Conclusion: Special issue on genetic and alcohol use disorder research with diverse racial/ethnic groups: Key findings and potential next steps.
- Authors
- Chartier, Karen G; Hesselbrock, Michie N; Hesselbrock, Victor M
- Year
- 2017
- Journal
- The American journal on addictions
- PMID
- 28745446
- DOI
- 10.1111/ajad.12585
- PMCID
- PMC5615400
BACKGROUND AND OBJECTIVES: This special issue brings together papers focusing on a wide range of topics relevant to the research and understanding of the role of race/ethnicity and genetic variation for the susceptibility of developing an alcohol use disorder (AUD). METHODS: The key findings from the issue's 10 articles are reviewed and organized here around three topics: I: addictive behaviors and potential environmental influences; II: a focus on four racial/ethnic groups; and III: special methodologies. RESULTS: Several potential next steps in improving effective research strategies are highlighted: (1) implementing best practices for outreach and community engagement may reduce reluctance to participate; (2) recruiting adequately sized and racially/ethnically diverse samples will require new collaborations with investigators who successfully work in diverse communities; (3) identifying and assessing environmental influences that are both unique to, and common among, racial/ethnic groups may inform preventions for AUD; (4) use of standardized measures will facilitate the generation of larger samples and meta-analysis of research findings; and (5) use of better analytic approaches and experimental methods will improve replication in gene finding research and help advance new areas of research. CONCLUSIONS: Genetic research of AUD in diverse racial/ethnic populations is advancing. The articles in this issue examined the general theme of including diverse population groups in genetic studies and offered potential strategies for addressing some common problems. SCIENTIFIC SIGNIFICANCE: Greater inclusion of diverse racial/ethnic populations in this research is important to ensure that the benefits of new knowledge and technology are equally shared. (Am J Addict 2017;26:532-537).
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| # | Section | Preview |
|---|---|---|
| 20 | Summary and some next steps | health of differences in genetic, environmental, and lifestyle factors 13. However, since… |
| 21 | Summary and some next steps | Our focus on four major racial/ethnic groups illustrates that some environmental exposures may have… |
| 22 | Summary and some next steps | We underscore the recommendation that investigators consider using standardized approaches to… |
| 23 | Summary and some next steps | Genetic diversity also requires special attention by investigators to avoid the reporting of… |
| 24 | Scientific significance | In conclusion, this special issue examined several topics relevant to the design and implementation… |
| 25 | Scientific significance | subject participation and engagement, the development of collaborations among investigators, and… |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Introduction: Special issue on genetic research of alcohol use disorder in diverse racial/ethnic populations. | 2017 | 28672076 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Perspectives on communication and engagement with regard to collecting biospecimens and family health histories for cancer research in a rural Alaska Native community. | Dirks LG et al. | — | 2019 | → |
| Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. | Polimanti R et al. | — | 2017 | → |
| Introduction: Special issue on genetic research of alcohol use disorder in diverse racial/ethnic populations. | Chartier KG et al. | — | 2017 | → |