073/pnas.1705974114.PMC556544928760987 | β | β | β |
| KawasakiY, ZhangL, ChengJ-K, JiR-R, 2008 Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J. Neurosci. 28, 5189β5194. 10.1523/JNEUROSCI.3338-07.2008.18480275PMC2408767 | β | β | β |
| KebirO, GorsaneM-A, BlechaL, KrebsM-O, ReynaudM, BenyaminaA, 2011 Association of inflammation genes with alcohol dependence/abuse: a systematic review and a meta-analysis. Eur. Addict. Res. 17, 146β153. 10.1159/000324849.21447951 | β | β | β |
| KelleyKW, Nakao-InoueH, MolofskyAV, OldhamMC, 2018 Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. Nat. Neurosci. 21, 1171β1184. 10.1038/s41593-018-0216-z30154505PMC6192711 | β | β | β |
| KennedySH, 2008 Core symptoms of major depressive disorder: relevance to diagnosis and treatment. Dialogues Clin. Neurosci. 10, 271β277.1897994010.31887/DCNS.2008.10.3/shkennedyPMC3181882 | β | β | β |
| Keren-ShaulH, SpinradA, WeinerA, Matcovitch-NatanO, Dvir-SzternfeldR, UllandTK, DavidE, BaruchK, Lara-AstaisoD, TothB, ItzkovitzS, ColonnaM, SchwartzM, AmitI, 2017 A unique microglia type associated with restricting development of Alzheimerβs disease. Cell 169, 1276β1290.e17. 10.1016/j.cell.2017.05.018.28602351 | β | β | β |
| KeshavarzianA, FarhadiA, ForsythCB, RanganJ, JakateS, ShaikhM, BananA, FieldsJZ, 2009 Evidence that chronic alcohol exposure promotes intestinal oxi-dative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J. Hepatol. 50, 538β547. 10.1016/j.jhep.2008.10.028.19155080PMC2680133 | β | β | β |
| KesslerRC, BerglundP, DemlerO, JinR, MerikangasKR, WaltersEE, 2005 Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 593β602. 10.1001/archpsyc.62.6.593.15939837 | β | β | β |
| KimelbergHK, CheemaM, OβConnorER, TongH, GoderieSK, RossmanPA, 1993 Ethanol-induced aspartate and taurine release from primary astrocyte cultures. J. Neurochem. 60, 1682β1689.847389010.1111/j.1471-4159.1993.tb13391.x | β | β | β |
| KimJ, JohnJ, LangfordD, WalkerE, WardS, RawlsSM, 2015 Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino Acids 48, 689β696. 10.1007/s00726-015-2117-8.26543027PMC4754134 | β | β | β |
| KimR, HealeyKL, Sepulveda-OrengoMT, ReissnerKJ, 2017 Astroglial correlates of neuropsychiatric disease: from astrocytopathy to astrogliosis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 10.1016/j.pnpbp.2017.10.002.PMC588936828989099 | β | β | β |
| KimSW, WiersCE, TylerR, Shokri-KojoriE, JangYJ, ZehraA, FreemanC, RamirezV, LindgrenE, MillerG, CabreraEA, StoddenT, GuoM, DemiralΕB, DiazgranadosN, ParkL, LiowJ-S, PikeV, MorseC, VendruscoloLF, InnisRB, KoobGF, TomasiD, WangG-J, VolkowND, 2018 Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents. Neuropsychopharmacology 43 (9), 1832β1839. 10.1038/s41386-018-0085-x.29777199PMC6046047 | β | β | β |
| KitamuraK, ItoR, UmeharaK, MorioH, SaitoK, SuzukiS, HashimotoM, SaitoY, AnzaiN, AkitaH, ChibaK, FurihataT, 2018 Differentiated HASTR/ci35 cells: a promising in vitro human astrocyte model for facilitating CNS drug development studies. J. Pharmacol. Sci. 137, 350β358. 10.1016/j.jphs.2018.06.01330150146 | β | β | β |
| KnackstedtLA, MelendezRI, KalivasPW, 2010 Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol. Psychiatry 67, 81β84. 10.1016/j.biopsych.2009.07.018.19717140PMC2795043 | β | β | β |
| KnappDJ, HarperKM, WhitmanBA, ZimomraZ, BreeseGR, 2016 Stress and withdrawal from chronic ethanol induce selective changes in neuroimmune mRNAs in differing brain sites. Brain Sci. 6, 25 10.3390/brainsci6030025.PMC503945427472367 | β | β | β |
| KoobGF, MasonBJ, 2016 Existing and future drugs for the treatment of the dark side of addiction. Annu. Rev. Pharmacol. Toxicol. 56, 299β322. 10.1146/annurev-pharmtox-010715-103143.26514207 | β | β | β |
| KoobGF, VolkowND, 2016 Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry 3, 760β773. 10.1016/S2215-0366(16)00104-8.27475769PMC6135092 | β | β | β |
| KrawczykN, FederKA, SalonerB, CrumRM, KealhoferM, MojtabaiR, 2017 The association of psychiatric comorbidity with treatment completion among clients admitted to substance use treatment programs in a U.S. national sample. Drug Alcohol Depend. 175, 157β163. 10.1016/j.drugalcdep.2017.02.006.28432939PMC5490486 | β | β | β |
| KrishnaswamiSR, GrindbergRV, NovotnyM, VenepallyP, LacarB, BhutaniK, LinkerSB, PhamS, ErwinJA, MillerJA, HodgeR, McCarthyJK, KelderM, McCorrisonJ, AevermannBD, FuertesFD, ScheuermannRH, LeeJ, LeinES, SchorkN, McConnellMJ, GageFH, LaskenRS, 2016 Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Nat. Protoc. 11, 499β524. 10.1038/nprot.2016.015.26890679PMC4941947 | β | β | β |
| LacagninaMJ, RiveraPD, BilboSD, 2017 Glial and neuroimmune mechanisms as critical modulators of drug use and abuse. Neuropsychopharmacology 42, 156β177. 10.1038/npp.2016.121.27402494PMC5143481 | β | β | β |
| LainiolaM, LindenA-M, 2017 Alcohol intake in two different mouse drinking models after recovery from the lipopolysaccharide-induced sickness reaction. Alcohol 65, 1β10. 10.1016/j.alcohol.2017.06.002.29084623 | β | β | β |
| LangE, MallienAS, VasilescuA-N, HefterD, LuoniA, RivaMA, BorgwardtS, SprengelR, LangUE, GassP, IntaD, 2018 Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets. Neurosci. Biobehav. Rev. 84, 352β358. 10.1016/j.neubiorev.2017.08.012.28843752 | β | β | β |
| LangleyA, BeeckerJ, 2017 Management of Common Side Effects of Apremilast. J. Cutan. Med. Surg. 75, 1203475417748886. 10.1177/1203475417748886.29290125 | β | β | β |
| LaRoweSD, KalivasPW, NicholasJS, RandallPK, MardikianPN, MalcolmRJ, 2013 A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am. J. Addict. 22, 443β452. 10.1111/j.1521-0391.2013.12034.x.23952889PMC4348575 | β | β | β |
| LasramMM, LamineAJ, DhouibIB, BouzidK, AnnabiA, BelhadjhmidaN, AhmedMB, El FazaaS, AbdelmoulaJ, GharbiN, 2014 Antioxidant and anti-inflammatory effects of N-acetylcysteine against malathion-induced liver damages and immunotoxicity in rats. Life Sci. 107, 50β58. 10.1016/j.lfs.2014.04.033.24810974 | β | β | β |
| LebourgeoisS, GonzΓ‘lez-MarΓnMC, JeanblancJ, NaassilaM, VilpouxC, 2018 Effect of N-acetylcysteine on motivation, seeking and relapse to ethanol self-administration. Addict. Biol. 23, 643β652. 10.1111/adb.12521.28557352 | β | β | β |
| LeclercqS, CaniPD, NeyrinckAM, StΓ€rkelP, JamarF, MikolajczakM, DelzenneNM, de TimaryP, 2012 Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain Behav. Immun. 26, 911β918. 10.1016/j.bbi.2012.04.001.22521198 | β | β | β |
| LeclercqS, De SaegerC, DelzenneN, de TimaryP, StΓ€rkelP, 2014a Role of inflammatory pathways, blood mononuclear cells, and gut-derived bacterial products in alcohol dependence. Biol. Psychiatry 76, 725β733. 10.1016/j.biopsych.2014.02.003.24629538 | β | β | β |
| LeclercqS, de TimaryP, DelzenneNM, StΓ€rkelP, 2017 The link between inflammation, bugs, the intestine and the brain in alcohol dependence. Transl. Psychiatry 7, e1048 10.1038/tp.2017.15.28244981PMC5545644 | β | β | β |
| LeclercqS, MatamorosS, CaniPD, NeyrinckAM, JamarF, StΓ€rkelP, WindeyK, TremaroliV, BΓ€ckhedF, VerbekeK, de TimaryP, DelzenneNM, 2014b Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc. Natl. Acad. Sci. U. S. A. 111, E4485βE4493. 10.1073/pnas.1415174111.25288760PMC4210345 | β | β | β |
| Leduc-PessahH, WeilingerNL, FanCY, BurmaNE, ThompsonRJ, TrangT, 2017 Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance. J. Neurosci. 37, 10154β10172. 10.1523/JNEUROSCI.0852-17.2017.28924009PMC6596546 | β | β | β |
| LeeMR, RubyCL, HintonDJ, ChoiS, AdamsCA, KangYoung N., ChoiDS, 2013 Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. Neuropsychopharmacology 38, 437β445. 10.1038/npp.2012.198.23032072PMC3547194 | β | β | β |
| Leow-DykeS, AllenC, DenesA, NilssonO, MaysamiS, BowieAG, RothwellNJ, PinteauxE, 2012 Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. J. Neuroinflammation 9, 230 10.1186/1742-2094-9-230.23034047PMC3481358 | β | β | β |
| LevkovitzY, FenchelD, KaplanZ, ZoharJ, CohenH, 2015 Early post-stressor intervention with minocycline, a second-generation tetracycline, attenuates post-traumatic stress response in an animal model of PTSD. Eur. Neuropsychopharmacol. 25, 124β132. 10.1016/j.euroneuro.2014.11.012.25487770 | β | β | β |
| LewitusGM, KonefalSC, GreenhalghAD, PribiagH, AugereauK, StellwagenD, 2016 Microglial TNF-Ξ± suppresses cocaine-induced plasticity and behavioral sensitization. Neuron 90, 483β491. 10.1016/j.neuron.2016.03.030.27112496PMC4860141 | β | β | β |
| LewitusGM, PribiagH, DusejaR, St-HilaireM, StellwagenD, 2014 An adaptive role of TNFΞ± in the regulation of striatal synapses. J. Neurosci. 34, 6146β6155.10.1523/JNEUROSCI.3481-13.2014.24790185PMC6608116 | β | β | β |
| LewohlJM, WangL, MilesMF, ZhangL, DoddPR, HarrisRA, 2000 Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol. Clin. Exp. Res. 24, 1873β1882.11141048 | β | β | β |
| LiangpunsakulS, TohE, RossRA, HeathersLE, ChandlerK, OshodiA, McGeeB, ModlikE, LintonT, MangiacarneD, JimenezC, DongXC, WangL, TuW, NelsonDE, 2017 Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation. Sci. Rep. 7, 4462 10.1038/s41598-017-04669-7.28667254PMC5493657 | β | β | β |
| LiaoK, GuoM, NiuF, YangL, CallenSE, BuchS, 2016 Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. J. Neuroinflammation 13, 33 10.1186/s12974-016-0501-2.26860188PMC4748483 | β | β | β |
| LiddelowSA, GuttenplanKA, ClarkeLE, BennettFC, BohlenCJ, SchirmerL, BennettML, MΓΌnchAE, ChungW-S, PetersonTC, WiltonDK, FrouinA, NapierBA, PanickerN, KumarM, BuckwalterMS, RowitchDH, DawsonVL, DawsonTM, StevensB, BarresBA, 2017 Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541, 481β487. 10.1038/nature21029.28099414PMC5404890 | β | β | β |
| LindbergD, Andres-BeckL, JiaY-F, KangS, ChoiD-S, 2018 Purinergic signaling in neuron-astrocyte interactions, circadian rhythms, and alcohol use disorder. Front. Physiol. 9, 9 10.3389/fphys.2018.00009.29467662PMC5808134 | β | β | β |
| LippaiD, BalaS, PetrasekJ, CsakT, LevinI, Kurt-JonesEA, SzaboG, 2013 Alcohol-induced IL-1 Ξ² in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J. Leukoc. Biol. 94, 171β182. 10.1189/jlb.1212659.23625200PMC3685015 | β | β | β |
| LiuJ, LewohlJM, HarrisRA, IyerVR, DoddPR, RandallPK, MayfieldRD, 2006 Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31, 1574β1582. 10.1038/sj.npp.1300947.16292326 | β | β | β |
| LiuL, HutchinsonMR, WhiteJM, SomogyiAA, CollerJK, 2009 Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenet. Genomics 19, 869β876. 10.1097/FPC.0b013e328331e68f.19801958 | β | β | β |
| LiuX, HaoP-D, YangM-F, SunJ-Y, MaoL-L, FanC-D, ZhangZ-Y, LiD-W, YangX-Y, SunB-L, ZhangH-T, 2017 The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice. Psychopharmacology 234, 2409β2419. 10.1007/s00213-017-4631-8.28477089 | β | β | β |
| LiY, DuX-F, LiuC-S, WenZ-L, DuJ-L, 2012 Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev. Cell 23, 1189β1202. 10.1016/j.devcel.2012.10.027.23201120 | β | β | β |
| LloydSA, CorkillB, BrusterMC, RobertsRL, ShanksRA, 2017 Chronic methamphetamine exposure significantly decreases microglia activation in the arcuate nucleus. J. Chem. Neuroanat. 82, 5β11. 10.1016/j.jchemneu.2017.03.001.28323108 | β | β | β |
| LogripML, 2015 Phosphodiesterase regulation of alcohol drinking in rodents. Alcohol 49, 795β802. 10.1016/j.alcohol.2015.03.007.26095589PMC4663182 | β | β | β |
| LogripML, VendruscoloLF, SchlosburgJE, KoobGF, ZorrillaEP, 2014Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.Neuropsychopharmacology 39, 1722β1731. 10.1038/npp.2014.20.24549104PMC4023146 | β | β | β |
| LohrJB, PalmerBW, EidtCA, AailaboyinaS, MausbachBT, WolkowitzOM, ThorpSR, JesteDV, 2015 Is post-traumatic stress disorder associated with pre-mature senescence? A review of the literature. Am. J. Geriatr. Psychiatry 23, 709β725. 10.1016/j.jagp.2015.04.001.25959921PMC4568841 | β | β | β |
| LotrichFE, 2015 Inflammatory cytokine-associated depression. Brain Res. 1617, 113β125. 10.1016/j.brainres.2014.06.032.25003554PMC4284141 | β | β | β |
| LuY-C, YehW-C, OhashiPS, 2008 LPS/TLR4 signal transduction pathway.Cytokine 42, 145β151. 10.1016/j.cyto.2008.01.006.18304834 | β | β | β |
| MaesM, BerkM, GoehlerL, SongC, AndersonG, GaΕeckiP, LeonardB, 2012 Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med. 10, 66 10.1186/1741-7015-10-66.22747645PMC3391987 | β | β | β |
| Mano, la, deA, GatoA, AlonsoMI, CarniceroE, MartΓnC, MoroJA, 2007 Role of interleukin-1beta in the control of neuroepithelial proliferation and differentiation of the spinal cord during development. Cytokine 37, 128β137. 10.1016/j.cyto.2007.03.004.17449272 | β | β | β |
| MantereO, SoronenP, UherR, KetokiviM, JylhΓ€P, MelartinT, PaunioT, IsometsΓ€E, 2012 Neuroticism mediates the effect of P2RX7 on outcomes of mood disorders. Depress. Anxiety 29, 816β823. 10.1002/da.21945.22623165 | β | β | β |
| MarcosM, PastorI, GonzΓ‘lez-SarmientoR, LasoFJ, 2008 Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease. Alcohol Alcohol. 43, 523β528. 10.1093/alcalc/agn026.18436572 | β | β | β |
| MarshallSA, CasachahuaJD, RinkerJA, BloseAK, LysleDT, ThieleTE, 2016 IL-1 receptor signaling in the basolateral amygdala modulates binge-like ethanol consumption in male C57BL/6J mice. Brain Behav. Immun. 51, 258β267. 10.1016/j.bbi.2015.09.006.26365025PMC4679505 | β | β | β |
| MarshallSA, McClainJA, KelsoML, HopkinsDM, PaulyJR, NixonK, 2013 Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: the importance of microglia phenotype. Neurobiol. Dis. 54, 239β251. 10.1016/j.nbd.2012.12.016.23313316PMC3629000 | β | β | β |
| MartΓn-FernΓ‘ndezM, JamisonS, RobinLM, ZhaoZ, MartΓnED, AguilarJ, BenneyworthMA, MarsicanoG, AraqueA, 2017 Synapse-specific astrocyte gating of amygdala-related behavior. Nat. Neurosci. 10, 1043 10.1038/nn.4649.PMC590328628945222 | β | β | β |
| MasonBJ, 2017 Emerging pharmacotherapies for alcohol use disorder.Neuropharmacology 122, 244β253. 10.1016/j.neuropharm.2017.04.032.28454983PMC5643030 | β | β | β |
| MasonBJ, RitvoEC, MorganRO, SalvatoFR, GoldbergG, WelchB, Mantero-AtienzaE, 1994 A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCI for alcohol dependence. Alcohol. Clin. Exp. Res. 18, 1162β1167. 10.1111/j.1530-0277.1994.tb00098.x.7847600 | β | β | β |
| MasonBJ, SalvatoFR, WilliamsLD, RitvoEC, CutlerRB, 1999 A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence. Arch. Gen. Psychiatry 56, 719 10.1001/archpsyc.56.8.719.10435606 | β | β | β |
| MatosM, ShenHY, AugustoE, WangY, WeiCJ, WangYT, AgostinhoP, BoisonD, CunhaRA, ChenJF, 2015 Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. Biol. Psychiatry 78, 763β774. 10.1016/j.biopsych.2015.02.026.25869810PMC4714966 | β | β | β |
| MattioliTA, Leduc-PessahH, Skelhorne-GrossG, NicolCJB, MilneB, TrangT, CahillCM, 2014 Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. PLoS One 9, e97361 10.1371/journal.pone.0097361.24824631PMC4019634 | β | β | β |
| MayfieldJ, ArendsMA, HarrisRA, BlednovYA, 2016 Genes and alcohol consumption: studies with mutant mice. Int. Rev. Neurobiol. 126, 293β355. 10.1016/bs.irn.2016.02.014.27055617PMC5302130 | β | β | β |
| MayfieldJ, FergusonL, HarrisRA, 2013 Neuroimmune signaling: a key component of alcohol abuse. Curr. Opin. Neurobiol. 23, 513β520. 10.1016/j.conb.2013.01.024.23434064PMC3694992 | β | β | β |
| MayfieldJ, HarrisRA, 2017 The neuroimmune basis of excessive alcohol consumption. Neuropsychopharmacology 42, 376 10.1038/npp.2016.177.27909320PMC5143494 | β | β | β |
| MayfieldRD, LewohlJM, DoddPR, HerlihyA, LiuJ, HarrisRA, 2002 Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J. Neurochem. 81, 802β813. 10.1046/j.1471-4159.2002.00860.x.12065639 | β | β | β |
| McAndrewA, LawnW, StevensT, PorffyL, BrandnerB, MorganCJA, 2017 A proof-of-concept investigation into ketamine as a pharmacological treatment for alcohol dependence: study protocol for a randomised controlled trial. Trials 18, 159 10.1186/s13063-017-1895-6.28372596PMC5379743 | β | β | β |
| McBrideWJ, KimpelMW, McClintickJN, DingZ-M, HauserSR, EdenbergHJ, BellRL, RoddZA, 2013 Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats. Alcohol 47, 367β380. 10.1016/j.alcohol.2013.04.002.23714385PMC3704142 | β | β | β |
| McCarthyGM, BridgesCR, BlednovYA, HarrisRA, 2017a CNS cell-type localization and LPS response of TLR signaling pathways. F1000Res 6, 1144 10.12688/f1000research.12036.1.29043065PMC5621151 | β | β | β |
| McCarthyGM, FarrisSP, BlednovYA, HarrisRA, MayfieldRD, 2017b Microglial-specific transcriptome changes following chronic alcohol consumption. Neuropharmacology 128, 416β424. 10.1016/j.neuropharm.2017.10.035.29101021PMC5990017 | β | β | β |
| McCarthyGM, WardenAS, BridgesCR, BlednovYA, HarrisRA, 2017c Chronic ethanol consumption: role of TLR3/TRIF-dependent signaling. Addict. Biol. 91, 289 10.1111/adb.12539.PMC582877928840972 | β | β | β |
| McClainJA, MorrisSA, DeenyMA, MarshallSA, HayesDM, KiserZM, NixonK, 2011 Adolescent binge alcohol exposure induces long-lasting partial activation of microglia. Brain Behav. Immun. 25 (Suppl. 1), S120βS128. 10.1016/j.bbi.2011.01.006.21262339PMC3098298 | β | β | β |
| MetzVE, JonesJD, ManubayJ, SullivanMA, MogaliS, SegoshiA, MaderaG, JohnsonKW, ComerSD, 2017 Effects of Ibudilast on the subjective, reinforcing, and analgesic effects of oxycodone in recently detoxified adults with opioid dependence. Neuropsychopharmacology 42, 1825β1832. 10.1038/npp.2017.70.28393896PMC5520790 | β | β | β |
| Miguel-HidalgoJ, ShoyamaY, WanzoV, 2009 Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats. J. Psychopharmacol. 23 (5), 550β557. 10.1177/0269881108091074.18562436PMC2697276 | β | β | β |
| Miguel-HidalgoJJ, 2005 Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats. Alcohol. Clin. Exp. Res. 29, 766β772.1589772110.1097/01.alc.0000164378.92680.faPMC2923206 | β | β | β |
| Miguel-HidalgoJJ, OverholserJC, MeltzerHY, StockmeierCA, RajkowskaG, 2006 Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship with suicide and duration of alcohol dependence. Alcohol. Clin. Exp. Res. 30, 1845β1855. 10.1111/j.1530-0277.2006.00221.x.17067348PMC2921167 | β | β | β |
| Miguel-HidalgoJJ, WeiJ, AndrewM, OverholserJC, JurjusG, StockmeierCA, RajkowskaG, 2002 Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms. Biol. Psychiatry 52, 1121β1133.1248805710.1016/s0006-3223(02)01439-7PMC3115671 | β | β | β |
| Miguel-HidalgoJJ, WilsonBA, HussainS, MeshramA, RajkowskaG, StockmeierCA, 2014 Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression. J. Psychiatr. Res. 55, 101β109. 10.1016/j.jpsychires.2014.04.007.24774648PMC4078739 | β | β | β |
| MillerAH, RaisonCL, 2016 The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat. Rev. Immunol. 16, 22β34. 10.1038/nri.2015.5.26711676PMC5542678 | β | β | β |
| MillerWR, FoxRG, StutzSJ, LaneSD, DennerL, CunninghamKA, DineleyKT, 2016 PPARΞ³ agonism attenuates cocaine cue reactivity. Addict. Biol. 4, e369 10.1111/adb.12471.PMC558127627862692 | β | β | β |
| MiyamotoA, WakeH, MoorhouseAJ, NabekuraJ, 2013 Microglia and synapse interactions: fine tuning neural circuits and candidate molecules. Front. Cell. Neurosci. 7 10.3389/fncel.2013.00070.PMC365420323720611 | β | β | β |
| MizeeMR, MiedemaSSM, van der PoelM, Adelia, SchuurmanKG, van StrienME, MeliefJ, SmoldersJ, HendrickxDA, HeutinckKM, HamannJ, HuitingaI, 2017 Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables. Acta Neuropathol. Commun. 5, 16 10.1186/s40478-017-0418-8.28212663PMC5316206 | β | β | β |
| ModabberniaA, TaslimiS, BrietzkeE, AshrafiM, 2013 Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol. Psychiatry 74, 15β25. 10.1016/j.biopsych.2013.01.007.23419545 | β | β | β |
| MontesinosJ, Alfonso-LoechesS, GuerriC, 2016a Impact of the innate immune response in the actions of ethanol on the central nervous system. Alcohol. Clin. Exp. Res. 40, 2260β2270. 10.1111/acer.13208.27650785 | β | β | β |
| MontesinosJ, GilA, GuerriC, 2017 Nalmefene prevents alcohol-induced neuroinflammation and alcohol drinking preference in adolescent female mice: role of TLR4. Alcohol. Clin. Exp. Res. 41, 1257β1270. 10.1111/acer.13416.28493563 | β | β | β |
| MontesinosJ, PascualM, RodrΓguez-AriasM, MiΓ±arroJ, GuerriC, 2016b Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence. Brain Behav. Immun. 53, 159β171. 10.1016/j.bbi.2015.12.006.26686767 | β | β | β |
| MunkholmK, BraΓΌnerJV, KessingLV, VinbergM, 2013 Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J. Psychiatr. Res. 47, 1119β1133. 10.1016/j.jpsychires.2013.05.018.23768870 | β | β | β |
| MutluE, KeshavarzianA, EngenP, ForsythCB, SikaroodiM, GillevetP, 2009 Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol. Clin. Exp. Res. 33, 1836β1846. 10.1111/j.1530-0277.2009.01022.x.19645728PMC3684271 | β | β | β |
| NagyosziP, WilhelmI, FarkasAE, FazakasC, DungNTK, HaskΓ³J, KrizbaiIA, 2010 Expression and regulation of toll-like receptors in cerebral endothelial cells. Neurochem. Int. 57, 556β564. 10.1016/j.neuint.2010.07.002.20637248 | β | β | β |
| NakagawaT, KanekoS, 2013 SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain. Curr. Mol. Pharmacol. 6, 66β73.2387615010.2174/18744672113069990033 | β | β | β |
| NarendranR, LoprestiBJ, MasonNS, DeuitchL, ParisJ, HimesML, KodavaliCV, NimgaonkarVL, 2014 Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28. J. Neurosci. 34, 9945β9950. 10.1523/JNEUROSCI.0928-14.2014.25057196PMC4107410 | β | β | β |
| NeupaneSP, 2016 Neuroimmune interface in the comorbidity between alcohol use disorder and major depression. Front. Immunol. 7, 743 10.3389/fimmu.2016.00655.PMC518678428082989 | β | β | β |
| NimmerjahnA, KirchhoffF, HelmchenF, 2005 Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314β1318. 10.1126/science.1110647.15831717 | β | β | β |
| NisticΓ²R, SalterE, NicolasC, FeligioniM, MangoD, BortolottoZA, GressensP, CollingridgeGL, PeineauS, 2017 Synaptoimmunology - roles in health and disease. Mol. Brain 10, 26 10.1186/s13041-017-0308-9.28637489PMC5480158 | β | β | β |
| NordenDM, TrojanowskiPJ, VillanuevaE, NavarroE, GodboutJP, 2016 Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge. Glia 64, 300β316. 10.1002/glia.22930.26470014PMC4707977 | β | β | β |
| NorthcuttAL, HutchinsonMR, WangX, BarattaMV, HiranitaT, CochranTA, PomrenzeMB, GalerEL, KopajticTA, LiCM, AmatJ, LarsonG, CooperDC, HuangY, OβNeillCE, YinH, ZahniserNR, KatzJL, RiceKC, MaierSF, BachtellRK, WatkinsLR, 2015 DAT isnβt all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Mol. Psychiatry 20, 1525β1537. 10.1038/mp.2014.177.25644383PMC4523496 | β | β | β |
| NunesEV, LevinFR, 2004 Treatment of depression in patients with alcohol or other drug dependence. JAMA 291, 1887 10.1001/jama.291.15.1887.15100209 | β | β | β |
| OberheimNA, GoldmanSA, NedergaardM, 2012 Heterogeneity of astrocytic form and function. Methods Mol. Biol. 814, 23β45. 10.1007/978-1-61779-452-0_3.22144298PMC3506190 | β | β | β |
| OberheimNA, TakanoT, HanX, HeW, LinJHC, WangF, XuQ, WyattJD, PilcherW, OjemannJG, RansomBR, GoldmanSA, NedergaardM, 2009 Uniquely hominid features of adult human astrocytes. J. Neurosci. 29, 3276β3287. 10.1523/JNEUROSCI.4707-08.2009.19279265PMC2819812 | β | β | β |
| OberheimNA, WangX, GoldmanS, NedergaardM, 2006 Astrocytic complexity distinguishes the human brain. Trends Neurosci. 29, 547β553. 10.1016/j.tins.2006.08.004.16938356 | β | β | β |
| OetjenLK, MackMR, FengJ, WhelanTM, NiuH, GuoCJ, ChenS, TrierAM, XuAZ, TripathiSV, LuoJ, GaoX, YangL, HamiltonSL, WangPL, BrestoffJR, CouncilML, BrasingtonR, SchafferA, BrombacherF, HsiehC-S, GereauRW, MillerMJ, ChenZ-F, HuH, DavidsonS, LiuQ, KimBS, 2017 Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell 171, 217β228.e13. 10.1016/j.cell.2017.08.006.28890086PMC5658016 | β | β | β |
| OhsawaK, KohsakaS, 2011 Dynamic motility of microglia: purinergic modulation of microglial movement in the normal and pathological brain. Glia 59, 1793β1799. 10.1002/glia.21238.21901756 | β | β | β |
| OlffM, van ZuidenM, 2017 Neuroendocrine and neuroimmune markers in PTSD: pre-, peri- and post-trauma glucocorticoid and inflammatory dysregulation. Curr. Opin. Psychol. 14, 132β137. 10.1016/j.copsyc.2017.01.001.28813312 | β | β | β |
| OliveiraJF, SardinhaVM, Guerra-GomesS, AraqueA, SousaN, 2015 Do stars govern our actions? Astrocyte involvement in rodent behavior. Trends Neurosci. 38, 535β549. 10.1016/j.tins.2015.07.006.26316036 | β | β | β |
| OlmosG, LladΓ³J, 2014 Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediat. Inflamm. 2014 10.1155/2014/861231.861231-12.PMC405542424966471 | β | β | β |
| OrsoR, CreutzbergKC, Centeno-SilvaA, CarapeΓ§osMS, LevandowskiML, Wearick-SilvaLE, ViolaTW, Grassi-OliveiraR, 2017 NFΞΊB1 and NFΞΊB2 gene expression in the prefrontal cortex and hippocampus of early life stressed mice exposed to cocaine-induced conditioned place preference during adolescence. Neurosci. Lett. 658, 27β31. 10.1016/j.neulet.2017.08.032.28823892 | β | β | β |
| Osterndorff-KahanekE, PonomarevI, BlednovYA, HarrisRA, 2013 Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation. PLoS One 8, e59870 10.1371/journal.pone.0059870.23555817PMC3612084 | β | β | β |
| Osterndorff-KahanekEA, BeckerHC, LopezMF, FarrisSP, TiwariGR, NunezYO, HarrisRA, MayfieldRD, 2015 Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. PLoS One 10, e0121522 10.1371/journal.pone.0121522.25803291PMC4372440 | β | β | β |
| OzawaT, NakagawaT, SekiyaY, MinamiM, SatohM, 2004 Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adeno-viruses on morphine physical dependence in rats. Eur. J. Neurosci. 19, 221β226. 10.1111/j.1460-9568.2004.03101.x.14750980 | β | β | β |
| OzawaT, NakagawaT, ShigeK, MinamiM, SatohM, 2001 Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal. Brain Res. 905, 254β258. 10.1016/S0006-8993(01)02536-7.11423104 | β | β | β |
| ParkhurstCN, YangG, NinanI, SavasJN, YatesJRIII, LafailleJJ, HempsteadBL, LittmanDR, GanW-B, 2013 Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155, 1596β1609. 10.1016/j.cell.2013.11.030.24360280PMC4033691 | β | β | β |
| ParlesakA, SchΓ€ferC, SchΓΌtzT, BodeJC, BodeC, 2000 Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J. Hepatol. 32, 742β747.1084566010.1016/s0168-8278(00)80242-1 | β | β | β |
| PascualM, BaliΓ±oP, Alfonso-LoechesS, AragΓ³nCMG, GuerriC, 2011 Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage. Brain Behav. Immun. 25, S80βS91. 10.1016/j.bbi.2011.02.012.21352907 | β | β | β |
| PascualM, BaliΓ±oP, AragΓ³nCMG, GuerriC, 2015 Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: role of TLR4 and TLR2. Neuropharmacology 89, 352β359. 10.1016/j.neuropharm.2014.10.014.25446779 | β | β | β |
| PascualM, MontesinosJ, GuerriC, 2018 Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking. J. Neurosci. Res. 96, 765β780. 10.1002/jnr.24203.29214654 | β | β | β |
| PascualM, MontesinosJ, MarcosM, TorresJ-L, Costa-AlbaP, GarcΓa-GarcΓaF, LasoFJ, GuerriC, 2017 Gender differences in the inflammatory cytokine and chemokine profiles induced by binge ethanol drinking in adolescence. Addict. Biol. 22, 1829β1841. 10.1111/adb.12461.27699959 | β | β | β |
| PassosIC, Vasconcelos-MorenoMP, CostaLG, KunzM, BrietzkeE, QuevedoJ, SalumG, MagalhΓ£esPV, KapczinskiF, Kauer-SantβAnnaM, 2015 Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression. Lancet Psychiatry 2, 1002β1012. 10.1016/S2215-0366(15)00309-0.26544749 | β | β | β |
| PastorIJ, LasoFJ, RomeroA, GonzΓ‘lez-SarmientoR, 2005a Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men. Alcohol Alcohol. 40, 181β186. 10.1093/alcalc/agh153.15797878 | β | β | β |
| PastorIJ, LasoFJ, RomeroA, GonzΓ‘lez-SarmientoR, 2005b β238 G > A polymorphism of tumor necrosis factor alpha gene (TNFA) is associated with alcoholic liver cirrhosis in alcoholic Spanish men. Alcohol. Clin. Exp. Res. 29, 1928β1931.1634044810.1097/01.alc.0000187595.19324.ca | β | β | β |
| PeknyM, PeknaM, 2014 Astrocyte reactivity and reactive astrogliosis: costs and benefits. Physiol. Rev. 94, 1077β1098. 10.1152/physrev.00041.2013.25287860 | β | β | β |
| PengL, VerkhratskyA, GuL, LiB, 2015 Targeting astrocytes in major depression. Expert. Rev. Neurother. 15, 1299β1306. 10.1586/14737175.2015.1095094.26471936 | β | β | β |
| PetrulliJR, KalishB, NabulsiNB, HuangY, HannestadJ, MorrisED, 2017 Systemic inflammation enhances stimulant-induced striatal dopamine elevation. Transl. Psychiatry 7, e1076 10.1038/tp.2017.18.28350401PMC5404612 | β | β | β |
| PietrzakRH, GoldsteinRB, SouthwickSM, GrantBF, 2011 Prevalence and Axis I comorbidity of full and partial posttraumatic stress disorder in the United States: results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. J. Anxiety Disord. 25, 456β465. 10.1016/j.janxdis.2010.11.010.21168991PMC3051041 | β | β | β |
| PlantingaL, BremnerJD, MillerAH, JonesDP, VeledarE, GoldbergJ, VaccarinoV, 2013 Association between posttraumatic stress disorder and inflammation: a twin study. Brain Behav. Immun. 30, 125β132. 10.1016/j.bbi.2013.01.081.23379997PMC3641167 | β | β | β |
| PolandRS, HahnY, KnappPE, BeardsleyPM, BowersMS, 2016 Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats. Neuropharmacology 109, 281β292. 10.1016/j.neuropharm.2016.06.024.27343385PMC5404892 | β | β | β |
| PonomarevI, WangS, ZhangL, HarrisRA, MayfieldRD, 2012 Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J. Neurosci. 32, 1884β1897. 10.1523/JNEUROSCI.3136-11.2012.22302827PMC3564514 | β | β | β |
| PotterWZ, BradyLS, 2014 Current drug development for antidepressants and ideas addressing downstream glutamate: the ketamine example. CNS Spectr. 19, 112β114. 10.1017/S1092852914000029.24565466 | β | β | β |
| PreedyVR, 2016 Neuropathology of Drug Addictions and Substance Misuse. vol. 3 Academic Press. | β | β | β |
| QinL, CrewsFT, 2012a Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration. J. Neuroinflammation 9, 130 10.1186/1742-2094-9-130.22709825PMC3412752 | β | β | β |
| QinL, CrewsFT, 2012b NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration. J. Neuroinflammation 9, 5 10.1186/1742-2094-9-5.22240163PMC3271961 | β | β | β |
| QinL, HeJ, HanesRN, PluzarevO, HongJ-S, CrewsFT, 2008 Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J. Neuroinflammation 5, 10 10.1186/1742-2094-5-10.18348728PMC2373291 | β | β | β |
| QinL-J, GuY-T, ZhangH, XueY-X, 2009 Bradykinin-induced blood-tumor barrier opening is mediated by tumor necrosis factor-alpha. Neurosci. Lett. 450, 172β175. 10.1016/j.neulet.2008.10.080.18983897 | β | β | β |
| QrunflehAM, AlaziziA, SariY, 2013 Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats. J. Psychopharmacol. 27, 541β549. 10.1177/0269881113482529.23518814PMC3657312 | β | β | β |
| QuelchDR, MickI, McGonigleJ, RamosAC, FlechaisRSA, BolstridgeM, RabinerE, WallMB, NewbouldRD, Steiniger-BrachB, van den BergF, BoyceM, Γstergaard NilausenD, SluthBreuning L., MeulienD, von der GoltzC, NuttD, Lingford-HughesA, 2017 Nalmefene reduces reward anticipation in alcohol dependence: an experimental functional magnetic resonance imaging study. Biol. Psychiatry 81, 941β948. 10.1016/j.biopsych.2016.12.029.28216062 | β | β | β |
| RaisonCL, RutherfordRE, WoolwineBJ, ShuoC, SchettlerP, DrakeDF, HaroonE, MillerAH, 2013 A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression. JAMA Psychiat. 70, 10.1001/2013.jamapsychiatry.4.PMC401534822945416 | β | β | β |
| RajkowskaG, StockmeierCA, 2013 Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr. Drug Targets 14, 1225β1236.2346992210.2174/13894501113149990156PMC3799810 | β | β | β |
| RalevskiE, Olivera-FigueroaLA, PetrakisI, 2014 PTSD and comorbid AUD: a review of pharmacological and alternative treatment options. Subst. Abus. Rehabil. 5, 25β36. 10.2147/SAR.S37399.PMC395303424648794 | β | β | β |
| RansohoffRM, 2016 A polarizing question: do M1 and M2 microglia exist? Nat. Neurosci. 19, 987β991. 10.1038/nn.4338.27459405 | β | β | β |
| RayLA, BujarskiS, ShoptawS, RocheDJ, HeinzerlingK, MiottoK, 2017 Development of the neuroimmune modulator Ibudilast for the treatment of alcoholism: a randomized, placebo-controlled, human laboratory trial. Neuropsychopharmacology 42, 1776β1788. 10.1038/npp.2017.10.28091532PMC5520778 | β | β | β |
| RobinsonG, MostD, FergusonLB, MayfieldJ, HarrisRA, BlednovYA, 2014 Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans. Int. Rev. Neurobiol. 118, 13β39. 10.1016/B978-0-12-801284-0.00002-6.25175860PMC4264574 | β | β | β |
| RohYS, SekiE, 2013 Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J. Gastroenterol. Hepatol. 28 (Suppl. 1), 38β42. 10.1111/jgh.12019.PMC372143023855294 | β | β | β |
| RollsA, ShechterR, LondonA, ZivY, RonenA, LevyR, SchwartzM, 2007 Toll-like receptors modulate adult hippocampal neurogenesis. Nat. Cell Biol. 9, 1081β1088. 10.1038/ncb1629.17704767 | β | β | β |
| Rubio-AraizA, PorcuF, PΓ©rez-HernΓ‘ndezM, GarcΓa-GutiΓ©rrezMS, Aracil-FernΓ‘ndezMA, Gutierrez-LΓ³pezMD, GuerriC, ManzanaresJ, OβSheaE, ColadoMI, 2016 Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model. Addict Biol. 10.1111/adb.12376.n/a-n/a.26949123 | β | β | β |
| RussoSJ, NestlerEJ, 2013 The brain reward circuitry in mood disorders. Nat. Rev. Neurosci. 14, 609β625. 10.1038/nrn3381.23942470PMC3867253 | β | β | β |
| SabaLM, FlinkSC, VanderlindenLA, IsraelY, TampierL, ColomboG, KiianmaaK, BellRL, PrintzMP, FlodmanP, KoobG, RichardsonHN, LombardoJ, HoffmanPL, TabakoffB, 2015 The sequenced rat brain transcriptomeβits use in identifying networks predisposing alcohol consumption. FEBS J. 282, 3556β3578. 10.1111/febs.13358.26183165PMC4573833 | β | β | β |
| SabaW, GoutalS, AuvityS, KuhnastB, CoulonC, KouyoumdjianV, BuvatI, LeroyC, TournierN, 2017 Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18 F-DPA-714. Addict. Biol. 23, 1000β1009. 10.1111/adb.12548.28944558 | β | β | β |
| SaizPA, Garcia-PortillaMP, FlorezG, CorcoranP, ArangoC, MoralesB, LezaJC, AlvarezS, DΓazEM, AlvarezV, CotoE, NogueirasL, BobesJ, 2009 Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study. Alcohol. Clin. Exp. Res. 33, 2147β2153. 10.1111/j.1530-0277.2009.01058.x.19764937 | β | β | β |
| SakataM, IshibashiK, ImaiM, WagatsumaK, IshiiK, HatanoK, IshiwataK, ToyoharaJ, 2017 Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers. EJNMMI Res. 7, 26 10.1186/s13550-017-0271-6.28337723PMC5364125 | β | β | β |
| SaladinME, BradyKT, DanskyBS, KilpatrickDG, 1995 Understanding comorbidity between ptsd and substance use disorders: two preliminary investigations. Addict. Behav. 20, 643β655. 10.1016/0306-4603(95)00024-7.8712061 | β | β | β |
| SalazarM, ParienteJA, SalidoGM, GonzΓ‘lezA, 2008 Ethanol induces glutamate secretion by Ca2+ mobilization and ROS generation in rat hippocampal astrocytes. Neurochem. Int. 52, 1061β1067. 10.1016/j.neuint.2007.11.001.18082912 | β | β | β |
| SariY, 2013 Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. OA Alcohol 1, 6.2440934410.13172/2053-0285-1-1-574PMC3883353 | β | β | β |
| SariY, SakaiM, WeedmanJM, RebecGV, BellRL, 2011 Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats. Alcohol Alcohol. 46, 239β246. 10.1093/alcalc/agr023.21422004PMC3104611 | β | β | β |
| SariY, ToalstonJE, RaoPSS, BellRL, 2016 Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Neuroscience 326, 117β125. 10.1016/j.neuroscience.2016.04.004.27060486PMC4853280 | β | β | β |
| SarrouilheD, MesnilM, DejeanC, 2018 Targeting gap junctions: new insights in the treatment of major depressive disorder. Curr. Med. Chem. 25, 1 10.2174/0929867325666180327103530.29589532 | β | β | β |
| SastreM, KlockgetherT, HenekaMT, 2006 Contribution of inflammatory processes to Alzheimerβs disease: molecular mechanisms. Int. J. Dev. Neurosci. 24, 167β176. 10.1016/j.ijdevneu.2005.11.014.16472958 | β | β | β |
| SatriotomoI, MikiT, ItohM, AmenoK, IjiriI, TakeuchiY, 2000 Short-term ethanol exposure alters calbindin D28k and glial fibrillary acidic protein immunoreactivity in hippocampus of mice. Brain Res. 879, 55β64.1101100610.1016/s0006-8993(00)02729-3 | β | β | β |
| SawayaBE, DeshmaneSL, MukerjeeR, FanS, KhaliliK, 2009 TNF alpha production in morphine-treated human neural cells is NF-kappaB-dependent. J. NeuroImmune Pharmacol. 4, 140β149. 10.1007/s11481-008-9137-z.19023660 | β | β | β |
| SchaferDP, LehrmanEK, KautzmanAG, KoyamaR, MardinlyAR, YamasakiR, RansohoffRM, GreenbergME, BarresBA, StevensB, 2012 Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691β705. 10.1016/j.neuron.2012.03.026.22632727PMC3528177 | β | β | β |
| SchipkeCG, HeuserI, PetersO, 2011 Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex. J. Psychiatr. Res. 45, 242β248. 10.1016/j.jpsychires.2010.06.005.20619420 | β | β | β |
| SchneiderH, PitossiF, BalschunD, WagnerA, del ReyA, BesedovskyHO, 1998 A neuromodulatory role of interleukin-1 in the hippocampus. Proc. Natl. Acad. Sci. U.S. A. 95, 7778β7783. 10.1073/pnas.95.13.7778.9636227PMC22755 | β | β | β |
| SchroederJA, TolmanNG, McKennaFF, WatkinsKL, PasseriSM, HsuAH, ShinnBR, RawlsSM, 2014 Clavulanic acid reduces rewarding, hyperthermic and locomotor-sensitizing effects of morphine in rats: a new indication for an old drug? Drug Alcohol Depend. 142, 41β45. 10.1016/j.drugalcdep.2014.05.012.24998018PMC4127119 | β | β | β |
| SchroederJR, PhillipsKA, EpsteinDH, JobesML, FurnariMA, KennedyAP, HeiligM, PrestonKL, 2018 Assessment of pioglitazone and proinflammatory cytokines during buprenorphine taper in patients with opioid use disorder. Psychopharmacology 235, 2957β2966. 10.1007/s00213-018-4986-5.30079432PMC7286070 | β | β | β |
| SchwarzJM, BilboSD, 2013 Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction. J. Neurosci. 33, 961β971. 10.1523/JNEUROSCI.2516-12.2013.23325235PMC3713715 | β | β | β |
| SchwarzJM, HutchinsonMR, BilboSD, 2011 Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. J. Neurosci. 31, 17835β17847. 10.1523/JNEUROSCI.3297-11.2011.22159099PMC3259856 | β | β | β |
| ScofieldMD, BogerHA, SmithRJ, LiH, HaydonPG, KalivasPW, 2015 Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking. Biol. Psychiatry 78, 441β451. 10.1016/j.biopsych.2015.02.016.25861696PMC4547911 | β | β | β |
| SekineY, OuchiY, SugiharaG, TakeiN, YoshikawaE, NakamuraK, IwataY, TsuchiyaKJ, SudaS, SuzukiK, KawaiM, TakebayashiK, YamamotoS, MatsuzakiH, UekiT, MoriN, GoldMS, CadetJL, 2008 Methamphetamine causes microglial activation in the brains of human abusers. J. Neurosci. 28, 5756β5761. 10.1523/JNEUROSCI.1179-08.2008.18509037PMC2491906 | β | β | β |
| ShenH-W, ScofieldMD, BogerH, HensleyM, KalivasPW, 2014 Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse. J. Neurosci. 34, 5649β5657. 10.1523/JNEUROSCI.4564-13.2014.24741055PMC3988415 | β | β | β |
| SimonssonP, HanssonE, AllingC, 1989 Ethanol potentiates serotonin stimulated inositol lipid metabolism in primary astroglial cell cultures. Biochem. Pharmacol. 38, 2801β2805.277530510.1016/0006-2952(89)90434-6 | β | β | β |
| SimpsonJE, WhartonSB, HeathPR, 2018 Immuno-laser-capture microdissection for the isolation of enriched glial populations from frozen post-mortem human brain. Methods Mol. Biol. 1723, 273β284. 10.1007/978-1-4939-7558-7_16.29344867 | β | β | β |
| SkaperSD, FacciL, ZussoM, GiustiP, 2018 An inflammation-centric view of neurological disease: beyond the neuron. Front. Cell. Neurosci. 12, 72 10.3389/fncel.2018.00072.29618972PMC5871676 | β | β | β |
| SkolnickP, DavisH, ArnelleD, DeaverD, 2014 Translational potential of naloxone and naltrexone as TLR4 antagonists. Trends Pharmacol. Sci. 35, 431β432. 10.1016/j.tips.2014.06.008.25109569 | β | β | β |
| SloanME, GowinJL, RamchandaniVA, HurdYL, Le FollB, 2017 The endocannabinoid system as a target for addiction treatment: trials and tribulations. Neuropharmacology 124, 73β83. 10.1016/j.neuropharm.2017.05.031.28564576 | β | β | β |
| SmithKL, JohnCS, SypekEI, ΓngΓΌrD, CohenBM, BarrySM, BechtholtAJ, 2014 Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice. Alcohol. Clin. Exp. Res. 38, 1307β1314. 10.1111/acer.12361.24655029 | β | β | β |
| SmithRS, 1991 The macrophage theory of depression. Med. Hypotheses 35, 298β306. 10.1016/0306-9877(91)90272-Z.β1943879 | β | β | β |
| SmithTL, NavratilovaE, 1999 Increased calcium/calmodulin protein kinase activity in astrocytes chronically exposed to ethanol: influences on glutamate transport. Neurosci. Lett. 269, 145β148.1045415310.1016/s0304-3940(99)00438-3 | β | β | β |
| SmithTL, NavratilovaE, 2003 The eff ect of ethanol exposure on mitogen-activated protein kinase activity and expression in cultured rat astrocytes. Neurosci. Lett. 341, 91β94.1268637310.1016/s0304-3940(03)00179-4 | β | β | β |
| SofroniewMV, 2015 Astrocyte barriers to neurotoxic inflammation. Nat. Rev. Neurosci. 16, 249β263. 10.1038/nrn3898.25891508PMC5253239 | β | β | β |
| SofuogluM, MooneyM, KostenT, WatersA, HashimotoK, 2011 Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans. Psychopharmacology 213, 61β68. 10.1007/s00213-010-2014-5.20838775PMC3014439 | β | β | β |
| SoronenP, MantereO, MelartinT, SuominenK, VuorilehtoM, RytsΓ€lΓ€H, ArvilommiP, HolmaI, HolmaM, JylhΓ€P, ValtonenHM, HaukkaJ, IsometsΓ€E, PaunioT, 2011 P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts. Am. J. Med. Genet. B Neuropsychiatr. Genet. 156B, 435β447. 10.1002/ajmg.b.31179.21438144 | β | β | β |
| SoykaM, 2015 Alcohol use disorders in opioid maintenance therapy: prevalence, clinical correlates and treatment. Eur. Addict. Res. 21, 78β87. 10.1159/000363232.25413371 | β | β | β |
| SrinivasanR, LuT-Y, ChaiH, XuJ, HuangBS, GolshaniP, CoppolaG, KhakhBS, 2016 New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo. Neuron 92, 1181β1195. 10.1016/j.neuron.2016.11.030.27939582PMC5403514 | β | β | β |
| StahreM, RoeberJ, KannyD, BrewerRD, ZhangX, 2014 Contribution of excessive alcohol consumption to deaths and years of potential life lost in the United States. Prev. Chronic Dis. 11, E109 10.5888/pcd11.130293.24967831PMC4075492 | β | β | β |
| SteinerJ, BielauH, BrischR, DanosP, UllrichO, MawrinC, BernsteinH-G, BogertsB, 2008 Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J. Psychiatr. Res. 42, 151β157. 10.1016/j.jpsychires.2006.10.013.17174336 | β | β | β |
| StellwagenD, MalenkaRC, 2006 Synaptic scaling mediated by glial TNF-alpha.Nature 440, 1054β1059. 10.1038/nature04671.16547515 | β | β | β |
| StopponiS, de GuglielmoG, SomainiL, CippitelliA, CannellaN, KallupiM, UbaldiM, HeiligM, DemopulosG, GaitanarisG, CiccocioppoR, 2013 Activation of PPARΞ³ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcohol. Clin. Exp. Res. 37, 1351β1360. 10.1111/acer.12091.23550625 | β | β | β |
| StopponiS, SomainiL, CippitelliA, CannellaN, BraconiS, KallupiM, RuggeriB, HeiligM, DemopulosG, GaitanarisG, MassiM, CiccocioppoR, 2011 Activation of nuclear PPARΞ³ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. Biol. Psychiatry 69, 642β649. 10.1016/j.biopsych.2010.12.010.21276964 | β | β | β |
| StreitWJ, 2002 Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40, 133β139. 10.1002/glia.10154.12379901 | β | β | β |
| SullivanLE, FiellinDA, OβConnorPG, 2005 The prevalence and impact of alcohol problems in major depression: a systematic review. Am. J. Med. 118, 330β341. 10.1016/j.amjmed.2005.01.007.15808128 | β | β | β |
| SunJ-D, LiuY, YuanY-H, LiJ, ChenN-H, 2012 Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. Neuropsychopharmacology 37, 1305β1320. 10.1038/npp.2011.319.22189291PMC3306892 | β | β | β |
| SureshchandraS, RaisM, StullC, GrantK, MessaoudiI, 2016 Transcriptome profiling reveals disruption of innate immunity in chronic heavy ethanol consuming female rhesus macaques. PLoS One 11, e0159295 10.1371/journal.pone.0159295.27427759PMC4948771 | β | β | β |
| SzuJI, BinderDK, 2016 The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory. Front. Integr. Neurosci. 10, 8 10.3389/fnint.2016.00008.26941623PMC4764708 | β | β | β |
| TajuddinN, KimH-Y, CollinsMA, 2018 PARP inhibition prevents ethanol-induced neuroinflammatory signaling and neurodegeneration in rat adult-age brain slice cultures. J. Pharmacol. Exp. Ther. 365, 117β126. 10.1124/jpet.117.245290.29339456PMC5830636 | β | β | β |
| TandaG, MereuM, HiranitaT, QuartermanJC, CoggianoM, KatzJL, 2016 Lack of specific involvement of (+)-naloxone and (+)-naltrexone on the reinforcing and neurochemical effects of cocaine and opioids. Neuropsychopharmacology 41, 2772β2781. 10.1038/npp.2016.91.27296151PMC5026747 | β | β | β |
| TangY, LeW, 2016 Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol. Neurobiol. 53, 1181β1194. 10.1007/s12035-014-9070-5.25598354 | β | β | β |
| TaylorAMW, CastonguayA, GhoghaA, VayssiereP, PradhanAAA, XueL, MehrabaniS, WuJ, LevittP, OlmsteadMC, De KoninckY, EvansCJ, CahillCM, 2016 Neuroimmune regulation of GABAergic neurons within the ventral tegmental area during withdrawal from chronic morphine. Neuropsychopharmacology 41, 949β959. 10.1038/npp.2015.221.26202104PMC4748420 | β | β | β |
| TerritoPR, MeyerJA, PetersJS, RileyAA, McCarthyBP, GaoM, WangM, GreenMA, ZhengQ-H, HutchinsGD, 2017 Characterization of11C-GSK1482160 for targeting the P2X7 receptor as a biomarker for neuroinflammation. J. Nucl. Med. 58, 458β465. 10.2967/jnumed.116.181354.27765863 | β | β | β |
| ThebergeFR, LiX, KambhampatiS, PickensCL, St LaurentR, BossertJM, , 2013 Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biol. Psychiatry 73 (8), 729β737. 10.1016/j.biopsych.2012.12.019.23384483PMC3615146 | β | β | β |
| TheodosisDT, PoulainDA, OlietSHR, 2008 Activity-dependent structural and functional plasticity of astrocyte-neuron interactions. Physiol. Rev. 88, 983β1008. 10.1152/physrev.00036.2007.18626065 | β | β | β |
| TilleuxS, HermansE, 2007 Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J. Neurosci. Res. 85, 2059β2070. 10.1002/jnr.21325.17497670 | β | β | β |
| TonelliLH, PostolacheTT, SternbergEM, 2005 Inflammatory genes and neural activity: involvement of immune genes in synaptic function and behavior. Front. Biosci. 10, 675β680.1556960810.2741/1562 | β | β | β |
| TongX, AoY, FaasGC, NwaobiSE, XuJ, HausteinMD, AndersonMA, ModyI, OlsenML, SofroniewMV, KhakhBS, 2014 Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntingtonβs disease model mice. Nat. Neurosci. 17, 694β703. 10.1038/nn.3691.24686787PMC4064471 | β | β | β |
| TruittJM, BlednovYA, BenavidezJM, BlackM, PonomarevaO, LawJ, MerrimanM, HoraniS, JamesonK, LasekAW, HarrisRA, MayfieldRD, 2016 Inhibition of IKKΞ² reduces ethanol consumption in C57BL/6J mice. eNeuro 3 10.1523/ENEURO.0256-16.2016.PMC508679927822501 | β | β | β |
| TursichM, NeufeldRWJ, FrewenPA, HarricharanS, KiblerJL, RhindSG, LaniusRA, 2014 Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis. Transl. Psychiatry 4, e413 10.1038/tp.2014.56.25050993PMC4119223 | β | β | β |
| ValentaJP, GonzalesRA, 2016 Chronic intracerebroventricular infusion of monocyte chemoattractant protein-1 leads to a persistent increase in sweetened ethanol consumption during operant self-administration but does not influence sucrose consumption in long-Evans rats. Alcohol. Clin. Exp. Res. 40, 187β195. 10.1111/acer.12928.26683974PMC4701601 | β | β | β |
| VasileF, DossiE, RouachN, 2017 Human astrocytes: structure and functions in the healthy brain. Brain Struct. Funct. 327, 1250 10.1007/s00429-017-1383-5.PMC550425828280934 | β | β | β |
| Veiga-FernandesH, ArtisD, 2018 Neuronal-immune system cross-talk in homeostasis. Science 359, 1465β1466. 10.1126/science.aap9598.29599230 | β | β | β |
| VelaJM, Molina-HolgadoE, ArΓ©valo-MartΓnA, AlmazΓ‘nG, GuazaC, 2002 Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol. Cell. Neurosci. 20, 489β502.1213992410.1006/mcne.2002.1127 | β | β | β |
| VerkhratskyA, NedergaardM, HertzL, 2015 Why are astrocytes important? Neurochem. Res. 40, 389β401. 10.1007/s11064-014-1403-2.25113122 | β | β | β |
| VivashL, OBrienTJ, 2016 Imaging microglial activation with TSPO PET: lighting up neurologic diseases? J. Nucl. Med. 57, 165β168. 10.2967/jnumed.114.141713.26697963 | β | β | β |
| WalterTJ, CrewsFT, 2017 Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal. J. Neuroinflammation 14, 86 10.1186/s12974-017-0856-z.28427424PMC5439231 | β | β | β |
| WalterTJ, VetrenoRP, CrewsFT, 2017 Alcohol and stress activation of microglia and neurons: brain regional effects. Alcohol. Clin. Exp. Res. 41, 2066β2081. 10.1111/acer.13511.28941277PMC5725687 | β | β | β |
| WangX, LoramLC, RamosK, de JesusAJ, ThomasJ, ChengK, ReddyA, SomogyiAA, HutchinsonMR, WatkinsLR, YinH, 2012 Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc. Natl. Acad. Sci. U. S. A. 109, 6325β6330. 10.1073/pnas.1200130109.22474354PMC3341002 | β | β | β |
| WangX, ZhangY, PengY, HutchinsonMR, RiceKC, YinH, WatkinsLR, 2016 Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4. Br. J. Pharmacol. 173, 856β869. 10.1111/bph.13394.26603732PMC4761092 | β | β | β |
| WangZ, CaughronB, YoungMRI, 2017 Posttraumatic stress disorder: an immunological disorder? Front. Psych. 8, 222 10.3389/fpsyt.2017.00222.PMC568148329163241 | β | β | β |
| WardenA, TruittJ, MerrimanM, PonomarevaO, JamesonK, FergusonLB, MayfieldRD, HarrisRA, 2016 Localization of PPAR isotypes in the adult mouse and human brain. Sci. Rep. 6, 27618 10.1038/srep27618.27283430PMC4901333 | β | β | β |
| WeiJ, PanX, PeiZ, WangW, QiuW, ShiZ, XiaoG, 2012 The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury. J. Trauma Acute Care Surg. 73, 654β660. 10.1097/TA.0b013e31825133c0.22710775 | β | β | β |
| WeilandA, GarciaS, KnackstedtLA, 2015 Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Front. Pharmacol. 6, 4049 10.3389/fphar.2015.00044.PMC435433325805996 | β | β | β |
| WelshJW, KnightJR, HouSS-Y, MalowneyM, SchramP, SherrittL, BoydJW, 2017 Association between substance use diagnoses and psychiatric disorders in an adolescent and young adult clinic-based population. J. Adolesc. Health 60, 648β652. 10.1016/j.jadohealth.2016.12.018.28202303 | β | β | β |
| WenR-T, ZhangF-F, ZhangH-T, 2018 Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder. Psychopharmacology 235, 1793β1805. 10.1007/s00213-018-4895-7.29663017PMC5949271 | β | β | β |
| WenR-T, ZhangM, QinW-J, LiuQ, WangW-P, LawrenceAJ, ZhangH-T, LiangJ-H, 2012 The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases ethanol seeking and consumption in alcohol-preferring Fawn-Hooded rats. Alcohol. Clin. Exp. Res. 36, 2157β2167. 10.1111/j.1530-0277.2012.01845.x.22671516PMC4335658 | β | β | β |
| WesPD, HoltmanIR, BoddekeEWGM, MΓΆllerT, EggenBJL, 2016 Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease. Glia 64, 197β213. 10.1002/glia.22866.26040959 | β | β | β |
| WhitmanBA, KnappDJ, WernerDF, CrewsFT, BreeseGR, 2013 The cytokine mRNA increase induced by withdrawal from chronic ethanol in the sterile environment of brain is mediated by CRF and HMGB1 release. Alcohol. Clin. Exp. Res. 37, 2086β2097. 10.1111/acer.12189.23895427PMC3815509 | β | β | β |
| WilhelmCJ, HashimotoJG, RobertsML, BloomSH, AndrewMR, WirenKM, 2015 Astrocyte dysfunction induced by alcohol in females but not males. Brain Pathol. 26, 433β451. 10.1111/bpa.12276.26088166PMC8028916 | β | β | β |
| WitkiewitzK, VowlesKE, 2018 Alcohol and opioid use, co-use, and chronic pain in the context of the opioid epidemic: a critical review. Alcohol. Clin. Exp. Res. 42, 478β488. 10.1111/acer.13594.29314075PMC5832605 | β | β | β |
| WohlebES, 2016 Neuron-microglia interactions in mental health disorders: βfor better, and for worseβ. Front. Immunol. 7, 544 10.3389/fimmu.2016.00544.27965671PMC5126117 | β | β | β |
| WojnarM, IlgenMA, JakubczykA, WnorowskaA, KlimkiewiczA, BrowerKJ, 2008 Impulsive suicide attempts predict post-treatment relapse in alcohol-dependent patients. Drug Alcohol Depend. 97, 268β275. 10.1016/j.drugalcdep.2008.04.006.18556146PMC3006072 | β | β | β |
| WorleyMJ, HeinzerlingKG, RocheDJO, ShoptawS, 2016 Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study. Drug Alcohol Depend. 162, 245β250. 10.1016/j.drugalcdep.2016.02.036.26993372PMC5349508 | β | β | β |
| WuYue, LousbergEL, MoldenhauerLM, HayballJD, RobertsonSA, CollerJK, WatkinsLR, SomogyiAA, HutchinsonMR, 2011 Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain Behav. Immun. 25 (Suppl. 1), S155βS164. 10.1016/j.bbi.2011.01.012.21276848 | β | β | β |
| WuYuwen, Dissing-OlesenL, MacVicarBA, StevensB, 2015 Microglia: dynamic mediators of synapse development and plasticity. Trends Immunol. 36, 605β613. 10.1016/j.it.2015.08.008.26431938PMC4841266 | β | β | β |
| YangL, QiY, YangY, 2015 Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors. Cell Rep. 11, 798β807. 10.1016/j.celrep.2015.04.002.25921535 | β | β | β |
| YirmiyaR, GoshenI, 2011 Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav. Immun. 25, 181β213. 10.1016/j.bbi.2010.10.015.20970492 | β | β | β |
| YuM, WangH, DingA, GolenbockDT, LatzE, CzuraCJ, FentonMJ, TraceyKJ, YangH, 2006 HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 26, 174β179. 10.1097/01.shk.0000225404.51320.82.16878026 | β | β | β |
| ZamanianJL, XuL, FooLC, NouriN, ZhouL, GiffardRG, BarresBA, 2012 Genomic analysis of reactive astrogliosis. J. Neurosci. 32, 6391β6410. 10.1523/JNEUROSCI.6221-11.2012.22553043PMC3480225 | β | β | β |
| ZebdaR, PallerAS, 2018 Phosphodiesterase 4 inhibitors. J. Am. Acad. Dermatol. 78, S43βS52. 10.1016/j.jaad.2017.11.056.29248522 | β | β | β |
| ZhangX, WangH, YinP, FanH, SunL, LiuY, 2017 Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. Lipids Health Dis. 16, 2223 10.1186/s12944-017-0431-8.PMC532264328228158 | β | β | β |
| ZhangY, LiH, LiY, SunX, ZhuM, HanleyG, LeSageG, YinD, 2011 Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice. Neurosci. Lett. 489, 43β47. 10.1016/j.neulet.2010.11.063.21130144PMC3018547 | β | β | β |
| ZhanY, PaolicelliRC, SforazziniF, WeinhardL, BolascoG, PaganiF, VyssotskiAL, BifoneA, GozziA, RagozzinoD, GrossCT, 2014 Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat. Neurosci. 17, 400β406. 10.1038/nn.3641.24487234 | β | β | β |
| ZhaoY-N, WangF, FanY-X, PingG-F, YangJ-Y, WuC-F, 2013 Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure. Behav. Brain Res. 236, 270β282. 10.1016/j.bbr.2012.08.052.22985845 | β | β | β |
| ZhongP, WangW, YuF, NazariM, LiuX, LiuQ-S, 2012 Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology 37, 2377β2387. 10.1038/npp.2012.93.22713909PMC3442353 | β | β | β |
| ZhuR, BuQ, FuD, ShaoX, JiangL, GuoW, ChenB, LiuB, HuZ, TianJ, ZhaoY, CenX, 2018 Toll-like receptor 3 modulates the behavioral effects of cocaine in mice. J. Neuroinflammation 15, 93 10.1186/s12974-018-1130-8.29571298PMC5865345 | β | β | β |
| ZouJ, CrewsF, 2010 Induction of innate immune gene expression cascades in brain slice cultures by ethanol: key role of NF-ΞΊB and proinflammatory cytokines. Alcohol. Clin. Exp. Res. 34, 777β789. 10.1111/j.1530-0277.2010.01150.x.20201932 | β | β | β |
| ZouJY, CrewsFT, 2014 Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. PLoS One 9, e87915 10.1371/journal.pone.0087915.24551070PMC3925099 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| RNA alternative splicing impacts the risk for alcohol use disorder. | 2023 | 37217680 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Astrocytes and Alcohol Throughout the Lifespan. | Guizzetti M et al. | β | 2026 | β |
| Chronic alcohol consumption sex-dependently affects IL-6 modulation of GABAergic synapses in the central amygdala of rhesus macaques. | Bajo M et al. | β | 2026 | β |
| Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder. | Crews FT et al. | β | 2026 | β |
| Early abstinence in severe alcohol use disorder: MCP-1 decline, choroid plexus shrinkage, and region-specific grey-matter volume changes. | Petit G et al. | β | 2026 | β |
| Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model. | Boreland AJ et al. | β | 2026 | β |
| Glia in the Spotlight: The Cellular Basis of Alcohol Use Disorder. | Codeluppi-Arrowsmith SA et al. | β | 2026 | β |
| Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder. | Warden AS et al. | β | 2026 | β |
| Phase-dependent cytokine signatures in alcohol use disorder: A systematic review of psychoneuroimmune links to withdrawal severity and return to drinking. | Sokolova S et al. | β | 2026 | β |
| Quantification of the neuropathology of alcohol use disorder using tissue microarrays. | Liu J et al. | β | 2026 | β |
| Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice. | Garcia-Rivas V et al. | β | 2025 | β |
| Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents. | Sommer WH et al. | β | 2025 | β |
| Alcohol-Induced Oxidative Stress and Gut-Liver-Brain Crosstalk: Expanding the Paradigm from ALD to MetALD. | Lee JY et al. | β | 2025 | β |
| Alcohol Preference Impacts Multi-Organ Transcriptome in MetALD. | Sikhwal S et al. | β | 2025 | β |
| Alcohol Use Disorder and the Gut-Brain Axis: A Narrative Review of the Role of Gut Microbiota and Implications for Treatment. | Shukla S et al. | β | 2025 | β |
| A Neuroimmune Modulator for Alcohol Use Disorder: A Randomized Clinical Trial. | Ray LA et al. | β | 2025 | β |
| A single-cell genomic atlas for the effects of chronic ethanol exposure in the mouse dorsal striatum. | Wildermuth E et al. | β | 2025 | β |
| Binge alcohol and the neuroendocrinology of the aging female. | Leasure JL et al. | β | 2025 | β |
| Combined stress and alcohol exposure: Synergistic effects on alcohol-seeking behaviors and neuroinflammation. | Wills LJ et al. | β | 2025 | β |
| Ethanol modulates astrocyte activation and neuroinflammation via miR-339/NLRP6 inflammasome signaling. | Singh S et al. | β | 2025 | β |
| Excessive Alcohol Use as a Risk Factor for Alzheimer's Disease: Epidemiological and Preclinical Evidence. | Anton PE et al. | β | 2025 | β |
| Exploring the Immunomodulatory Role of Forkhead Box Protein 3 (FOXP3) in the Pathophysiology of Neuropsychiatric Disorders. | Mohan M et al. | β | 2025 | β |
| Gut Microbiome-Liver-Brain axis in Alcohol Use Disorder. The role of gut dysbiosis and stress in alcohol-related cognitive impairment progression: possible therapeutic approaches. | Pich EM et al. | β | 2025 | β |
| Identification of Interleukin-1Ξ² in Whole Blood as a Candidate Biomarker for Alcohol Use Disorder Risk Based on AUDIT Scores. | Balan I et al. | β | 2025 | β |
| Impact of Omega-3 Polyunsaturated Fatty Acids on Alcohol Use and Negative Consequences: A Systematic Review. | Cardona D et al. | β | 2025 | β |
| Investigating Therapeutic Targets for Alcohol Use Disorder: Pharmacological View of ClinicalTrials.gov Data. | Alorfi NM | β | 2025 | β |
| Mechanisms Underlying Hazardous Alcohol Use After Mild Traumatic Brain Injury. | Patarino M et al. | β | 2025 | β |
| Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models. | Hitzemann R et al. | β | 2025 | β |
| Molecular mechanisms of 10-butyl ether minocycline, a novel nonantibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders. | Shaik AA et al. | β | 2025 | β |
| Naltrexone Alters Neurochemical and Behavioral Parameters in a Zebrafish Model of Repeated Alcohol Exposure. | Bernardo HT et al. | β | 2025 | β |
| Neuroimmune regulation of the prefrontal cortex tetrapartite synapse. | Liss A et al. | β | 2025 | β |
| New insights into the molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease. | Diaz LA et al. | β | 2025 | β |
| Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: AΒ critical review. | Clark SL et al. | β | 2025 | β |
| Nutritional and Psychological Support as a Multidisciplinary Coordinated Approach in the Management of Chronic Liver Disease: A Scoping Review. | Romeo M et al. | β | 2025 | β |
| Prolonged drinking in the dark in adult female mice attenuates the central and peripheral cytokine response to lipopolysaccharide. | Singleton LG et al. | β | 2025 | β |
| Shaken and stirred: Stress and alcohol are a potent mix driving behavior and neuroinflammation. | Schank JR et al. | β | 2025 | β |
| The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation. | Gil de Biedma-Elduayen L et al. | β | 2025 | β |
| Variations in alcohol craving and negative mood during a clinical trial of ibudilast for alcohol use disorder. | Meredith LR et al. | β | 2025 | β |
| Adolescent alcohol drinking interaction with the gut microbiome: implications for adult alcohol use disorder. | Getachew B et al. | β | 2024 | β |
| Adolescent intermittent ethanol (AIE) sensitized fever in male Sprague Dawley rats exposed to poly I:C in adulthood. | Gano A et al. | β | 2024 | β |
| Alcohol, HMGB1, and Innate Immune Signaling in the Brain. | Crews FT et al. | β | 2024 | β |
| A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder. | Xiao T et al. | β | 2024 | β |
| Association of Peripheral Markers of Oxidative Stress with Clinical Parameters and Inflammatory Factors in Alcoholic Patients. | Prokopieva VD et al. | β | 2024 | β |
| Divergent gene expression patterns in alcohol and opioid use disorders lead to consistent alterations in functional networks within the dorsolateral prefrontal cortex. | MacDonald M et al. | β | 2024 | β |
| Divergent Roles of APOAI and APOM in the Identification of Alcohol Use Disorder and Their Association With Inflammation and Cognitive Decline: A Pilot Study. | Escudero B et al. | β | 2024 | β |
| Does sex moderate the effects of early life stress on peripheral inflammation in alcohol use disorder? A preliminary investigation. | Kirsch DE et al. | β | 2024 | β |
| Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder. | Kirsch DE et al. | β | 2024 | β |
| Ginsenoside Rg1 ameliorates cerebral ischemia-reperfusion injury by regulating Pink1/ Parkin-mediated mitochondrial autophagy and inhibiting microglia NLRP3 activation. | Sui C et al. | β | 2024 | β |
| Hippocampal gray matter volume in young adulthood varies with adolescent alcohol use. | Purcell JB et al. | β | 2024 | β |
| Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease. | He YX et al. | β | 2024 | β |
| Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database. | Ugiliweneza B et al. | β | 2024 | β |
| Influence of sex and liver cirrhosis on the expression of miR-146a-5p and its target genes, IRAK1 and TRAF6. | Naidu C et al. | β | 2024 | β |
| Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice. | Dilly GA et al. | β | 2024 | β |
| Lactobacillusβrhamnosus GG attenuates depression-like behaviour and cognitive deficits in chronic ethanol exposure mice by down-regulating systemic inflammatory factors. | Pan X et al. | β | 2024 | β |
| Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice. | Kang S et al. | β | 2024 | β |
| Microglia activity in the human basal ganglia is altered in alcohol use disorder and reversed with remission from alcohol. | Rasool AE et al. | β | 2024 | β |
| Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets. | Aguilar JS et al. | β | 2024 | β |
| Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study. | Ho MF et al. | β | 2024 | β |
| Novel medications for problematic alcohol use. | Heilig M et al. | β | 2024 | β |
| Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. | Li X et al. | β | 2024 | β |
| Toll-like receptor 7: A novel neuroimmune target to reduce excessive alcohol consumption. | Allard RL et al. | β | 2024 | β |
| Acute and Chronic Ethanol Effects during Adolescence on Neuroimmune Responses: Consequences and Potential Pharmacologic Interventions. | Nwachukwu KN et al. | β | 2023 | β |
| Acute Ethanol Modulates Synaptic Inhibition in the Basolateral Amygdala via Rapid NLRP3 Inflammasome Activation and Regulates Anxiety-Like Behavior in Rats. | Munshi S et al. | β | 2023 | β |
| Animal model for high consumption and preference of ethanol and its interplay with high sugar and butter diet, behavior, and neuroimmune system. | Moreira-JΓΊnior RE et al. | β | 2023 | β |
| A review on the reciprocal interactions between neuroinflammatory processes and substance use and misuse, with a focus on alcohol misuse. | Gano A et al. | β | 2023 | β |
| A whole exome sequencing study to identify rare variants in multiplex families with alcohol use disorder. | Hill SY et al. | β | 2023 | β |
| Brain proteomic atlas of alcohol use disorder in adult males. | Teng PN et al. | β | 2023 | β |
| Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain. | Dugan MP et al. | β | 2023 | β |
| Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder. | Xiao T et al. | β | 2023 | β |
| Conserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure. | Carvalho L et al. | β | 2023 | β |
| Differential Effects of Nicotine, Alcohol, and Coexposure on Neuroimmune-Related Protein and Gene Expression in Corticolimbic Brain Regions of Rats. | Randall CA et al. | β | 2023 | β |
| Effects of comorbid alcohol use disorder on bipolar disorder: Focusing on neurocognitive function and inflammatory markers. | Liou YJ et al. | β | 2023 | β |
| <i>Drosophila</i> Stat92E Signaling Following Pre-exposure to Ethanol. | Wilson A et al. | β | 2023 | β |
| Imaging the brain's immune response to alcohol with [<sup>11</sup>C]PBR28 TSPO Positron Emission Tomography. | Raval NR et al. | β | 2023 | β |
| Impact of Elevated Brain IL-6 in Transgenic Mice on the Behavioral and Neurochemical Consequences of Chronic Alcohol Exposure. | Gruol DL et al. | β | 2023 | β |
| Intermittent Exposure to a Single Bottle of Ethanol Modulates Stress Sensitivity: Impact of Age at Exposure Initiation. | Marsland P et al. | β | 2023 | β |
| Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. | Guo ML et al. | β | 2023 | β |
| Neuroimmune interactions with binge alcohol drinking in the cerebellum of IL-6 transgenic mice. | Gruol DL et al. | β | 2023 | β |
| Neuroimmune pathways as targets to reduce alcohol consumption. | Grantham EK et al. | β | 2023 | β |
| Neuropharmacology of Alcohol Addiction with Special Emphasis on Proteomic Approaches for Identification of Novel Therapeutic Targets. | Ray SK et al. | β | 2023 | β |
| Prevalence of co-occurring severe depression and psychotic symptoms in college students and its relationship with childhood maltreatment. | Zhang Y et al. | β | 2023 | β |
| RNA alternative splicing impacts the risk for alcohol use disorder. | Li R et al. | β | 2023 | β |
| Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study. | McGregor R et al. | β | 2023 | β |
| Sex-dependent factors of alcohol and neuroimmune mechanisms. | Cruz B et al. | β | 2023 | β |
| Sex-specific differences in alcohol-induced pain sensitization. | Alexander SN et al. | β | 2023 | β |
| Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents. | Zhou C et al. | β | 2023 | β |
| Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood. | Crews FT et al. | β | 2023 | β |
| The Disease Model of Addiction: The Impact of Genetic Variability in the Oxidative Stress and Inflammation Pathways on Alcohol Dependance and Comorbid Psychosymptomatology. | Tsermpini EE et al. | β | 2023 | β |
| The Effect of Very-Long-Chain <i>n</i>-3 Polyunsaturated Fatty Acids in the Central Nervous System and Their Potential Benefits for Treating Alcohol Use Disorder: Reviewing Pre-Clinical and Clinical Data. | Carvajal F et al. | β | 2023 | β |
| The neuroimmune system - Where aging and excess alcohol intersect. | Carlson ER et al. | β | 2023 | β |
| Toll-like receptor 3 neuroimmune signaling and behavior change: A strain comparison between Lewis and Wistar rats. | Giffin KA et al. | β | 2023 | β |
| Adolescent neuroimmune function and its interaction with alcohol. | Doremus-Fitzwater TL et al. | β | 2022 | β |
| Alterations and correlations of gut microbiota, fecal, and serum metabolome characteristics in a rat model of alcohol use disorder. | Wang X et al. | β | 2022 | β |
| A Non-Nuclear NF-ΞΊB Modulates Alcohol Sensitivity But Not Immunity. | Wijesekera TP et al. | β | 2022 | β |
| A Scientometric Visualization Analysis for Molecular Mechanisms of Substance Abuse and Its Neurotoxicity From 1997 to 2021. | Zhang A et al. | β | 2022 | β |
| Astrogliosis and compensatory neurogenesis after the first ethanol binge drinking-like exposure in the adolescent rat. | Vilpoux C et al. | β | 2022 | β |
| Blocking of P2X7r Reduces Mitochondrial Stress Induced by Alcohol and Electronic Cigarette Exposure in Brain Microvascular Endothelial Cells. | Mekala N et al. | β | 2022 | β |
| Blood and brain gene expression signatures of chronic intermittent ethanol consumption in mice. | Ferguson LB et al. | β | 2022 | β |
| Brain gene expression differences related to ethanol preference in the collaborative cross founder strains. | Anderson JQ et al. | β | 2022 | β |
| Central role of intestinal epithelial glucocorticoid receptor in alcohol- and corticosterone-induced gut permeability and systemic response. | Shukla PK et al. | β | 2022 | β |
| Chronic ethanol consumption exacerbates future stress-enhanced fear learning, an effect mediated by dorsal hippocampal astrocytes. | Barkell GA et al. | β | 2022 | β |
| Circulating corticosterone levels mediate the relationship between acute ethanol intoxication and markers of NF-ΞΊB activation in male rats. | Barney TM et al. | β | 2022 | β |
| Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder? | Olsen CM et al. | β | 2022 | β |
| Epigenome-wide association study of alcohol use disorder in five brain regions. | Zillich L et al. | β | 2022 | β |
| Ibudilast moderates the effect of mood on alcohol craving during stress exposure. | Meredith LR et al. | β | 2022 | β |
| Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats. | Lovelock DF et al. | β | 2022 | β |
| Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification. | Huang MC et al. | β | 2022 | β |
| Innate immune activation: Parallels in alcohol use disorder and Alzheimer's disease. | Ramos A et al. | β | 2022 | β |
| Knowledge atlas of the involvement of glutamate and GABA in alcohol use disorder: A bibliometric and scientometric analysis. | Wang Z et al. | β | 2022 | β |
| Plasma tau, NfL, GFAP and UCHL1 as candidate biomarkers of alcohol withdrawal-associated brain damage: A pilot study. | Clergue-Duval V et al. | β | 2022 | β |
| Prevention and mitigation of alcohol-induced neuroinflammation by <i>Lactobacillus plantarum</i> by an EGF receptor-dependent mechanism. | Shukla PK et al. | β | 2022 | β |
| Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry. | Borrego MB et al. | β | 2022 | β |
| RNA biomarkers for alcohol use disorder. | Ferguson LB et al. | β | 2022 | β |
| Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder. | Hitzemann R et al. | β | 2022 | β |
| Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking. | Gao L et al. | β | 2022 | β |
| Synaptic effects of IL-1Ξ² and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques. | Patel RR et al. | β | 2022 | β |
| Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression. | Grigsby K et al. | β | 2022 | β |
| The effect of neuroimmune modulation on subjective response to alcohol in the natural environment. | Meredith LR et al. | β | 2022 | β |
| Translational Structural and Functional Signatures of Chronic Alcohol Effects in Mice. | Degiorgis L et al. | β | 2022 | β |
| Alcohol-Induced Blood-Brain Barrier Impairment: An In Vitro Study. | Carrino D et al. | β | 2021 | β |
| Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer's Disease. | LeΓ³n BE et al. | β | 2021 | β |
| Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation. | Israel Y et al. | β | 2021 | β |
| Binge-like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex. | Hamada K et al. | β | 2021 | β |
| Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain. | Guo F et al. | β | 2021 | β |
| Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis. | Shukla PK et al. | β | 2021 | β |
| Chronic Voluntary Alcohol Drinking Causes Anxiety-like Behavior, Thiamine Deficiency, and Brain Damage of Female Crossed High Alcohol Preferring Mice. | Xu H et al. | β | 2021 | β |
| Clinical Neuroscience of Addiction: What Clinical Psychologists Need to Know and Why. | Ray LA et al. | β | 2021 | β |
| Contribution of TSPO imaging in the understanding of the state of gliosis in substance use disorders. | Leroy C et al. | β | 2021 | β |
| Cortical astrocytes regulate ethanol consumption and intoxication in mice. | Erickson EK et al. | β | 2021 | β |
| Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice. | Blednov YA et al. | β | 2021 | β |
| Immune treatments for alcohol use disorder: A translational framework. | Meredith LR et al. | β | 2021 | β |
| Impact of Alcohol Abuse on Susceptibility to Rare Neurodegenerative Diseases. | Araujo I et al. | β | 2021 | β |
| Increased Toll-like Receptor-MyD88-NFΞΊB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder. | Vetreno RP et al. | β | 2021 | β |
| Inflammatory Biomarkers in Addictive Disorders. | Morcuende A et al. | β | 2021 | β |
| Loss of Basal Forebrain Cholinergic Neurons Following Adolescent Binge Ethanol Exposure: Recovery With the Cholinesterase Inhibitor Galantamine. | Crews FT et al. | β | 2021 | β |
| Mechanistic insights into the efficacy of memantine in treating certain drug addictions. | Montemitro C et al. | β | 2021 | β |
| Nalmefene alleviates the neuroimmune response to repeated binge-like ethanol exposure: A TSPO PET imaging study in adolescent rats. | Tournier N et al. | β | 2021 | β |
| Neuroepigenetic consequences of adolescent ethanol exposure. | Brocato E et al. | β | 2021 | β |
| Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice. | GonzΓ‘lez-Portilla M et al. | β | 2021 | β |
| Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking. | Melbourne JK et al. | β | 2021 | β |
| Quantitative evidence of suppressed TMEM119 microglial immunohistochemistry in fatal morphine intoxications. | Bohnert S et al. | β | 2021 | β |
| Reduced alcohol use in patients prescribed pioglitazone. | Dieperink E et al. | β | 2021 | β |
| Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders. | Sagheddu C et al. | β | 2021 | β |
| Role of cannabinoids in alcohol-induced neuroinflammation. | GarcΓa-Baos A et al. | β | 2021 | β |
| Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains. | Jimenez Chavez CL et al. | β | 2021 | β |
| Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain. | Aranda J et al. | β | 2021 | β |
| The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathology: A role for the neuroimmune system and epigenetics. | Coleman LG et al. | β | 2021 | β |
| Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure. | Chen WY et al. | β | 2021 | β |
| Alcohol Causes Lasting Differential Transcription in <i>Drosophila</i> Mushroom Body Neurons. | Petruccelli E et al. | β | 2020 | β |
| Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling. | Blednov YA et al. | β | 2020 | β |
| Atrial natriuretic peptide (ANP): A novel mechanism for reducing ethanol consumption and seeking behaviors in female alcohol preferring (P) rats. | Hauser SR et al. | β | 2020 | β |
| Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46. | Walter NAR et al. | β | 2020 | β |
| Curcumin treatment attenuates alcohol-induced alterations in a mouse model of foetal alcohol spectrum disorders. | Cantacorps L et al. | β | 2020 | β |
| Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. | Socodato R et al. | β | 2020 | β |
| Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication. | Ozburn AR et al. | β | 2020 | β |
| Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice. | Grigsby KB et al. | β | 2020 | β |
| Gut Microbiota-Induced Changes in Ξ²-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. | Leclercq S et al. | β | 2020 | β |
| Lingering Effects of Prenatal Alcohol Exposure on Basal and Ethanol-Evoked Expression of Inflammatory-Related Genes in the CNS of Adolescent and Adult Rats. | Doremus-Fitzwater TL et al. | β | 2020 | β |
| Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. | Warden AS et al. | β | 2020 | β |
| Phenotyping CCL2 Containing Central Amygdala Neurons Controlling Alcohol Withdrawal-Induced Anxiety. | Harper KM et al. | β | 2020 | β |
| Role of toll-like receptor 7 (TLR7) in voluntary alcohol consumption. | Grantham EK et al. | β | 2020 | β |
| Therapeutic Potential of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists in Substance Use Disorders: A Synthesis of Preclinical and Human Evidence. | Matheson J et al. | β | 2020 | β |
| Toll-Like Receptor 4 Signaling and Drug Addiction. | Wu R et al. | β | 2020 | β |
| Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder. | Alvarez Cooper I et al. | β | 2020 | β |
| Alcohol causes lasting differential transcription in<i>Drosophila</i>mushroom body neurons | Petruccelli E et al. | β | 2019 | β |
| A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder. | Ferguson LB et al. | β | 2019 | β |
| Cannabis and Alcohol: From Basic Science to Public Policy. | Chung T et al. | β | 2019 | β |
| From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan. | Perkins AE et al. | β | 2019 | β |
| GABA<sub>A</sub>R Ξ±2-activated neuroimmune signal controls binge drinking and impulsivity through regulation of the CCL2/CX3CL1 balance. | Aurelian L et al. | β | 2019 | β |
| Glial gene networks associated with alcohol dependence. | Erickson EK et al. | β | 2019 | β |
| Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders. | Melbourne JK et al. | β | 2019 | β |