Estimation of the multiple testing burden for genomewide association studies of nearly all common variants.
paper
Cited
Public
Unavailable
- Authors
- Pe'er, Itsik; Yelensky, Roman; Altshuler, David; Daly, Mark J
- Year
- 2008
- Journal
- Genetic epidemiology
- PMID
- 18348202
- DOI
- 10.1002/gepi.20303
Genomewide association studies are an exciting strategy in genetics, recently becoming feasible and harvesting many novel genes linked to multiple phenotypes. Determining the significance of results in the face of testing a genomewide set of multiple hypotheses, most of which are producing noisy, null-distributed association signals, presents a challenge to the wide community of association researchers. Rather than each study engaging in independent evaluation of significance standards, we have undertaken the task of developing such standards for genomewide significance, based on data collected by the International Haplotype Map Consortium. We report an estimated testing burden of a million independent tests genomewide in Europeans, and twice that number in Africans. We further identify the sensitivity of the testing burden to the required significance level, with implications to staged design of association studies.
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| GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. | Wiemels JL et al. | β | 2018 | β |
| Human Genetic Susceptibility to Native Valve <i>Staphylococcus aureus</i> Endocarditis in Patients With <i>S. aureus</i> Bacteremia: Genome-Wide Association Study. | Moreau K et al. | β | 2018 | β |
| Imputation-Based Whole-Genome Sequence Association Study Reveals Constant and Novel Loci for Hematological Traits in a Large-Scale Swine F<sub>2</sub> Resource Population. | Yan G et al. | β | 2018 | β |
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| Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. | Wyss AB et al. | β | 2018 | β |
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| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. | Walters RK et al. | β | 2018 | β |
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| ABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohort. | Son CN et al. | β | 2017 | β |
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| Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry. | Gray LA et al. | β | 2017 | β |
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| Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism. | Li M et al. | β | 2017 | β |
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| Fine mapping analysis of HLA-DP/DQ gene clusters on chromosome 6 reveals multiple susceptibility loci for HBV infection. | Tao J et al. | β | 2015 | β |
| Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study. | Weiss FU et al. | β | 2015 | β |
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| Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. | Sung YJ et al. | β | 2015 | β |
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| Genome-Wide Association Studies and Liver Disease. | Speliotes EK | β | 2015 | β |
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| Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. | Draisma HHM et al. | β | 2015 | β |
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| Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes. | Regele F et al. | β | 2015 | β |
| GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP. | Ramanan VK et al. | β | 2015 | β |
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| Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. | SegrΓ¨ AV et al. | β | 2015 | β |
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| Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. | Chen DT et al. | β | 2013 | β |
| Genome-wide association study of chronic periodontitis in a general German population. | Teumer A et al. | β | 2013 | β |
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| Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity. | Rahmioglu N et al. | β | 2013 | β |
| Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. | Coram MA et al. | β | 2013 | β |
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| Identification of seven loci affecting mean telomere length and their association with disease. | Codd V et al. | β | 2013 | β |
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| Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. | Grallert H et al. | β | 2012 | β |
| Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets. | Li MX et al. | β | 2012 | β |
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| Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways. | Vaughn SE et al. | β | 2012 | β |
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| Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. | Reiner AP et al. | β | 2012 | β |
| Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. | Fox CS et al. | β | 2012 | β |
| Genome-wide association of pericardial fat identifies a unique locus for ectopic fat. | Fox CS et al. | β | 2012 | β |
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| Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. | Bergen SE et al. | β | 2012 | β |
| Genome-wide association study indicates two novel resistance loci for severe malaria. | Timmann C et al. | β | 2012 | β |
| Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. | Hancock DB et al. | β | 2012 | β |
| Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. | Estrada K et al. | β | 2012 | β |
| Genome-wide meta-analysis of common variant differences between men and women. | Boraska V et al. | β | 2012 | β |
| Impact of ancestry and common genetic variants on QT interval in African Americans. | Smith JG et al. | β | 2012 | β |
| Incorporating prior information into association studies. | Darnell G et al. | β | 2012 | β |
| Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. | Chasman DI et al. | β | 2012 | β |
| Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. | Stergiakouli E et al. | β | 2012 | β |
| Meta-analysis of new genome-wide association studies of colorectal cancer risk. | Peters U et al. | β | 2012 | β |
| Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. | Rawal R et al. | β | 2012 | β |
| Multiplicities in cancer research: ubiquitous and necessary evils. | Berry D | β | 2012 | β |
| Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. | Inouye M et al. | β | 2012 | β |
| Population-based case-control association studies. | Hancock DB et al. | β | 2012 | β |
| Rapid and robust resampling-based multiple-testing correction with application in a genome-wide expression quantitative trait loci study. | Zhang X et al. | β | 2012 | β |
| Replication analysis for severe diabetic retinopathy. | Grassi MA et al. | β | 2012 | β |
| Seventy-five genetic loci influencing the human red blood cell. | van der Harst P et al. | β | 2012 | β |
| The role of variation at AΞ²PP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. | Gerrish A et al. | β | 2012 | β |
| Transferability and fine mapping of genome-wide associated loci for lipids in African Americans. | Adeyemo A et al. | β | 2012 | β |
| What causes attention deficit hyperactivity disorder? | Thapar A et al. | β | 2012 | β |
| What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. | Panagiotou OA et al. | β | 2012 | β |
| A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. | Surakka I et al. | β | 2011 | β |
| A hybrid framework for genome wide epistasis discovery. | Tan Z et al. | β | 2011 | β |
| A new approach to account for the correlations among single nucleotide polymorphisms in genome: wide association studies. | Chen Z et al. | β | 2011 | β |
| Association mapping. | Painter JN et al. | β | 2011 | β |
| Basic statistical analysis in genetic case-control studies. | Clarke GM et al. | β | 2011 | β |
| Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). | Sobrin L et al. | β | 2011 | β |
| Chronic kidney disease: novel insights from genome-wide association studies. | BΓΆger CA et al. | β | 2011 | β |
| Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. | Hollingworth P et al. | β | 2011 | β |
| Discovery of sexual dimorphisms in metabolic and genetic biomarkers. | Mittelstrass K et al. | β | 2011 | β |
| Fast and Accurate Approximation to Significance Tests in Genome-Wide Association Studies. | Zhang Y et al. | β | 2011 | β |
| Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel. | Lewis GJ et al. | β | 2011 | β |
| Genetic determinants of serum testosterone concentrations in men. | Ohlsson C et al. | β | 2011 | β |
| Genetics of schizophrenia: new findings and challenges. | Gejman PV et al. | β | 2011 | β |
| Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. | Wan ES et al. | β | 2011 | β |
| Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. | ParΓ© G et al. | β | 2011 | β |
| Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. | Albagha OM et al. | β | 2011 | β |
| Genome-wide association studies and type 2 diabetes. | Wheeler E et al. | β | 2011 | β |
| Genome-wide association studies of alcohol dependence and substance use disorders. | Treutlein J et al. | β | 2011 | β |
| Genome-wide association studies of the PR interval in African Americans. | Smith JG et al. | β | 2011 | β |
| Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. | Deelen J et al. | β | 2011 | β |
| Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. | Teumer A et al. | β | 2011 | β |
| Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. | Chambers JC et al. | β | 2011 | β |
| Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. | Mick E et al. | β | 2011 | β |
| Genome-wide association study of recurrent early-onset major depressive disorder. | Shi J et al. | β | 2011 | β |
| Genome-wide association study of relative telomere length. | Prescott J et al. | β | 2011 | β |
| Genome-wide association study of the child behavior checklist dysregulation profile. | Mick E et al. | β | 2011 | β |
| Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). | Reiner AP et al. | β | 2011 | β |
| Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease. | Latourelle JC et al. | β | 2011 | β |
| Genome-wide meta-analysis for severe diabetic retinopathy. | Grassi MA et al. | β | 2011 | β |
| Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. | Cornelis MC et al. | β | 2011 | β |
| GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development. | Larsson M et al. | β | 2011 | β |
| Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. | Arking DE et al. | β | 2011 | β |
| Implications of discoveries from genome-wide association studies in current cardiovascular practice. | Jeemon P et al. | β | 2011 | β |
| Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. | Liu Y et al. | β | 2011 | β |
| Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. | Dehghan A et al. | β | 2011 | β |
| Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS. | Shi G et al. | β | 2011 | β |
| Multiple phenotypes in genome-wide genetic mapping studies. | Ott J et al. | β | 2011 | β |
| Multiple testing corrections for imputed SNPs. | Gao X | β | 2011 | β |
| Multivariate analysis of regulatory SNPs: empowering personal genomics by considering cis-epistasis and heterogeneity. | Turner SD et al. | β | 2011 | β |
| Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. | Oexle K et al. | β | 2011 | β |
| Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. | Shyn SI et al. | β | 2011 | β |
| Novel rank-based approaches for discovery and replication in genome-wide association studies. | Kuo CL et al. | β | 2011 | β |
| Pharmacogenetics in type 2 diabetes: potential implications for clinical practice. | Huang C et al. | β | 2011 | β |
| PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies. | Huang J et al. | β | 2011 | β |
| Progress and promise of genome-wide association studies for human complex trait genetics. | Stranger BE et al. | β | 2011 | β |
| Sampling GWAS subjects from risk populations. | Oexle K et al. | β | 2011 | β |
| The false-positive to false-negative ratio in epidemiologic studies. | Ioannidis JP et al. | β | 2011 | β |
| The state of genome-wide association studies in pulmonary disease: a new perspective. | Todd JL et al. | β | 2011 | β |
| Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. | Miki D et al. | β | 2011 | β |
| A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. | Tsai HT et al. | β | 2010 | β |
| A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP et al. | β | 2010 | β |
| A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. | Yamauchi T et al. | β | 2010 | β |
| A genome-wide association study of treated A1C: a genetic needle in an environmental haystack? | Florez JC | β | 2010 | β |
| A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. | Yoon KA et al. | β | 2010 | β |
| Association analyses identify six new psoriasis susceptibility loci in the Chinese population. | Sun LD et al. | β | 2010 | β |
| A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. | Xing C et al. | β | 2010 | β |
| Bayes factors in complex genetics. | Sawcer S | β | 2010 | β |
| Blood pressure and human genetic variation in the general population. | Arora P et al. | β | 2010 | β |
| Case-control genome-wide association study of attention-deficit/hyperactivity disorder. | Neale BM et al. | β | 2010 | β |
| Common genetic determinants of vitamin D insufficiency: a genome-wide association study. | Wang TJ et al. | β | 2010 | β |
| Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. | Sotoodehnia N et al. | β | 2010 | β |
| Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. | Jablonski KA et al. | β | 2010 | β |
| Estimating genome-wide IBD sharing from SNP data via an efficient hidden Markov model of LD with application to gene mapping. | Bercovici S et al. | β | 2010 | β |
| Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. | Mick E et al. | β | 2010 | β |
| Genetic causes of high and low serum HDL-cholesterol. | Weissglas-Volkov D et al. | β | 2010 | β |
| Genetics of bronchopulmonary dysplasia in the age of genomics. | Lavoie PM et al. | β | 2010 | β |
| Genetic variation in SCN10A influences cardiac conduction. | Chambers JC et al. | β | 2010 | β |
| Genome-wide analysis of genetic loci associated with Alzheimer disease. | Seshadri S et al. | β | 2010 | β |
| Genome-wide association analysis identifies multiple loci related to resting heart rate. | Eijgelsheim M et al. | β | 2010 | β |
| Genome-wide association studies and beyond. | Witte JS | β | 2010 | β |
| Genome-wide association studies: a primer. | Corvin A et al. | β | 2010 | β |
| Genome-wide association studies--data generation, storage, interpretation, and bioinformatics. | Pare G | β | 2010 | β |
| Genome-wide association studies in nephrology research. | KΓΆttgen A | β | 2010 | β |
| Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. | Marzi C et al. | β | 2010 | β |
| Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone. | Albagha OM et al. | β | 2010 | β |
| Genome-wide association study of major recurrent depression in the U.K. population. | Lewis CM et al. | β | 2010 | β |
| Genome-wide association study of PR interval. | Pfeufer A et al. | β | 2010 | β |
| Genome-wide meta-analyses identify multiple loci associated with smoking behavior. | Tobacco and Genetics Consortium | β | 2010 | β |
| Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. | Uher R et al. | β | 2010 | β |
| Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. | Weissglas-Volkov D et al. | β | 2010 | β |
| Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. | Assimes TL et al. | β | 2010 | β |
| Learning in glaucoma genetic risk assessment. | Zhang Z et al. | β | 2010 | β |
| Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. | Hancock DB et al. | β | 2010 | β |
| Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. | Neale BM et al. | β | 2010 | β |
| Methodological challenges of genome-wide association analysis in Africa. | Teo YY et al. | β | 2010 | β |
| Multiple common variants for celiac disease influencing immune gene expression. | Dubois PC et al. | β | 2010 | β |
| Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. | Yang Q et al. | β | 2010 | β |
| New findings in the genetics of major psychoses. | NΓΆthen MM et al. | β | 2010 | β |
| New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia? | Nieratschker V et al. | β | 2010 | β |
| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. | Dupuis J et al. | β | 2010 | β |
| New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8. | Vitart V et al. | β | 2010 | β |
| Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. | Bictash M et al. | β | 2010 | β |
| PERMORY: an LD-exploiting permutation test algorithm for powerful genome-wide association testing. | Pahl R et al. | β | 2010 | β |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | β | 2010 | β |
| The genetics of type 2 diabetes: what have we learned from GWAS? | Billings LK et al. | β | 2010 | β |
| The psychiatric GWAS consortium: big science comes to psychiatry. | Sullivan PF | β | 2010 | β |
| The role of genetics in the etiology of schizophrenia. | Gejman PV et al. | β | 2010 | β |
| A framework for interpreting genome-wide association studies of psychiatric disorders. | Psychiatric GWAS Consortium Steering Committee | β | 2009 | β |
| A genome-wide association study of acenocoumarol maintenance dosage. | Teichert M et al. | β | 2009 | β |
| A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. | Estrada K et al. | β | 2009 | β |
| Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. | Dehghan A et al. | β | 2009 | β |
| Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. | Chambers JC et al. | β | 2009 | β |
| Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. | Nolte IM et al. | β | 2009 | β |
| Common variants at 30 loci contribute to polygenic dyslipidemia. | Kathiresan S et al. | β | 2009 | β |
| Common variants at ten loci influence QT interval duration in the QTGEN Study. | Newton-Cheh C et al. | β | 2009 | β |
| Failure to replicate a genetic association may provide important clues about genetic architecture. | Greene CS et al. | β | 2009 | β |
| Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. | Elliott P et al. | β | 2009 | β |
| Genome-wide and fine-resolution association analysis of malaria in West Africa. | Jallow M et al. | β | 2009 | β |
| Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. | Myocardial Infarction Genetics Consortium et al. | β | 2009 | β |
| Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. | Khoury MJ et al. | β | 2009 | β |
| Genomewide association studies: history, rationale, and prospects for psychiatric disorders. | Psychiatric GWAS Consortium Coordinating Committee et al. | β | 2009 | β |
| Genome-wide association studies in ADHD. | Franke B et al. | β | 2009 | β |
| Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. | Lowe JK et al. | β | 2009 | β |
| Genomewide association study for onset age in Parkinson disease. | Latourelle JC et al. | β | 2009 | β |
| Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. | van Es MA et al. | β | 2009 | β |
| Genome-wide association study identifies eight loci associated with blood pressure. | Newton-Cheh C et al. | β | 2009 | β |
| Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. | Chambers JC et al. | β | 2009 | β |
| Genome-wide association study in humans. | Smith JG et al. | β | 2009 | β |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | β | 2009 | β |
| Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. | Smith JG et al. | β | 2009 | β |
| Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. | Hazra A et al. | β | 2009 | β |
| Methodological Issues in Multistage Genome-wide Association Studies. | Thomas DC et al. | β | 2009 | β |
| Multiple loci associated with indices of renal function and chronic kidney disease. | KΓΆttgen A et al. | β | 2009 | β |
| Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles. | Bennett DA et al. | β | 2009 | β |
| Polygenic susceptibility to breast cancer: current state-of-the-art. | Ghoussaini M et al. | β | 2009 | β |
| Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers. | Ioannidis JP | β | 2009 | β |
| Rapid and accurate multiple testing correction and power estimation for millions of correlated markers. | Han B et al. | β | 2009 | β |
| Replication in genome-wide association studies. | Kraft P et al. | β | 2009 | β |
| Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. | Rivadeneira F et al. | β | 2009 | β |
| Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. | Silverberg MS et al. | β | 2009 | β |
| Understanding cardiovascular disease through the lens of genome-wide association studies. | Arking DE et al. | β | 2009 | β |
| Validating, augmenting and refining genome-wide association signals. | Ioannidis JP et al. | β | 2009 | β |
| Variation near complement factor I is associated with risk of advanced AMD. | Fagerness JA et al. | β | 2009 | β |
| Genetic mapping in human disease. | Altshuler D et al. | β | 2008 | β |
| Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. | Barrett JC et al. | β | 2008 | β |
| Genome-wide association scan of attention deficit hyperactivity disorder. | Neale BM et al. | β | 2008 | β |
| Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. | Mick E et al. | β | 2008 | β |
| Perspective on the genetics of attention deficit/hyperactivity disorder. | Neale BM et al. | β | 2008 | β |
| Practical aspects of imputation-driven meta-analysis of genome-wide association studies. | de Bakker PI et al. | β | 2008 | β |