Gene-Environment Interaction Effects of Peer Deviance, Parental Knowledge and Stressful Life Events on Adolescent Alcohol Use.
- Authors
- Cooke, Megan E; Meyers, Jacquelyn L; Latvala, Antti; Korhonen, Tellervo; Rose, Richard J; Kaprio, Jaakko; Salvatore, Jessica E; Dick, Danielle M
- Year
- 2015
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 26290350
- DOI
- 10.1017/thg.2015.56
- PMCID
- PMC4827773
The purpose of this study was to address two methodological issues that have called into question whether previously reported gene-environment interaction (GxE) effects for adolescent alcohol use are 'real'. These issues are (1) the potential correlation between the environmental moderator and the outcome across twins and (2) non-linear transformations of the behavioral outcome. Three environments that have been previously studied (peer deviance, parental knowledge, and potentially stressful life events) were examined here. For each moderator (peer deviance, parental knowledge, and potentially stressful life events), a series of models was fit to both a raw and transformed measure of monthly adolescent alcohol use in a sample that included 825 dizygotic (DZ) and 803 monozygotic (MZ) twin pairs. The results showed that the moderating effect of peer deviance was robust to transformation, and that although the significance of moderating effects of parental knowledge and potentially stressful life events were dependent on the scale of the adolescent alcohol use outcome, the overall results were consistent across transformation. In addition, the findings did not vary across statistical models. The consistency of the peer deviance results and the shift of the parental knowledge and potentially stressful life events results between trending and significant, shed some light on why previous findings for certain moderators have been inconsistent and emphasize the importance of considering both methodological issues and previous findings when conducting and interpreting GxE analyses.
The bivariate moderation model. This figure illustrates the bivariate model (for one twin) with the addition of moderation components on the appropriate paths.
The Extended Univariate model. This figure illustrates the extended univariate moderation model (for one twin).
Bivariate moderation models and moderation results. On the left are the bivariate moderation models with the moderation paths for each of the moderators. On the right are graphs of the raw variance of A, C, and E as a function of the moderators on both the unique and cross paths.
| # | Section | Preview |
|---|---|---|
| 40 | Discussion | influences on alcohol use showed a trend in the raw variable and was significant using a transformed… |
| Name | Type |
|---|---|
| A component local | phenotype |
| additive genetic influences | cohort |
| adolescent alcohol use | phenotype |
| Adolescent Alcohol Use Frequency local | phenotype |
| adolescent conduct problems | phenotype |
| adolescent drinking | phenotype |
| adolescent female alcohol use local | phenotype |
| adolescents | cohort |
| Adolescents Age 14 local | cohort |
| adolescent smoking | phenotype |
| adolescent substance use | phenotype |
| age 14 | cohort |
| Age 14 assessment local | cohort |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol Problems | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use frequency local | phenotype |
| Alcohol use frequency local | phenotype |
| alcohol use frequency (logarithmic transformed) local | phenotype |
| alcohol use frequency (raw) local | phenotype |
| alcohol use frequency (square root transformed) local | phenotype |
| Alcohol use related behaviors local | phenotype |
| behavioral outcome | phenotype |
| best friend's substance use local | drug |
| Best friend's substance use local | drug |
| C component local | phenotype |
| complex traits | phenotype |
| conduct disorder | phenotype |
| drug dependence | phenotype |
| E component local | phenotype |
| externalizing behavior | phenotype |
| externalizing disorders | phenotype |
| Finnish population | cohort |
| Finnish sample (Dick et al., 2007) local | cohort |
| Finnish twins | cohort |
| Finntwin12 | cohort |
| friends' alcohol use local | drug |
| genetic factors | cohort |
| Genetic influences local | drug |
| Harden et al. 2008 sample local | cohort |
| Kendler et al. 2011 sample local | cohort |
| life events score local | phenotype |
| Moderator variable local | phenotype |
| parental closeness | phenotype |
| parental knowledge | phenotype |
| parental monitoring | phenotype |
| Peer alcohol use local | drug |
| peer deviance | phenotype |
| problematic alcohol use | phenotype |
| sex | phenotype |
| Shared C Component local | phenotype |
| shared environmental influence | phenotype |
| Shared environmental influences local | drug |
| stressful life events | phenotype |
| substance use | phenotype |
| Twin cohort | cohort |
| Unique A Component local | phenotype |
| Unique E Component local | phenotype |
| unique environmental influences | phenotype |
| Unique environmental influences local | drug |
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| Association between adolescent alcohol use and cognitive function in young adulthood: A co-twin comparison study. | Cooke ME et al. | — | 2024 | → |
| Gene-environment transactions between peer cigarette use, parental supervision, and Chinese adolescent cigarette smoking initiation. | Meyer Z et al. | — | 2024 | → |
| Gene-environment interplay linking perceived parental supervision and peer drunkenness with Chinese adolescent alcohol initiation. | Zheng Y et al. | — | 2023 | → |
| Cumulative Stressors and Adolescent Substance Use: A Review of 21st-Century Literature. | Hoffmann JP et al. | — | 2022 | → |
| Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment. | Su J et al. | — | 2022 | → |
| Genetic versus environmental influences on callous-unemotional traits in preadolescence: The role of parenting and parental psychopathology. | Perlstein S et al. | — | 2022 | → |
| Maternal Parenting Behaviors Amplify Environmental Influences on Developmental Trajectories of Alcohol Use During Adolescence. | Zheng Y et al. | — | 2021 | → |
| "Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era. | Harden KP | — | 2021 | → |
| Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients. | Williams PT | — | 2020 | → |
| The Genetics of Externalizing Problems. | Barr PB et al. | — | 2020 | → |
| Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples. | Barr PB et al. | — | 2020 | → |
| FinnTwin12 Cohort: An Updated Review. | Rose RJ et al. | — | 2019 | → |
| Peer Alcohol Use Differentially Amplifies Genetic and Environmental Effects on Different Developmental Trajectories of Adolescent Alcohol Use. | Zheng Y et al. | — | 2019 | → |
| Polygenic Prediction of Substance Use Disorders in Clinical and Population Samples | Barr PB et al. | — | 2019 | — |
| Polygenic risk for alcohol misuse is moderated by romantic partnerships. | Barr PB et al. | — | 2019 | → |
| Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk. | Barr PB et al. | — | 2018 | → |
| Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students. | Su J et al. | — | 2018 | → |
| Polygenic risk for alcohol consumption and its association with alcohol-related phenotypes: Do stress and life satisfaction moderate these relationships? | Mies GW et al. | — | 2018 | → |
| Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. | Su J et al. | — | 2018 | → |
| Developmental Etiologies of Alcohol Use and Their Relations to Parent and Peer Influences Over Adolescence and Young Adulthood: A Genetically Informed Approach. | Deutsch AR et al. | — | 2017 | → |
| Social Relationships Moderate Genetic Influences on Heavy Drinking in Young Adulthood. | Barr PB et al. | — | 2017 | → |
| The Role of Social, Familial, and Individual-Level Factors on Multiple Alcohol Use Outcomes During the First Year of University. | Cooke ME et al. | — | 2017 | → |
| Education and alcohol use: A study of gene-environment interaction in young adulthood. | Barr PB et al. | — | 2016 | → |