The genetic signatures of noncoding RNAs.

paper Cited Public

Authors: Mattick, John S
Year: 2009
Journal: PLoS genetics
PMID: 19390609
DOI: 10.1371/journal.pgen.1000459
PMCID: PMC2667263

The majority of the genome in animals and plants is transcribed in a developmentally regulated manner to produce large numbers of non-protein-coding RNAs (ncRNAs), whose incidence increases with developmental complexity. There is growing evidence that these transcripts are functional, particularly in the regulation of epigenetic processes, leading to the suggestion that they compose a hitherto hidden layer of genomic programming in humans and other complex organisms. However, to date, very few have been identified in genetic screens. Here I show that this is explicable by an historic emphasis, both phenotypically and technically, on mutations in protein-coding sequences, and by presumptions about the nature of regulatory mutations. Most variations in regulatory sequences produce relatively subtle phenotypic changes, in contrast to mutations in protein-coding sequences that frequently cause catastrophic component failure. Until recently, most mapping projects have focused on protein-coding sequences, and the limited number of identified regulatory mutations have been interpreted as affecting conventional cis-acting promoter and enhancer elements, although these regions are often themselves transcribed. Moreover, ncRNA-directed regulatory circuits underpin most, if not all, complex genetic phenomena in eukaryotes, including RNA interference-related processes such as transcriptional and post-transcriptional gene silencing, position effect variegation, hybrid dysgenesis, chromosome dosage compensation, parental imprinting and allelic exclusion, paramutation, and possibly transvection and transinduction. The next frontier is the identification and functional characterization of the myriad sequence variations that influence quantitative traits, disease susceptibility, and other complex characteristics, which are being shown by genome-wide association studies to lie mostly in noncoding, presumably regulatory, regions. There is every possibility that many of these variations will alter the interactions between regulatory RNAs and their targets, a prospect that should be borne in mind in future functional analyses.

#	Section	Preview
0	Introduction	Genome sequencing projects have shown that the numbers of protein-coding genes and the extent of…
1	Introduction	In recent years it has also become evident that the vast majority of the mammalian genome, and that…
2	Introduction	There is also compelling genome-wide evidence that the large numbers of identified but as yet…
3	Introduction	Indeed, a recent study of over 1,300 mouse ncRNAs showed that almost half of them exhibit precise…
4	Introduction	It is widely accepted that animals have a relatively common set of protein-coding genes and that,…
5	Introduction	Regulatory sequences are also generally assumed to operate through their interactions with…
6	Introduction	However, if these ncRNAs are functional and important in developmental and physiological processes,…
7	Phenotypic Impact	The ability to detect a relevant mutation or variation is dependent on the sensitivity of the…
8	Phenotypic Impact	use of the word “mutation”, as opposed to “variation”, reflects an inherent bias in the…
9	Phenotypic Impact	There is, of course, a wide spectrum of effects of both coding and noncoding mutations (Figure 2),…
10	Phenotypic Impact	On the other hand, the potential subtlety of mutations in ncRNAs, even when they are targeted by…
11	Monogenic Diseases and High Penetrance Mutations	The generally stronger effects of protein-coding mutations leads to a sampling bias, in that more…
12	Complex Traits and GWA Studies	Indeed, functional classification of sequence variations that have been identified by GWA studies to…
13	Complex Traits and GWA Studies	The identification of the sequence changes that directly underpin quantitative trait variations has…
14	Complex Traits and GWA Studies	of protein-coding and ncRNA genes [119] associated with an unusual genetic phenomena termed “polar…
15	Type of Mutation and Sensitivity of the Model System	The nature of the organism under study and the type of mutations also affect the outcome of genetic…
16	Type of Mutation and Sensitivity of the Model System	Most mutations induced by ENU mutagenesis involve single-base changes, which are also, along with…
17	Type of Mutation and Sensitivity of the Model System	On the other hand, insertions and deletions dominate mutational screens in Drosophila, and a large…
18	Type of Mutation and Sensitivity of the Model System	Similarly the iab regulatory elements of the bithorax complex that control the expression of…
19	Type of Mutation and Sensitivity of the Model System	Despite the now known importance of miRNAs in the control of gene expression [67],[132], only four…

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In this knowledge base

Title	Year	PMID
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.	2014	24962325
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.	2013	23743675
lincRNAs act in the circuitry controlling pluripotency and differentiation.	2011	21874018
Genome-wide association studies: hypothesis-"free" or "engaged"?	2009	19766959

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The role of non-coding RNA network in atherosclerosis.	Yuan Y et al.	—	2021	→
The role of tumor suppressor short non-coding RNAs on breast cancer.	Salimimoghadam S et al.	—	2021	→
Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry.	Baraniak D et al.	—	2021	→
Variability in the levels of exosomal miRNAs among human subjects could be explained by differential interactions of exosomes with the endothelium.	Felekkis K et al.	—	2021	→
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.	Fan Z et al.	—	2020	→
A switch in bidirectional histone mark leads to differential modulation of lincRNAs involved in neuronal and hematopoietic cell differentiation from their progenitors.	Murad MW et al.	—	2020	→
A Weighted Gene Co-expression Network Analysis Reveals lncRNA Abnormalities in the Peripheral Blood Associated With Ultra-High-Risk for Psychosis.	Ren Y et al.	—	2020	→
Circulating microRNAs as potential biomarkers and therapeutic targets in spinal muscular atrophy.	Chen TH	—	2020	→
Epigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations.	Ben Maamar M et al.	—	2020	→
Identification of expression signatures for non-small-cell lung carcinoma subtype classification.	Su R et al.	—	2020	→
LncRNA <i>DDX11-AS1</i> Promotes Bladder Cancer Occurrence Via Protecting <i>LAMB3</i> from Downregulation by Sponging <i>miR-2355-5p</i>.	Chen D et al.	—	2020	→
LncRNA XIST promotes myocardial infarction by regulating <i>FOS</i> through targeting miR-101a-3p.	Lin B et al.	—	2020	→
Long Noncoding RNA <i>Ahit</i> Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A).	Yu J et al.	—	2020	→
Long noncoding RNA SNHG12 modulated by human papillomavirus 16 E6/E7 promotes cervical cancer progression via ERK/Slug pathway.	Lai SY et al.	—	2020	→
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.	Yang G et al.	—	2020	→
miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A.	Gupta N et al.	—	2020	→
Mitotically associated long non-coding RNA is a tumor promoter in anaplastic thyroid cancer.	Huang NS et al.	—	2020	→
Molecular Regulation of Circadian Chromatin.	Zhu Q et al.	—	2020	→
m<sup>6</sup>A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway.	Liu P et al.	—	2020	→
New insights on human essential genes based on integrated analysis and the construction of the HEGIAP web-based platform.	Chen H et al.	—	2020	→
Oncogenic Role of PVT1 and Therapeutic Implications.	Onagoruwa OT et al.	—	2020	→
Overexpression of lncRNA SNGH3 Predicts Unfavorable Prognosis and Clinical Outcomes in Human Cancers: Evidence from a Meta-Analysis.	Jiang Y et al.	—	2020	→
PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10.	Shen G et al.	—	2020	→
Regulation of laryngeal squamous cell cancer progression by the lncRNA RP11-159K7.2/miR-206/DNMT3A axis.	Wang X et al.	—	2020	→
Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review.	Taghizadeh E et al.	—	2020	→
Seq'ing identity and function in a repeat-derived noncoding RNA world.	O'Neill RJ	—	2020	→
SNPs in lncRNA Regions and Breast Cancer Risk.	Suvanto M et al.	—	2020	→
Structure encoding in DNA.	Van der Mude A	—	2020	→
The role of long noncoding RNAs in atrial fibrillation.	Babapoor-Farrokhran S et al.	—	2020	→
The value of lncRNA <i>FENDRR</i> and <i>FOXF1</i> as a prognostic factor for survival of lung adenocarcinoma.	Herrera-Merchan A et al.	—	2020	→
Use of Stem Cell Extracellular Vesicles as a "Holistic" Approach to CNS Repair.	Branscome H et al.	—	2020	→
Advanced glycation end products of bovine serum albumin affect the cell growth of human umbilical vein endothelial cells via modulation of MEG3/miR-93/p21 pathway.	Ju C et al.	—	2019	→
Comparing biological information contained in mRNA and non-coding RNAs for classification of lung cancer patients.	Smolander J et al.	—	2019	→
Computational models for lncRNA function prediction and functional similarity calculation.	Chen X et al.	—	2019	→
Identification of Disease-miRNA Networks Across Different Cancer Types Using SWIM.	Fiscon G et al.	—	2019	→
In silico survey of the central conserved regions in viroids of the <i>Pospiviroidae</i> family for conserved asymmetric loop structures.	Freidhoff P et al.	—	2019	→
Integrating Multiple Heterogeneous Networks for Novel LncRNA-Disease Association Inference.	Zhang J et al.	—	2019	→
LncRNA-MALAT1 mediates cisplatin resistance via miR-101-3p/VEGF-C pathway in bladder cancer.	Liu P et al.	—	2019	→
LncRNA-SNHG15 enhances cell proliferation in colorectal cancer by inhibiting miR-338-3p.	Li M et al.	—	2019	→
Long Noncoding RNA HOXA-AS3 Integrates NF-κB Signaling To Regulate Endothelium Inflammation.	Zhu X et al.	—	2019	→
Long Noncoding RNA UCA1 Overexpression Is Associated with Poor Prognosis in Digestive System Malignancies: A Meta-analysis.	Shi FT et al.	—	2019	→
Low expression of long noncoding RNA CTC-297N7.9 predicts poor prognosis in patients with hepatocellular carcinoma.	Zhu S et al.	—	2019	→
Non-Coding RNA Networks in ALK-Positive Anaplastic-Large Cell Lymphoma.	Fuchs S et al.	—	2019	→
Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers.	Jiang YF et al.	—	2019	→
The lncRNA DAPK-IT1 regulates cholesterol metabolism and inflammatory response in macrophages and promotes atherogenesis.	Zhen Z et al.	—	2019	→
The Pseudogene PTTG3P Promotes Cell Migration and Invasion in Esophageal Squamous Cell Carcinoma.	Zhang Z et al.	—	2019	→
A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.	Beermann J et al.	—	2018	→
Antisense RNA: the new favorite in genetic research.	Xu JZ et al.	—	2018	→
Characterization of Transcription Termination-Associated RNAs: New Insights into their Biogenesis, Tailing, and Expression in Primary Tumors.	Laudadio I et al.	—	2018	→
Differentially expressed host long intergenic noncoding RNA and mRNA in HIV-1 and HIV-2 infection.	Biswas S et al.	—	2018	→
Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21.	Zhu B et al.	—	2018	→
Environmentally induced epigenetic transgenerational inheritance of disease.	Nilsson EE et al.	—	2018	→
Functional Variants in Linc-ROR are Associated with mRNA Expression of Linc-ROR and Breast Cancer Susceptibility.	Luo C et al.	—	2018	→
HIF‑1α‑induced upregulation of lncRNA UCA1 promotes cell growth in osteosarcoma by inactivating the PTEN/AKT signaling pathway.	Li T et al.	—	2018	→
Identification of small non-coding RNA classes expressed in swine whole blood during HP-PRRSV infection.	Fleming DS et al.	—	2018	→
<i>Dlk1-Dio3</i> locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity.	Yen YP et al.	—	2018	→
LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3.	Liu T et al.	—	2018	→
LncRNAs and CircRNAs from the same gene: Masterpieces of RNA splicing.	Huang MS et al.	—	2018	→
LncRNA SNHG12 promotes the proliferation and metastasis of papillary thyroid carcinoma cells through regulating wnt/β-catenin signaling pathway.	Ding S et al.	—	2018	→
Long non‑coding nuclear paraspeckle assembly transcript 1 acts as prognosis biomarker and increases cell growth and invasion in cervical cancer by sequestering microRNA‑101.	Wang L et al.	—	2018	→
Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2.	Li X et al.	—	2018	→
Long Noncoding RNA FEZF1-AS1 Promotes Osteosarcoma Progression by Regulating the miR-4443/NUPR1 Axis.	Zhou C et al.	—	2018	→
Long non-coding RNA p10247, high expressed in breast cancer (lncRNA-BCHE), is correlated with metastasis.	Yang YX et al.	—	2018	→
Long Noncoding RNAs and mRNA Regulation in Peripheral Blood Mononuclear Cells of Patients with Chronic Obstructive Pulmonary Disease.	Qu X et al.	—	2018	→
Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies.	Wong NK et al.	—	2018	→
Long noncoding RNA UFC1 is activated by E2F1 and exerts oncogenic properties by functioning as a ceRNA of FOXP3.	Xi J et al.	—	2018	→
<i>HOXD-AS1</i> Exerts Oncogenic Functions and Promotes Chemoresistance in Cisplatin-Resistant Cervical Cancer Cells.	Chi C et al.	—	2018	→
Noncoding RNAs in ischemic stroke: time to translate.	Kaur H et al.	—	2018	→
Noncoding RNAs: New Players in Pulmonary Medicine and Sarcoidosis.	Salamo O et al.	—	2018	→
Sequencing and characterization of lncRNAs in the breast muscle of Gushi and Arbor Acres chickens.	Ren T et al.	—	2018	→
Some implications of an epigenetic-based omnigenic model of psychiatric disorders.	Peedicayil J et al.	—	2018	→
The "dark matter" of DNA and the regulation of bone metabolism: The role of non-coding RNAs.	Yavropoulou MP et al.	—	2018	→
The Long Non-coding RNA <i>Flatr</i> Anticipates Foxp3 Expression in Regulatory T Cells.	Brajic A et al.	—	2018	→
The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.	Xu Y et al.	—	2018	→
The State of Long Non-Coding RNA Biology.	Mattick JS	—	2018	→
Upregulation of LncRNA FEZF-AS1 is associated with advanced clinical stages and family history of cancer in patients with NSCLC.	Gong W et al.	—	2018	→
Upregulation of lncRNA PlncRNA-1 indicates the poor prognosis and promotes glioma progression by activation of Notch signal pathway.	Wang X et al.	—	2018	→
A comprehensive benchmark of RNA-RNA interaction prediction tools for all domains of life.	Umu SU et al.	—	2017	→
Acute liver failure is associated with altered cerebral expression profiles of long non-coding RNAs.	Silva VR et al.	—	2017	→
Altered Long Noncoding RNA Expression Precedes the Course of Parkinson's Disease-a Preliminary Report.	Kraus TFJ et al.	—	2017	→
A new paramutation-like example at the Delta gene of Drosophila.	Capovilla M et al.	—	2017	→
Can lncRNAs be indicators for the diagnosis of early onset or acute schizophrenia and distinguish major depressive disorder and generalized anxiety disorder?-A cross validation analysis.	Cui X et al.	—	2017	→
Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging.	Schneider A et al.	—	2017	→
Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.	Okugawa Y et al.	—	2017	→
Comprehensive analysis of mRNA-lncRNA co-expression profile revealing crucial role of imprinted gene cluster DLK1-MEG3 in chordoma.	Chen H et al.	—	2017	→
Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs.	Schlackow M et al.	—	2017	→
Down-regulation of lncRNA CASC2 promotes cell proliferation and metastasis of bladder cancer by activation of the Wnt/β-catenin signaling pathway.	Pei Z et al.	—	2017	→
Dysregulated expression of long noncoding RNAs in gynecologic cancers.	Hosseini ES et al.	—	2017	→
Epigenetics and Vascular Diseases: Influence of Non-coding RNAs and Their Clinical Implications.	Elia L et al.	—	2017	→
Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles.	Matjašič A et al.	—	2017	→
Knockdown of Long Noncoding RNA CCAT2 Inhibits Cellular Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Glioma Cells.	Zeng J et al.	—	2017	→
LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation.	Liu YW et al.	—	2017	→
'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.	Ong MS et al.	—	2017	→
LncRNA Expression in CD4+ T Cells in Neurosyphilis Patients.	Liu LL et al.	—	2017	→
lncRNAs as Novel Indicators of Patients' Prognosis in Stage I Epithelial Ovarian Cancer: A Retrospective and Multicentric Study.	Martini P et al.	—	2017	→
Long non-coding RNA in pancreatic adenocarcinoma and pancreatic neuroendocrine tumors.	Moschovis D et al.	—	2017	→
Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A.	Wu D et al.	—	2017	→
Long noncoding RNA MALAT1 promotes cell proliferation through suppressing miR-205 and promoting SMAD4 expression in osteosarcoma.	Li Q et al.	—	2017	→
Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis.	Zhang K et al.	—	2017	→
Long non-coding RNAs: potential molecular biomarkers for gliomas diagnosis and prognosis.	Wang L et al.	—	2017	→
Long non-coding RNA SPRY4-IT1 promotes proliferation and invasion by acting as a ceRNA of miR-101-3p in colorectal cancer cells.	Jin J et al.	—	2017	→
Long non-coding RNAs: The novel diagnostic biomarkers for leukemia.	Chen S et al.	—	2017	→
Long Non-Coding RNA Uc.187 Is Upregulated in Preeclampsia and Modulates Proliferation, Apoptosis, and Invasion of HTR-8/SVneo Trophoblast Cells.	Cao C et al.	—	2017	→
Long non-coding RNA XLOC_006390 promotes cervical cancer proliferation and metastasis through the regulation of SET domain containing 8.	Luan X et al.	—	2017	→
Long non-coding RNA ZFAS1 correlates with clinical progression and prognosis in cancer patients.	Liu F et al.	—	2017	→
MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression.	Chen W et al.	—	2017	→
MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2.	Huo Y et al.	—	2017	→
MEG3 is a prognostic factor for CRC and promotes chemosensitivity by enhancing oxaliplatin-induced cell apoptosis.	Li L et al.	—	2017	→
Microarray expression profiling in the denervated hippocampus identifies long noncoding RNAs functionally involved in neurogenesis.	Deng B et al.	—	2017	→
Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension.	Han B et al.	—	2017	→
Molecular interplay of pro-inflammatory transcription factors and non-coding RNAs in esophageal squamous cell carcinoma.	Sundaram GM et al.	—	2017	→
nRC: non-coding RNA Classifier based on structural features.	Fiannaca A et al.	—	2017	→
Regulatory BC1 RNA in cognitive control.	Iacoangeli A et al.	—	2017	→
Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications.	Cai M et al.	—	2017	→
Structural and Functional Annotation of Long Noncoding RNAs.	Smith MA et al.	—	2017	→
Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease.	Lu Q et al.	—	2017	→
Technological Developments in lncRNA Biology.	Jathar S et al.	—	2017	→
The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome.	Deveson IW et al.	—	2017	→
The Importance of ncRNAs as Epigenetic Mechanisms in Phenotypic Variation and Organic Evolution.	Frías-Lasserre D et al.	—	2017	→
Transcriptome-Wide Discovery of PASRs (Promoter-Associated Small RNAs) and TASRs (Terminus-Associated Small RNAs) in Arabidopsis thaliana.	Ma X et al.	—	2017	→
Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes.	Zhao X et al.	—	2017	→
Ultraconserved long non-coding RNA uc.63 in breast cancer.	Marini A et al.	—	2017	→
Upregulation of long noncoding RNA TUG1 promotes cervical cancer cell proliferation and migration.	Hu Y et al.	—	2017	→
Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia.	Zhang J et al.	—	2016	→
Capillary electrophoresis of RNA in hydroxyethylcellulose polymer with various molecular weights.	Li Z et al.	—	2016	→
Comprehensive analysis of lncRNAs microarray profile and mRNA-lncRNA co-expression in oncogenic HPV-positive cervical cancer cell lines.	Yang L et al.	—	2016	→
Discovery and functional analysis of lncRNAs: Methodologies to investigate an uncharacterized transcriptome.	Kashi K et al.	—	2016	→
Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer.	Zhong Y et al.	—	2016	→
Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches.	Niiranen TJ et al.	—	2016	→
Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring.	Silva JP et al.	—	2016	→
Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer.	Jadaliha M et al.	—	2016	→
Functional role of lncRNA DB327252 in lung cancer.	Xu E et al.	—	2016	→
Genetic variants in lncRNA SRA and risk of breast cancer.	Yan R et al.	—	2016	→
Genome-wide Long Non-coding RNA Analysis Identified Circulating LncRNAs as Novel Non-invasive Diagnostic Biomarkers for Gynecological Disease.	Wang WT et al.	—	2016	→
HIC1 modulates uveal melanoma progression by activating lncRNA-numb.	Cheng G et al.	—	2016	→
Identification and analysis of mouse non-coding RNA using transcriptome data.	Zhao Y et al.	—	2016	→
Improved definition of the mouse transcriptome via targeted RNA sequencing.	Bussotti G et al.	—	2016	→
Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer.	Zhou H et al.	—	2016	→
Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation.	Sun C et al.	—	2016	→
Integrated Analysis of Long Noncoding RNA and mRNA Expression Profile in Advanced Laryngeal Squamous Cell Carcinoma.	Feng L et al.	—	2016	→
Knockdown of Long Noncoding RNA uc.338 by siRNA Inhibits Cellular Migration and Invasion in Human Lung Cancer Cells.	Gao X et al.	—	2016	→
LncRNA-uc.167 influences cell proliferation, apoptosis and differentiation of P19 cells by regulating Mef2c.	Song G et al.	—	2016	→
LOC100287225, novel long intergenic non-coding RNA, misregulates in colorectal cancer.	Kazemzadeh M et al.	—	2016	→
Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) interacts with estrogen receptor and predicted poor survival in breast cancer.	Huang NS et al.	—	2016	→
Long Noncoding RNA: Recent Updates in Atherosclerosis.	Li H et al.	—	2016	→
Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar).	Boltaña S et al.	—	2016	→
Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells.	Ruan W et al.	—	2016	→
Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway.	Wang L et al.	—	2016	→
MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway.	Sun CC et al.	—	2016	→
Non-Coding RNAs in Thyroid Cancer.	Zhang R et al.	—	2016	→
Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases.	Martin TJ	—	2016	→
Relationship of long noncoding RNA and viruses.	Ding YZ et al.	—	2016	→
RNA-Sequencing to Elucidate Early Patterns of Dysregulation Underlying the Onset of Alzheimer's Disease.	Chen BJ et al.	—	2016	→
Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression.	Lu J et al.	—	2016	→
Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-β induction in patients with COPD.	Tang W et al.	—	2016	→
The expanding regulatory universe of p53 in gastrointestinal cancer.	Fesler A et al.	—	2016	→
The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition.	Sun J et al.	—	2016	→
Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling.	Han Y et al.	—	2016	→
Upregulated long intergenic noncoding RNA KRT18P55 acts as a novel biomarker for the progression of intestinal-type gastric cancer.	Ma B et al.	—	2016	→
A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration.	Cai H et al.	—	2015	→
Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin.	Tsoi LC et al.	—	2015	→
Apoptosis, autophagy, necroptosis, and cancer metastasis.	Su Z et al.	—	2015	→
Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity.	Chen X et al.	—	2015	→
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.	Lai KM et al.	—	2015	→
Dynamic and Widespread lncRNA Expression in a Sponge and the Origin of Animal Complexity.	Gaiti F et al.	—	2015	→
Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure.	Greco CM et al.	—	2015	→
Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.	Luo X et al.	—	2015	→
Epigenetics and Cardiovascular Disease in Diabetes.	Pasquier J et al.	—	2015	→
Exploration of Deregulated Long Non-Coding RNAs in Association with Hepatocarcinogenesis and Survival.	Shen J et al.	—	2015	→
Exploring the secrets of long noncoding RNAs.	Quan M et al.	—	2015	→
GeneFriends: a human RNA-seq-based gene and transcript co-expression database.	van Dam S et al.	—	2015	→
Heterogeneous network model to infer human disease-long intergenic non-coding RNA associations.	Ganegoda GU et al.	—	2015	→
HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer.	Wang Y et al.	—	2015	→
Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions.	Sokol M et al.	—	2015	→
Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long noncoding RNAs.	Wang P et al.	—	2015	→
Integrative transcriptome-wide analyses reveal critical HER2-regulated mRNAs and lincRNAs in HER2+ breast cancer.	Merry CR et al.	—	2015	→
Interferon-alpha competing endogenous RNA network antagonizes microRNA-1270.	Kimura T et al.	—	2015	→
Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice.	Motterle A et al.	—	2015	→
Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326.	Ke J et al.	—	2015	→
Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma.	Li DD et al.	—	2015	→
LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer.	Liu YW et al.	—	2015	→
Linking RNA biology to lncRNAs.	Goff LA et al.	—	2015	→
LncRNA-AP001631.9 promotes cell migration in gastric cancer.	Cai H et al.	—	2015	→
LncRNAs and neoplasia.	Isin M et al.	—	2015	→
LncRNAs: emerging players in gene regulation and disease pathogenesis.	Kazemzadeh M et al.	—	2015	→
Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression.	Hirano T et al.	—	2015	→
Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice.	Spadaro PA et al.	—	2015	→
Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value.	Zhang W et al.	—	2015	→
Long non-coding RNA HOTAIR is associated with human cervical cancer progression.	Kim HJ et al.	—	2015	→
Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.	Hall JR et al.	—	2015	→
Long noncoding RNAs as a novel component of the Myc transcriptional network.	Winkle M et al.	—	2015	→
Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets.	Fatima R et al.	—	2015	→
Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1.	Chen S et al.	—	2015	→
MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway.	Dong Y et al.	—	2015	→
Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy.	Yang W et al.	—	2015	→
Multidrug-Resistance Related Long Non-Coding RNA Expression Profile Analysis of Gastric Cancer.	Wang Y et al.	—	2015	→
ncRNA-regulated immune response and its role in inflammatory lung diseases.	Xie N et al.	—	2015	→
Non-coding RNAs: biological functions and applications.	Santosh B et al.	—	2015	→
Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer.	Pang EJ et al.	—	2015	→
Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma.	Yan TH et al.	—	2015	→
Prognostic value of long noncoding RNA MALAT1 in digestive system malignancies.	Zhai H et al.	—	2015	→
Reciprocal repression between TUSC7 and miR-23b in gastric cancer.	Qi P et al.	—	2015	→
RNA 3D Modules in Genome-Wide Predictions of RNA 2D Structure.	Theis C et al.	—	2015	→
RNA (Epi)genetics in cardiovascular diseases.	Elia L et al.	—	2015	→
Roles of lncRNA in breast cancer.	Liu Y et al.	—	2015	→
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.	Hu YW et al.	—	2015	→
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.	Pastori C et al.	—	2015	→
The code of non-coding RNAs in lung fibrosis.	Cui H et al.	—	2015	→
The Landscape of long noncoding RNA classification.	St Laurent G et al.	—	2015	→
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.	Ranzani V et al.	—	2015	→
The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression.	Dong S et al.	—	2015	→
The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.	Shi Y et al.	—	2015	→
The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells.	Dal Bo M et al.	—	2015	→
Transcriptome responses to heat- and cold-stress in ladybirds (Cryptolaemus montrouzieri Mulasnt) analyzed by deep-sequencing.	Zhang Y et al.	—	2015	→
Transpositional shuffling and quality control in male germ cells to enhance evolution of complex organisms.	Werner A et al.	—	2015	→
Using RNA nanoparticles with thermostable motifs and fluorogenic modules for real-time detection of RNA folding and turnover in prokaryotic and eukaryotic cells.	Zhang H et al.	—	2015	→
Antisense oligonucleotide-based therapies for diseases caused by pre-mRNA processing defects.	Rigo F et al.	—	2014	→
Applications of bioinformatics to non-coding RNAs in the era of next-generation sequencing.	Cheng C et al.	—	2014	→
Arabidopsis RAN1 mediates seed development through its parental ratio by affecting the onset of endosperm cellularization.	Liu P et al.	—	2014	→
Assessing the state of substitution models describing noncoding RNA evolution.	Allen JE et al.	—	2014	→
Biomarkers of coronary artery disease: the promise of the transcriptome.	Siemelink MA et al.	—	2014	→
Cognitive mediators and disparities in the relation between teen depressiveness and smoking.	Mistry R et al.	—	2014	→
Computational analysis identifies a sponge interaction network between long non-coding RNAs and messenger RNAs in human breast cancer.	Paci P et al.	—	2014	→
Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.	Tan JY et al.	—	2014	→
DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer.	Toiyama Y et al.	—	2014	→
Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.	Liu PY et al.	—	2014	→
Emerging paradigms of long non-coding RNAs in gastrointestinal cancer.	Jiang HJ et al.	—	2014	→
Epigenetics: the language of the cell?	Huang B et al.	—	2014	→
Evidence for a crucial role of a host non-coding RNA in influenza A virus replication.	Winterling C et al.	—	2014	→
Fam40b is required for lineage commitment of murine embryonic stem cells.	Wagh V et al.	—	2014	→
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.	Kapoor M et al.	—	2014	→
HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptome.	Yarmishyn AA et al.	—	2014	→
Identification of differentially expressed genes in hepatopancreas of oriental river prawn, Macrobrachium nipponense exposed to environmental hypoxia.	Sun S et al.	—	2014	→
Integrating the roles of long and small non-coding RNA in brain function and disease.	Barry G	—	2014	→
Investigation of circulating lncRNAs in B-cell neoplasms.	Isin M et al.	—	2014	→
Long noncoding RNAs: emerging stars in gene regulation, epigenetics and human disease.	Bhan A et al.	—	2014	→
Long noncoding RNAs expression profile of the developing mouse heart.	Zhu JG et al.	—	2014	→
Long non-coding RNAs in colorectal cancer: implications for pathogenesis and clinical application.	Xu MD et al.	—	2014	→
Low expression of novel lncRNA RP11-462C24.1 suggests a biomarker of poor prognosis in colorectal cancer.	Shi D et al.	—	2014	→
MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF.	Wang J et al.	—	2014	→
MicroRNAs in cancer therapeutic response: Friend and foe.	Xue J et al.	—	2014	→
New gene models and alternative splicing in the maize pathogen Colletotrichum graminicola revealed by RNA-Seq analysis.	Schliebner I et al.	—	2014	→
Nitrite-induced hepatotoxicity in Bluntsnout bream (Megalobrama amblycephala): the mechanistic insight from transcriptome to physiology analysis.	Sun S et al.	—	2014	→
Optimization of reference genes for normalization of the quantitative polymerase chain reaction in tissue samples of gastric cancer.	Zhao LM et al.	—	2014	→
Programmable folding of fusion RNA in vivo and in vitro driven by pRNA 3WJ motif of phi29 DNA packaging motor.	Shu D et al.	—	2014	→
Regulation of mammary epithelial cell homeostasis by lncRNAs.	Shore AN et al.	—	2014	→
Regulation of transcription by long noncoding RNAs.	Bonasio R et al.	—	2014	→
Regulatory non-coding RNAs: revolutionizing the RNA world.	Huang B et al.	—	2014	→
RNA-Seq Data: A Complexity Journey.	Capobianco E	—	2014	→
Role of non-coding RNAs in pancreatic cancer: the bane of the microworld.	Tang YT et al.	—	2014	→
The DNA damage response: the omics era and its impact.	Derks KW et al.	—	2014	→
The epigenome and cancer prevention: A complex story of dietary supplementation.	Lee HS et al.	—	2014	→
The novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer.	Chen X et al.	—	2014	→
The putative Leishmania telomerase RNA (LeishTER) undergoes trans-splicing and contains a conserved template sequence.	Vasconcelos EJ et al.	—	2014	→
The rise of regulatory RNA.	Morris KV et al.	—	2014	→
Toward enhanced MIQE compliance: reference residual normalization of qPCR gene expression data.	Edmunds RC et al.	—	2014	→
Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term.	Romero R et al.	—	2014	→
Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma.	Shahryari A et al.	—	2014	→
A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations.	Wu H et al.	—	2013	→
Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks.	Holdt LM et al.	—	2013	→
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.	Kapoor M et al.	—	2013	→
An emerging role for long non-coding RNA dysregulation in neurological disorders.	Fenoglio C et al.	—	2013	→
Characteristics and significance of intergenic polyadenylated RNA transcription in Arabidopsis.	Moghe GD et al.	—	2013	→
Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer.	Zhai H et al.	—	2013	→
Detecting and comparing non-coding RNAs in the high-throughput era.	Bussotti G et al.	—	2013	→
Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells.	Özgür E et al.	—	2013	→
Differential expression of long non-coding RNAs in bleomycin-induced lung fibrosis.	Cao G et al.	—	2013	→
Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model.	Petazzi P et al.	—	2013	→
Gene regulation by antisense transcription.	Pelechano V et al.	—	2013	→
[Genetic hair diseases. An update].	Frank J et al.	—	2013	→
Growth hormone gene variability and its effects on milk traits in primiparous Sarda goats.	Dettori ML et al.	—	2013	→
Highly conserved elements discovered in vertebrates are present in non-syntenic loci of tunicates, act as enhancers and can be transcribed during development.	Sanges R et al.	—	2013	→
HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts.	Ferdin J et al.	—	2013	→
Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.	Gumireddy K et al.	—	2013	→
Integrated analysis of dysregulated lncRNA expression in fetal cardiac tissues with ventricular septal defect.	Song G et al.	—	2013	→
Long non-coding RNA-guided regulation in organisms.	Qi W et al.	—	2013	→
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.	Tripathi V et al.	—	2013	→
Long non-coding RNAs in haematological malignancies.	Garitano-Trojaola A et al.	—	2013	→
Long Noncoding RNAs: Insights from Biological Features and Functions to Diseases.	Li X et al.	—	2013	→
Mechanical regulation of epigenetics in vascular biology and pathobiology.	Chen LJ et al.	—	2013	→
MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer.	Hauptman N et al.	—	2013	→
MicroRNAs and other non-coding RNAs as targets for anticancer drug development.	Ling H et al.	—	2013	→
Molecular functions of small regulatory noncoding RNA.	Huang Y et al.	—	2013	→
Natural antisense transcripts as therapeutic targets.	Halley P et al.	—	2013	→
Next-generation sequencing: from understanding biology to personalized medicine.	Frese KS et al.	—	2013	→
Noncoding RNAs in chromatin organization and transcription regulation: an epigenetic view.	Dhanasekaran K et al.	—	2013	→
Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective.	Amaral PP et al.	—	2013	→
Non-coding RNAs regulate tumor cell plasticity.	Liu B et al.	—	2013	→
Novel human lncRNA-disease association inference based on lncRNA expression profiles.	Chen X et al.	—	2013	→
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.	Hangauer MJ et al.	—	2013	→
Probing the phenomics of noncoding RNA.	Mattick JS	—	2013	→
Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide.	Bennett CL et al.	—	2013	→
RNA-sequencing from single nuclei.	Grindberg RV et al.	—	2013	→
RNAsnp: efficient detection of local RNA secondary structure changes induced by SNPs.	Sabarinathan R et al.	—	2013	→
Simultaneous transcriptional profiling of bacteria and their host cells.	Humphrys MS et al.	—	2013	→
Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes.	Davies B et al.	—	2013	→
Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder.	Szafranski P et al.	—	2013	→
Strand-Specific RNA-Seq Provides Greater Resolution of Transcriptome Profiling.	Mills JD et al.	—	2013	→
Structure and function of long noncoding RNAs in epigenetic regulation.	Mercer TR et al.	—	2013	→
Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.	Guo YF et al.	—	2013	→
Systematic classification of non-coding RNAs by epigenomic similarity.	Dozmorov MG et al.	—	2013	→
The characteristics and expression profiles of the mitochondrial genome for the Mediterranean species of the Bemisia tabaci complex.	Wang HL et al.	—	2013	→
The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine.	Qi P et al.	—	2013	→
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis.	Benetatos L et al.	—	2013	→
The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor.	Cui Z et al.	—	2013	→
The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element.	Fukunaga J et al.	—	2013	→
Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo.	Zou Y et al.	—	2013	→
Viroids: a light in the darkness of the lncRNA-directed regulatory networks in plants.	Gómez G et al.	—	2013	→
Ancestral susceptibility to colorectal cancer.	Huhn S et al.	—	2012	→
A new level of complexity: the role of microRNAs in cardiovascular development.	Boettger T et al.	—	2012	→
An insertion/deletion polymorphism within RERT-lncRNA modulates hepatocellular carcinoma risk.	Zhu Z et al.	—	2012	→
Annotation of the domestic dog genome sequence: finding the missing genes.	Derrien T et al.	—	2012	→
A novel molecular mechanism in human genetic disease: a DNA repeat-derived lncRNA.	Cabianca DS et al.	—	2012	→
Beyond DNA origami: the unfolding prospects of nucleic acid nanotechnology.	Michelotti N et al.	—	2012	→
Bioinformatics tools and novel challenges in long non-coding RNAs (lncRNAs) functional analysis.	Da Sacco L et al.	—	2012	→
Characterization of the intronic portion of cadherin superfamily members, common cancer orchestrators.	Oliveira P et al.	—	2012	→
Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.	Gullerova M et al.	—	2012	→
Dark Matter RNA: Existence, Function, and Controversy.	Kapranov P et al.	—	2012	→
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs.	Moran VA et al.	—	2012	→
Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction.	Guay C et al.	—	2012	→
Imprinted gene dosage is critical for the transition to independent life.	Charalambous M et al.	—	2012	→
Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.	Liu X et al.	—	2012	→
Long noncoding RNA: its physiological and pathological roles.	Yan B et al.	—	2012	→
Long non-coding RNAs and cancer: a new frontier of translational research?	Spizzo R et al.	—	2012	→
Long non-coding RNAs and human disease.	Harries LW	—	2012	→
Long non-coding RNAs and p53 regulation.	Baldassarre A et al.	—	2012	→
Long noncoding RNAs in cardiac development and pathophysiology.	Schonrock N et al.	—	2012	→
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.	Davison LJ et al.	—	2012	→
Mammalian cells as biopharmaceutical production hosts in the age of omics.	Dietmair S et al.	—	2012	→
Modular regulatory principles of large non-coding RNAs.	Guttman M et al.	—	2012	→
Molecular biology: RNA discrimination.	Kowalczyk MS et al.	—	2012	→
Molecular mechanisms and function prediction of long noncoding RNA.	Ma H et al.	—	2012	→
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation.	Menet JS et al.	—	2012	→
Neurodegeneration as an RNA disorder.	Johnson R et al.	—	2012	→
Next-generation sequencing-based transcriptome analysis of Cryptolaemus montrouzieri under insecticide stress reveals resistance-relevant genes in ladybirds.	Zhang Y et al.	—	2012	→
Noncoding RNAs in Acute Myeloid Leukemia: From Key Regulators to Clinical Players.	Fatica A	—	2012	→
Overview of the creative genome: effects of genome structure and sequence on the generation of variation and evolution.	Caporale LH	—	2012	→
PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling.	Ferreira LB et al.	—	2012	→
Perspectives of Long Non-Coding RNAs in Cancer Diagnostics.	Reis EM et al.	—	2012	→
Regulatory variations in the era of next-generation sequencing: implications for clinical molecular diagnostics.	Jarinova O et al.	—	2012	→
RNA-Seq defines novel genes, RNA processing patterns and enhancer maps for the early stages of nephrogenesis: Hox supergenes.	Brunskill EW et al.	—	2012	→
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.	Derrien T et al.	—	2012	→
The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina.	Meola N et al.	—	2012	→
The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes.	Bomben R et al.	—	2012	→
The QTN program and the alleles that matter for evolution: all that's gold does not glitter.	Rockman MV	—	2012	→
Transcripts with in silico predicted RNA structure are enriched everywhere in the mouse brain.	Seemann SE et al.	—	2012	→
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?	Salmena L et al.	—	2011	→
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs.	Broadbent KM et al.	—	2011	→
Annotation of novel transcripts putatively relevant for bovine fat metabolism.	Eberlein A et al.	—	2011	→
A novel nuclear miRNA mediated modulation of a non-coding antisense RNA and its cognate sense coding mRNA.	Rossi JJ	—	2011	→
ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS.	Pasmant E et al.	—	2011	→
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.	Koldobskaya Y et al.	—	2011	→
Autoregulation of convergent RNAi genes in fission yeast.	Gullerova M et al.	—	2011	→
Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells.	Moison C et al.	—	2011	→
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.	Sharma S et al.	—	2011	→
Diabetic embryopathy: a role for the epigenome?	Salbaum JM et al.	—	2011	→
Disrupted post-transcriptional regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by a 5'UTR mutation is associated with a CFTR-related disease.	Lukowski SW et al.	—	2011	→
Distinct RNA degradation pathways and 3' extensions of yeast non-coding RNA species.	Marquardt S et al.	—	2011	→
Dual nature of translational control by regulatory BC RNAs.	Eom T et al.	—	2011	→
ELAV-mediated 3'-end processing of ewg transcripts is evolutionarily conserved despite sequence degeneration of the ELAV-binding site.	Haussmann IU et al.	—	2011	→
Enrichment of mRNA-like noncoding RNAs in the divergence of Drosophila males.	Jiang ZF et al.	—	2011	→
Evolution of eukaryotic genome architecture: Insights from the study of a rapidly evolving metazoan, Oikopleura dioica: Non-adaptive forces such as elevated mutation rates may influence the evolution of genome architecture.	Chavali S et al.	—	2011	→
Evolution under environmental stress at macro- and microscales.	Nevo E	—	2011	→
Exploiting Oxytricha trifallax nanochromosomes to screen for non-coding RNA genes.	Jung S et al.	—	2011	→
Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma.	Braconi C et al.	—	2011	→
Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging.	Liu J et al.	—	2011	→
Functional consequences of bidirectional promoters.	Wei W et al.	—	2011	→
Genomics and genetics in the biology of adaptation to exercise.	Bouchard C et al.	—	2011	→
Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor.	Psarra AM et al.	—	2011	→
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs.	Brameier M et al.	—	2011	→
Human cancer long non-coding RNA transcriptomes.	Gibb EA et al.	—	2011	→
Human genetics and genomics a decade after the release of the draft sequence of the human genome.	Naidoo N et al.	—	2011	→
Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk.	Jin G et al.	—	2011	→
In Silico Prediction of Evolutionarily Conserved GC-Rich Elements Associated with Antigenic Proteins of Plasmodium falciparum.	Panneerselvam P et al.	—	2011	→
Intragene higher order repeats in neuroblastoma breakpoint family genes distinguish humans from chimpanzees.	Paar V et al.	—	2011	→
Introduction--Epiphanies in epigenetics.	Cheng X et al.	—	2011	→
lincRNAs act in the circuitry controlling pluripotency and differentiation.	Guttman M et al.	—	2011	→
lncRNAdb: a reference database for long noncoding RNAs.	Amaral PP et al.	—	2011	→
Long intergenic noncoding RNAs: new links in cancer progression.	Tsai MC et al.	—	2011	→
Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer.	Tahira AC et al.	—	2011	→
Long non-coding RNAs and enhancers.	Ørom UA et al.	—	2011	→
Long noncoding RNAs and human disease.	Wapinski O et al.	—	2011	→
Long noncoding RNAs in cell biology.	Clark MB et al.	—	2011	→
Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.	Rana T et al.	—	2011	→
ncRAN, a newly identified long noncoding RNA, enhances human bladder tumor growth, invasion, and survival.	Zhu Y et al.	—	2011	→
Noncoding RNAs and enhancers: complications of a long-distance relationship.	Orom UA et al.	—	2011	→
Non-coding RNAs for medical practice in oncology.	Setoyama T et al.	—	2011	→
Non-coding RNAs in schistosomes: an unexplored world.	Oliveira KC et al.	—	2011	→
Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation.	Yang Z et al.	—	2011	→
Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications.	Huhn S et al.	—	2011	→
Principles of microRNA involvement in human cancers.	Ling H et al.	—	2011	→
Regulation of chromatin by histone modifications.	Bannister AJ et al.	—	2011	→
Representational Difference Analysis (RDA) reveals differential expression of conserved as well as novel genes during caste-specific development of the honey bee (Apis mellifera L.) ovary.	Humann FC et al.	—	2011	→
Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming.	Díaz-García C et al.	—	2011	→
RNA degradome--its biogenesis and functions.	Jackowiak P et al.	—	2011	→
RNA-protein interactions in human health and disease.	Khalil AM et al.	—	2011	→
RNA splicing control: yet another gene regulatory role for long nuclear noncoding RNAs.	Zong X et al.	—	2011	→
Structural and functional differences in the long non-coding RNA hotair in mouse and human.	Schorderet P et al.	—	2011	→
Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.	Egli M et al.	—	2011	→
The central role of RNA in human development and cognition.	Mattick JS	—	2011	→
The expression of the pro-apoptotic gene Air is inducible in human pancreatic adenocarcinoma cells.	d'Avenia M et al.	—	2011	→
The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell.	Michael DR et al.	—	2011	→
The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity.	Chen CH et al.	—	2011	→
Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.	Williamson CM et al.	—	2011	→
Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates.	Paz-Yaacov N et al.	—	2010	→
A global view of genomic information--moving beyond the gene and the master regulator.	Mattick JS et al.	—	2010	→
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.	Huarte M et al.	—	2010	→
Biochemical principles of small RNA pathways.	Liu Q et al.	—	2010	→
Both noncoding and protein-coding RNAs contribute to gene expression evolution in the primate brain.	Babbitt CC et al.	—	2010	→
Cancer biomarker discovery: the entropic hallmark.	Berretta R et al.	—	2010	→
Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications.	Haddad F et al.	—	2010	→
Comparative analyses of vertebrate posterior HoxD clusters reveal atypical cluster architecture in the caecilian Typhlonectes natans.	Mannaert A et al.	—	2010	→
De novo prediction of structured RNAs from genomic sequences.	Gorodkin J et al.	—	2010	→
Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34.	Stanke F et al.	—	2010	→
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons.	Moroz LL et al.	—	2010	→
Epigenetic modifications and human disease.	Portela A et al.	—	2010	→
Evolutionary history of regulatory variation in human populations.	Lappalainen T et al.	—	2010	→
Exploring molecular signaling in plant-fungal symbioses using high throughput RNA sequencing.	Cox MP et al.	—	2010	→
Exploring RNA structure by integrative molecular modelling.	Masquida B et al.	—	2010	→
Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics.	Cooper DN et al.	—	2010	→
Identification of long stress-induced non-coding transcripts that have altered expression in cancer.	Silva JM et al.	—	2010	→
Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes.	Schmitz KM et al.	—	2010	→
Long noncoding RNAs as enhancers of gene expression.	Ørom UA et al.	—	2010	→
Long non-coding RNAs in nervous system function and disease.	Qureshi IA et al.	—	2010	→
Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation.	Mercer TR et al.	—	2010	→
Long noncoding RNAs with enhancer-like function in human cells.	Ørom UA et al.	—	2010	→
MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseases.	Edwards JK et al.	—	2010	→
microRNAs in diseases: from candidate to modifier genes.	Bandiera S et al.	—	2010	→
Mining mammalian transcript data for functional long non-coding RNAs.	Khachane AN et al.	—	2010	→
Most "dark matter" transcripts are associated with known genes.	van Bakel H et al.	—	2010	→
Natural antisense transcripts regulate gene expression in an epigenetic manner.	Su WY et al.	—	2010	→
Non-coding RNAs: regulators of disease.	Taft RJ et al.	—	2010	→
Nuclear organization and dynamics of 7SK RNA in regulating gene expression.	Prasanth KV et al.	—	2010	→
Polypurine-repeat-containing RNAs: a novel class of long non-coding RNA in mammalian cells.	Zheng R et al.	—	2010	→
Protein-coding and non-coding gene expression analysis in differentiating human keratinocytes using a three-dimensional epidermal equivalent.	Mazar J et al.	—	2010	→
Regulatory RNAs in brain function and disorders.	Iacoangeli A et al.	—	2010	→
[The amazing story of ANRIL, a long non-coding RNA].	Pasmant E et al.	—	2010	→
The central role of RNA in the genetic programming of complex organisms.	Mattick JS	—	2010	→
The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation.	Tripathi V et al.	—	2010	→
Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs.	Malecová B et al.	—	2010	→
Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology.	David JP et al.	—	2010	→
Translation efficiency in humans: tissue specificity, global optimization and differences between developmental stages.	Waldman YY et al.	—	2010	→
Video Q&A: Non-coding RNAs and eukaryotic evolution - a personal view.	Mattick J	—	2010	→
Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes.	Calin GA et al.	—	2009	→
Complex architecture and regulated expression of the Sox2ot locus during vertebrate development.	Amaral PP et al.	—	2009	→
Deconstructing the dogma: a new view of the evolution and genetic programming of complex organisms.	Mattick JS	—	2009	→
Establishing legitimacy and function in the new transcriptome.	van Bakel H et al.	—	2009	→
Evolutionarily stable association of intronic snoRNAs and microRNAs with their host genes.	Hoeppner MP et al.	—	2009	→
Expression profiling of Drosophila mitochondrial genes via deep mRNA sequencing.	Torres TT et al.	—	2009	→
Genome-wide association studies: hypothesis-"free" or "engaged"?	Kitsios GD et al.	—	2009	→
Linking genotypes to phenotypes and fitness: how mechanistic biology can inform molecular ecology.	Dalziel AC et al.	—	2009	→
Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells.	Morris KV	—	2009	→
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.	Khalil AM et al.	—	2009	→
New levels of sophistication in the transcriptional landscape of bacteria.	van Vliet AH et al.	—	2009	→
Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications.	Dinger ME et al.	—	2009	→
The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila.	Mallik M et al.	—	2009	→