Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.
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- Authors
- Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; 23andMe Research Team; HUNT All-In Psychiatry; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D; Haessler, Jeffrey; Hottenga, Jouke-Jan; Huang, Hongyan; Jang, Seon-Kyeong; Jansen, Philip R; Ling, Yueh; Mägi, Reedik; Matoba, Nana; McMahon, George; Mulas, Antonella; Orrù, Valeria; Palviainen, Teemu; Pandit, Anita; Reginsson, Gunnar W; Skogholt, Anne Heidi; Smith, Jennifer A; Taylor, Amy E; Turman, Constance; Willemsen, Gonneke; Young, Hannah; Young, Kendra A; Zajac, Gregory J M; Zhao, Wei; Zhou, Wei; Bjornsdottir, Gyda; Boardman, Jason D; Boehnke, Michael; Boomsma, Dorret I; Chen, Chu; Cucca, Francesco; Davies, Gareth E; Eaton, Charles B; Ehringer, Marissa A; Esko, Tõnu; Fiorillo, Edoardo; Gillespie, Nathan A; Gudbjartsson, Daniel F; Haller, Toomas; Harris, Kathleen Mullan; Heath, Andrew C; Hewitt, John K; Hickie, Ian B; Hokanson, John E; Hopfer, Christian J; Hunter, David J; Iacono, William G; Johnson, Eric O; Kamatani, Yoichiro; Kardia, Sharon L R; Keller, Matthew C; Kellis, Manolis; Kooperberg, Charles; Kraft, Peter; Krauter, Kenneth S; Laakso, Markku; Lind, Penelope A; Loukola, Anu; Lutz, Sharon M; Madden, Pamela A F; Martin, Nicholas G; McGue, Matt; McQueen, Matthew B; Medland, Sarah E; Metspalu, Andres; Mohlke, Karen L; Nielsen, Jonas B; Okada, Yukinori; Peters, Ulrike; Polderman, Tinca J C; Posthuma, Danielle; Reiner, Alexander P; Rice, John P; Rimm, Eric; Rose, Richard J; Runarsdottir, Valgerdur; Stallings, Michael C; Stančáková, Alena; Stefansson, Hreinn; Thai, Khanh K; Tindle, Hilary A; Tyrfingsson, Thorarinn; Wall, Tamara L; Weir, David R; Weisner, Constance; Whitfield, John B; Winsvold, Bendik Slagsvold; Yin, Jie; Zuccolo, Luisa; Bierut, Laura J; Hveem, Kristian; Lee, James J; Munafò, Marcus R; Saccone, Nancy L; Willer, Cristen J; Cornelis, Marilyn C; David, Sean P; Hinds, David A; Jorgenson, Eric; Kaprio, Jaakko; Stitzel, Jerry A; Stefansson, Kari; Thorgeirsson, Thorgeir E; Abecasis, Gonçalo; Liu, Dajiang J; Vrieze, Scott
- Year
- 2019
- Journal
- Nature genetics
- PMID
- 30643251
- DOI
- 10.1038/s41588-018-0307-5
- PMCID
- PMC6358542
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders. They are heritable and etiologically related behaviors that have been resistant to gene discovery efforts. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures.
Genetic correlations between substance use phenotypes and phenotypes from other large genome-wide association studies.Genetic correlations between each of the phenotypes are shown in the first 5 rows, with heritability estimates displayed down the diagonal. All genetic correlations and heritability estimates were calculated using LD Score Regression. Blue shading represents negative genetic correlations, and red shading represents positive correlations, with increasing color intensity reflecting increasing strength of a correlation. A single asterisk reflects significant genetic correlations at the p<.05 level. Double asterisks reflect significant genetic correlations at the Bonferroni-correction p<.000278 level (corrected for 180 independent tests). Note that SmkCes was oriented such that higher scores reflected current smoking, and for AgeSmk lower scores reflect earlier ages of initiation, both of which are typically associated with negative outcomes. AgeSmk=Age of Initiation of Smoking; CigDay=Cigarettes per Day; SmkInit=Smoking Initiation; SmkCes=Smoking Cessation; DrnkWk=Drinks per Week.
Pleiotropy.Depicted here are results from the multivariate analysis of pleiotropy. For each locus, the method returns the best fitting solution of which phenotypes were associated with that locus. All loci with one or more associated phenotypes are shown here. For example, every locus associated with AgeSmk was found to be pleiotropic for other phenotypes (green, blue, red, purple, and fuchsia bars), and no locus showed association with only AgeSmk (no dark grey bar for AgeSmk). When sample sizes are unequal across phenotypes, the method also improves power for those phenotypes with smaller samples. The total number of loci associated with each trait (whether pleiotropic or not) from these analyses was 40 (AgeSmk), 48 (SmkCes), 72 (CigDay), 111 (DrnkWk), and 278 (SmkInit). Full information is in Supplementary Table 11.
Heritability and polygenic prediction.The light gray bars reflect SNP heritability, estimated with LD Score Regression. The light blue and gold bars reflect the predictive power of polygenic risk scores in Add Health and the Health and Retirement Study (HRS), respectively. Despite the 41-year generational gap between participants from these two studies, and major tobacco-related policy changes during that time, the polygenic scores are similarly predictive in both samples. Error bars are 95% confidence intervals estimated with 1000 bootstrapped repetitions. Dark gray bars represent the total phenotypic variance explained by only genome-wide significant SNPs. H2=heritability.
Correlations among exemplary DEPICT gene sets.There were 68 clusters available for Smoking initiation and 10 for Drinks Per Week (CigDay, AgeSmk, and SmkCes did not have > 1 exemplary sets.) Blue shading represents positive correlations, and red shading represents negative correlations, with increasing color intensity reflecting increasing strength of a correlation. Cluster names are truncated for space, with a full list of all names in Supplementary Table 18. The number after each name is the number of gene sets in each cluster. The matrix naturally falls into three blue superclusters along the diagonal. The largest supercluster contains primarily gene sets related to neurotransmitter receptors, ion channels (sodium, potassium, calcium), learning/memory, and other aspects of CNS function. The middle supercluster includes gene sets defined by regulation of transcription and translation, including RNA binding and transcription factor activity. The final supercluster is composed primarily of gene sets related to development of the nervous system.
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| Spatial GWAS Atlas: a knowledgebase for decoding the genetic architecture of complex traits in spatial resolution. | Kang H et al. | — | 2026 | → |
| Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries. | Khan Y et al. | — | 2026 | → |
| Unique and shared internalizing and externalizing genetic factors associated with suicidal thoughts and behaviors: Findings from the adolescent brain cognitive development study. | Thomas NS et al. | — | 2026 | → |
| Using human genetics to understand the epidemiological association between child obesity at different ages and MASLD. | Ge Q et al. | — | 2026 | → |
| Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders. | Qiu S et al. | — | 2026 | → |
| Variant-to-Biomarker Pathways in Peripheral Artery Disease: Multiomics Integration and Clinical Translation. | Wang W et al. | — | 2026 | → |
| 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. | Martin SS et al. | — | 2025 | → |
| A contextual genomic perspective on physical activity and its relationship to health, well being and illness. | Galimberti M et al. | — | 2025 | → |
| Addiction Susceptibility: Genetic Factors, Personality Traits, and Epigenetic Interactions with the Gut Microbiome. | Borrego-Ruiz A et al. | — | 2025 | → |
| A Genome-wide study on the genetic and causal effects of smoking in neurodegeneration. | Chen C et al. | — | 2025 | → |
| Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data. | Larsson SC et al. | — | 2025 | → |
| A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking. | Rosoff DB et al. | — | 2025 | → |
| Analysis of Genetic Risk Factors Associated with Charcot Foot Based on the FinnGen Study R9 Data: A Wide-angle Mendelian Randomization Study. | Jiang S et al. | — | 2025 | → |
| An integrative multi-omics study to identify candidate DNA methylation biomarkers associated with gastric cancer prognosis. | Gu J et al. | — | 2025 | → |
| Anorexia nervosa and gastrointestinal diseases: A multivariable Mendelian randomization study. | Pu C | — | 2025 | → |
| A phenome-wide association study of genetically determined nicotine metabolism reveals novel links with health-related outcomes. | Buchwald J et al. | — | 2025 | → |
| (Apo)Lipoprotein Profiling with Multi-Omics Analysis Identified Medium-HDL-Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease. | Li Y et al. | — | 2025 | → |
| A review of post-GWAS studies in schizophrenia. | Maserrat S et al. | — | 2025 | → |
| Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis. | Wei L et al. | — | 2025 | → |
| Association between cardiovascular risk factors and dilated and hypertrophic cardiomyopathy: Mendelian randomization analysis. | Zou C et al. | — | 2025 | → |
| Association Between Chronic Obstructive Pulmonary Disease and Rheumatoid Arthritis: Findings of the Observational and Mendelian Randomization Study. | Wang K et al. | — | 2025 | → |
| Association between depression and asthma: insight from observational and genetic evidence. | Ji T et al. | — | 2025 | → |
| Association Between Educational Attainment and Chronic Pain: A Mediation Mendelian Randomization Study. | Wang H et al. | — | 2025 | → |
| Association between rheumatoid arthritis and blood lipid levels: An integrated epidemiological observational analysis and Mendelian randomization study. | Yi J et al. | — | 2025 | → |
| Association of sleep traits with risk of adverse pregnancy outcomes: a Mendelian randomisation analysis. | Shao S et al. | — | 2025 | → |
| Associations between post-traumatic stress disorder and neurological disorders: A genetic correlation and Mendelian randomization study. | Li M et al. | — | 2025 | → |
| Associations of Genetically Predicted CKD With Urinary Tract Cancer and Lung Cancer: A Mendelian Randomization Analysis. | Luo L et al. | — | 2025 | → |
| A Systematic Investigation of the Common Genetic Architecture of Substance Use Traits and the Relationship with Mental Health. | Pasman JA et al. | — | 2025 | → |
| Bidirectional causal relationship between depression and Type 2 diabetes: a multi-ancestry and sex stratified Mendelian Randomization analysis. | Liu HY et al. | — | 2025 | → |
| Causal Association Between Lung Cancer and Rash: A Bidirectional Mendelian Randomization Study. | Xiao Y et al. | — | 2025 | → |
| Causal association between modifiable risk factors and esophageal cancer: A Mendelian randomization study. | Wang X et al. | — | 2025 | → |
| Causal association of dietary intake habits and telomere lengths: A Mendelian randomization study. | Chen J et al. | — | 2025 | → |
| Causal association of inflammation with ischemic stroke and its subtypes: a bidirectional Mendelian randomization study. | Qian F et al. | — | 2025 | → |
| Causal associations between primary sclerosing cholangitis and systemic lupus erythematosus: Evidence from Mendelian randomization and transcriptomic analyses. | Wang Y et al. | — | 2025 | → |
| Causal associations between smoking and ocular diseases: a Mendelian randomization study. | Huang Z et al. | — | 2025 | → |
| Causal Associations of Obstructive Sleep Apnea With Cancer Risk: A Mendelian Randomization Study. | He X et al. | — | 2025 | → |
| Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study. | Verdiesen RMG et al. | — | 2025 | → |
| Causality of genetically predicted solid cancers on risk of sepsis: insights from Mendelian randomization. | Qiu L et al. | — | 2025 | → |
| Causal link between ankylosing spondylitis and thyroid dysfunction: A Mendelian randomization study. | Ye Q et al. | — | 2025 | → |
| Causal plasma metabolites for breast cancer risk: a two-sample Mendelian randomization study with colocalization evidence. | Chen H et al. | — | 2025 | → |
| Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study. | Lin W et al. | — | 2025 | → |
| Causal Relationship Between Intelligence, Noncognitive Education, Cognition and Urinary Tract or Kidney Infection: A Mendelian Randomization Study. | Fu S et al. | — | 2025 | → |
| Causal relationship between serum urate and asthma: a Mendelian randomization study. | Jia G et al. | — | 2025 | → |
| Causal relationship between sleep traits and erectile dysfunction: evidence from Mendelian randomization analysis. | Zhu L et al. | — | 2025 | → |
| Causal Relationships Among Lifestyle, Lipidome, and Polycystic Ovary Syndrome: A Mendelian Randomization Study. | Kou X et al. | — | 2025 | → |
| Causal relationships between 25-hydroxyvitamin D levels and laryngeal cancer risk: A two-sample Mendelian randomization study. | Wang D et al. | — | 2025 | → |
| Causal Relationships Between Environmental Exposures, Iron Metabolism, Hematuria Markers, and Rheumatoid Arthritis: An Investigation Using Mendelian Randomization. | Wang C et al. | — | 2025 | → |
| Causal relationships between modifiable risk factors and heart failure: A comprehensive Mendelian randomization study. | Fu Y et al. | — | 2025 | → |
| Causal relationships between plasma proteins and Alzheimer's disease using bidirectional Mendelian randomization. | Li Y et al. | — | 2025 | → |
| Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study. | Ge C et al. | — | 2025 | → |
| CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women. | Jones SK et al. | — | 2025 | → |
| Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. | Lee DSM et al. | — | 2025 | → |
| Comprehensive Mendelian Randomization Analysis of Smoking and Its Effects on Venous Thromboembolism. | Li Y et al. | — | 2025 | → |
| Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites. | Ebrahimi E et al. | — | 2025 | → |
| Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes. | Ji Y et al. | — | 2025 | → |
| Disentangling the effects of nicotine versus non-nicotine constituents of tobacco smoke on major depressive disorder: A multivariable Mendelian randomisation study. | Burke C et al. | — | 2025 | → |
| Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study. | Lin BD et al. | — | 2025 | → |
| Dissecting the causal effects of smoking, alcohol consumption, and related DNA methylation markers on electrocardiographic indices. | Zheng Z et al. | — | 2025 | → |
| Dissecting the genetic basis and mechanisms underlying the associations between multiple extrahepatic factors and autoimmune liver diseases. | Zhang Z et al. | — | 2025 | → |
| Distinguishing specific from broad genetic associations between external correlates and common factors. | de la Fuente J et al. | — | 2025 | → |
| Early-life exposures and risk of hematological malignancies in adulthood: a cohort study, meta-analysis and Mendelian randomization analysis. | Guo Y et al. | — | 2025 | → |
| Educational attainment, body mass index, and smoking as mediators in kidney disease risk: a two-step Mendelian randomization study. | Zhang L et al. | — | 2025 | → |
| Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study. | Campbell DD et al. | — | 2025 | → |
| Employing plasma proteins in proteomic Mendelian randomization analysis to identify therapeutic targets for duodenal ulcer. | Luo X et al. | — | 2025 | → |
| Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control. | Perry S et al. | — | 2025 | → |
| Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson's disease. | Zhang H et al. | — | 2025 | → |
| Estimating Causal Effects on a Disease Progression Trait Using Bivariate Mendelian Randomisation. | Cai S et al. | — | 2025 | → |
| Evaluating the relationship between educational attainment, obesity-related indicators, and prostate diseases: A univariable and multivariable Mendelian randomization study. | Ji WT et al. | — | 2025 | → |
| Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders. | Breunig S et al. | — | 2025 | → |
| Examining the genetic relationship between Alzheimer's disease, schizophrenia and their shared risk factors using genomic structural equation modelling. | Almeida E Sousa I et al. | — | 2025 | → |
| Exploring and Accounting for Genetically Driven Effect Heterogeneity in Mendelian Randomization. | Jaitner A et al. | — | 2025 | → |
| Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with 'cigarette smoking initiation' really capturing? | Reed ZE et al. | — | 2025 | → |
| Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization. | Pan L et al. | — | 2025 | → |
| Exploring the causal associations between obesity indicators and male reproductive diseases: new evidence from Mendelian randomization. | Wei H et al. | — | 2025 | → |
| Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis. | Cheng Z et al. | — | 2025 | → |
| Exploring the causal relationship between vitiligo and psoriasis: a bidirectional Mendelian randomization analysis. | Xu Z et al. | — | 2025 | → |
| Exploring the genetic intersection of dried fruit intake and breast cancer risk: a multi-trait genomic analysis with epidemiological context. | Zou K et al. | — | 2025 | → |
| Exploring the roles of conserved context-dependent cis-regulatory elements (cdCREs) in multicellularity, human health and disease. | McEwan A et al. | — | 2025 | → |
| Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children. | Deng WQ et al. | — | 2025 | → |
| Factorial Mendelian randomization of lipoprotein (a) lowering, low-density lipoprotein cholesterol lowering, and lifestyle improvements: joint associations with cardiovascular risk. | Wang L et al. | — | 2025 | → |
| Functional Validation of Alcohol Dependence-Associated <i>FYN</i> Variants Using Gene Editing and Stem Cell Study Approaches. | Cakir B et al. | — | 2025 | → |
| Gene-by-Environment Interactions Involving Maternal Exposures with Orofacial Cleft Risk in Filipinos. | Erdogan-Yildirim Z et al. | — | 2025 | → |
| Gene expression differences associated with alcohol use disorder in human brain. | Willis C et al. | — | 2025 | → |
| Genetically-predicted effects of lifestyle factors on frailty: Evidence from Mendelian randomization study. | Xin M et al. | — | 2025 | → |
| Genetically predicted modifiable risk factors for Helicobacter pylori infection: A Mendelian randomization study. | Zhang Z et al. | — | 2025 | → |
| Genetic analysis of alcohol use disorder: GWAS of alcohol use disorders identification test (AUDIT) and polygenic risk scores in an east slavic population. | Trofimov M et al. | — | 2025 | → |
| Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation. | Yang Y et al. | — | 2025 | → |
| Genetic and molecular assessment of the relationship between smoking and EBV reactivation: A two-sample Mendelian randomization and in-vitro experimental study. | Xiang W et al. | — | 2025 | → |
| Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses. | Nielsen TT et al. | — | 2025 | → |
| Genetic association and potential mediators between subjective well-being and cardiovascular events: A bidirectional two-sample, two-step Mendelian randomization study. | Shen R et al. | — | 2025 | → |
| Genetic Association of Mood Swings with Lung Function and Respiratory Diseases. | Ku Y et al. | — | 2025 | → |
| Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use. | Aliev F et al. | — | 2025 | → |
| Genetic causal effects of multi-site chronic pain on post-traumatic stress disorder: Evidence from a two-sample, two-step Mendelian randomization study. | Wang Z et al. | — | 2025 | → |
| Genetic Correlation and Mendelian Randomization Analysis Revealed an Unidirectional Causal Relationship Between Left Caudal Middle Frontal Surface Area and Cigarette Consumption. | Xie H et al. | — | 2025 | → |
| Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males. | Waller TC et al. | — | 2025 | → |
| Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases. | Wu Y et al. | — | 2025 | → |
| Genetic insights into drug targets for alzheimer's disease: integrative multi-omics analysis. | Liu X et al. | — | 2025 | → |
| Genetic liability to atrial fibrillation, aortic valve disease, and mitral valve disease: a two-sample Mendelian randomization study. | Zhang Y et al. | — | 2025 | → |
| Genetic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats. | King CP et al. | — | 2025 | → |
| Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine. | Schoenrock SA et al. | — | 2025 | → |
| Genetic modifiers of frequent vaso-occlusive hospitalizations among individuals with sickle cell disease (SCD). | Ozahata MC et al. | — | 2025 | → |
| Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis. | Zhang M et al. | — | 2025 | → |
| Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study. | Skelton M et al. | — | 2025 | → |
| Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study. | Choi M et al. | — | 2025 | → |
| Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression. | Spychala KM et al. | — | 2025 | → |
| Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis. | Chen Z et al. | — | 2025 | → |
| Genome-wide analysis of screen behaviors among adolescents identifies novel loci and overlap with educational attainment and mental disorders. | Frei E et al. | — | 2025 | → |
| Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures. | Jee YH et al. | — | 2025 | → |
| Genome-Wide Association Study of Exercise Addiction Among Elite Wrestlers. | Bulgay C et al. | — | 2025 | → |
| Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats. | Kuhn BN et al. | — | 2025 | → |
| Global impact of air pollution on cancer: causal evidence and health inequities across regions from 1990 to 2021. | Zhou J et al. | — | 2025 | → |
| Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis. | Zhou S et al. | — | 2025 | → |
| GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders. | Chan M et al. | — | 2025 | → |
| Gut microbiota mediates the relationship between smoking and fall risk: A 2-step Mendelian randomization study. | Zhang J et al. | — | 2025 | → |
| GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis. | Yuan S et al. | — | 2025 | → |
| Human genetic variants in SLC39A8 impact uptake and steady-state metal levels within the cell. | Wang WA et al. | — | 2025 | → |
| Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder. | Icick R et al. | — | 2025 | → |
| Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis. | Lyu J et al. | — | 2025 | → |
| Identifying causal genes for prostatitis through drug-targeted Mendelian randomization. | Yan K et al. | — | 2025 | → |
| Identifying Targets and Drugs for Rheumatoid Arthritis Stratified Therapy Using Mendelian Randomization and a Pretraining Model. | Yan Y et al. | — | 2025 | → |
| Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution. | Liu Y et al. | — | 2025 | → |
| Independent effects of mental health disorders on breast cancer and their mediating factors: evidence from NHANES and two-step Mendelian randomization. | Ma K et al. | — | 2025 | → |
| Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study. | Li Z et al. | — | 2025 | → |
| Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits. | Wang L et al. | — | 2025 | → |
| Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages. | Wang C et al. | — | 2025 | → |
| Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study. | Zeng J et al. | — | 2025 | → |
| Integrative genetic analysis to decode the causal effect of air pollution on accelerated aging. | Xiao P et al. | — | 2025 | → |
| Intergenerational transmission of complex traits and the offspring methylome. | Hagenbeek FA et al. | — | 2025 | → |
| Intra-aortic infusion of nicotine can induce a novel mouse model of abdominal aortic aneurysm. | Liu H et al. | — | 2025 | → |
| Investigating causal effects of income on health using two-sample Mendelian randomisation. | Igelström E et al. | — | 2025 | → |
| Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study. | Reed ZE et al. | — | 2025 | → |
| Investigation of Novel Therapeutic Targets for Rheumatoid Arthritis Through Human Plasma Proteome. | Wang H et al. | — | 2025 | → |
| L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validation. | Wang H et al. | — | 2025 | → |
| Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking. | He W et al. | — | 2025 | → |
| Leisure-Time Physical Activity, Sedentary Behavior, and Biological Aging: Evidence From Genetic Correlation and Mendelian Randomization Analyses. | Zhao X et al. | — | 2025 | → |
| Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies. | Tang B et al. | — | 2025 | → |
| Life behaviors, educational attainment, and risk for endometriosis: a Mendelian randomization study. | Kong S et al. | — | 2025 | → |
| Lifestyle factors and rotator cuff injury: A Mendelian randomization analysis of smoking, alcohol, and coffee consumption. | Li C et al. | — | 2025 | → |
| Lipids, Lipid-Lowering Drug Target Genes, and COPD Risk: A Mendelian Randomization Study. | Jia G et al. | — | 2025 | → |
| Mapping the role of macro and micronutrients in bone mineral density: a comprehensive Mendelian randomization study. | Xiang R et al. | — | 2025 | → |
| Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans. | Romero Villela PN et al. | — | 2025 | → |
| Mediating effects of gastroesophageal reflux disease and smoking behavior on the relationship between depression and chronic obstructive pulmonary disease: Trans-ethnic Mendelian randomization study. | Cheng Z et al. | — | 2025 | → |
| Mediating factors in the association between educational attainment and stroke: A mendelian randomization study. | Xu N et al. | — | 2025 | → |
| Medical risk factors, ApoE haplotype, and Alzheimer's disease: a large-scale analysis. | Elias U et al. | — | 2025 | → |
| Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea. | Wang Z et al. | — | 2025 | → |
| Mendelian randomization analysis of smoking, BMI, and nonalcoholic fatty liver disease in European descent populations. | Ma L et al. | — | 2025 | → |
| Mendelian Randomization Analysis Reveals Causal Associations Between Beverages and Irritable Bowel Syndrome: Alcohol, but Not Others. | Yuan R et al. | — | 2025 | → |
| miRNA Signatures in Alveolar Macrophages Related to Cigarette Smoke: Assessment and Bioinformatics Analysis. | Mirra D et al. | — | 2025 | → |
| Modifiable lifestyle factors influencing neurological and psychiatric disorders mediated by structural brain reserve: An observational and Mendelian randomization study. | Dong Y et al. | — | 2025 | → |
| Modifiable risk factors for sleep apnea: evidence from meta-analysis of traditional observational studies and 2-sample mendelian randomization. | Xu JW et al. | — | 2025 | → |
| Molecular determinants of lung function decline: a multi-level analysis of gene expression. | Elhusseini ZW et al. | — | 2025 | → |
| Mood instability and 22 gastrointestinal disorders: investigating the causal relationships and the mediating factors by Mendelian randomization analysis. | Yan F et al. | — | 2025 | → |
| MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses. | Xing A et al. | — | 2025 | → |
| Multitrait GWAS of non-suicidal self-injury and the polygenetic effects on child psychopathology and brain structures. | Sun Y et al. | — | 2025 | → |
| Multivariable MR Can Mitigate Bias in Two-Sample MR Using Covariable-Adjusted Summary Associations. | Gilbody J et al. | — | 2025 | → |
| Multivariate Bayesian variable selection for multi-trait genetic fine mapping. | Canida T et al. | — | 2025 | → |
| New insights into the paradox between smoking and the risk of SARS-CoV-2 infection (COVID-19): Insufficient evidence for a causal association. | Kramer I et al. | — | 2025 | → |
| Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review. | Clark SL et al. | — | 2025 | → |
| Nicotine reward in the conditioned place preference test across a panel of male inbred mice and F1 crosses: genetic influence and correlation with variation in nicotine antinociception. | Buzzi B et al. | — | 2025 | → |
| No genetic causal relationship between smoking and acute respiratory distress syndrome: insights from Mendelian randomization and transcriptomics. | Zhang Y et al. | — | 2025 | → |
| Novel causal associations between plasma metabolites and prostate cancer risk revealed by mendelian randomization. | Chen H et al. | — | 2025 | → |
| Optimizing treatment of cardiovascular risk factors in cerebral small vessel disease using genetics. | Koohi F et al. | — | 2025 | → |
| Patterns of shared genetic risk between chronic pain, psychopathologies, and neuroticism. | Zorina-Lichtenwalter K et al. | — | 2025 | → |
| Pharmacogenomic variants in the Pumi population from Yunnan, China. | Yang X et al. | — | 2025 | → |
| Phenotypic screening and genetic insights for predicting major vascular-related diseases using retinal imaging. | Lu M et al. | — | 2025 | → |
| Physical fitness and physical activity in psoriatic arthritis: a systematic review. | Kaerts M et al. | — | 2025 | → |
| PIGEON: a statistical framework for estimating gene-environment interaction for polygenic traits. | Miao J et al. | — | 2025 | → |
| PM2.5 increases the risk of early-onset COPD mediated by smoking and shared genes: a large-scale genetic analysis. | Wen J et al. | — | 2025 | → |
| Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations. | Al-Soufi L et al. | — | 2025 | → |
| Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms. | Han A et al. | — | 2025 | → |
| Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth. | Sosnowski DW et al. | — | 2025 | → |
| Prolonged leisure time television watching as a risk factor for chronic obstructive pulmonary disease: Insights from Mendelian randomization. | Li Y et al. | — | 2025 | → |
| Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm. | Qi Y et al. | — | 2025 | → |
| Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations. | Xiao S et al. | — | 2025 | → |
| Psychological, social factors, and smoking behavior mediated the effects of cannabis use on personality disorders: A Mendelian randomization study. | Ni Y et al. | — | 2025 | → |
| Reassessing the Association of Sedentary Behavior and Physical Activity with Ischemic Stroke: A Mendelian Randomization Study. | Lin Y et al. | — | 2025 | → |
| Revealing the genetic architectures underlying organ-specific aging based on proteomic data. | Zhu RJ et al. | — | 2025 | → |
| Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study. | Jia G et al. | — | 2025 | → |
| Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization. | Jiang C et al. | — | 2025 | → |
| Sex dependent genetic architecture of biochemically verified tobacco use. | Chenoweth MJ et al. | — | 2025 | → |
| Shared biological pathways linking ADHD and cortisol variability are related to externalizing behaviors. | Ramos JKN et al. | — | 2025 | → |
| Shared genetics and causal relationship between sociability and the brain's default mode network. | Fanelli G et al. | — | 2025 | → |
| Similarities and Differences in Genetics. | Liu W et al. | — | 2025 | → |
| Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease. | Ray A et al. | — | 2025 | → |
| Smoking, alcohol and risk of sarcopenia: a Mendelian randomisation study. | Sha T et al. | — | 2025 | → |
| Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study. | Yang Y et al. | — | 2025 | → |
| Smoking can increase the risk of osteoarthritis in European women. | Mao B et al. | — | 2025 | → |
| Smoking may be a risk factor for carpal tunnel syndrome: Insights from Mendelian randomization analysis. | Shi W et al. | — | 2025 | → |
| Smoking may increase the usage of antidepressant: evidence from genomic perspective analysis. | Qu Y et al. | — | 2025 | → |
| Smoking promotes the progression of bladder cancer through FOXM1/CKAP2L axis. | Wu F et al. | — | 2025 | → |
| Socioeconomic status, individual behaviors and risk of anxiety disorders: A Mendelian randomization study. | Lu Q et al. | — | 2025 | → |
| Socioeconomic status, individual behaviors and the risk of aneurysmal subarachnoid hemorrhage: a Mendelian randomization study. | Luo S et al. | — | 2025 | → |
| Stratification-based instrumental variable analysis framework for nonlinear effect analysis. | Tian H et al. | — | 2025 | → |
| Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases. | Ma Y et al. | — | 2025 | → |
| Telomere Length and Clear Cell Renal Cell Carcinoma: Unraveling Causal Mechanisms Through Integrative Genetic and Single-Cell Transcriptomic Analysis. | Zhang K et al. | — | 2025 | → |
| The Associations of Tobacco, Alcohol, and Coffee Consumption with Upper and Lower Gastrointestinal Disease Risk: A Mendelian Randomization Study. | Xue F et al. | — | 2025 | → |
| The causal and mediation effect of chronic obstructive pulmonary disease on lung cancer subtypes: a two-sample mendelian randomization study. | Zhang X et al. | — | 2025 | → |
| The causal association between 91 inflammatory Circulating proteins and intracerebral hemorrhage: A bidirectional two-sample Mendelian randomization study. | Liu C et al. | — | 2025 | → |
| The causal effect of smoking on psychiatric disorders: an examination of brain volume as a potential pathway. | van de Weijer MP et al. | — | 2025 | → |
| The Causal Effects of Lifestyle Factors on Osteoarthritis: A Two-sample Mendelian Randomisation Study. | Ho J et al. | — | 2025 | → |
| The causal impact of smoking behavior on osteoarthritis: a Mendelian randomization analysis. | Xiao Q et al. | — | 2025 | → |
| The Causal Relationship Between Multiple Modifiable Risk Factors and Hallux Valgus: A Two-Sample Mendelian Randomization Study. | Liu S et al. | — | 2025 | → |
| The causal relationship between smoking, alcohol consumption, and sepsis: A 2-sample mendelian randomized study. | Luo Y et al. | — | 2025 | → |
| The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota. | Zhang J et al. | — | 2025 | → |
| The causal relationship of inflammation-related factors with osteoporosis: A Mendelian Randomization Analysis. | Yang X et al. | — | 2025 | → |
| The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study. | Xin X et al. | — | 2025 | → |
| The impact of common and rare genetic variants on bradyarrhythmia development. | Weng LC et al. | — | 2025 | → |
| The Impact of Smoking-Associated Genetic Variants on Post-Exercise Heart Rate. | Al Ashkar H et al. | — | 2025 | → |
| The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans. | de Chaumont F et al. | — | 2025 | → |
| The Lipidomic Profile Discriminates Between MASLD and MetALD. | Schneider KM et al. | — | 2025 | → |
| The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity. | Ehlers CL et al. | — | 2025 | → |
| The relationship between major depression, attention-deficit hyperactivity disorder and coronary artery disease: A two-sample Mendelian randomization analysis. | Zhang X et al. | — | 2025 | → |
| Tobacco use and impulsivity in people with mental illness: A systematic review. | Praecht A et al. | — | 2025 | → |
| Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling. | Foote IF et al. | — | 2025 | → |
| Understanding causal estimates of smoking behaviors for cognitive impairment: A Mendelian randomization study. | Fu M et al. | — | 2025 | → |
| Understanding the alcohol harm paradox: A multivariable mendelian randomization approach. | Sawyer G et al. | — | 2025 | → |
| Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis. | Cao S et al. | — | 2025 | → |
| Unveiling causal relationships between addiction phenotypes and inflammatory cytokines: insights from bidirectional mendelian randomization and bibliometric analysis. | Cao S et al. | — | 2025 | → |
| Unveiling causal relationships between tobacco use phenotypes and neuroimaging: Insights from bidirectional Mendelian randomization and bibliometric analysis. | Zhang Z et al. | — | 2025 | → |
| Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies. | Lv Z et al. | — | 2025 | → |
| Unveiling the Role of Cathepsins on Lung Function in Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis. | Zhang X et al. | — | 2025 | → |
| Use of genetic correlations to examine selection bias. | Shapland CY et al. | — | 2025 | → |
| Using human genetics to understand the epidemiological association between neuroticism and lung cancer. | Wu D et al. | — | 2025 | → |
| Violence and nicotine replacement therapy in a high dependency mental health unit. | Spiers A et al. | — | 2025 | → |
| 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. | Martin SS et al. | — | 2024 | → |
| Accounting for genetic effect heterogeneity in fine-mapping and improving power to detect gene-environment interactions with SharePro. | Zhang W et al. | — | 2024 | → |
| A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden. | Taraszka K et al. | — | 2024 | → |
| A concerted neuron-astrocyte program declines in ageing and schizophrenia. | Ling E et al. | — | 2024 | → |
| A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency. | Thomas NS et al. | — | 2024 | → |
| A Genetic Analysis of Current Medication Use in the UK Biobank. | Rohde PD | — | 2024 | → |
| A high-resolution PheWAS approach to alcohol-related polygenic risk scores reveals mechanistic influences of alcohol reinforcing value and drinking motives. | Deng WQ et al. | — | 2024 | → |
| Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies. | Bouajila N et al. | — | 2024 | → |
| Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study. | Kassaw NA et al. | — | 2024 | → |
| Alcohol drinking, DNA methylation and psychiatric disorders: A multi-omics Mendelian randomization study to investigate causal pathways. | Shi X et al. | — | 2024 | → |
| Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking. | Li M et al. | — | 2024 | → |
| Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex. | White JD et al. | — | 2024 | → |
| Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease. | Zhang H et al. | — | 2024 | → |
| A mammalian-specific Alex3/Gα<sub>q</sub> protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival. | Izquierdo-Villalba I et al. | — | 2024 | → |
| A Mendelian randomization analysis identifies causal association between sarcopenia and gastroesophageal reflux disease. | Hu R et al. | — | 2024 | → |
| A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi-ancestry population from the Million Veteran Program. | Kember RL et al. | — | 2024 | → |
| A multi-ancestry cerebral cortex transcriptome-wide association study identifies genes associated with smoking behaviors. | Tan Q et al. | — | 2024 | → |
| A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer. | Wu D et al. | — | 2024 | → |
| Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior. | Sullivan KA et al. | — | 2024 | → |
| An approach to identify gene-environment interactions and reveal new biological insight in complex traits. | Zhu X et al. | — | 2024 | → |
| A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. | Jennings MV et al. | — | 2024 | → |
| Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization. | Mi C et al. | — | 2024 | → |
| Assessing the causal role of physical activity and leisure sedentary behaviours with chronic obstructive pulmonary disease: a Mendelian randomisation study. | Xiao L et al. | — | 2024 | → |
| Assessment of bidirectional relationships between frailty and acute respiratory distress syndrome: a bidirectional Mendelian Randomization study. | Chen Y et al. | — | 2024 | → |
| Association and mediation between educational attainment and respiratory diseases: a Mendelian randomization study. | Lan G et al. | — | 2024 | → |
| Association between alcohol consumption and incidence of dementia in current drinkers: linear and non-linear mendelian randomization analysis. | Zheng L et al. | — | 2024 | → |
| Association between alcohol consumption and sleep traits: observational and mendelian randomization studies in the UK biobank. | Zheng JW et al. | — | 2024 | → |
| Association between biological ageing and periodontitis: Evidence from a cross-sectional survey and multi-omics Mendelian randomization analysis. | Huang Z et al. | — | 2024 | → |
| Association between coffee consumption and metabolic syndrome: A cross-sectional and Mendelian randomization study. | Wong THT et al. | — | 2024 | → |
| Association between educational attainment and thyroid cancer: evidence from a univariable and multivariable Mendelian randomization study. | Fan S et al. | — | 2024 | → |
| Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study. | Chen M et al. | — | 2024 | → |
| Association between obstructive sleep apnea and risk of lung cancer: findings from a collection of cohort studies and Mendelian randomization analysis. | Yao J et al. | — | 2024 | → |
| Association between primary biliary cholangitis with diabetes and cardiovascular diseases: A bidirectional multivariable Mendelian randomization study. | Lin YL et al. | — | 2024 | → |
| Association Between the Weight-Adjusted Waist Index and OSA Risk: Insights from the NHANES 2017-2020 and Mendelian Randomization Analyses. | Wang H et al. | — | 2024 | → |
| Association of alcohol consumption with aortic aneurysm and dissection risk: results from the UK Biobank cohort study. | Liang Y et al. | — | 2024 | → |
| Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study. | Li CL et al. | — | 2024 | → |
| Association of sleep traits with risk of hypertensive disorders of pregnancy: a mendelian randomization study. | Zhao H et al. | — | 2024 | → |
| Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study. | Li Y et al. | — | 2024 | → |
| Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury. | Edwards AC et al. | — | 2024 | → |
| Autoimmune diseases and their genetic link to bronchiectasis: insights from a genetic correlation and Mendelian randomization study. | Su Y et al. | — | 2024 | → |
| Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders. | Que H et al. | — | 2024 | → |
| Bidirectional two-sample Mendelian randomization study of association between smoking initiation and atrial fibrillation. | Wu Z et al. | — | 2024 | → |
| Body mass index, smoking behavior, and depression mediated the effects of schizophrenia on chronic obstructive pulmonary disease: trans-ethnic Mendelian-randomization analysis. | Ni Y et al. | — | 2024 | → |
| Branched-chain amino acids and risk of lung cancer: insights from mendelian randomization and NHANES III. | Li Z et al. | — | 2024 | → |
| Breaking down causes, consequences, and mediating effects of telomere length variation on human health. | Moix S et al. | — | 2024 | → |
| Breast cancer and neoplasms of the thyroid gland: a bidirectional two-sample Mendelian randomization study. | Sun Y et al. | — | 2024 | → |
| Bridging Three Years of Insights: Examining the Association Between Depression and Gallstone Disease. | Wang HZ et al. | — | 2024 | → |
| Cardiometabolic traits mediating the effect of education on the risk of DKD and CKD: a Mendelian randomization study. | Wang Y et al. | — | 2024 | → |
| Causal association between particulate matter 2.5 and Alzheimer's disease: a Mendelian randomization study. | Dang M et al. | — | 2024 | → |
| Causal association between sleep traits and autoimmune arthritis: Evidence from a bidirectional Mendelian randomization study. | Li Y et al. | — | 2024 | → |
| Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies. | Yang L et al. | — | 2024 | → |
| Causal association of smoking, blood lipids, and bladder cancer: Insights from a multivariable and mediation mendelian randomization investigation. | Wei H et al. | — | 2024 | → |
| Causal associations between atrial fibrillation and breast cancer: A bidirectional Mendelian randomization analysis. | Gong Z et al. | — | 2024 | → |
| Causal associations between leisure sedentary behaviors and sleep status with frailty: insight from Mendelian randomization study. | Li C et al. | — | 2024 | → |
| Causal associations between modifiable risk factors and intervertebral disc degeneration. | Guo W et al. | — | 2024 | → |
| Causal Associations of Education Level With Cardiovascular Diseases, Cardiovascular Biomarkers, and Socioeconomic Factors. | Hu M et al. | — | 2024 | → |
| Causal Associations of Modifiable Risk Factors With Migraine: Evidence From Mendelian Randomization Analysis. | Jareebi MA et al. | — | 2024 | → |
| Causal effect of physical activity and sedentary behavior on the risk of alcohol dependence: A bidirectional two-sample Mendelian randomization study. | Wei M et al. | — | 2024 | → |
| Causal effects of body mass index, education, and lifestyle behaviors on intervertebral disc disorders: Mendelian randomization study. | Liu C et al. | — | 2024 | → |
| Causal effects of dietary composition on multiple sclerosis risk and severity: a Mendelian randomization study. | Nan H | — | 2024 | → |
| Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study. | Ruan LC et al. | — | 2024 | → |
| Causal effects of sleep traits on metabolic syndrome and its components: a Mendelian randomization study. | Yang Y et al. | — | 2024 | → |
| Causal effects of smoking, alcohol consumption, and coffee intake on hepatobiliary and pancreatic diseases: A Mendelian randomization study. | Zhao B et al. | — | 2024 | → |
| Causal impacts of smoking on pain conditions and the mediating pathways: a mendelian randomization study. | Zhang K et al. | — | 2024 | → |
| Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization. | Wang Z et al. | — | 2024 | → |
| Causal Relationship Between Gastroesophageal Reflux Disease and the Risk of Chronic Rhinosinusitis: Insights from Multivariable and Mediation Mendelian Randomization Analysis. | Wu C et al. | — | 2024 | → |
| Causal relationship between green tea intake and gastrointestinal disorders: a two-sample Mendelian randomization study. | Chen C et al. | — | 2024 | → |
| Causal relationship between neuroticism and frailty: A bidirectional Mendelian randomization study. | Chen Q et al. | — | 2024 | → |
| Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis. | Zhou J et al. | — | 2024 | → |
| Causal relationships between modifiable risk factors and polycystic ovary syndrome: a comprehensive Mendelian randomization study. | Zhao Y et al. | — | 2024 | → |
| Causations between obesity, diabetes, lifestyle factors and the risk of low back pain. | Liu Y et al. | — | 2024 | → |
| Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence. | Salem NA et al. | — | 2024 | → |
| Clarifying Chronic Obstructive Pulmonary Disease Genetic Associations Observed in Biobanks via Mediation Analysis of Smoking. | Bazemore K et al. | — | 2024 | → |
| Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses. | Cao M et al. | — | 2024 | → |
| Coffee and Risk of Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization Analyses. | Lu Y et al. | — | 2024 | → |
| COLOCdb: a comprehensive resource for multi-model colocalization of complex traits. | Pan S et al. | — | 2024 | → |
| Complex trait susceptibilities and population diversity in a sample of 4,145 Russians. | Usoltsev D et al. | — | 2024 | → |
| Considerations for the application of polygenic scores to clinical care of individuals with substance use disorders. | Kember RL et al. | — | 2024 | → |
| Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. | Bigdeli TB et al. | — | 2024 | → |
| Correlation between cigarette smoking and alcohol consumption and Rosacea: A two-sample Mendelian randomization study. | Wang J et al. | — | 2024 | → |
| Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. | Johnson EC et al. | — | 2024 | → |
| CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility. | Du M et al. | — | 2024 | → |
| Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. | Cinciripini PM et al. | — | 2024 | → |
| Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study. | Sun T et al. | — | 2024 | → |
| Depression and risk of infectious diseases: A mendelian randomization study. | Shi L et al. | — | 2024 | → |
| Diet-derived circulating antioxidants and functional outcome after ischemic stroke: Evidence from genetic studies. | Li X et al. | — | 2024 | → |
| Different effects of 24 dietary intakes on gastroesophageal reflux disease: A mendelian randomization. | Liu YX et al. | — | 2024 | → |
| Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer. | Ahmed A et al. | — | 2024 | → |
| Disentangling differing relationships between internalizing disorders and alcohol use. | Brasher MS et al. | — | 2024 | → |
| Dissecting the association between blood pressure traits, hypertension, antihypertensive medications and epilepsy: A Mendelian randomization study. | Yu C et al. | — | 2024 | → |
| Dissecting the pathogenic effects of smoking in blood DNA methylation on allergic diseases. | Tu J et al. | — | 2024 | → |
| Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease. | Bergstedt J et al. | — | 2024 | → |
| Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons. | Tochon L et al. | — | 2024 | → |
| Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data. | Ramne S et al. | — | 2024 | → |
| DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study. | Schuurmans IK et al. | — | 2024 | → |
| Does Tobacco Smoking Increase Social Isolation? A Mendelian Randomization Study. | Matsuyama Y et al. | — | 2024 | → |
| Dopamine Pharmacodynamics: New Insights. | Lauretani F et al. | — | 2024 | → |
| Effect of Household Income on Cardiovascular Diseases, Cardiovascular Biomarkers, and Socioeconomic Factors. | Hu M et al. | — | 2024 | → |
| Effect of smoking cessation medications on intracranial aneurysm risk: A Mendelian randomization study. | Liang X et al. | — | 2024 | → |
| Effect of smoking on prostate cancer: Results from the National Health and Nutrition Examination Survey 2003-2018 and Mendelian randomization analyses. | He H et al. | — | 2024 | → |
| Effects of common lifestyle factors on obstructive sleep apnea: precautions in daily life based on causal inferences. | Liu K et al. | — | 2024 | → |
| Effects of the Phosphodiesterase 10A Inhibitor MR1916 on Alcohol Self-Administration and Striatal Gene Expression in Post-Chronic Intermittent Ethanol-Exposed Rats. | Bertotto LB et al. | — | 2024 | → |
| Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer. | Tang M et al. | — | 2024 | → |
| Estimating causality between smoking and abdominal obesity by Mendelian randomization. | Carrasquilla GD et al. | — | 2024 | → |
| Estimating the health impact of nicotine exposure by dissecting the effects of nicotine versus non-nicotine constituents of tobacco smoke: A multivariable Mendelian randomisation study. | Khouja JN et al. | — | 2024 | → |
| Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits. | Mize TJ et al. | — | 2024 | → |
| Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex. | Voorhies K et al. | — | 2024 | → |
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| Exploring the Bidirectional Causal Pathways Between Smoking Behaviors and Headache: A Mendelian Randomization Study. | Lloyd K et al. | — | 2024 | → |
| Exploring the Chemopreventive Effect of Medication on Gene Expression Linked to Colorectal Cancer: An Observational and Mendelian Randomization Analysis in Healthy Colon Mucosa. | Moratalla-Navarro F et al. | — | 2024 | → |
| Exploring the contribution of lifestyle to the impact of education on the risk of cancer through Mendelian randomization analysis. | Zagkos L et al. | — | 2024 | → |
| Exploring the effect of lifestyle behaviors and socioeconomic status on atrial fibrillation: the mediating role of 91 inflammatory cytokines. | Liu Y et al. | — | 2024 | → |
| Exploring the mediating role of calcium homeostasis in the association between diabetes mellitus, glycemic traits, and vascular and valvular calcifications: a comprehensive Mendelian randomization analysis. | Zhu XG et al. | — | 2024 | → |
| Exploring the relationship between sarcopenia and 11 respiratory diseases: a comprehensive mendelian randomization analysis. | Su Y et al. | — | 2024 | → |
| GABAergic mechanisms in alcohol dependence. | Uusi-Oukari M et al. | — | 2024 | → |
| Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. | Friligkou E et al. | — | 2024 | → |
| Generalized genetic liability to substance use disorders. | Miller AP et al. | — | 2024 | → |
| Genetically influenced tobacco and alcohol use behaviors impact erythroid trait variation. | Shivakumar S et al. | — | 2024 | → |
| Genetically predicted high serum sex hormone-binding globulin levels are associated with lower ischemic stroke risk: A sex-stratified Mendelian randomization study. | Sun W et al. | — | 2024 | → |
| Genetically predicted smoking and body mass index mediate the relationship between insomnia and myocardial infarction. | Deng L et al. | — | 2024 | → |
| Genetic analyses of the bidirectional associations between common mental disorders and asthma. | Yan Z et al. | — | 2024 | → |
| Genetic Analysis of Perceived Youthfulness Reveals Differences in How Men's and Women's Age Is Assessed. | Ingold N et al. | — | 2024 | → |
| Genetic and Modifiable Risk Factors for Postoperative Complications of Total Joint Arthroplasty: A Genome-Wide Association and Mendelian Randomization Study. | Guo S et al. | — | 2024 | → |
| Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. | Koyanagi YN et al. | — | 2024 | → |
| Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits. | Ge YJ et al. | — | 2024 | → |
| Genetic causality between modifiable risk factors and the risk of rheumatoid arthritis: Evidence from Mendelian randomization. | Ge M et al. | — | 2024 | → |
| Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. | Koller D et al. | — | 2024 | → |
| Genetic correlation between smoking behavior and gastroesophageal reflux disease: insights from integrative multi-omics data. | Yan Z et al. | — | 2024 | → |
| Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways. | Wang Y et al. | — | 2024 | → |
| Genetic evidence strengthens the bidirectional connection between oral health status and psychiatric disorders: A two-sample Mendelian randomization study. | Pi Y et al. | — | 2024 | → |
| Genetic factors associated with suicidal behaviors and alcohol use disorders in an American Indian population. | Peng Q et al. | — | 2024 | → |
| Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors. | Savage JE et al. | — | 2024 | → |
| Genetic influences on alcohol sensitivity: A critical review. | Yeung EW et al. | — | 2024 | → |
| Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study. | Xu W et al. | — | 2024 | → |
| Genetic Insights into the causal relationship between cannabis use and diabetic phenotypes: A genetic correlation and Mendelian randomization study. | Zhang Y et al. | — | 2024 | → |
| Genetic landscape of interval and screen detected breast cancer. | Mills C et al. | — | 2024 | → |
| Genetic liability to elevated circulating IP-10, IFNγ and SCGFβ levels in relation to thoracic aortic aneurysm: A mendelian randomization study. | Ye Q et al. | — | 2024 | → |
| Genetic liability to frailty in relation to functional outcome after ischemic stroke. | Cai H et al. | — | 2024 | → |
| Genetic prediction of modifiable lifestyle factors for erectile dysfunction. | Xi YJ et al. | — | 2024 | → |
| Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline. | Chenoweth MJ et al. | — | 2024 | → |
| Genetic proxies for therapy of insulin drug targets and risk of osteoarthritis: a drug-target Mendelian randomization analysis. | Cao Z et al. | — | 2024 | → |
| Genetics of chronic respiratory disease. | Sayers I et al. | — | 2024 | → |
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| Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. | Jurgens SJ et al. | — | 2024 | → |
| Genome-Wide Search for Nonadditive Allele Effects Identifies <i>PSKH2</i> as Involved in the Variability of Factor V Activity. | Gendre B et al. | — | 2024 | → |
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| Identification and validation of a novel gene <i>ARVCF</i> associated with alcohol dependence among Chinese population. | Shi X et al. | — | 2024 | → |
| Identification and validation of supervariants reveal novel loci associated with human white matter microstructure. | Wang S et al. | — | 2024 | → |
| Identification of molecular mediators of renal sarcopenia risk: a mendelian randomization analysis. | Yan P et al. | — | 2024 | → |
| Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis. | Sun W et al. | — | 2024 | → |
| Immune-mediated inflammatory diseases and the risk of valvular heart disease: a Mendelian randomization study. | Cai D et al. | — | 2024 | → |
| Impact of Alcohol Consumption on Lifespan: a Mendelian randomization study in Europeans. | Jiesisibieke ZL et al. | — | 2024 | → |
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| Inflammatory bowel disease and risk of autoimmune hepatitis: A univariable and multivariable Mendelian randomization study. | Chi G et al. | — | 2024 | → |
| Integrative analysis of causal associations between neurodegenerative diseases and colorectal cancer. | Wang F et al. | — | 2024 | → |
| Integrative analysis of genetics, epigenetics and RNA expression data reveal three susceptibility loci for smoking behavior in Chinese Han population. | Li MD et al. | — | 2024 | → |
| Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder. | Hubers N et al. | — | 2024 | → |
| Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study. | Duncan MS et al. | — | 2024 | → |
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| Investigating causal associations between pneumonia and lung cancer using a bidirectional mendelian randomization framework. | Song L et al. | — | 2024 | → |
| Investigating the Causal Relationship Between Sleep Behaviors and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study. | Zhang J et al. | — | 2024 | → |
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| Investigating the Relationship Between Smoking Behavior and Global Brain Volume. | Chang Y et al. | — | 2024 | → |
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| Leisure television watching exerts a causal effect on gastroesophageal reflux disease: evidence from a two-step mendelian randomization study. | Fan Q et al. | — | 2024 | → |
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| Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization Study. | Salih AM et al. | — | 2024 | → |
| Lifestyle factors, glycemic traits, and lipoprotein traits and risk of liver cancer: a Mendelian randomization analysis. | Zhang H et al. | — | 2024 | → |
| Liver Function Biomarkers and Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank. | Sun X et al. | — | 2024 | → |
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| Management and Nursing Approaches to Low Back Pain: Investigating the Causal Association with Lifestyle-Related Risk Factors. | Geng J et al. | — | 2024 | → |
| Mapping biological influences on the human plasma proteome beyond the genome. | Carrasco-Zanini J et al. | — | 2024 | → |
| Mediating effect of metabolic syndrome in the association of educational attainment with intervertebral disc degeneration and low back pain. | Tang X et al. | — | 2024 | → |
| Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes: A Mendelian Randomization Study. | Rogne T et al. | — | 2024 | → |
| Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study. | Zhang J et al. | — | 2024 | → |
| Mendelian randomization analyses clarify the effects of height on cardiovascular diseases. | Hui D et al. | — | 2024 | → |
| Mendelian randomization analysis separated the independent impact of childhood obesity and adult obesity on socioeconomic status, psychological status, and substance use. | Cai J et al. | — | 2024 | → |
| Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants. | Sysojev AÖ et al. | — | 2024 | → |
| Modifiable risk factors that mediate the effect of insomnia on the risk of low back pain: a network mendelian randomization study. | Lu W et al. | — | 2024 | → |
| MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures. | Zhang W et al. | — | 2024 | → |
| Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk. | Gorman BR et al. | — | 2024 | → |
| Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. | Toikumo S et al. | — | 2024 | → |
| Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder. | Miller AP et al. | — | 2024 | → |
| Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. | Yang BZ et al. | — | 2024 | → |
| Nicotine Motivated Behavior in <i>C. elegans</i>. | Salim C et al. | — | 2024 | → |
| Nightmares share genetic risk factors with sleep and psychiatric traits. | Ollila HM et al. | — | 2024 | → |
| No Causal Association Between Genetic Markers of Smoking Behaviors and Genetic Markers of Atopic Dermatitis®: Evidence From a Mendelian Randomization Study. | Xiao Y et al. | — | 2024 | → |
| Obesity-related indicators and tuberculosis: A Mendelian randomization study. | Cai N et al. | — | 2024 | → |
| Observational and genetic analyses of the bidirectional relationship between depression and hypertension. | Xu Z et al. | — | 2024 | → |
| Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling. | Horwitz TB et al. | — | 2024 | → |
| Passion fruit (<i>Passiflora edulis Sims</i>) by-products as a source of bioactive compounds for non-communicable disease prevention: extraction methods and mechanisms of action: a systematic review. | Weyya G et al. | — | 2024 | → |
| PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity. | Tang S et al. | — | 2024 | → |
| Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. | Koller D et al. | — | 2024 | → |
| Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles. | Venkateswaran V et al. | — | 2024 | → |
| Prevalence and risk factors for isolated systolic hypertension among the oldest-old population in southwestern China: A community-based cross-sectional study. | Huang X et al. | — | 2024 | → |
| Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study. | Du Y et al. | — | 2024 | → |
| Proteome-wide Mendelian randomization identifies potential therapeutic targets for nonalcoholic fatty liver diseases. | Li J et al. | — | 2024 | → |
| Rare and common variants associated with alcohol consumption identify a conserved molecular network. | Leger BS et al. | — | 2024 | → |
| Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction. | Savage JE et al. | — | 2024 | → |
| Relationship between alcohol consumption and dementia with Mendelian randomization approaches among older adults in the United States. | Campbell KA et al. | — | 2024 | → |
| Relationship between socioeconomic status and stroke: An observational and network Mendelian randomization study. | Zhang R et al. | — | 2024 | → |
| Relationships of dietary habits with prostate cancer risk: results from Mendelian randomization analyses and the National Health and Nutrition Examination Survey. | Zhou Z et al. | — | 2024 | → |
| Restriction of salt, alcohol and coffee intake and Ménière's disease: insight from Mendelian randomization study. | Gao W et al. | — | 2024 | → |
| Returning Genetic Information About Risk for Alcohol Use Disorder to Adolescents: Findings of a Preliminary Qualitative Study of Precision Prevention. | Weitzman ER et al. | — | 2024 | → |
| Risk Factors for Pelvic Organ Prolapse: Wide-Angled Mendelian Randomization Analysis. | Xiong Z et al. | — | 2024 | → |
| Schizophrenia and Types of Stroke: A Mendelian Randomization Study. | Nakada S et al. | — | 2024 | → |
| Sedentary and 21 gastrointestinal disorders: A Mendelian randomization study. | Lin Y et al. | — | 2024 | → |
| Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysis. | Chen J et al. | — | 2024 | → |
| Separating the effects of life course adiposity on diabetic nephropathy: a comprehensive multivariable Mendelian randomization study. | Zhang H et al. | — | 2024 | → |
| Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis. | Qin C et al. | — | 2024 | → |
| Single Nucleotide Polymorphisms Within <i>DRD2, COMT, and DBH</i> and Smoking Cessation: A Systematic Review Considering Genetic Differences by Ancestry and Biological Sex. | Jones SK et al. | — | 2024 | → |
| Smoking, Alcohol Consumption, and Risk of Arterial Stiffness: A Two-Sample Mendelian Randomization Study. | Gu Y et al. | — | 2024 | → |
| Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study. | Thakral A et al. | — | 2024 | → |
| Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses. | Xu Z et al. | — | 2024 | → |
| Smoking as a mediator in the association between major depressive disorder and schizophrenia on lung cancer risk: a bidirectional/multivariable and mediation Mendelian randomization study. | Zhu X et al. | — | 2024 | → |
| Smoking, Corneal Biomechanics, and Glaucoma: Results From Two Large Population-Based Cohorts. | Stuart KV et al. | — | 2024 | → |
| Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study. | Jaitner A et al. | — | 2024 | → |
| Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci. | Carnes MU et al. | — | 2024 | → |
| Socioeconomic status, individual behaviors and risk for Lymphomas: a Mendelian randomization study. | Tan Z et al. | — | 2024 | → |
| Socioeconomic traits and the risk of Barrett's esophagus and gastroesophageal reflux disease: A Mendelian randomization study. | Liu YX et al. | — | 2024 | → |
| Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease. | Miyoshi E et al. | — | 2024 | → |
| Statin Use, Lipids, and 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase Inhibition on Risk of Idiopathic Pulmonary Fibrosis. | Zhao SS et al. | — | 2024 | → |
| Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma. | Zhang L et al. | — | 2024 | → |
| Tea intake and lung diseases: a Mendelian randomization study. | Wu Z et al. | — | 2024 | → |
| The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study. | Yamazaki H et al. | — | 2024 | → |
| The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study. | Yang J et al. | — | 2024 | → |
| The causal relationship between sarcopenia-related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses. | Song J et al. | — | 2024 | → |
| The causal relationship between severe mental illness and risk of lung carcinoma. | Chen X et al. | — | 2024 | → |
| The effect of heavy smoking on retirement risk: A mendelian randomisation analysis. | Gaggero A et al. | — | 2024 | → |
| The epidemiology of pregnancy loss: global burden, variable risk factors, and predictions. | Tong F et al. | — | 2024 | → |
| The genetic architecture of substance use and its diverse correlations with mental health traits. | Wormington B et al. | — | 2024 | → |
| The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders. | Chen SD et al. | — | 2024 | → |
| The genetic landscape of substance use disorders. | Gerring ZF et al. | — | 2024 | → |
| The impact of educational attainment on mental health: A Causal Assessment from the UKB and FinnGen Cohorts. | Jareebi MA et al. | — | 2024 | → |
| The impact of maternal smoking during pregnancy and the age of smoking initiation on incident dementia: A prospective cohort study. | Liu J et al. | — | 2024 | → |
| The impact of smoking and alcohol consumption on rosacea: a multivariable Mendelian randomization study. | Chu Z et al. | — | 2024 | → |
| The interaction effects of age, APOE and common environmental risk factors on human brain structure. | Chen J et al. | — | 2024 | → |
| The role of hypertension in the relationship between leisure screen time, physical activity and migraine: a 2-sample Mendelian randomization study. | Gan Q et al. | — | 2024 | → |
| The Role of the Gut-Joint Axis in the Care of Psoriatic Arthritis: A Two-Sample Bidirectional Mendelian Randomization Study. | Gan Y et al. | — | 2024 | → |
| Tobacco use: a smoking gun for IPF? | Hall I | — | 2024 | → |
| Ubiquitous bias and false discovery due to model misspecification in analysis of statistical interactions: The role of the outcome's distribution and metric properties. | Domingue BW et al. | — | 2024 | → |
| Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study. | Li X et al. | — | 2024 | → |
| Unraveling the causal association between leukocyte telomere length and infertility: A two-sample Mendelian randomization study. | An G et al. | — | 2024 | → |
| Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and Schizophrenia. | Shen J et al. | — | 2024 | → |
| Unravelling the complex causal effects of substance use behaviours on common diseases. | Xue A et al. | — | 2024 | → |
| Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging. | Patel K et al. | — | 2024 | → |
| Using Alternative Definitions of Controls to Increase Statistical Power in GWAS. | Benstock SE et al. | — | 2024 | → |
| Using Instrumental Variables to Measure Causation over Time in Cross-Lagged Panel Models. | Singh M et al. | — | 2024 | → |
| Using Machine Learning to Evaluate the Value of Genetic Liabilities in the Classification of Hypertension within the UK Biobank. | MacCarthy G et al. | — | 2024 | → |
| Vitamin D levels and risk of ocular disorders: insights from bidirectional and multivariable Mendelian randomization analysis. | Fan S et al. | — | 2024 | → |
| Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains. | Rahman Y et al. | — | 2024 | → |
| Whole exome sequencing analysis identifies genes for alcohol consumption. | Kang J et al. | — | 2024 | → |
| 15 years of GWAS discovery: Realizing the promise. | Abdellaoui A et al. | — | 2023 | → |
| 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics. | Gameiro-Ros I et al. | — | 2023 | → |
| A Case-Only Genome-Wide Interaction Study of Smoking and Bladder Cancer Risk: Results from the COBLAnCE Cohort. | Karimi M et al. | — | 2023 | → |
| Additional Evidence for the Relationship Between Type 2 Diabetes and Stroke Through Observational and Genetic Analyses. | Zhang W et al. | — | 2023 | → |
| ADuLT: An efficient and robust time-to-event GWAS. | Pedersen EM et al. | — | 2023 | → |
| A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage. | Myserlis EP et al. | — | 2023 | → |
| Alcohol Consumption and Alcohol Use Disorder: Exposing an Increasingly Shared Genetic Architecture. | White JD et al. | — | 2023 | → |
| Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults. | Su J et al. | — | 2023 | → |
| A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders. | Poore HE et al. | — | 2023 | → |
| Analysis of the brain transcriptome for substance-associated genes: An update on large-scale genome-wide association studies. | Zhao Y et al. | — | 2023 | → |
| An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses. | Kim JY et al. | — | 2023 | → |
| An atlas of genetic determinants of forearm fracture. | Nethander M et al. | — | 2023 | → |
| An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset. | Yang A et al. | — | 2023 | → |
| Apolipoprotein B and interleukin 1 receptor antagonist: reversing the risk of coronary heart disease. | Yang F et al. | — | 2023 | → |
| A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations. | Prom-Wormley EC et al. | — | 2023 | → |
| Assessing the associations between known genetic variants and substance use in people with HIV in the United States. | Haas CB et al. | — | 2023 | → |
| Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study. | Cheng X et al. | — | 2023 | → |
| Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study. | Huang T et al. | — | 2023 | → |
| Association between Dietary Habits and Pancreatitis among Individuals of European Ancestry: A Two-Sample Mendelian Randomization Study. | Mao X et al. | — | 2023 | → |
| Association between dietary habits and the risk of migraine: a Mendelian randomization study. | Liu X et al. | — | 2023 | → |
| Association between genetic risk of alcohol consumption and alcohol-related morbidity and mortality under different alcohol policy conditions: Evidence from the Finnish alcohol price reduction of 2004. | Lahtinen H et al. | — | 2023 | → |
| Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization. | Zhao SS et al. | — | 2023 | → |
| Association between vascular risk factors and idiopathic normal pressure hydrocephalus: a Mendelian randomization study. | Deng Z et al. | — | 2023 | → |
| Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study. | Zhou W et al. | — | 2023 | → |
| Association of coffee and caffeine consumption with risk and prognosis of endometrial cancer and its subgroups: a Mendelian randomization. | Chen Z et al. | — | 2023 | → |
| Association of educational attainment with esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease, and the mediating role of modifiable risk factors: A Mendelian randomization study. | Zhang X et al. | — | 2023 | → |
| Association of Genetically Predicted Insomnia With Risk of Sepsis: A Mendelian Randomization Study. | Thorkildsen MS et al. | — | 2023 | → |
| Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study. | Chen Y et al. | — | 2023 | → |
| Association of smoking, alcohol, and coffee consumption with the risk of ovarian cancer and prognosis: a mendelian randomization study. | Liu S et al. | — | 2023 | → |
| Association of smoking with brain gray and white matter volume: a Mendelian randomization study. | Lin W et al. | — | 2023 | → |
| Associations between adiposity, diabetes, lifestyle factors and the risk of gliomas. | Liu X et al. | — | 2023 | → |
| Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa). | Wootton RE et al. | — | 2023 | → |
| Associations between modifiable risk factors and frailty: a Mendelian randomisation study. | Zhang N et al. | — | 2023 | → |
| Associations between polygenic risk scores and accelerated brain ageing in smokers. | Yang Z et al. | — | 2023 | → |
| Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans. | Rabinowitz JA et al. | — | 2023 | → |
| BDNF Val66Met polymorphism is associated with consolidation of episodic memory during sleep. | Rovný R et al. | — | 2023 | → |
| Benchmarking of local genetic correlation estimation methods using summary statistics from genome-wide association studies. | Zhang C et al. | — | 2023 | → |
| Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits. | Pan S et al. | — | 2023 | → |
| Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases. | de Klein N et al. | — | 2023 | → |
| CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. | Sanchez-Roige S et al. | — | 2023 | → |
| Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study. | de La Harpe R et al. | — | 2023 | → |
| Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach. | Gentry AE et al. | — | 2023 | → |
| Causal association between basal metabolic rate and risk of cardiovascular diseases: a univariable and multivariable Mendelian randomization study. | Li Y et al. | — | 2023 | → |
| Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study. | Li Q et al. | — | 2023 | → |
| Causal association of leisure sedentary behavior with arthritis: A Mendelian randomization analysis. | Cao Z et al. | — | 2023 | → |
| Causal associations between modifiable risk factors and pancreatitis: A comprehensive Mendelian randomization study. | Mao X et al. | — | 2023 | → |
| Causal Associations Between Tobacco, Alcohol Use and Risk of Infectious Diseases: A Mendelian Randomization Study. | Zhu H et al. | — | 2023 | → |
| Causal associations of obstructive sleep apnea with cardiovascular disease: a Mendelian randomization study. | Li Y et al. | — | 2023 | → |
| Causal associations of Sjögren's syndrome with cancers: a two-sample Mendelian randomization study. | Jia Y et al. | — | 2023 | → |
| Causal associations of sleep apnea, snoring with cardiovascular diseases, and the role of body mass index: a two-sample Mendelian randomization study. | Wang J et al. | — | 2023 | → |
| Causal effects from tobacco smoking initiation on obesity-related traits: a Mendelian randomization study. | Park S et al. | — | 2023 | → |
| Causal Effects of Modifiable Behaviors on Prostate Cancer in Europeans and East Asians: A Comprehensive Mendelian Randomization Study. | Zhan Y et al. | — | 2023 | → |
| Causal effects of potential risk factors on postpartum depression: a Mendelian randomization study. | Zuo M et al. | — | 2023 | → |
| Causal effects of serum testosterone levels on brain volume: a sex-stratified Mendelian randomization study. | Niu PP et al. | — | 2023 | → |
| Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia. | Park S et al. | — | 2023 | → |
| Causal relationship between addictive behaviors and epilepsy risk: A mendelian randomization study. | Liang Z et al. | — | 2023 | → |
| Causal relationship between gastro-esophageal reflux disease and risk of lung cancer: insights from multivariable Mendelian randomization and mediation analysis. | Liu Y et al. | — | 2023 | → |
| Causal relationship between rheumatoid arthritis and hypothyroidism or hyperthyroidism: a bidirectional two-sample univariable and multivariable Mendelian randomization study. | Lai R et al. | — | 2023 | → |
| Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking. | Bierut L et al. | — | 2023 | → |
| Characterizing Alcohol Expectancies in the ABCD Study: Associations with Sociodemographic Factors, the Immediate Social Environment, and Genetic Propensities. | Johnson EC et al. | — | 2023 | → |
| Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. | Rødevand L et al. | — | 2023 | → |
| Childhood sunburn and risk of melanoma and non-melanoma skin cancer: a Mendelian randomization study. | Li Y et al. | — | 2023 | → |
| Cigarette smoking and thyroid cancer risk: A Mendelian randomization study. | Jiang H et al. | — | 2023 | → |
| Circulating macrophage colony-stimulating factor levels and stroke: A Mendelian randomization study. | Cao L et al. | — | 2023 | → |
| Clonal haematopoiesis and risk of chronic liver disease. | Wong WJ et al. | — | 2023 | → |
| Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor. | Winsvold BS et al. | — | 2023 | → |
| Cohort profile: Genetic data in the German Socio-Economic Panel Innovation Sample (SOEP-G). | Koellinger PD et al. | — | 2023 | → |
| Comment on 'Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia' by Park et al. | Liu M et al. | — | 2023 | → |
| Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome. | Cortez Cardoso Penha R et al. | — | 2023 | → |
| Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study. | Fan J et al. | — | 2023 | → |
| Depression and 24 gastrointestinal diseases: a Mendelian randomization study. | Ruan X et al. | — | 2023 | → |
| Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. | Als TD et al. | — | 2023 | → |
| Determination of genetic correlation between tobacco smoking and coronary artery disease. | Zhu Z et al. | — | 2023 | → |
| Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes. | Bountress KE et al. | — | 2023 | → |
| Disentangling the interplay between genes, cognitive skills, and educational level in adolescent and young adult smoking - The TRAILS study. | Schmengler H et al. | — | 2023 | → |
| Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits. | Campbell ML et al. | — | 2023 | → |
| Does ACE2 mediate the detrimental effect of exposures related to COVID-19 risk: A Mendelian randomization investigation. | Au Yeung SL et al. | — | 2023 | → |
| Education plays a crucial role in the pathway from poverty to smoking: a Mendelian randomization study. | Shi X et al. | — | 2023 | → |
| Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs. | van Dongen J et al. | — | 2023 | → |
| Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank. | Feng L et al. | — | 2023 | → |
| Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank. | Mo C et al. | — | 2023 | → |
| Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis: a multivariable Mendelian randomization analysis. | Wan B et al. | — | 2023 | → |
| Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization. | Gormley M et al. | — | 2023 | → |
| Evaluating the role of non-alcoholic fatty liver disease in cardiovascular diseases and type 2 diabetes: a Mendelian randomization study in Europeans and East Asians. | Au Yeung SL et al. | — | 2023 | → |
| Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis. | O'Farrell F et al. | — | 2023 | → |
| Exploration of the Causal Association Between Behavioral Risk Factors and Gallstone Disease Development in Two European Ancestry Populations. | Alyahyawi KO et al. | — | 2023 | → |
| Exploring Determinants of HIV/AIDS Self-Testing Uptake in South Africa Using Generalised Linear Poisson and Geographically Weighted Poisson Regression. | Fundisi E et al. | — | 2023 | → |
| Exploring the cross-cancer effect of smoking and its fingerprints in blood DNA methylation on multiple cancers: A Mendelian randomization study. | Zhou Y et al. | — | 2023 | → |
| Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. | Zhong C et al. | — | 2023 | → |
| Genetically determined alcohol consumption and cancer risk in Korea. | Jung KJ et al. | — | 2023 | → |
| Genetically predicted blood pressure, antihypertensive drugs and risk of heart failure: a Mendelian randomization study. | Lian J et al. | — | 2023 | → |
| Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study. | Wu D et al. | — | 2023 | → |
| Genetically predicted lifestyle factors, socioeconomic status and risk of coronary artery disease in individuals with diabetes: a Mendelian randomization study. | Mai Z et al. | — | 2023 | → |
| Genetically Predicted Sleep Traits and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study. | Zhang Z et al. | — | 2023 | → |
| Genetically predicted tobacco consumption and risk of intracranial aneurysm: a Mendelian randomization study. | Zeng C et al. | — | 2023 | → |
| Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes. | Ribasés M et al. | — | 2023 | → |
| Genetic association of telomere length, obesity and tobacoo smoking with idiopathic pulmonary fibrosis risk. | Wu W et al. | — | 2023 | → |
| Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach. | Bountress KE et al. | — | 2023 | → |
| Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease. | European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration et al. | — | 2023 | → |
| Genetic Associations Between Smoking- and Glaucoma-Related Traits. | Tran JH et al. | — | 2023 | → |
| Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia. | Hang SMT et al. | — | 2023 | → |
| Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on Epigenetic-Age Acceleration. | Kong L et al. | — | 2023 | → |
| Genetic influences on alcohol flushing in East Asian populations. | Cho Y et al. | — | 2023 | → |
| Genetic liability to migraine and functional outcome after ischemic stroke. | Wang M et al. | — | 2023 | → |
| Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study. | Qu Y et al. | — | 2023 | → |
| Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study. | Pingault JB et al. | — | 2023 | → |
| Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder. | Karpyak VM et al. | — | 2023 | → |
| Genetic predisposition to smoking in relation to the risk of frailty in ageing. | Liu W et al. | — | 2023 | → |
| Genetic support of a causal relationship between cannabis use and educational attainment: a two-sample Mendelian randomization study of European ancestry. | Chen D et al. | — | 2023 | → |
| Genetic susceptibility for schizophrenia after adjustment by genetic susceptibility for smoking: implications in identification of risk genes and genetic correlation with related traits. | Al-Soufi L et al. | — | 2023 | → |
| Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample. | Kember RL et al. | — | 2023 | → |
| Genetic variants for smoking behaviour and risk of skin cancer. | Dusingize JC et al. | — | 2023 | → |
| Genome- and transcriptome-wide splicing associations with alcohol use disorder. | Huggett SB et al. | — | 2023 | → |
| Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. | Demontis D et al. | — | 2023 | → |
| Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. | Roychowdhury T et al. | — | 2023 | → |
| Genome-wide association study meta-analysis of suicide death and suicidal behavior. | Li QS et al. | — | 2023 | → |
| Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection. | Packer RJ et al. | — | 2023 | → |
| Genomic medicine to reduce tobacco and related disorders: Translation to precision prevention and treatment. | Chen LS et al. | — | 2023 | → |
| Geographic variation of mutagenic exposures in kidney cancer genomes | Senkin S et al. | — | 2023 | — |
| Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. | Williams CM et al. | — | 2023 | → |
| Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study. | Wei Z et al. | — | 2023 | → |
| GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. | Docherty AR et al. | — | 2023 | → |
| GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. | Lagou V et al. | — | 2023 | → |
| Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association. | Tsao CW et al. | — | 2023 | → |
| Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study. | Pettit RW et al. | — | 2023 | → |
| Hyperconnectivity of Two Separate Long-Range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity during Nicotine Withdrawal in Male Mice. | Carrette LLG et al. | — | 2023 | → |
| Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice. | Smith ML et al. | — | 2023 | → |
| Identifying genetic loci and phenomic associations of substance use traits: A multi-trait analysis of GWAS (MTAG) study. | Xu H et al. | — | 2023 | → |
| <i>In Utero</i> and Childhood/Adolescence Exposure to Tobacco Smoke, Genetic Risk, and Lung Cancer Incidence and Mortality in Adulthood. | He H et al. | — | 2023 | → |
| Immunology in COPD and the use of combustible cigarettes and heated tobacco products. | Błach J et al. | — | 2023 | → |
| Integrated Analyses of Single-Cell Transcriptome and Mendelian Randomization Reveal the Protective Role of Resistin in Sepsis Survival in Intensive Care Unit. | Chen H et al. | — | 2023 | → |
| Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma. | Wang Q et al. | — | 2023 | → |
| Integrative Multi-omics Analysis of Childhood Aggressive Behavior. | Hagenbeek FA et al. | — | 2023 | → |
| Investigating effect modification between childhood maltreatment and genetic risk for cardiovascular disease in the UK Biobank. | Urquijo H et al. | — | 2023 | → |
| Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse. | Thijssen AB et al. | — | 2023 | → |
| Investigating modifiable pathways in psoriasis: A Mendelian randomization study. | Chalitsios CV et al. | — | 2023 | → |
| Investigating the relationship between depression and breast cancer: observational and genetic analyses. | Wu X et al. | — | 2023 | → |
| Investigation on the association between serum lipid levels and periodontitis: a bidirectional Mendelian randomization analysis. | Chen Z et al. | — | 2023 | → |
| Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis. | Blum K et al. | — | 2023 | → |
| Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA. | Tervi A et al. | — | 2023 | → |
| Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases. | Li Y et al. | — | 2023 | → |
| Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults. | Deng WQ et al. | — | 2023 | → |
| Lifestyle factors, metabolic factors and socioeconomic status for pelvic organ prolapse: a Mendelian randomization study. | Liu H et al. | — | 2023 | → |
| Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study. | Liu M et al. | — | 2023 | → |
| Low Dopamine D2 Receptor Expression Drives Gene Networks Related to GABA, cAMP, Growth and Neuroinflammation in Striatal Indirect Pathway Neurons. | Guerri L et al. | — | 2023 | → |
| Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two-sample mendelian randomization analyses. | Ren Q et al. | — | 2023 | → |
| Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns. | Oliva V et al. | — | 2023 | → |
| Mendelian randomization analyses explore the relationship between cathepsins and lung cancer. | Li J et al. | — | 2023 | → |
| Mendelian randomization analysis suggests no causal influence of gastroesophageal reflux disease on the susceptibility and prognosis of idiopathic pulmonary fibrosis. | Sun D et al. | — | 2023 | → |
| Mendelian randomization for cardiovascular diseases: principles and applications. | Larsson SC et al. | — | 2023 | → |
| Mendelian randomization study of diabetes and dementia in the Million Veteran Program. | Litkowski EM et al. | — | 2023 | → |
| Mendelian randomization study on the causal effects of systemic lupus erythematosus on major depressive disorder. | Li W et al. | — | 2023 | → |
| Mendelian randomization study shows a causal effect of asthma on chronic obstructive pulmonary disease risk. | Li Y et al. | — | 2023 | → |
| Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases. | Qiu S et al. | — | 2023 | → |
| Mendelian randomization to explore the direct or mediating associations between socioeconomic status and lung cancer. | Wu H et al. | — | 2023 | → |
| Modifiable pathways for longevity: A Mendelian randomization analysis. | Ni X et al. | — | 2023 | → |
| Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study. | Wan B et al. | — | 2023 | → |
| Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. | Shrine N et al. | — | 2023 | → |
| Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. | Zhou H et al. | — | 2023 | → |
| Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. | Chen F et al. | — | 2023 | → |
| Multi-omics cannot replace sample size in genome-wide association studies. | Baranger DAA et al. | — | 2023 | → |
| Multiple solutions at the genomic level in response to selective breeding for high locomotor activity. | Hillis DA et al. | — | 2023 | → |
| Multisite chronic pain and the risk of autoimmune diseases: A Mendelian randomization study. | Tang Y et al. | — | 2023 | → |
| Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization. | Zhu J et al. | — | 2023 | → |
| Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis. | Han Y et al. | — | 2023 | → |
| Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program. | Cheng Y et al. | — | 2023 | → |
| Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. | Hatoum AS et al. | — | 2023 | → |
| Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases. | Vallés AS et al. | — | 2023 | → |
| Obesity, birth weight, and lifestyle factors for frailty: a Mendelian randomization study. | Gu Y et al. | — | 2023 | → |
| Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease. | Yan P et al. | — | 2023 | → |
| Partners in Health: Investigating Social Genetic Effects Among Married and Cohabiting Couples. | Otten K et al. | — | 2023 | → |
| Paternal and Maternal Problem Drinking and Lifetime Problem Drinking of Their Adult Children. | Sipilä PN et al. | — | 2023 | → |
| Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis. | Wang Y et al. | — | 2023 | → |
| Polygenic risk for alcohol consumption and multisite chronic pain: Associations with ad lib drinking behavior. | White KM et al. | — | 2023 | → |
| Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent alcohol use and parental alcohol use disorder. | Wang FL et al. | — | 2023 | → |
| Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV. | Lee WJ et al. | — | 2023 | → |
| Preclinical and clinical evidence for suppression of alcohol intake by apremilast. | Grigsby KB et al. | — | 2023 | → |
| Preliminary Evidence for Genetic Nurture in Depression and Neuroticism Through Polygenic Scores. | Tubbs JD et al. | — | 2023 | → |
| Prevalence of tobacco smoking in people at clinical high-risk for psychosis: Systematic review and meta-analysis. | De Micheli A et al. | — | 2023 | → |
| Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization. | Tao H et al. | — | 2023 | → |
| Rare coding variants in CHRNB2 reduce the likelihood of smoking. | Rajagopal VM et al. | — | 2023 | → |
| Reassessing the Casual Effects of Genetically Predicted Obesity on Pelvic Organ Prolapse: Letter to the Editor on "Lifestyle factors, metabolic factors and socioeconomic status for pelvic organ prolapse: a Mendelian randomization study". | Chen Z et al. | — | 2023 | → |
| Reassessing the causal role of obesity in breast cancer susceptibility: a comprehensive multivariable Mendelian randomization investigating the distribution and timing of exposure. | Hao Y et al. | — | 2023 | → |
| Reciprocal causation mixture model for robust Mendelian randomization analysis using genome-scale summary data. | Liu Z et al. | — | 2023 | → |
| Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method. | Tian H et al. | — | 2023 | → |
| Role of lifestyle factors in mediating the effect of educational attainment on bone mineral density: a Mendelian randomization study. | Liu Q et al. | — | 2023 | → |
| Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence. | Buzzi B et al. | — | 2023 | → |
| Serum uric acid and risk of diabetic neuropathy: a genetic correlation and mendelian randomization study. | Zhang Y et al. | — | 2023 | → |
| Shared genetic liability for alcohol consumption, alcohol problems, and suicide attempt: Evaluating the role of impulsivity. | Stephenson M et al. | — | 2023 | → |
| Single-cell DNA methylation and 3D genome architecture in the human brain. | Tian W et al. | — | 2023 | → |
| Single nucleotide polymorphisms rs148582811 regulates its host gene <i>ARVCF</i> expression to affect nicotine-associated hippocampus-dependent memory. | Yang Z et al. | — | 2023 | → |
| Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. | Zhou JL et al. | — | 2023 | → |
| Sleep Health at the Genomic Level: Six Distinct Factors and Their Relationships With Psychopathology. | Morrison CL et al. | — | 2023 | → |
| Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis. | Yuan S et al. | — | 2023 | → |
| Smoking, alcohol consumption, and frailty: A Mendelian randomization study. | Lv J et al. | — | 2023 | → |
| Smoking, alcohol consumption and risk of Dupuytren's disease: a Mendelian randomization study. | Wang Z et al. | — | 2023 | → |
| Smoking and coronary artery disease risk in patients with diabetes: A Mendelian randomization study. | Chen S et al. | — | 2023 | → |
| Smoking cessation and vaccination. | Montes de Oca M et al. | — | 2023 | → |
| Smoking cessation, harm reduction, and biomarkers protocols in the PhenX Toolkit: Tools for standardized data collection. | Bierut LJ et al. | — | 2023 | → |
| Smoking, Coffee Consumption, Alcohol Intake, and Obstructive Sleep Apnea: A Mendelian Randomization Study. | Yang Y et al. | — | 2023 | → |
| Smoking-related dysregulation of plasma circulating microRNAs: the Rotterdam study. | Karabegović I et al. | — | 2023 | → |
| Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults. | Edstorp J et al. | — | 2023 | → |
| Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression. | Mitchell RE et al. | — | 2023 | → |
| Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention. | Volkow ND et al. | — | 2023 | → |
| Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes. | Mize TJ et al. | — | 2023 | → |
| Testing relationship between tea intake and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study. | Lu RB et al. | — | 2023 | → |
| Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study. | Iob E et al. | — | 2023 | → |
| The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank. | Stuart KV et al. | — | 2023 | → |
| The Causal Association between Alcohol, Smoking, Coffee Consumption, and the Risk of Arthritis: A Meta-Analysis of Mendelian Randomization Studies. | Wang J et al. | — | 2023 | → |
| The causal association between smoking initiation, alcohol and coffee consumption, and women's reproductive health: A two-sample Mendelian randomization analysis. | Jiang Z et al. | — | 2023 | → |
| The Causal Effect of Obesity on the Risk of 15 Autoimmune Diseases: A Mendelian Randomization Study. | Li X et al. | — | 2023 | → |
| The causal relationship between metabolic factors, drinking, smoking and intrahepatic cholangiocarcinoma: a Mendelian randomization study. | Qin SS et al. | — | 2023 | → |
| The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study. | Ma X et al. | — | 2023 | → |
| The effect of antioxidant dietary supplements and diet-derived circulating antioxidants on vitiligo outcome: evidence from genetic association and comprehensive Mendelian randomization. | Ni Y et al. | — | 2023 | → |
| The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study. | Taylor K et al. | — | 2023 | → |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | — | 2023 | → |
| The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS. | Alemany-Navarro M et al. | — | 2023 | → |
| The Physiological and Pathological Role of Acyl-CoA Oxidation. | Szrok-Jurga S et al. | — | 2023 | → |
| The prediction of Alzheimer's disease through multi-trait genetic modeling. | Clark K et al. | — | 2023 | → |
| The Promise of an Evolutionary Perspective of Alcohol Consumption. | Clites BL et al. | — | 2023 | → |
| The relationship of airflow limitation with lung squamous cell carcinoma: evidence from mendelian randomization analysis. | Zhang Q et al. | — | 2023 | → |
| The role of nicotinic receptors in alcohol consumption. | Kamens HM et al. | — | 2023 | → |
| The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders. | Yang Y et al. | — | 2023 | → |
| TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility. | Margaritte-Jeannin P et al. | — | 2023 | → |
| Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice. | Browne CJ et al. | — | 2023 | → |
| Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits. | Evans LM et al. | — | 2023 | → |
| Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study. | Tan L et al. | — | 2023 | → |
| Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks. | Fritsche LG et al. | — | 2023 | → |
| Understanding the consequences of leisure sedentary behavior on periodontitis: A two-step, multivariate Mendelian randomization study. | Zhang Z et al. | — | 2023 | → |
| Unraveling the Complex Relationship Between Gastroesophageal Reflux Disease, Lifestyle Factors, and Interstitial Lung Disease: Insights From Two-Sample Mendelian Randomization Analyses. | Jareebi MA et al. | — | 2023 | → |
| Using allele scores to identify confounding by reverse causation: studies of alcohol consumption as an exemplar. | Sallis HM et al. | — | 2023 | → |
| Waterpipe and cigarette epigenome analysis reveals markers implicated in addiction and smoking type inference. | Awada Z et al. | — | 2023 | → |
| Women's reproductive traits and cerebral small-vessel disease: A two-sample Mendelian randomization study. | Wang Z et al. | — | 2023 | → |
| Women's reproductive traits and ischemic stroke: a two-sample Mendelian randomization study. | Wang Z et al. | — | 2023 | → |
| Women's reproductive traits and major depressive disorder: A two-sample Mendelian randomization study. | Wang Z et al. | — | 2023 | → |
| Work-related factors and risk of amyotrophic lateral sclerosis: A multivariable Mendelian randomization study. | Li M et al. | — | 2023 | → |
| A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits. | Battram T et al. | — | 2022 | → |
| Addictive behavior and incident gallstone disease: A dose-response meta-analysis and Mendelian randomization study. | Bai Y et al. | — | 2022 | → |
| Adjusting for collider bias in genetic association studies using instrumental variable methods. | Cai S et al. | — | 2022 | → |
| A genome-wide association study of a rage-related misophonia symptom and the genetic link with audiological traits, psychiatric disorders, and personality. | Smit DJA et al. | — | 2022 | → |
| A Genome-Wide Association Study Reveals a <i>BDNF</i>-Centered Molecular Network Associated with Alcohol Dependence and Related Clinical Measures. | Levchenko A et al. | — | 2022 | → |
| Alcohol consumption and hepatocellular carcinoma: novel insights from a prospective cohort study and nonlinear Mendelian randomization analysis. | Liu Z et al. | — | 2022 | → |
| Alcohol consumption and smoking in relation to psoriasis: a Mendelian randomization study. | Wei J et al. | — | 2022 | → |
| Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects. | Topiwala A et al. | — | 2022 | → |
| Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study. | Zhou X et al. | — | 2022 | → |
| Alcohol Use and Use Disorder and Cancer Risk: Perspective on Causal Inference. | Zhou H et al. | — | 2022 | → |
| A Mendelian randomization study of the effect of tea intake on breast cancer. | Deng Y et al. | — | 2022 | → |
| A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma. | Seviiri M et al. | — | 2022 | → |
| An ethical analysis of endoscopic therapy decision-making in patients with refractory substance use disorder and chronic pancreatitis. | Al-Moussally F et al. | — | 2022 | → |
| Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies. | Larsson SC et al. | — | 2022 | → |
| A practical problem with Egger regression in Mendelian randomization. | Lin Z et al. | — | 2022 | → |
| Apremilast-induced increases in acute ethanol intoxication and decreases in ethanol drinking in mice involve PKA phosphorylation of GABA<sub>A</sub> β3 subunits. | Blednov YA et al. | — | 2022 | → |
| Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study. | Nethander M et al. | — | 2022 | → |
| Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study. | Mavromatis LA et al. | — | 2022 | → |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | — | 2022 | → |
| Association of autoimmune diseases with Alzheimer's disease: A mendelian randomization study. | Yeung CHC et al. | — | 2022 | → |
| Association of cannabis use disorder with cardiovascular diseases: A two-sample Mendelian randomization study. | Chen M et al. | — | 2022 | → |
| Association of cardiovascular risk factors and lifestyle behaviors with aortic aneurysm: A Mendelian randomization study. | Zhou J et al. | — | 2022 | → |
| Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses. | Topiwala A et al. | — | 2022 | → |
| A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse. | de Marco A et al. | — | 2022 | → |
| A systematic review of genetic variation within nicotinic acetylcholine receptor genes and cigarette smoking cessation. | Jones SK et al. | — | 2022 | → |
| Avoiding collider bias in Mendelian randomization when performing stratified analyses. | Coscia C et al. | — | 2022 | → |
| Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. | Banna FKE et al. | — | 2022 | → |
| Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass. | Xia JW et al. | — | 2022 | → |
| Cancers and COVID-19 Risk: A Mendelian Randomization Study. | Li Z et al. | — | 2022 | → |
| Cannabis use and the risk of periodontitis: A two-sample Mendelian randomization study. | Baumeister SE et al. | — | 2022 | → |
| Capturing additional genetic risk from family history for improved polygenic risk prediction. | Lu T et al. | — | 2022 | → |
| Causal Association between Chronic Kidney Disease and Risk of 19 Site-Specific Cancers: A Mendelian Randomization Study. | Tang L et al. | — | 2022 | → |
| Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach. | Hoek AG et al. | — | 2022 | → |
| Causal Associations of Obesity With Achilles Tendinopathy: A Two-Sample Mendelian Randomization Study. | He L et al. | — | 2022 | → |
| Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study. | Fu L et al. | — | 2022 | → |
| Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study. | Wang YB et al. | — | 2022 | → |
| Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study. | Wang H et al. | — | 2022 | → |
| Characterisation of the genetic relationship between the domains of sleep and circadian-related behaviours with substance use phenotypes. | Hatoum AS et al. | — | 2022 | → |
| Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. | Sey NYA et al. | — | 2022 | → |
| Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses. | Dimou N et al. | — | 2022 | → |
| Cigarette smoking, coffee consumption, alcohol intake, and clozapine metabolism: A Mendelian randomization study. | Zeng L et al. | — | 2022 | → |
| Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements. | Smith-Byrne K et al. | — | 2022 | → |
| Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics. | Zhang N et al. | — | 2022 | → |
| Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts. | Barr PB et al. | — | 2022 | → |
| Coffee consumption and cancer risk: a Mendelian randomisation study. | Carter P et al. | — | 2022 | → |
| Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies. | Chang XW et al. | — | 2022 | → |
| Common variants contribute to intrinsic human brain functional networks. | Zhao B et al. | — | 2022 | → |
| Contribution of <i>ZBTB20</i> Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population. | Yu S et al. | — | 2022 | → |
| Contribution of metabolic risk factors and lifestyle behaviors to cardiovascular disease: A mendelian randomization study. | Jia Y et al. | — | 2022 | → |
| Coronary artery disease and cancer: a significant resemblance. | Rakshit S et al. | — | 2022 | → |
| Could Alcohol Abuse and Dependence on Junk Foods Inducing Obesity and/or Illicit Drug Use Represent Danger to Liver in Young People with Altered Psychological/Relational Spheres or Emotional Problems? | Tarantino G et al. | — | 2022 | → |
| Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. | Byun J et al. | — | 2022 | → |
| Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. | Kember RL et al. | — | 2022 | → |
| Cross-sectional analysis of the humoral response after SARS-CoV-2 vaccination in Sardinian multiple sclerosis patients, a follow-up study. | Idda ML et al. | — | 2022 | → |
| Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk. | Yang W et al. | — | 2022 | → |
| Diabetic retinopathy risk in patients with unhealthy lifestyle: A Mendelian randomization study. | Su Z et al. | — | 2022 | → |
| Diet, Lifestyle Behaviours and Other Risk Factors Associated With Type 2 Diabetes Beyond Body Mass Index: A Mendelian Randomization Study. | Jia Y et al. | — | 2022 | → |
| Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation? | Yu C et al. | — | 2022 | → |
| Does smoking protect against developing osteoarthritis? Evidence from a genetically informed perspective. | Ni J et al. | — | 2022 | → |
| EasySMPC: a simple but powerful no-code tool for practical secure multiparty computation. | Wirth FN et al. | — | 2022 | → |
| Educational attainment and offspring birth weight: A bidirectional Mendelian randomization study. | Liu Y et al. | — | 2022 | → |
| Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank. | Carter AR et al. | — | 2022 | → |
| Effects of metabolic traits, lifestyle factors, and pharmacological interventions on liver fat: mendelian randomisation study. | Yuan S et al. | — | 2022 | → |
| Estimating the causal effect of frailty index on vestibular disorders: A two-sample Mendelian randomization. | Xiao G et al. | — | 2022 | → |
| Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization. | Sanderson E et al. | — | 2022 | → |
| Evaluation of the causal relationship between smoking and schizophrenia in East Asia. | Su MH et al. | — | 2022 | → |
| Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study. | Chen L et al. | — | 2022 | → |
| ExPRSweb: An online repository with polygenic risk scores for common health-related exposures. | Ma Y et al. | — | 2022 | → |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | — | 2022 | → |
| Gene-by-peer-environment interaction effects on cigarette, alcohol, and marijuana use among US high school students of European Ancestry. | Zheng B et al. | — | 2022 | → |
| GeneCup: mining PubMed and GWAS catalog for gene-keyword relationships. | Gunturkun MH et al. | — | 2022 | → |
| Gene-environment correlations across geographic regions affect genome-wide association studies. | Abdellaoui A et al. | — | 2022 | → |
| General intelligence and executive functioning are overlapping but separable at genetic and molecular pathway levels: An analytical review of existing GWAS findings. | Ciobanu LG et al. | — | 2022 | → |
| Genes regulating levels of ω-3 long-chain polyunsaturated fatty acids are associated with alcohol use disorder and consumption, and broader externalizing behavior in humans. | Aliev F et al. | — | 2022 | → |
| Genetic Addiction Risk Severity Assessment Identifies Polymorphic Reward Genes as Antecedents to Reward Deficiency Syndrome (RDS) Hypodopaminergia's Effect on Addictive and Non-Addictive Behaviors in a Nuclear Family. | Dennen CA et al. | — | 2022 | → |
| Genetically predicted adiponectin causally reduces the risk of chronic kidney disease, a bilateral and multivariable mendelian randomization study. | Wu R et al. | — | 2022 | → |
| Genetically predicted higher educational attainment decreases the risk of stroke: a multivariable Mendelian randomization study. | Zhang W et al. | — | 2022 | → |
| Genetically Predicted Smoking and Alcohol Consumption and Functional Outcome After Ischemic Stroke. | Zhang Z et al. | — | 2022 | → |
| Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden. | Gabriel AAG et al. | — | 2022 | → |
| Genetic and environmental etiology of drinking motives in college students. | Savage JE et al. | — | 2022 | → |
| Genetic control of RNA splicing and its distinct role in complex trait variation. | Qi T et al. | — | 2022 | → |
| Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study. | Ma M et al. | — | 2022 | → |
| Genetic diversity fuels gene discovery for tobacco and alcohol use. | Saunders GRB et al. | — | 2022 | → |
| Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease. | Sun Y et al. | — | 2022 | → |
| Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians. | Xiu X et al. | — | 2022 | → |
| Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction. | Xiong Y et al. | — | 2022 | → |
| Genetic evidence that the causal association of educational attainment with reduced risk of Alzheimer's disease is driven by intelligence. | Thorp JG et al. | — | 2022 | → |
| Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK. | Piga NN et al. | — | 2022 | → |
| Genetic liability to obesity and peptic ulcer disease: a Mendelian randomization study. | Li Z et al. | — | 2022 | → |
| Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk. | Yuan S et al. | — | 2022 | → |
| Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings. | Icick R et al. | — | 2022 | → |
| Genetic risk factors have a substantial impact on healthy life years. | Jukarainen S et al. | — | 2022 | → |
| Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment. | Su J et al. | — | 2022 | → |
| Genetic risk of smoking and alcohol use examined. | — | — | 2022 | → |
| Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. | Kar SP et al. | — | 2022 | → |
| Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program. | Huang RDL et al. | — | 2022 | → |
| Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH. | Larsson SC et al. | — | 2022 | → |
| Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. | Parker CC et al. | — | 2022 | → |
| Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. | Deak JD et al. | — | 2022 | → |
| Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. | Deak JD et al. | — | 2022 | → |
| Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease. | Zhou W et al. | — | 2022 | → |
| Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study. | Niu PP et al. | — | 2022 | → |
| Identifying Causes of Fracture Beyond Bone Mineral Density: Evidence From Human Genetics. | Lu T et al. | — | 2022 | → |
| Increased brain volume from higher cereal and lower coffee intake: shared genetic determinants and impacts on cognition and metabolism. | Kang J et al. | — | 2022 | → |
| Increased genetic contribution to wellbeing during the COVID-19 pandemic. | Warmerdam CAR et al. | — | 2022 | → |
| Inferring causal effects of homocysteine and B-vitamin concentrations on bone mineral density and fractures: Mendelian randomization analyses. | Fu L et al. | — | 2022 | → |
| Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits. | Toikumo S et al. | — | 2022 | → |
| Investigating the causal nature of the relationship of subcortical brain volume with smoking and alcohol use. | Logtenberg E et al. | — | 2022 | → |
| Is there a causal relationship between executive function and liability to mental health and substance use? A Mendelian randomization approach. | Burton SMI et al. | — | 2022 | → |
| Longitudinal effects and environmental moderation of <i>ALDH2</i> and <i>ADH1B</i> gene variants on substance use from age 14 to 40. | Saunders GRB et al. | — | 2022 | → |
| Low vitamin D concentrations and BMI are causal factors for primary biliary cholangitis: A mendelian randomization study. | Xu H et al. | — | 2022 | → |
| Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study. | Zhang J et al. | — | 2022 | → |
| Mendelian randomization analyses of 23 known and suspected risk factors and biomarkers for breast cancer overall and by molecular subtypes. | Chen F et al. | — | 2022 | → |
| Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis. | Yao Y et al. | — | 2022 | → |
| Mendelian randomization highlights the causal association of obesity with periodontal diseases. | Dong J et al. | — | 2022 | → |
| Mendelian Randomization Shows a Causal Effect of Low Vitamin D on Non-infectious Uveitis and Scleritis Risk. | Susarla G et al. | — | 2022 | → |
| Modifiable traits, healthy behaviours, and leukocyte telomere length: a population-based study in UK Biobank. | Bountziouka V et al. | — | 2022 | → |
| Molecular Alterations Caused by Alcohol Consumption in the UK Biobank: A Mendelian Randomisation Study. | O'Farrell F et al. | — | 2022 | → |
| Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond. | Gaddis N et al. | — | 2022 | → |
| NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population. | Thomas CE et al. | — | 2022 | → |
| Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. | Huang N et al. | — | 2022 | → |
| Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance. | Greco LA et al. | — | 2022 | → |
| Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk. | Barr PB et al. | — | 2022 | → |
| Phenome-wide screening of the putative causal determinants of depression using genetic data. | Aman AM et al. | — | 2022 | → |
| Pleiotropic genetic architecture and novel loci for C-reactive protein levels. | Koskeridis F et al. | — | 2022 | → |
| Predicting nicotine metabolism across ancestries using genotypes. | Baurley JW et al. | — | 2022 | → |
| Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults. | Su J et al. | — | 2022 | → |
| Rare genetic variants explain missing heritability in smoking. | Jang SK et al. | — | 2022 | → |
| Reply of the Authors: Smoking, alcohol, and coffee consumption and pregnancy loss: a Mendelian randomization investigation. | Yuan S et al. | — | 2022 | → |
| Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data. | Xue H et al. | — | 2022 | → |
| Roles of 21 Genera of Human Gut Microbiota in Barrett's Esophagus Risk: A Mendelian Randomization Study. | Yang Z et al. | — | 2022 | → |
| Selection bias when inferring the effect direction in Mendelian randomization. | Lutz SM et al. | — | 2022 | → |
| Smoking, alcohol consumption, diabetes, body mass index, and peptic ulcer risk: A two-sample Mendelian randomization study. | Liu Y et al. | — | 2022 | → |
| Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. | Hernáez Á et al. | — | 2022 | → |
| Smoking quantitatively increases risk for COVID-19. | Zhang F et al. | — | 2022 | → |
| Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. | Silventoinen K et al. | — | 2022 | → |
| Socioeconomic status, individual behaviors and risk for mental disorders: A Mendelian randomization study. | Cai J et al. | — | 2022 | → |
| Statistical Validation of Risk Alleles in Genetic Addiction Risk Severity (GARS) Test: Early Identification of Risk for Alcohol Use Disorder (AUD) in 74,566 Case-Control Subjects. | Blum K et al. | — | 2022 | → |
| Substance use and common contributors to morbidity: A genetics perspective. | Sanchez-Roige S et al. | — | 2022 | → |
| Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke. | Chen L et al. | — | 2022 | → |
| The association between plasma chemokines and breast cancer risk and prognosis: A mendelian randomization study. | Yu X et al. | — | 2022 | → |
| The association of genetic susceptibility to smoking with cardiovascular disease mortality and the benefits of adhering to a DASH diet: The Singapore Chinese Health Study. | Geng T et al. | — | 2022 | → |
| The CADM2 Gene and Behavior: A Phenome-Wide Scan in UK-Biobank. | Pasman JA et al. | — | 2022 | → |
| The detrimental effects of smoking on the course and outcome in adults with bipolar disorder-A narrative review. | Grunze A et al. | — | 2022 | → |
| The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond. | Verweij KJH et al. | — | 2022 | → |
| The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness. | Reay WR et al. | — | 2022 | → |
| The HUNT study: A population-based cohort for genetic research. | Brumpton BM et al. | — | 2022 | → |
| The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: Mendelian randomization study. | Zhao SS et al. | — | 2022 | → |
| The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited. | Domenighetti C et al. | — | 2022 | → |
| The Promise and Peril of Genetics. | Dick DM | — | 2022 | → |
| The Promise of Polygenic Risk Prediction in Smoking Cessation: Evidence From Two Treatment Trials. | Bray M et al. | — | 2022 | → |
| Thirty novel sequence variants impacting human intracranial volume. | Nawaz MS et al. | — | 2022 | → |
| Tobacco Addiction. | Selby P et al. | — | 2022 | → |
| Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure. | Jiang X et al. | — | 2022 | → |
| Using Local and Global Genetic Correlation Approaches to Help Elucidate the Shared Genetic Etiology of Psychiatric and Substance Use Traits. | Deak JD | — | 2022 | → |