Risks for early substance involvement associated with parental alcoholism and parental separation in an adolescent female cohort.
paper
Cited
Public
- Authors
- Waldron, Mary; Vaughan, Ellen L; Bucholz, Kathleen K; Lynskey, Michael T; Sartor, Carolyn E; Duncan, Alexis E; Madden, Pamela A F; Heath, Andrew C
- Year
- 2014
- Journal
- Drug and alcohol dependence
- PMID
- 24647368
- DOI
- 10.1016/j.drugalcdep.2014.02.020
- PMCID
- PMC4012919
BACKGROUND: We examined timing of substance involvement as a joint function of parental history of alcoholism and parental separation during childhood. METHOD: Data were drawn from a large cohort of female like-sex twins [n=613 African Ancestry (AA), n=3550 European or other ancestry (EA)]. Cox proportional hazards regression was conducted predicting age at first use of alcohol, first alcohol intoxication, first use and regular use of cigarettes, and first use of cannabis and other illicit drugs from dummy variables coding for parental alcoholism and parental separation. Propensity score analysis was also conducted comparing intact and separated families by predicted probability of parental separation. RESULTS: In EA families, increased risk of substance involvement was found in both alcoholic and separated families, particularly through ages 10 or 14 years, with risk to offspring from alcoholic separated families further increased. In AA families, associations with parental alcoholism and parental separation were weak and with few exceptions statistically nonsignificant. While propensity score findings confirmed unique risks observed in EA families, intact and separated AA families were poorly matched on risk-factors presumed to predate parental separation, especially parental alcoholism, requiring cautious interpretation of AA survival-analytic findings. CONCLUSION: For offspring of European ancestry, parental separation predicts early substance involvement that is not explained by parental alcoholism nor associated family background characteristics. Additional research is needed to better characterize risks associated with parental separation in African American families.
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| Name | Type |
|---|---|
| AA families | cohort |
| AA twins | cohort |
| adolescents | cohort |
| African American | cohort |
| African American offspring local | cohort |
| African ancestry families local | cohort |
| African ancestry female twins | cohort |
| age at first use | phenotype |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| alcoholic separated families local | phenotype |
| Alcoholic separated families local | cohort |
| alcohol intoxication | phenotype |
| alcoholism | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| Asian/Pacific Islander local | cohort |
| Australian population | cohort |
| cannabis use | phenotype |
| children of alcoholic parents | phenotype |
| Children of nonalcoholic parents local | cohort |
| cigarettes | phenotype |
| cocaine | phenotype |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| Compromised parenting behavior local | phenotype |
| conduct disorder | phenotype |
| Coparent alcohol dependence local | phenotype |
| Dizygotic (DZ) twinning local | phenotype |
| EA families | cohort |
| Early alcohol intoxication local | phenotype |
| early alcohol use | phenotype |
| early cannabis use | phenotype |
| Early illicit drug use local | phenotype |
| Early initiation of other drugs local | phenotype |
| Early regular smoking local | phenotype |
| early smoking | phenotype |
| early substance use | phenotype |
| EA twins | cohort |
| European ancestry | cohort |
| European ancestry families local | cohort |
| European ancestry female twins | cohort |
| European or other Ancestry (EA) local | cohort |
| excessive alcohol consumption | phenotype |
| Family History Research Diagnostic Criteria assessment local | cohort |
| Frequent use of substance classes local | phenotype |
| hallucinogens | drug |
| Harder substances local | phenotype |
| heavy drinking | phenotype |
| hyperactivity | phenotype |
| illicit drugs | phenotype |
| illicit drug use | phenotype |
| inattention | phenotype |
| Intact African American families local | cohort |
| Intact alcoholic families local | cohort |
| intact families | cohort |
| Lifetime substance use local | phenotype |
| major depressive disorder | phenotype |
| maternal age | phenotype |
| maternal age at twins’ birth | phenotype |
| Maternal age at twins' birth local | phenotype |
| Maternal alcohol dependence symptoms local | phenotype |
| maternal smoking | phenotype |
| Missouri Adolescent Female Twin Study | cohort |
| Monozygotic (MZ) twinning local | phenotype |
| nonalcoholic families with parental separation local | phenotype |
| nonalcoholic intact families local | phenotype |
| Nonalcoholic intact families local | cohort |
| Nonalcoholic separated families local | cohort |
| non-cannabis illicit drug use local | phenotype |
| offspring alcohol involvement | phenotype |
| Offspring early alcohol involvement local | phenotype |
| Offspring illicit drug involvement local | phenotype |
| Offspring sex local | phenotype |
| Offspring tobacco involvement local | phenotype |
| onset of drinking | phenotype |
| oppositional defiant disorder | phenotype |
| other drugs | drug |
| other drug use | phenotype |
| Other illicit substances local | drug |
| parental alcoholism | phenotype |
| parental divorce/separation | phenotype |
| parental education | phenotype |
| Parental smoking local | drug |
| parent positive local | phenotype |
| paternal alcoholism | phenotype |
| paternal alcohol use disorder | phenotype |
| Paternal educational attainment local | phenotype |
| Peer influences | phenotype |
| physical abuse | phenotype |
| Population-representative U.S. sample local | cohort |
| problematic alcohol use | phenotype |
| problem use | phenotype |
| regular smoking | phenotype |
| risky sexual behavior | phenotype |
| self-report local | cohort |
| Separated African American families local | cohort |
| sex | phenotype |
| singletons | cohort |
| smoking | phenotype |
| smoking initiation | phenotype |
| social anxiety | phenotype |
| Social networks local | phenotype |
| socioeconomic status | phenotype |
| Stepparent local | phenotype |
| substance use | phenotype |
| suicide | phenotype |
| Timing of substance involvement local | phenotype |
| Timing of substance use local | phenotype |
| tobacco use | phenotype |
| Twin cohort | cohort |
| Twin parents and their children local | cohort |
| twin report local | cohort |
| Twins from nonalcoholic families local | cohort |
| Twin Study Cohort local | cohort |
| twin substance involvement local | phenotype |
| Twin substance involvement local | phenotype |
| Unintentional accidents local | phenotype |
| U.S. 8th graders local | cohort |
| Very early substance involvement local | phenotype |
| victimization | phenotype |
| wave 2 | cohort |
| White European ancestry families local | cohort |
| zygosity | phenotype |
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| Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder. | Kuo SI et al. | — | 2023 | → |
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| Parental Divorce and Trajectories of Alcohol Consumption in Men: A Genetically Informative Perspective. | Salvatore JE et al. | — | 2023 | → |
| Role of parental divorce and discord in the intergenerational transmission of alcohol use disorder. | Salvatore JE et al. | — | 2022 | → |
| Estimating the number of children in households with substance use disorders in Germany. | Kraus L et al. | — | 2021 | → |
| Alcohol Dependence and Reproductive Onset in Women, Updated: Analyses of Research and State-Level Administrative Data. | Waldron M et al. | — | 2020 | → |
| Commentary on Holst et al. (2020): Genetically informative research can clarify mechanisms linking non-intact family structure and alcohol use disorder. | Salvatore JE | — | 2020 | → |
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