Dipole source analysis of auditory P300 response in depressive and anxiety disorders.
- Authors
- Li, Yuezhi; Hu, Yong; Liu, Tiebang; Wu, Dongling
- Year
- 2011
- Journal
- Cognitive neurodynamics
- PMID
- 21826191
- DOI
- 10.1007/s11571-011-9156-y
- PMCID
- PMC3100469
This paper is to study auditory event-related potential P300 in patients with anxiety and depressive disorders using dipole source analysis. Auditory P300 using 2-stimulus oddball paradigm was collected from 35 patients with anxiety disorder, 32 patients with depressive disorder, and 30 healthy controls. P300 dipole sources and peak amplitude of dipole activities were analyzed. The source analysis resulted in a 4-dipole configuration, where temporal dipoles displayed greater P300 amplitude than that of frontal dipoles. In addition, a right-greater-than-left hemispheric asymmetry of dipole magnitude was found in patients with anxiety disorder, whereas a left-greater-than-right hemispheric asymmetry of dipole magnitude was observed in depressed patients. Results indicated that the asymmetry was more prominent over the temporal dipole than that of frontal dipoles in patients. Patients with anxiety disorder may increase their efforts to enhance temporal dipole activity to compensate for a deficit in frontal cortex processing, while depressed patients show dominating reduction of right temporal activity. The opposite nature of results observed with hemispheric asymmetry in depressive and anxiety disorders could serve to be valuable information for psychiatric studies.
Grand average ERPs of the healthy controls, patients having anxiety disorders and patients having depressive disorders in response to target stimuli, where ERPs are respectively from the Fz,Cz and Pz electrode sites
Grand average ERPs of the healthy controls, patients with anxiety disorders and patients with depressive disorders in response to standard stimuli, where ERPs are respectively from the Fz,Cz and Pz electrode sites
ERPs potential maps to target stimuli and standard stimuli of the healthy control and patient groups at P300 peak latency. The upper row presents maps to target stimuli and the low row presents maps to standard stimuli
The upper part presents grand average dipole source waveforms of the healthy control and patient groups, where two kinds of P300 activities are observed in each group, monophasic P300 peak and small P300 peak followed by a slow negative wave. The low part illustrates dipole locations and orientations superimposed on MNI305 anatomical template brain
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|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
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