Power and predictive accuracy of polygenic risk scores.
paper
Cited
Public
- Authors
- Dudbridge, Frank
- Year
- 2013
- Journal
- PLoS genetics
- PMID
- 23555274
- DOI
- 10.1371/journal.pgen.1003348
- PMCID
- PMC3605113
Polygenic scores have recently been used to summarise genetic effects among an ensemble of markers that do not individually achieve significance in a large-scale association study. Markers are selected using an initial training sample and used to construct a score in an independent replication sample by forming the weighted sum of associated alleles within each subject. Association between a trait and this composite score implies that a genetic signal is present among the selected markers, and the score can then be used for prediction of individual trait values. This approach has been used to obtain evidence of a genetic effect when no single markers are significant, to establish a common genetic basis for related disorders, and to construct risk prediction models. In some cases, however, the desired association or prediction has not been achieved. Here, the power and predictive accuracy of a polygenic score are derived from a quantitative genetics model as a function of the sizes of the two samples, explained genetic variance, selection thresholds for including a marker in the score, and methods for weighting effect sizes in the score. Expressions are derived for quantitative and discrete traits, the latter allowing for case/control sampling. A novel approach to estimating the variance explained by a marker panel is also proposed. It is shown that published studies with significant association of polygenic scores have been well powered, whereas those with negative results can be explained by low sample size. It is also shown that useful levels of prediction may only be approached when predictors are estimated from very large samples, up to an order of magnitude greater than currently available. Therefore, polygenic scores currently have more utility for association testing than predicting complex traits, but prediction will become more feasible as sample sizes continue to grow.
Expected βlog10(P) of linear regression estimate as a function of P-value threshold for selecting markers into the polygenic score.Training sample, 3322 cases and 3587 controls; replication sample, 2687 cases and 2656 controls. Marker panel of 74062 independent SNPs. Variance explained by markers, 28.7%. pi0, proportion of markers with no effect on disease.
Expected βlog10(P) of allele score estimate as a function of P-value threshold for selecting markers into the polygenic score.Training sample, 3322 cases and 3587 controls; replication sample, 2687 cases and 2656 controls. Marker panel of 74062 independent SNPs. Variance explained by markers, 28.7%. pi0, proportion of markers with no effect on disease.
AUC as a function of sample size, using a panel of 100,000 markers that explains half the heritability of liability. n, number of cases and of controls in training sample. Heritability of liability, 76% for Crohn's disease. 44% for breast cancer. Line annotations are the proportion of markers with no effect on disease.
AUC as a function of sample size, using a panel of 1,000,000 markers that explains the full heritability. n, number of cases and of controls in training sample. Heritability of liability, 76% for Crohn's disease. 44% for breast cancer. Line annotations are the proportion of markers with no effect on disease.
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| Using a Genetic Risk Score Approach to Predict Headache Response to Triptans in Migraine Without Aura. | Cargnin S et al. | β | 2019 | β |
| Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood. | Newbury DF et al. | β | 2019 | β |
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| Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women. | Rivera-Paredez B et al. | β | 2018 | β |
| Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition. | Ranlund S et al. | β | 2018 | β |
| Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial. | Tang L et al. | β | 2018 | β |
| A tutorial on conducting genome-wide association studies: Quality control and statistical analysis. | Marees AT et al. | β | 2018 | β |
| Autism spectrum disorders and autistic traits share genetics and biology. | Bralten J et al. | β | 2018 | β |
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| Combined accelerometer and genetic analysis to differentiate essential tremor from Parkinson's disease. | Molparia B et al. | β | 2018 | β |
| Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma. | Gu F et al. | β | 2018 | β |
| Common DNA Variants Accurately Rank an Individual of Extreme Height. | Sexton CE et al. | β | 2018 | β |
| Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test. | Curtis D | β | 2018 | β |
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| Differential Burden of Rare and Common Variants on Tumor Characteristics, Survival, and Mode of Detection in Breast Cancer. | Li J et al. | β | 2018 | β |
| DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. | O'Donnell KJ et al. | β | 2018 | β |
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| Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits. | Zhang Y et al. | β | 2018 | β |
| Evaluating the genetic susceptibility to peer reported bullying behaviors. | Musci RJ et al. | β | 2018 | β |
| Evidence for association between familial bipolar risk and ventral striatal volume. | Lancaster TM | β | 2018 | β |
| Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression. | Guo W et al. | β | 2018 | β |
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| Genetic Determinants of Telomere Length in African American Youth. | Zeiger AM et al. | β | 2018 | β |
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| Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing. | Wehby GL et al. | β | 2018 | β |
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| Genetics Factors in Major Depression Disease. | Shadrina M et al. | β | 2018 | β |
| Genetics of co-developing conduct and emotional problems during childhood and adolescence. | Hannigan LJ et al. | β | 2018 | β |
| Genetic susceptibility to cerebrovascular disease: A systematic review. | Griessenauer CJ et al. | β | 2018 | β |
| Genetic variants in COL13A1, ADIPOQ and SAMM50, in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population. | Larrieta-Carrasco E et al. | β | 2018 | β |
| Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence. | Hiemstra M et al. | β | 2018 | β |
| Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. | Arnau-Soler A et al. | β | 2018 | β |
| Genome-wide pleiotropy and shared biological pathways for resistance to bovine pathogens. | Mahmoud M et al. | β | 2018 | β |
| Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention. | Inouye M et al. | β | 2018 | β |
| Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention | Inouye M et al. | β | 2018 | β |
| Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer. | Scannell Bryan M et al. | β | 2018 | β |
| Higher Polygenetic Predisposition for Asthma in Cow's Milk Allergic Children. | Jansen PR et al. | β | 2018 | β |
| Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography. | LukΓ‘cs Krogager M et al. | β | 2018 | β |
| Imaging and Genetic Biomarkers Predicting Transition to Psychosis. | Hunter SA et al. | β | 2018 | β |
| Improving genetic prediction by leveraging genetic correlations among human diseases and traits. | Maier RM et al. | β | 2018 | β |
| Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems. | Salvatore JE et al. | β | 2018 | β |
| Intellectual Investment, Dopaminergic Gene Variation, and Life Events: A Critical Examination. | Strobel A et al. | β | 2018 | β |
| Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology. | Howe LJ et al. | β | 2018 | β |
| Largest GWAS of PTSD (N=20β070) yields genetic overlap with schizophrenia and sex differences in heritability. | Duncan LE et al. | β | 2018 | β |
| Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. | Wang J et al. | β | 2018 | β |
| Missing single nucleotide polymorphisms in Genetic Risk Scores: A simulation study. | Chagnon M et al. | β | 2018 | β |
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| Of genes and microbes: solving the intricacies in host genomes. | Wang J et al. | β | 2018 | β |
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| Polygenic influences on dyslipidemias. | Dron JS et al. | β | 2018 | β |
| Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms. | Lin YF et al. | β | 2018 | β |
| Polygenic prediction of obsessive compulsive symptoms. | ZilhΓ£o NR et al. | β | 2018 | β |
| Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations. | Li J et al. | β | 2018 | β |
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| Polygenic Risk of Spasmodic Dysphonia is Associated With Vulnerable Sensorimotor Connectivity. | Putzel GG et al. | β | 2018 | β |
| Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort. | Santoro ML et al. | β | 2018 | β |
| Polygenic risk score of shorter telomere length and risk of depression and anxiety in women. | Chang SC et al. | β | 2018 | β |
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| Preliminary evidence for genetic overlap between body mass index and striatal reward response. | Lancaster TM et al. | β | 2018 | β |
| Rigor and reproducibility in genetic research on eating disorders. | HΓΌbel C et al. | β | 2018 | β |
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| SNP association study in PMS2-associated Lynch syndrome. | Ten Broeke SW et al. | β | 2018 | β |
| Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel. | Fernandez-Rozadilla C et al. | β | 2018 | β |
| The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. | Piel JH et al. | β | 2018 | β |
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| Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density. | Zhou X et al. | β | 2018 | β |
| Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. | Su J et al. | β | 2018 | β |
| Understanding the effects of education through the lens of biology. | Sokolowski HM et al. | β | 2018 | β |
| Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders. | Calafato MS et al. | β | 2018 | β |
| Using Full Genomic Information to Predict Disease: Breaking Down the Barriers Between Complex and Mendelian Diseases. | Jordan DM et al. | β | 2018 | β |
| Using genetic data to strengthen causal inference in observational research. | Pingault JB et al. | β | 2018 | β |
| Value of multilocus genetic risk score for atrial fibrillation in end-stage kidney disease patients in a Polish population. | Saracyn M et al. | β | 2018 | β |
| Wide educational disparities in young adult cardiovascular health. | Lawrence EM et al. | β | 2018 | β |
| A bidirectional relationship between depression and the autoimmune disorders - New perspectives from the National Child Development Study. | Euesden J et al. | β | 2017 | β |
| Advancing psychiatric genetics through dissecting heterogeneity. | Hodgson K et al. | β | 2017 | β |
| Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity. | Elam KK et al. | β | 2017 | β |
| A genetic link between prepregnancy body mass index, postpartum weight retention, and offspring weight in early childhood. | Li A et al. | β | 2017 | β |
| An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis. | Vassos E et al. | β | 2017 | β |
| APPROXIMATING PRINCIPAL GENETIC COMPONENTS OF SUBCORTICAL SHAPE. | Gutman BA et al. | β | 2017 | β |
| Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data. | Gibson J et al. | β | 2017 | β |
| A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores. | Levine ME et al. | β | 2017 | β |
| Building a genetic risk model for bipolar disorder from genome-wide association data with random forest algorithm. | Chuang LC et al. | β | 2017 | β |
| Can We Validate the Results of Twin Studies? A Census-Based Study on the Heritability of Educational Achievement. | Schwabe I et al. | β | 2017 | β |
| Cognitive genomics: Searching for the genetic roots of neuropsychological functioning. | Bearden CE et al. | β | 2017 | β |
| Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis. | Rivera NV et al. | β | 2017 | β |
| Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies. | HΓΌls A et al. | β | 2017 | β |
| Concepts, estimation and interpretation of SNP-based heritability. | Yang J et al. | β | 2017 | β |
| Contributions of polygenic risk for obesity to PTSD-related metabolic syndrome and cortical thickness. | Wolf EJ et al. | β | 2017 | β |
| Copy Number Variation in Syndromic Forms of Psychiatric Illness: The Emerging Value of Clinical Genetic Testing in Psychiatry. | Bouwkamp CG et al. | β | 2017 | β |
| Demographic, genetic and phenotypic characteristics of centenarians in Italy: Focus on gender differences. | Montesanto A et al. | β | 2017 | β |
| Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19β762), UK Biobank (n=24β048) and the English Longitudinal Study of Ageing (n=5766). | Wigmore EM et al. | β | 2017 | β |
| DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia. | Pergola G et al. | β | 2017 | β |
| Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study. | Sardahaee FS et al. | β | 2017 | β |
| Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. | Uher R et al. | β | 2017 | β |
| Everything in moderation, even hype: learning from vaccine controversies to strike a balance with CRISPR. | Benston S | β | 2017 | β |
| Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits. | So HC et al. | β | 2017 | β |
| Genetic and environmental influences on household financial distress. | Xu Y et al. | β | 2017 | β |
| Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. | Desikan RS et al. | β | 2017 | β |
| Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA). | Wang Z et al. | β | 2017 | β |
| Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS. | Kalmbach DA et al. | β | 2017 | β |
| Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study. | Christie S et al. | β | 2017 | β |
| Genetic Heterogeneity in Depressive Symptoms Following the Death of a Spouse: Polygenic Score Analysis of the U.S. Health and Retirement Study. | Domingue BW et al. | β | 2017 | β |
| Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development. | Nivard MG et al. | β | 2017 | β |
| Genetic Risk as a Marker of Amyloid-Ξ² and Tau Burden in Cerebrospinal Fluid. | Voyle N et al. | β | 2017 | β |
| Genetics of Schizophrenia: Overview of Methods, Findings and Limitations. | Henriksen MG et al. | β | 2017 | β |
| Genetic Test, Risk Prediction, and Counseling. | Wang MH et al. | β | 2017 | β |
| Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. | Han L et al. | β | 2017 | β |
| Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD). | Ritter ML et al. | β | 2017 | β |
| Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders. | Coleman JRI et al. | β | 2017 | β |
| Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years. | Selzam S et al. | β | 2017 | β |
| Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. | Rietschel L et al. | β | 2017 | β |
| Helicobacter pylori colonization and obesity - a Mendelian randomization study. | den Hollander WJ et al. | β | 2017 | β |
| How Can Genetically Informed Research Help Inform the Next Generation of Interparental and Parenting Interventions? | Harold GT et al. | β | 2017 | β |
| How close are we to implementing a genetic risk score for coronary heart disease? | Beaney K et al. | β | 2017 | β |
| Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations. | Martin AR et al. | β | 2017 | β |
| Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. | Bogdan R et al. | β | 2017 | β |
| Improving polygenic risk prediction from summary statistics by an empirical Bayes approach. | So HC et al. | β | 2017 | β |
| Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study. | Garasia S et al. | β | 2017 | β |
| Influence of genetic ancestry and socioeconomic status on type 2 diabetes in the diverse Colombian populations of ChocΓ³ and Antioquia. | Chande AT et al. | β | 2017 | β |
| Integrative genetic risk prediction using non-parametric empirical Bayes classification. | Zhao SD | β | 2017 | β |
| Investigating the genetic underpinnings of early-life irritability. | Riglin L et al. | β | 2017 | β |
| Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies. | de Vlaming R et al. | β | 2017 | β |
| Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students. | Webb BT et al. | β | 2017 | β |
| Mortality selection in a genetic sample and implications for association studies. | Domingue BW et al. | β | 2017 | β |
| Multiethnic polygenic risk scores improve risk prediction in diverse populations. | MΓ‘rquez-Luna C et al. | β | 2017 | β |
| Neuroimaging genomics in psychiatry-a translational approach. | Mufford MS et al. | β | 2017 | β |
| Neuropsychology of Learning Disabilities: The Past and the Future. | Fletcher JM et al. | β | 2017 | β |
| Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. | Patel CJ et al. | β | 2017 | β |
| Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study. | Robiou-du-Pont S et al. | β | 2017 | β |
| Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels. | Ibanez L et al. | β | 2017 | β |
| Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-Ξ² Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease. | Darst BF et al. | β | 2017 | β |
| Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution. | Abadi A et al. | β | 2017 | β |
| Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method. | Chen GB et al. | β | 2017 | β |
| Pharmacogenetics of antidepressant response: A polygenic approach. | GarcΓa-GonzΓ‘lez J et al. | β | 2017 | β |
| Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. | Schuit E et al. | β | 2017 | β |
| Phenotypic and genotypic correlation between myopia and intelligence. | Williams KM et al. | β | 2017 | β |
| Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry. | Lareau CA et al. | β | 2017 | β |
| Polygenic risk for depression and the neural correlates of working memory in healthy subjects. | YΓΌksel D et al. | β | 2017 | β |
| Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations. | Wang T et al. | β | 2017 | β |
| Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations. | Liu B et al. | β | 2017 | β |
| Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia. | Wimberley T et al. | β | 2017 | β |
| Polygenic scores via penalized regression on summary statistics. | Mak TSH et al. | β | 2017 | β |
| Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders. | Benca CE et al. | β | 2017 | β |
| Predicting educational achievement from DNA. | Selzam S et al. | β | 2017 | β |
| Rationale and design of GENEiUS: a prospective observational study on the genetic and environmental determinants of body mass index evolution in Canadian undergraduate students. | Morassut RE et al. | β | 2017 | β |
| Recent Developments in Mendelian Randomization Studies. | Zheng J et al. | β | 2017 | β |
| Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. | Hong EP et al. | β | 2017 | β |
| Schizophrenia genetics comes to translation. | Domenici E | β | 2017 | β |
| Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies. | Stalder O et al. | β | 2017 | β |
| Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development. | Stergiakouli E et al. | β | 2017 | β |
| Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes. | Luciano M et al. | β | 2017 | β |
| Statistical methods to detect pleiotropy in human complex traits. | Hackinger S et al. | β | 2017 | β |
| The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci. | Kisiel B et al. | β | 2017 | β |
| The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. | Maciejewski DF et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls. | Morgan CJ et al. | β | 2017 | β |
| Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders. | Verduijn J et al. | β | 2017 | β |
| Using information of relatives in genomic prediction to apply effective stratified medicine. | Lee SH et al. | β | 2017 | β |
| Using Polygenic Risk Scores to Establish Endophenotypes: Considerations and Current Constraints. | Glahn DC et al. | β | 2017 | β |
| A current snapshot of common genomic variants contribution in psychiatric disorders. | Santoro ML et al. | β | 2016 | β |
| Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children. | Abadi A et al. | β | 2016 | β |
| Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. | Cuellar-Partida G et al. | β | 2016 | β |
| Association of Acetaminophen Use During Pregnancy With Behavioral Problems in Childhood: Evidence Against Confounding. | Stergiakouli E et al. | β | 2016 | β |
| Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population. | Riglin L et al. | β | 2016 | β |
| Assortative mating and differential fertility by phenotype and genotype across the 20th century. | Conley D et al. | β | 2016 | β |
| Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett's Esophagus. | Dai JY et al. | β | 2016 | β |
| Developing and evaluating polygenic risk prediction models for stratified disease prevention. | Chatterjee N et al. | β | 2016 | β |
| DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases. | Bettencourt C et al. | β | 2016 | β |
| EigenGWAS: finding loci under selection through genome-wide association studies of eigenvectors in structured populations. | Chen GB et al. | β | 2016 | β |
| Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents. | Langlois C et al. | β | 2016 | β |
| Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort. | Taylor M et al. | β | 2016 | β |
| From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia. | Cariaga-Martinez A et al. | β | 2016 | β |
| Genetic Association Studies of Suicidal Behavior: A Review of the Past 10βYears, Progress, Limitations, and Future Directions. | Mirkovic B et al. | β | 2016 | β |
| Genetic cardiovascular risk prediction: are we already there? | Assimes TL et al. | β | 2016 | β |
| Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. | Kurita GP et al. | β | 2016 | β |
| Genome-Wide Association of Heroin Dependence in Han Chinese. | Kalsi G et al. | β | 2016 | β |
| Identifying Multimodal Intermediate Phenotypes Between Genetic Risk Factors and Disease Status in Alzheimer's Disease. | Hao X et al. | β | 2016 | β |
| Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis. | Harrisberger F et al. | β | 2016 | β |
| Imputation of DNA Methylation Levels in the Brain Implicates a Risk Factor for Parkinson's Disease. | Rawlik K et al. | β | 2016 | β |
| Longitudinal relationships between glycemic status and body mass index in a multiethnic study: evidence from observational and genetic epidemiology. | Ishola AF et al. | β | 2016 | β |
| Marginal role for 53 common genetic variants in cardiovascular disease prediction. | Morris RW et al. | β | 2016 | β |
| Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse. | PeΓ±a-Oliver Y et al. | β | 2016 | β |
| Multivariate Methods for Genetic Variants Selection and Risk Prediction in Cardiovascular Diseases. | Malovini A et al. | β | 2016 | β |
| On the use of genetic risk scores to predict cardiovascular disease in the general population. | Pereira AC | β | 2016 | β |
| Personality Polygenes, Positive Affect, and Life Satisfaction. | Weiss A et al. | β | 2016 | β |
| PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases. | Ayati M et al. | β | 2016 | β |
| Polygenetic components for schizophrenia, bipolar disorder and rheumatoid arthritis predict risk of schizophrenia. | Ohi K et al. | β | 2016 | β |
| Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. | Otto JM et al. | β | 2016 | β |
| Predicting quantitative traits from genome and phenome with near perfect accuracy. | MΓ€rtens K et al. | β | 2016 | β |
| Racial and Socioeconomic Variation in Genetic Markers of Telomere Length: A Cross-Sectional Study of U.S. Older Adults. | Hamad R et al. | β | 2016 | β |
| Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015. | Zai G et al. | β | 2016 | β |
| Telomere length and health outcomes: A two-sample genetic instrumental variables analysis. | Hamad R et al. | β | 2016 | β |
| The Bell Curve Revisited: Testing Controversial Hypotheses with Molecular Genetic Data. | Conley D et al. | β | 2016 | β |
| The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. | Belsky DW et al. | β | 2016 | β |
| The Sum of Its Parts: The Polygenic Basis of Coronary Artery Disease. | McPherson R et al. | β | 2016 | β |
| Using Genetic Distance to Infer the Accuracy of Genomic Prediction. | Scutari M et al. | β | 2016 | β |
| Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations. | Saigi-Morgui N et al. | β | 2016 | β |
| Whole genome prediction and heritability of childhood asthma phenotypes. | McGeachie MJ et al. | β | 2016 | β |
| Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data. | Shi J et al. | β | 2016 | β |