Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task.
- Authors
- Meyers, Jacquelyn; McCutcheon, Vivia V; Pandey, Ashwini K; Kamarajan, Chella; Subbie, Stacey; Chorlian, David; Salvatore, Jessica; Pandey, Gayathri; Almasy, Laura; Anokhin, Andrey; Bauer, Lance; Bender, Annah; Dick, Danielle M; Edenberg, Howard J; Hesselbrock, Victor; Kramer, John; Kuperman, Samuel; Agrawal, Arpana; Bucholz, Kathleen; Porjesz, Bernice
- Year
- 2019
- Journal
- Journal of the American Academy of Child and Adolescent Psychiatry
- PMID
- 30738551
- DOI
- 10.1016/j.jaac.2018.07.905
- PMCID
- PMC6537865
OBJECTIVE: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally. METHOD: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task. Data were drawn from the Collaborative Study of the Genetics of Alcoholism (COGA) prospective cohort, composed of offspring who were aged 12 through 22 years at enrollment from high-risk and comparison families, with follow-ups at 2-year intervals since 2004. In addition, other important predictors of neurophysiologic functioning (eg, substance use, impulsivity, and parental alcohol use disorders) were investigated. Moreover, associations of neurophysiologic functioning with alcohol and cannabis use disorder symptom counts and externalizing and internalizing psychopathology were examined. RESULTS: Individuals exposed to sexual assaultive trauma before 10 years of age had slower rates of change in developmental trajectories of no-go frontal theta during response inhibition. Importantly, effects remained significant after accounting for exposure to other traumatic exposures, such as parental history of alcohol use disorder and participants' substance use, but not measures of impulsivity. Further, slower rates of change in no-go frontal theta adolescent and young adult development were associated with increased risk for alcohol use disorder symptoms and internalizing psychopathology, but not for cannabis use disorder symptoms or externalizing psychopathology. CONCLUSION: Childhood sexual assault is associated with atypical frontal neurophysiologic development during response inhibition. This could reflect alterations in frontal lobe development, synaptic pruning, and/or cortical maturation involving neural circuits for inhibitory control. These same areas could be associated with increased risk for young adult alcohol use disorder symptoms and internalizing psychopathology. These findings support the hypothesis that changes in neurocognitive development related to early sexual trauma exposure could increase the risk for mental health and substance use problems in young adulthood.
Effects of Early Trauma Exposure on No-Go Frontal Theta Power From Baseline Through Follow-Up 4 and Associations With Substance Use Disorder and PsychopathologyNote: Parameter estimates (and standard errors) are displayed only for statistically significant pathways. Not pictured, but also included in this model, are the following covariates: gender, race/ethnicity, age, alcohol use and cannabis use, and parental alcohol use disorder. Internalizing psychopathology count scores included DSM-IV lifetime symptoms for major depressive disorder, panic disorder, social phobia, and an additional itemβsuicidal ideation. Externalizing psychopathology count scores included conduct disorder and oppositional defiant disorder symptoms. Data from each individualβs most recent interview were used. Sx = symptom.*p < .05; **p < .01; ***p < .001.
LLM interpretation
This figure is a path diagram representing a latent growth curve model. It shows the effects of three types of trauma exposure (Non-Assaultive, Assaultive, and Sexual-Assaultive) on the intercept and slope of "No-Go Frontal Theta Power" measured from baseline through follow-up 4. The slope is further linked to DSM-V Alcohol Use Disorder and Internalizing Disorder diagnoses, with statistically significant pathways indicated by parameter estimates and asterisks (*p < .05, **p < .01, ***p < .001).
Adjusted Mean Trajectories of No-Go Frontal Theta by Sexual Assaultive Trauma ExposureNote: Models are adjusted for gender, self-reported race/ethnicity, age at assessment, and parental history of alcohol dependence. The comparison group includes participants who were not exposed to sexual trauma before 10 years of age (93.4% of analytic sample).
LLM interpretation
This line graph shows the adjusted mean trajectories of No-Go Frontal Theta Power (log-transformed) across four time points from age 17 to 23.4 for a control group (no sexual trauma) and a sexual trauma group. Both groups exhibit a downward trend over time, with the control group starting at a higher mean power at baseline and converging with the sexual trauma group by Follow-up 2. No statistical significance markers or p-values are visible on the plot.
No-Go Frontal Theta by Early Sexual Assaultive Trauma ExposureNote: This figure depicts differences in frontal theta no-go power values at baseline observed in participants who (A) were not exposed and (B) were exposed to sexual trauma before 10 years of age. Note the more focused frontal topography and more efficient neural synchronization (ie, higher theta event-related oscillation power values) during response inhibition (no-go condition of go/no-go task) in participants who were not exposed to trauma. In contrast, the frontal topography indicates a less efficient neural synchronization (ie, lower event-related oscillation power values) during response inhibition (no-go condition of go/no-go task) in participants who were exposed to trauma. Please note color figures are available online.
LLM interpretation
This figure consists of topographic maps and time-frequency spectrograms comparing frontal theta power during a no-go task between participants with (B) and without (A) early sexual assaultive trauma exposure. The topographic maps show a more concentrated area of high power (red) in the frontal region for the no-trauma group compared to the trauma-exposed group. The accompanying spectrograms, with axes for frequency (Hz) and time (ms), illustrate higher power values (warmer colors) within the white-boxed theta range for the no-trauma group.
No entities extracted from this document yet.
No uploaded files.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AfifiTO, HenriksenCA, AsmundsonGJG, SareenJ. Childhood maltreatment and substance use disorders among men and women in a nationally representative sample. Can J Psychiatry. 2012;57:677β686.2314928310.1177/070674371205701105 | β | β | β |
| AndaRF, FelittiVJ, BremnerJD, The enduring effects of abuse and related adverse experiences in childhood. Eur Arch Psychiatry Clin Neurosci. 2006;256:174β186.1631189810.1007/s00406-005-0624-4PMC3232061 | β | β | β |
| AndersenSL, TeicherMH. Delayed effects of early stress on hippocampal development. Neuropsychopharmacology. 2004;29:1988β1993.1531656910.1038/sj.npp.1300528 | β | β | β |
| AndersenSL, TeicherMH. Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci. 2008;31:183β191.1832973510.1016/j.tins.2008.01.004 | β | β | β |
| BarryRJ, ClarkeAR, McCarthyR, SelikowitzM, JohnstoneSJ, RushbyJA. Age and gender effects in EEG coherence: I. Developmental trends in normal children. Clin Neurophysiol. 2004;115:2252β2258.1535136610.1016/j.clinph.2004.05.004 | β | β | β |
| BarryRJ, RushbyJA, JohnstoneSJ, ClarkeAR, CroftRJ, LawrenceCA. Event-related potentials in the auditory oddball as a function of EEG alpha phase at stimulus onset. Clin Neurophysiol. 2004;115:2593β2601.1546544910.1016/j.clinph.2004.06.004 | β | β | β |
| BasarE, Basar-ErogluC, KarakasS, SchΓΌrmannM. Oscillatory brain theory: a new trend in neuroscience. IEEE Eng Med Biol Mag. 1999;18:56β66.10.1109/51.76519010337564 | β | β | β |
| BaΕarE, BaΕar-EroΔluC, KarakasS, SchΓΌrmannM. Brain oscillations in perception and memory. Int J Psychophysiol. 2000;35:95β124.1067764110.1016/s0167-8760(99)00047-1 | β | β | β |
| BaΕarE, FemirB, Emek-SavaΕDD, GΓΌntekinB, YenerGG. Increased long distance event-related gamma band connectivity in Alzheimerβs disease. NeuroImage Clin. 2017; 14:580β590.2836740210.1016/j.nicl.2017.02.021PMC5361871 | β | β | β |
| BegleiterH, PorjeszB. What is inherited in the predisposition toward alcoholism? A proposed model. Alcohol Clin Exp Res. 1999;23:1125β1135.1044397710.1111/j.1530-0277.1999.tb04269.x | β | β | β |
| BokuraH, YamaguchiS, KobayashiS. Electrophysiological correlates for response inhibition in a go/no-go task. Clin Neurophysiol. 2001;112:2224β2232.1173819210.1016/s1388-2457(01)00691-5 | β | β | β |
| BreslauN, PetersonEL. Assaultive violence and the risk of posttraumatic stress disorder following a subsequent trauma. Behav Res Ther. 2010;48:1063β1066.2067387010.1016/j.brat.2010.07.001PMC2935269 | β | β | β |
| BucholzKK, CadoretR, CloningerCR, A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol. 1994;55:149β158.818973510.15288/jsa.1994.55.149 | β | β | β |
| BucholzKK, McCutcheonVV, AgrawalA, Comparison of parent, peer, psychiatric, and cannabis use influences across stages of offspring alcohol involvement: evidence from the COGA prospective study. Alcohol Clin Exp Res. 2017;41:359β368.2807315710.1111/acer.13293PMC5272776 | β | β | β |
| CarrionVG, GarrettA, MenonV, WeemsCF, ReissAL. Posttraumatic stress symptoms and brain function during a response-inhibition task: an fMRI study in youth. Depress Anxiety. 2008;25:514β526.1759814510.1002/da.20346 | β | β | β |
| ChechikG, MeilijsonI, RuppinE. Neuronal regulation: a mechanism for synaptic pruning during brain maturation. Neural Comput. 1999;11:2061β2080.1057804410.1162/089976699300016089 | β | β | β |
| CostelloEJ, ErkanliA, FairbankJA, AngoldA. The prevalence of potentially traumatic events in childhood and adolescence. J Trauma Stress. 2002;15:99β112.1201307010.1023/A:1014851823163 | β | β | β |
| CoullJT, FrithCD, FrackowiakRS, GrasbyPM. A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neuropsychologia. 1996;34:1085β1095.890474610.1016/0028-3932(96)00029-2 | β | β | β |
| CoullJT. Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Prog Neurobiol. 1998;55:343β361.965438410.1016/s0301-0082(98)00011-2 | β | β | β |
| DannlowskiU, StuhrmannA, BeutelmannV, Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biol Psychiatry. 2012;71:286β293.2211292710.1016/j.biopsych.2011.10.021 | β | β | β |
| De BellisMD, ZiskA. The biological effects of childhood trauma. Child Adolesc Psychiatr Clin North Am. 2014;23:185β222.10.1016/j.chc.2014.01.002PMC396831924656576 | β | β | β |
| DubeSR, FelittiVJ, DongM, ChapmanDP, GilesWH, AndaRF. Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the Adverse Childhood Experiences Study. Pediatrics. 2003;111:564β572.1261223710.1542/peds.111.3.564 | β | β | β |
| EnochM-A. The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology (Berl). 2011;214:17β31.2059685710.1007/s00213-010-1916-6PMC3005022 | β | β | β |
| ErscheKD, JonesPS, WilliamsGB, TurtonAJ, RobbinsTW, BullmoreET. Abnormal brain structure implicated in stimulant drug addiction. Science. 2012;335:601β604.2230132110.1126/science.1214463 | β | β | β |
| GieddJN, RapoportJL. Structural MRI of pediatric brain development: what have we learned and where are we going? Neuron. 2010;67:728.2082630510.1016/j.neuron.2010.08.040PMC3285464 | β | β | β |
| GogtayN, SpornA, ClasenLS, Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. Arch Gen Psychiatry. 2004;61:17.1470694010.1001/archpsyc.61.1.17 | β | β | β |
| GogtayN, ThompsonPM. Mapping gray matter development: implications for typical development and vulnerability to psychopathology. Brain Cogn. 2010; 72:6β15.1979686310.1016/j.bandc.2009.08.009PMC2815268 | β | β | β |
| HansonJL, ChungMK, AvantsBB, Early Stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk. J Neurosci. 2010;30:7466β7472.2051952110.1523/JNEUROSCI.0859-10.2010PMC2893146 | β | β | β |
| HansonJL, ChungMK, AvantsBB, Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk. J Neurosci. 2010;30:7466β7472.2051952110.1523/JNEUROSCI.0859-10.2010PMC2893146 | β | β | β |
| HartH, RubiaK. Neuroimaging of child abuse: a critical review. Front Hum Neurosci. 2012;6.10.3389/fnhum.2012.00052PMC330704522457645 | β | β | β |
| HeimC, BinderEB. Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Exp Neurol. 2012;233:102β111.2210100610.1016/j.expneurol.2011.10.032 | β | β | β |
| HertingMM, GautamP, SpielbergJM, DahlRE, SowellER. A longitudinal study: changes in cortical thickness and surface area during pubertal maturation. PLoS One. 2015;10:e0119774.2579338310.1371/journal.pone.0119774PMC4368209 | β | β | β |
| HowellsFM, SteinDJ, RussellVA. Childhood trauma is associated with altered cortical arousal: insights from an EEG study. Front Integr Neurosci. 2012;6:120.2326991610.3389/fnint.2012.00120PMC3529303 | β | β | β |
| JonesKA, PorjeszB, ChorlianD, S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism. Clin Neurophysiol. 2006;117: 2128β2143.1692611310.1016/j.clinph.2006.02.028 | β | β | β |
| KamarajanC, PorjeszB, JonesK, Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism. Biol Psychiatry. 2006;59:625β634.1621347210.1016/j.biopsych.2005.08.017PMC3766847 | β | β | β |
| KellyAMC, Di MartinoA, UddinLQ, Development of anterior cingulate functional connectivity from late childhood to early adulthood. Cereb Cortex. 2009;19: 640β657.1865366710.1093/cercor/bhn117 | β | β | β |
| KesslerRC, Aguilar-GaxiolaS, AlonsoJ, The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas. Mol Psychiatry. 2018;23:1β8.10.1038/mp.2017.194PMC585895428924183 | β | β | β |
| KristjanssonS, McCutcheonVV, AgrawalA, The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders. Brain Behav. 2016;6:e00432.2681180310.1002/brb3.432PMC4720689 | β | β | β |
| KupermanS, ChanG, KramerJR, A model to determine the likely age of an adolescentβs first drink of alcohol. Pediatrics. 2013;131:242β248.2329643110.1542/peds.2012-0880PMC3557403 | β | β | β |
| LimL, HartH, MehtaMA, SimmonsA, MirzaK, RubiaK. Neural correlates of error processing in young people with a history of severe childhood abuse: an fMRI study. Am J Psychiatry. 2015;172:892β900.2588232410.1176/appi.ajp.2015.14081042 | β | β | β |
| LoboI, PortugalLC, FigueiraI, EEG correlates of the severity of posttraumatic stress symptoms: a systematic review of the dimensional PTSD literature. J Affect Disord. 2015;183:210β220.2602536710.1016/j.jad.2015.05.015 | β | β | β |
| MarshallPJ, FoxNA. Bucharest Early Intervention Project Core Group. A comparison of the electroencephalogram between institutionalized and community children in Romania. J Cogn Neurosci. 2004;16:1327β1338.1553212810.1162/0898929042304723 | β | β | β |
| MarusakHA, MartinKR, EtkinA, ThomasonME. Childhood trauma exposure disrupts the automatic regulation of emotional processing. Neuropsychopharmacology. 2015;40: 1250β1258.2541318310.1038/npp.2014.311PMC4367470 | β | β | β |
| McCroryE, De BritoSA, VidingE. The impact of childhood maltreatment: a review of neurobiological and genetic factors. Front Psychiatry. 2011;2:48.2184738210.3389/fpsyt.2011.00048PMC3148713 | β | β | β |
| McCutcheonVV, AgrawalA, KuoSI-C, Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families. Addiction. 2018;113:336β345.2880496610.1111/add.14003PMC5760304 | β | β | β |
| McDermottJM, Troller-RenfreeS, VanderwertR, NelsonCA, ZeanahCH, FoxNA. Psychosocial deprivation, executive functions, and the emergence of socio-emotional behavior problems. Front Hum Neurosci. 2013;7:167.2367533310.3389/fnhum.2013.00167PMC3650621 | β | β | β |
| McLaughlinKA, FoxNA, ZeanahCH, NelsonCA. Adverse rearing environments and neural development in children: the development of frontal electroencephalogram asymmetry. Biol Psychiatry. 2011;70:1008β1015.2196233210.1016/j.biopsych.2011.08.006PMC3207006 | β | β | β |
| McLaughlinKA, FoxNA, ZeanahCH, SheridanMA, MarshallP, NelsonCA. Delayed maturation in brain electrical activity partially explains the association between early environmental deprivation and symptoms of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;68:329β336.2049789910.1016/j.biopsych.2010.04.005PMC3010237 | β | β | β |
| McLaughlinKA, PeverillM, GoldAL, AlvesS, SheridanMA. Child maltreatment and neural systems underlying emotion regulation. J Am Acad Child Adolesc Psychiatry. 2015;54:753β762.2629929710.1016/j.jaac.2015.06.010PMC4548288 | β | β | β |
| McLaughlinKA, SheridanMA, AlvesS, MendesWB. Child maltreatment and autonomic nervous system reactivity. Psychosom Med. 2014;76:538β546.2517075310.1097/PSY.0000000000000098PMC4163065 | β | β | β |
| MuellerSC, MaheuFS, DozierM, Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study. Neuropsychologia. 2010;48: 3037β3044.2056153710.1016/j.neuropsychologia.2010.06.013PMC2916226 | β | β | β |
| NelsonCA, BosK, GunnarMR, Sonuga-BarkeEJSV. The neurobiological toll of early human deprivation. Monogr Soc Res Child Dev. 2011;76:127β146.2501856510.1111/j.1540-5834.2011.00630.xPMC4088355 | β | β | β |
| NelsonCA, McCleeryJP. Use of event-related potentials in the study of typical and atypical development. J Am Acad Child Adolesc Psychiatry. 2008;47:1252β1261.1882772210.1097/CHI.0b013e318185a6d8PMC2791670 | β | β | β |
| OteroGA, Pliego-RiveroFB, FernΓ‘ndezT, RicardoJ. EEG development in children with sociocultural disadvantages: a follow-up study. Clin Neurophysiol. 2003;114: 1918β1925.1449975410.1016/s1388-2457(03)00173-1 | β | β | β |
| PandeyAK, KamarajanC, ManzN, ChorlianDB, StimusA, PorjeszB. Delta, theta, and alpha event-related oscillations in alcoholics during go/no-go task: neurocognitive deficits in execution, inhibition, and attention processing. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:158β171.2645673010.1016/j.pnpbp.2015.10.002PMC4679474 | β | β | β |
| PandeyAK, KamarajanC, ManzN, ChorlianDB, StimusA, PorjeszB. Delta, theta, and alpha event-related oscillations in alcoholics during go/no-go task: Neurocognitive deficits in execution, inhibition, and attention processing. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:158β171.2645673010.1016/j.pnpbp.2015.10.002PMC4679474 | β | β | β |
| PandeyAK, KamarajanC, TangY, Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability go/no-go task. Biol Psychol. 2012;89:170β182.2202440910.1016/j.biopsycho.2011.10.009PMC3245806 | β | β | β |
| PattonJH, StanfordMS, BarrattES. Factor structure of the Barratt Impulsiveness Scale. J Clin Psychol. 1995;51:768β774.877812410.1002/1097-4679(199511)51:6<768::aid-jclp2270510607>3.0.co;2-1 | β | β | β |
| PechtelP, PizzagalliDA. Effects of early life stress on cognitive and affective function: an integrated review of human literature. Psychopharmacology (Berl). 2011;214:55β70.2086525110.1007/s00213-010-2009-2PMC3050094 | β | β | β |
| PetanjekZ, JudaΕ‘M, Ε imicG, Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc Natl Acad Sci U S A. 2011;108:13281β13286.2178851310.1073/pnas.1105108108PMC3156171 | β | β | β |
| PosnerMI, PetersenSE. The attention system of the human brain. Annu Rev Neurosci. 1990;13:25β42.218367610.1146/annurev.ne.13.030190.000325 | β | β | β |
| PosnerMI, RothbartMK. Research on attention networks as a model for the integration of psychological science. Annu Rev Psychol. 2007;58:1β23.1702956510.1146/annurev.psych.58.110405.085516 | β | β | β |
| PosnerMI, SheeseBE, OdludaΕY, TangY. Analyzing and shaping human attentional networks. Neural Networks. 2006;19:1422β1429.1705987910.1016/j.neunet.2006.08.004 | β | β | β |
| RaineA, VenablesPH, DalaisC, MellingenK, ReynoldsC, MednickSA. Early educational and health enrichment at age 3β5 years is associated with increased autonomic and central nervous system arousal and orienting at age 11 years: evidence from the Mauritius Child Health Project. Psychophysiology. 2001;38:254β266.11347871 | β | β | β |
| RiceJP, ReichT, BucholzKK, Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res. 1995;19:1018β1023.748581110.1111/j.1530-0277.1995.tb00983.x | β | β | β |
| RobbinsTW, ErscheKD, EverittBJ. Drug Addiction and the Memory Systems of the Brain. Ann N Y Acad Sci. 2008;1141:1β21.1899194910.1196/annals.1441.020 | β | β | β |
| SartorCE, LynskeyMT, HeathAC, JacobT, TrueW. The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction. 2007;102: 216β225.1722227510.1111/j.1360-0443.2006.01661.x | β | β | β |
| SegalowitzSJ, SantessoDL, JethaMK. Electrophysiological changes during adolescence: a review. Brain Cogn. 2010;72:86β100.1991476110.1016/j.bandc.2009.10.003 | β | β | β |
| SlopenN, McLaughlinKA, FoxNA, ZeanahCH, NelsonCA. Alterations in neural processing and psychopathology in children raised in institutions. Arch Gen Psychiatry. 2012;69:1022β1030.2263793810.1001/archgenpsychiatry.2012.444PMC3513656 | β | β | β |
| SowellER, DelisD, StilesJ, JerniganTL. Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study. J Int Neuropsychol Soc. 2001;7:312β322.1131103210.1017/s135561770173305x | β | β | β |
| SowellER, PetersonBS, ThompsonPM, WelcomeSE, HenkeniusAL, TogaAW. Mapping cortical change across the human life span. Nat Neurosci. 2003;6:309β315.1254828910.1038/nn1008 | β | β | β |
| StamoulisC, VanderwertRE, ZeanahCH, FoxNA, NelsonCA. Early psychosocial neglect adversely impacts developmental trajectories of brain oscillations and their interactions. J Cogn Neurosci. 2015;27:2512β2528.2635199010.1162/jocn_a_00877PMC4654401 | β | β | β |
| StamoulisC, VanderwertRE, ZeanahCH, FoxNA, NelsonCA. Neuronal networks in the developing brain are adversely modulated by early psychosocial neglect. J Neurophysiol. 2017;118:2275β2288.2867983710.1152/jn.00014.2017PMC5629272 | β | β | β |
| StevensMC. The developmental cognitive neuroscience of functional connectivity. Brain Cogn. 2009;70:1β12.1918540610.1016/j.bandc.2008.12.009 | β | β | β |
| TeicherMH, AndersenSL, PolcariA, AndersonCM, NavaltaCP. Developmental neurobiology of childhood stress and trauma. Psychiatr Clin North Am. 2002;25: 397β426. vii-viii.1213650710.1016/s0193-953x(01)00003-x | β | β | β |
| TeicherMH, AndersonCM, PolcariA. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci U S A. 2012;109:E563βE572.2233191310.1073/pnas.1115396109PMC3295326 | β | β | β |
| TeicherMH, AndersonCM, PolcariA. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci USA. 2012;109:E563βE572.2233191310.1073/pnas.1115396109PMC3295326 | β | β | β |
| ThomasonME, MarusakHA. Toward understanding the impact of trauma on the early developing human brain. Neuroscience. 2017;342:55β67.2689229410.1016/j.neuroscience.2016.02.022PMC4985495 | β | β | β |
| TrickettPK, NollJG, PutnamFW. The impact of sexual abuse on female development: lessons from a multigenerational, longitudinal research study. Dev Psychopathol. 2011; 23:453β476.2378668910.1017/S0954579411000174PMC3693773 | β | β | β |
| VanderwertRE, MarshallPJ, NelsonCA, ZeanahCH, FoxNA. Timing of intervention affects brain electrical activity in children exposed to severe psychosocial neglect. PLoS One. 2010;5:e11415.2061717510.1371/journal.pone.0011415PMC2895657 | β | β | β |
| VanderwertRE, WesterlundA, MontoyaL, McCormickSA, MiguelHO, NelsonCA. Looking to the eyes influences the processing of emotion on facesensitive event-related potentials in 7-month-old infants. Dev Neurobiol. 2015; 75:1154β1163.2496246510.1002/dneu.22204PMC4284144 | β | β | β |
| VanderwertRE, ZeanahCH, FoxNA, NelsonCA. Normalization of EEG activity among previously institutionalized children placed into foster care: a 12-year follow-up of the Bucharest Early Intervention Project. Dev Cogn Neurosci. 2016;17:68β75.2672456410.1016/j.dcn.2015.12.004PMC4727988 | β | β | β |
| WernerKB, GrantJD, McCutcheonVV, Differences in childhood physical abuse reporting and the association between CPA and alcohol use disorder in European American and African American women. Psychol Addict Behav. 2016;30: 423β433.2732280110.1037/adb0000174PMC4915219 | β | β | β |
| WernerKB, McCutcheonVV, AgrawalA, The association of specific traumatic experiences with cannabis initiation and transition to problem use: differences between African-American and European-American women. Drug Alcohol Depend. 2016;162: 162β169.2701243410.1016/j.drugalcdep.2016.03.003PMC4833569 | β | β | β |
| WilliamsBR, PonesseJS, SchacharRJ, LoganGD, TannockR. Development of inhibitory control across the life span. Dev Psychol. 1999;35:205β213.992347510.1037//0012-1649.35.1.205 | β | β | β |
| YordanovaJ, KolevV, HeinrichH, WoernerW, BanaschewskiT, RothenbergerA. Developmental event-related gamma oscillations: effects of auditory attention. Eur J Neurosci. 2002;16:2214β2224.1247308910.1046/j.1460-9568.2002.02286.x | β | β | β |
| YordanovaJ, KolevV. Developmental changes in the event-related EEG theta response and P300. Electroencephalogr Clin Neurophysiol. 1997;104:418β430.934407810.1016/s0168-5597(97)00054-3 | β | β | β |
| YordanovaJ, KolevV. Event-related brain oscillations. J Psychophysiol. 2009;23: 174β182. | β | β | β |
| ZuckermanM, NeebM. Sensation seeking and psychopathology. Psychiatry Res. 1979; 1:255β264.29835310.1016/0165-1781(79)90007-6 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder. | 2023 | 37803048 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes. | Koo JS et al. | β | 2025 | β |
| Childhood Trauma and<i>APOEΞ΅4</i>are Associated with Adolescent Brain Function, Posttraumatic Stress, and Alcohol-related Outcomes | Neale ZE et al. | β | 2025 | β |
| Frontal Theta Event-Related Oscillations During a Continuous Performance Test: The Influence of Trauma Type and Fluid Intelligence Polygenic Score. | Saenz de Viteri S et al. | β | 2025 | β |
| Childhood stress, gender, and cognitive control: Midline theta power. | Kavanaugh BC et al. | β | 2024 | β |
| Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms. | Neale ZE et al. | β | 2024 | β |
| Associations of parent-adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder. | Pandey G et al. | β | 2023 | β |
| Characterizing patterns of substance use in trauma exposed youth. | Clark SL et al. | β | 2023 | β |
| COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder. | Meyers JL et al. | β | 2023 | β |
| Effects of institutional rearing and foster care intervention on error monitoring and externalizing behaviors in adolescence. | Debnath R et al. | β | 2023 | β |
| Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task. | Elton A et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | β | 2023 | β |
| The Collaborative Study on the Genetics of Alcoholism: Overview. | Agrawal A et al. | β | 2023 | β |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | β | 2023 | β |
| A developmental examination of medial frontal theta dynamics and inhibitory control. | van Noordt S et al. | β | 2022 | β |
| FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. | Bowen MT et al. | β | 2022 | β |
| Impaired functional cortical networks in the theta frequency band of patients with post-traumatic stress disorder during auditory-cognitive processing. | Shim M et al. | β | 2022 | β |
| Resting-state theta activity is linked to information content-specific coding levels during response inhibition. | Pscherer C et al. | β | 2022 | β |
| A latent class analysis of alcohol and posttraumatic stress symptoms among offspring of parents with and without alcohol use disorder. | Bender AK et al. | β | 2021 | β |
| Boosting working memory with accelerated clocks. | ThΓΆnes S et al. | β | 2021 | β |
| Impulsivity and the effects of alcohol in women with a history of childhood sexual abuse: A pilot study. | Evans SM et al. | β | 2021 | β |
| Grant Report on the Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression. | Gillespie ML et al. | β | 2020 | β |
| Pathways to post-traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults. | Subbie-Saenz de Viteri S et al. | β | 2020 | β |