Social regulation of gene expression in human leukocytes.
paper
Cited
Public
- Authors
- Cole, Steve W; Hawkley, Louise C; Arevalo, Jesusa M; Sung, Caroline Y; Rose, Robert M; Cacioppo, John T
- Year
- 2007
- Journal
- Genome biology
- PMID
- 17854483
- DOI
- 10.1186/gb-2007-8-9-r189
- PMCID
- PMC2375027
BACKGROUND: Social environmental influences on human health are well established in the epidemiology literature, but their functional genomic mechanisms are unclear. The present study analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations in the activity of transcription control pathways that might contribute to increased adverse health outcomes in social isolates. RESULTS: DNA microarray analysis identified 209 genes that were differentially expressed in circulating leukocytes from 14 high- versus low-lonely individuals, including up-regulation of genes involved in immune activation, transcription control, and cell proliferation, and down-regulation of genes supporting mature B lymphocyte function and type I interferon response. Promoter-based bioinformatic analyses showed under-expression of genes bearing anti-inflammatory glucocorticoid response elements (GREs; p = 0.032) and over-expression of genes bearing response elements for pro-inflammatory NF-kappaB/Rel transcription factors (p = 0.011). This reciprocal shift in pro- and anti-inflammatory signaling was not attributable to differences in circulating cortisol levels, or to other demographic, psychological, or medical characteristics. Additional transcription control pathways showing differential activity in bioinformatic analyses included the CREB/ATF, JAK/STAT, IRF1, C/EBP, Oct, and GATA pathways. CONCLUSION: These data provide the first indication that human genome-wide transcriptional activity is altered in association with a social epidemiological risk factor. Impaired transcription of glucocorticoid response genes and increased activity of pro-inflammatory transcription control pathways provide a functional genomic explanation for elevated risk of inflammatory disease in individuals who experience chronically high levels of subjective social isolation.
Differential gene expression in high- versus low-lonely individuals. Genome-wide transcriptional profiles were assessed in peripheral blood leukocyte RNA samples collected from individuals in the top and bottom 15% of the distribution of subjective social isolation. Analysis by Affymetrix U133A high-density oligonucleotide arrays identified 209 transcripts showing >30% difference in mean expression levels across groups (green = over-expression in high-lonely, red = under-expression). High subjective social isolation is associated with a statistically significant net reduction in the number of expressed genes (131 down-regulated versus 78 up-regulated, p value by exact binomial test).
Transcriptional activity of GR and NF-ΞΊB signaling pathways. TELiS bioinformatics analysis assessed trans-activational activity based on the relative prevalence of GR and NF-ΞΊB response elements in the promoters of all 209 transcripts over-expressed in high- versus low-lonely individuals (data represent mean Β± standard error prevalence of response elements within promoters from each group). Contributions of in-trans regulatory influences to the observed inverse skew of NF-ΞΊB and GR response elements within differentially expressing promoters was tested by comparison to a null distribution of genome-wide DNA cis-structural associations generated by 10,000 random samples of 209 transcripts assayed by Affymetrix U133A arrays.
Transcription control pathways differentially active in high- versus low-lonely individuals. Data represent the mean (Β± standard error) prevalence of transcription factor-binding motifs in primary TELiS bioinformatics analysis of genes over-expressed in leukocytes from high- versus low-lonely individuals.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases. | Chen N et al. | β | 2026 | β |
| In-hospital psychological stress and post-hospital outcomes. | Ford DM et al. | β | 2026 | β |
| Prevalence of social alienation in community-dwelling older adults: a systematic review and meta-analysis. | Lin Y et al. | β | 2026 | β |
| Social isolation of aged mice drives dramatic release of inflammatory lipoxygenase-derived oxylipins. | Wichmann-Costaganna M et al. | β | 2026 | β |
| Time-Dynamic analysis of sex-specific NREM sleep disturbance induced by social isolation among adolescent mice. | Li S et al. | β | 2026 | β |
| ANCA-related vasculitis incidence and features before and during the COVID-19 pandemic in Los Angeles, Biobio Province, Chile: an observational retrospective analysis. | Enos D et al. | β | 2025 | β |
| Association of social isolation and loneliness with incident rheumatoid arthritis in a population-based cohort study. | Zhang RD et al. | β | 2025 | β |
| Associations between the neural-hematopoietic-inflammatory axis and DNA methylation of stress-related genes in human leukocytes: Data from the Washington, D.C. cardiovascular health and needs assessment. | Cintron MA et al. | β | 2025 | β |
| Bridging social isolation, loneliness, and brain aging: A narrative review of mechanisms and translational interventions. | Wnuk HK et al. | β | 2025 | β |
| Chronic loneliness and isolation phenotypes, incident functional impairment and mortality in England between 2004 and 2018. | Gao Q et al. | β | 2025 | β |
| Could loneliness accelerate the progression of diabetes among adults with prediabetes: national longitudinal cohort. | Wang W et al. | β | 2025 | β |
| Differential associations between relationship stressors and natural killer cell gene expression by race/ethnicity and sex among older U.S. adults. | Rodrigues M et al. | β | 2025 | β |
| Genome-wide transcriptome differences associated with perceived discrimination in an urban, community-dwelling middle-aged cohort. | Pacheco NL et al. | β | 2025 | β |
| Housing density affects the survivorship post infection of Drosophila melanogaster males in a pathogen dependent manner. | Choton T et al. | β | 2025 | β |
| How community connection, homophobia, and racism shape gene expression in sexual minority men with and without HIV. | Alley J et al. | β | 2025 | β |
| Identifying leading anti-inflammatory dietary determinants of depression and loneliness in older adults. | Zhang Y et al. | β | 2025 | β |
| Living arrangements and lonely life expectancy: a multistate life table based on Markov chains. | Yu Q et al. | β | 2025 | β |
| Loneliness associates with endothelial dysfunction in a community-based cohort: a pilot study and translational approach. | Baumer Y et al. | β | 2025 | β |
| Mindfulness vs. sleep education during autologous hematopoietic cell transplantation for multiple myeloma: Feasibility of a randomized controlled pilot study. | Henley EC et al. | β | 2025 | β |
| Pathways to maternal health inequities: Structural racism, sleep, and physiological stress. | Christian LM et al. | β | 2025 | β |
| Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood. | Heumann J et al. | β | 2025 | β |
| Physical health correlates of co-occurring chronic pain and PTSD Among U.S. Veterans: Results from a nationally representative study. | Reed DE et al. | β | 2025 | β |
| Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality. | Shen C et al. | β | 2025 | β |
| Positive social relations, loneliness, and immune system gene regulation. | Lee SH et al. | β | 2025 | β |
| Prevalence and clinical significance of loneliness in older patients admitted to acute hospital wards. | Brombo G et al. | β | 2025 | β |
| Psychometric analysis of the social connectedness instrument. | Kelley B et al. | β | 2025 | β |
| Recorded Loneliness and Adverse Outcomes in Older Acute Care Inpatients Receiving Psychiatric Assessment. | Joseph M et al. | β | 2025 | β |
| Social isolation and loneliness increase the risk of coronary heart disease: Insights from a prospective cohort study. | Yang Z et al. | β | 2025 | β |
| Social isolation: an integrated molecular web that disrupts cellular homeostasis. | Qaisiya M et al. | β | 2025 | β |
| Social Isolation Is Associated With the Acceleration of Death and Incident Cardiovascular Disease in Adults With Chronic Kidney Disease. | Zeng X et al. | β | 2025 | β |
| The Etiology of Loneliness: Insights from Twin and Family, Genome-Wide, and Epigenetic Studies. | Freilich CD et al. | β | 2025 | β |
| 'They think we're just in God's waiting room': A discursive study on identity aloneness in stroke survivors. | Jefferson L et al. | β | 2025 | β |
| Walking autonomy in chronic dialysis patients: insights from a nationwide registry and focus group analysis. | Naudin M et al. | β | 2025 | β |
| Affective reactivity to daily stressors and immune cell gene expression in the MIDUS study. | Apsley AT et al. | β | 2024 | β |
| Association between loneliness and mental health among nurses: a cross-sectional research in China. | Qiao Y et al. | β | 2024 | β |
| Associations Between Loneliness, Epigenetic Aging, and Multimorbidity Through Older Adulthood. | Freilich CD et al. | β | 2024 | β |
| Can social adversity alter the epigenome, trigger oral disease, and affect future generations? | Khalid S et al. | β | 2024 | β |
| Experiences of racial discrimination and adverse gene expression among black individuals in a level 1 trauma center sample. | Bird CM et al. | β | 2024 | β |
| Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review. | Duarte M et al. | β | 2024 | β |
| Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats. | Girella A et al. | β | 2024 | β |
| Hearing loss and dementia in older adults: A narrative review. | Huang AR et al. | β | 2024 | β |
| Immune transcriptomic profile in adult female pigs: dominance status has more influence than environmental enrichment. | Lopes MM et al. | β | 2024 | β |
| Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing. | Hajj J et al. | β | 2024 | β |
| Increases in Psychological Stress Are Associated With Higher Fasting Glucose in US Chinese Immigrants. | Fang CY et al. | β | 2024 | β |
| Interpersonal relationships, PNI, and health: Seeds in the 1980s, fruiting trees today. | Robles TF | β | 2024 | β |
| Loneliness, epigenetic age acceleration, and chronic health conditions. | Freilich CD et al. | β | 2024 | β |
| Measuring the experience of social connection within specific social interactions: The Connection During Conversations Scale (CDCS). | Okabe-Miyamoto K et al. | β | 2024 | β |
| Mindfulness-Based Stress Reduction Reduces Proinflammatory Gene Regulation But Not Systemic Inflammation Among Older Adults: A Randomized Controlled Trial. | Lindsay EK et al. | β | 2024 | β |
| Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes. | Pangrazzi L et al. | β | 2024 | β |
| Psychological and neurobiological mechanisms involved in the relationship between loneliness and cognitive decline in older adults. | Dabiri S et al. | β | 2024 | β |
| Psychosocial stressors and breast cancer gene expression in the Black Women's Health Study. | Barnard ME et al. | β | 2024 | β |
| Social Determinants of Health in Cardio-Oncology: Multi-Level Strategies to Overcome Disparities in Care: <i>JACC:Β CardioOncology</i> State-of-the-Art Review. | Osei Baah F et al. | β | 2024 | β |
| Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes. | Goel N et al. | β | 2024 | β |
| Social genomics, cognition, and well-being during the COVID-19 pandemic. | Bateman JR et al. | β | 2024 | β |
| Social Isolation Changes and Long-Term Outcomes Among Older Adults. | Lyu C et al. | β | 2024 | β |
| Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood. | Matthews T et al. | β | 2024 | β |
| Stress-related gene regulation: Do isolated and connected individuals differ? | Yang YS et al. | β | 2024 | β |
| The association of social isolation and loneliness with sarcopenia among the middle-aged and elderly in China. | Tu L et al. | β | 2024 | β |
| Transcriptomics and psychotherapy: An integrative review. | Ricon-Becker I et al. | β | 2024 | β |
| ZIP Code to Genomic Code: Neighborhood Disadvantage, Aggressive Breast Cancer Biology, and Breast Cancer Outcomes. | Goel N et al. | β | 2024 | β |
| Acculturation in Context and Brain Health in Older Latino Adults: A Diffusion Tensor Imaging Study. | Fleischman DA et al. | β | 2023 | β |
| Advancing Health Equity in Lung Cancer Screening and the Role of Humanomics. | Hartley-Blossom Z et al. | β | 2023 | β |
| Are social isolation and loneliness associated with cognitive decline in ageing? | Cardona M et al. | β | 2023 | β |
| Associations Between Longitudinal Loneliness, DNA Methylation Age Acceleration, and Cognitive Functioning. | Lynch M et al. | β | 2023 | β |
| A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality. | Wang F et al. | β | 2023 | β |
| Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction. | Edelmann S et al. | β | 2023 | β |
| Breaking the vicious cycle: The interplay between loneliness, metabolic illness, and mental health. | Ahmed M et al. | β | 2023 | β |
| Co-Expression Network Analysis Identifies Molecular Determinants of Loneliness Associated with Neuropsychiatric and Neurodegenerative Diseases. | Santiago JA et al. | β | 2023 | β |
| Endocannabinoid system genes regulation in the effects evoked by social isolation in rats | Girella A et al. | β | 2023 | β |
| Examining racial differences in treatment and survival among patients with Paget's disease of the breast. | Owusu-Brackett N et al. | β | 2023 | β |
| Fight the Fire: Association of Cytokine Genomic Markers and Suicidal Behavior May Pave the Way for Future Therapies. | Gonda X et al. | β | 2023 | β |
| How does loneliness "get under the skin" to become biologically embedded? | Freilich CD | β | 2023 | β |
| Human social genomics: Concepts, mechanisms, and implications for health. | Slavich GM et al. | β | 2023 | β |
| Loneliness and Functional Decline in Aging: A Systematic Review. | Pollak C et al. | β | 2023 | β |
| Loneliness - Cancer of the Mind. | Benjamin DG et al. | β | 2023 | β |
| Loneliness Trajectories, Associated Factors and Subsequent Health in Children and Young People During the COVID-19 Pandemic: A National Matched Cohort Study. | Schneider V et al. | β | 2023 | β |
| Longitudinal analyses indicate bidirectional associations between loneliness and health. | Phillips DM et al. | β | 2023 | β |
| Longitudinal Associations Between Loneliness and β¨Self-Rated Health Among Black and White Older Adults. | Sol K et al. | β | 2023 | β |
| Neurogenetics and Epigenetics of Loneliness. | Bowirrat A et al. | β | 2023 | β |
| Persistence of social isolation and mortality: 10-year follow-up of the Guangzhou Biobank Cohort study. | Wang J et al. | β | 2023 | β |
| Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences. | Zang JCS et al. | β | 2023 | β |
| Relationship of Chronic Systemic Inflammation to Both Chronic Lifestyle-Related Diseases and Osteoarthritis: The Case for Lifestyle Medicine for Osteoarthritis. | Prather H et al. | β | 2023 | β |
| Serial multiple mediation of loneliness and depressive symptoms in the relationship between pain and cognitive function among older people. | Kong X et al. | β | 2023 | β |
| Social Isolation: A Narrative Review on the Dangerous Liaison between the Autonomic Nervous System and Inflammation. | ScatΓ C et al. | β | 2023 | β |
| Social isolation and loneliness: Undervalued risk factors for disease states and mortality. | Kanbay M et al. | β | 2023 | β |
| Social network position and the Conserved Transcriptional Response to Adversity in older Koreans. | Lee SH et al. | β | 2023 | β |
| The Effects of <i>Mukbang</i> Watching on Enteral Feeding Intolerance Among Critically Ill Patients: Study Protocol for a Randomized Controlled Trail. | Yin Y et al. | β | 2023 | β |
| The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review. | O'Brien JR et al. | β | 2023 | β |
| Unfavorable transcriptome profiles and social disadvantage in hematopoietic cell transplantation: a CIBMTR analysis. | Taylor MR et al. | β | 2023 | β |
| Associations between loneliness and frailty among older adults: Evidence from the China Health and Retirement Longitudinal Study. | Sha S et al. | β | 2022 | β |
| Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study. | Wang J et al. | β | 2022 | β |
| Chronic stress increases transcriptomic indicators of biological aging in mouse bone marrow leukocytes. | Rentscher KE et al. | β | 2022 | β |
| Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model. | Zenga J et al. | β | 2022 | β |
| Combinatorial approaches for treating neuropsychiatric social impairment. | Wei D et al. | β | 2022 | β |
| Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons. | Anderson JA et al. | β | 2022 | β |
| Flourishing in Healthcare Trainees: Psychological Well-Being and the Conserved Transcriptional Response to Adversity. | Mascaro JS et al. | β | 2022 | β |
| Impact of the COVID-19 pandemic on inflammatory bowel disease: The role of emotional stress and social isolation. | Nass BYS et al. | β | 2022 | β |
| Individual Differences in Cerebral Perfusion as a Function of Age and Loneliness. | Chen YW et al. | β | 2022 | β |
| Inflammatory and environmental contributions to social information processing. | Venta A et al. | β | 2022 | β |
| Integrating biobehavioral information to predict mood disorder suicide risk. | Jackson NA et al. | β | 2022 | β |
| Loneliness and Health Indicators in Middle-Aged and Older Females and Males. | Crespo-Sanmiguel I et al. | β | 2022 | β |
| Loneliness, Depression, and Genetics in the Elderly: Prognostic Factors of a Worse Health Condition? | Delgado-Losada ML et al. | β | 2022 | β |
| Loneliness in Posttraumatic Stress Disorder: A Neglected Factor in Accelerated Aging? | Palmer BW et al. | β | 2022 | β |
| Natural disaster and immunological aging in a nonhuman primate. | Watowich MM et al. | β | 2022 | β |
| Psychosocial stress and cancer risk: a narrative review. | Mohan A et al. | β | 2022 | β |
| Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interaction. | Snodgrass JG et al. | β | 2022 | β |
| Social environment as a modulator of immunosenescence. | Garrido A et al. | β | 2022 | β |
| Social Genomics as a Framework for Understanding Health Disparities Among Adolescent and Young Adult Cancer Survivors: A Commentary. | Ghazal LV et al. | β | 2022 | β |
| Stress-induced biological aging: A review and guide for research priorities. | Polsky LR et al. | β | 2022 | β |
| The association between social network index, atrial fibrillation, and mortality in the Framingham Heart Study. | Kornej J et al. | β | 2022 | β |
| The genomic impact of kindness to self vs. others: A randomized controlled trial. | Regan A et al. | β | 2022 | β |
| The neuroimmunology of social-stress-induced sensitization. | Biltz RG et al. | β | 2022 | β |
| A biopsychosocial framework for understanding sexual and gender minority health: A call for action. | Christian LM et al. | β | 2021 | β |
| Adverse Life Trajectories Are a Risk Factor for SARS-CoV-2 IgA Seropositivity. | Holuka C et al. | β | 2021 | β |
| A genetic screen for Drosophila social isolation mutants and analysis of sex pistol. | Eddison M | β | 2021 | β |
| Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities. | Pourriyahi H et al. | β | 2021 | β |
| An observational study protocol to explore loneliness and systemic inflammation in an older adult population with chronic venous leg ulcers. | Kelechi TJ et al. | β | 2021 | β |
| Associations Between Loneliness, Reading Ability and Episodic Memory in Non-Hispanic Black and White Older Adults. | Sol K et al. | β | 2021 | β |
| Bidirectional longitudinal associations between loneliness and pain, and the role of inflammation. | Loeffler A et al. | β | 2021 | β |
| Early origins of socioeconomic inequalities in chronic inflammation: Evaluating the contributions of low birth weight and short breastfeeding. | McDade TW et al. | β | 2021 | β |
| Friends from the Future: A Scoping Review of Research into Robots and Computer Agents to Combat Loneliness in Older People. | Gasteiger N et al. | β | 2021 | β |
| Glucocorticoid resistance and Ξ²2-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: A systematic review across species. | Walsh CP et al. | β | 2021 | β |
| Hearing Loss and Cognitive Impairment: Epidemiology, Common Pathophysiological Findings, and Treatment Considerations. | Bisogno A et al. | β | 2021 | β |
| Impact of Surgical Status, Loneliness, and Disability on Interleukin 6, C-Reactive Protein, Cortisol, and Estrogen in Females with Symptomatic Type I Chiari Malformation. | Garcia MA et al. | β | 2021 | β |
| Learning from and Leveraging Multi-Level Changes in Responses to the COVID 19 Pandemic to Facilitate Breast Cancer Prevention Efforts. | Bowen DJ et al. | β | 2021 | β |
| Loneliness and mental health during the COVID-19 pandemic in older breast cancer survivors and noncancer controls. | Rentscher KE et al. | β | 2021 | β |
| Loneliness: An Immunometabolic Syndrome. | Pourriyahi H et al. | β | 2021 | β |
| Loneliness Is Associated with Depressive Affect, But Not with Most Other Symptoms of Depression in Community-Dwelling Individuals: A Network Analysis. | von KΓ€nel R et al. | β | 2021 | β |
| Mindfulness-Based Stress Reduction Buffers Glucocorticoid Resistance Among Older Adults: A Randomized Controlled Trial. | Lindsay EK et al. | β | 2021 | β |
| Post-weaning social isolation increases ΞFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice. | Noback M et al. | β | 2021 | β |
| Psychosocial Stress Alters the Immune Response and Results in Higher Viral Load During Acute Simian Immunodeficiency Virus Infection in a Pigtailed Macaque Model of Human Immunodeficiency Virus. | Guerrero-Martin SM et al. | β | 2021 | β |
| Rapid Support for Older Adults during the Initial Stages of the COVID-19 Pandemic: Results from a Geriatric Psychiatry Helpline. | Wahl AS et al. | β | 2021 | β |
| Social isolation causes downregulation of immune and stress response genes and behavioural changes in a social insect. | Scharf I et al. | β | 2021 | β |
| Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS). | Zhou W et al. | β | 2021 | β |
| Stress and Health: A Review of Psychobiological Processes. | O'Connor DB et al. | β | 2021 | β |
| Systemic inflammation as a driver of health disparities among sexually-diverse and gender-diverse individuals. | Diamond LM et al. | β | 2021 | β |
| The Association Between Loneliness and Inflammation: Findings From an Older Adult Sample. | Van Bogart K et al. | β | 2021 | β |
| The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review. | Kumar A et al. | β | 2021 | β |
| The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. | Lee CR et al. | β | 2021 | β |
| The Relationship Between Multidimensional Motivation and Endocrine-Related Responses: A Systematic Review. | Steel RP et al. | β | 2021 | β |
| The roles of depression and social relationships in the onset and course of loneliness amongst Nigerian elders. | Ojagbemi A et al. | β | 2021 | β |
| The Type I interferon antiviral gene program is impaired by lockdown and preserved by caregiving. | Cole SW et al. | β | 2021 | β |
| Tone it down: Vagal nerve activity is associated with pro-inflammatory and anti-viral factors in breast cancer - An exploratory study. | Ricon-Becker I et al. | β | 2021 | β |
| Unwelcome Companions: Loneliness Associates with the Cluster of Pain, Fatigue, and Depression in Older Adults. | Powell VD et al. | β | 2021 | β |
| A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. | CastagnΓ© R et al. | β | 2020 | β |
| Association of social network structure and physical function in patients with multiple sclerosis. | Levin SN et al. | β | 2020 | β |
| Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs. | Niculescu AB et al. | β | 2020 | β |
| Brain-body interactions underlying the association of loneliness with mental and physical health. | Quadt L et al. | β | 2020 | β |
| Cardiovascular and immunological implications of social distancing in the context of COVID-19. | D'Acquisto F et al. | β | 2020 | β |
| Differential associations between interpersonal variables and quality-of-life in a sample of college students. | Kuczynski AM et al. | β | 2020 | β |
| Differential impact of transient and chronic loneliness on health status. A longitudinal study. | MartΓn-MarΓa N et al. | β | 2020 | β |
| Evaluation of the Effectiveness of One- and Multi-Session Exposure-Based Treatments in Reducing Biological and Psychological Responses to Rat Phobia Among Students. | Hemyari C et al. | β | 2020 | β |
| Genomic and physiological resilience in extreme environments are associated with a secure attachment style. | Caputo V et al. | β | 2020 | β |
| Investigating the impact of early-life adversity on physiological, immune, and gene expression responses to acute stress: A pilot feasibility study. | Shalev I et al. | β | 2020 | β |
| Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context. | Mattos Dos Santos R | β | 2020 | β |
| Loneliness and psychotic experiences in a general population sample. | Narita Z et al. | β | 2020 | β |
| Loneliness as a risk factor for frailty transition among older Chinese people. | Sha S et al. | β | 2020 | β |
| Loneliness during a strict lockdown: Trajectories and predictors during the COVID-19 pandemic in 38,217 United Kingdom adults. | Bu F et al. | β | 2020 | β |
| Long-Term Impact of Social Isolation and Molecular Underpinnings. | Arzate-MejΓa RG et al. | β | 2020 | β |
| Propranolol inhibits molecular risk markers in HCT recipients: a phase 2 randomized controlled biomarker trial. | Knight JM et al. | β | 2020 | β |
| Psychosocial variables and quality of life during the COVID-19 lockdown: a correlational study on a convenience sample of young Italians. | Lardone A et al. | β | 2020 | β |
| SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities? | Gelaye B et al. | β | 2020 | β |
| Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. | Sanz J et al. | β | 2020 | β |
| Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report. | Donovan NJ et al. | β | 2020 | β |
| Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis. | Brown KM et al. | β | 2020 | β |
| Stressed-Out Oral Immunity: A Gateway From Socioeconomic Adversity to Periodontal Disease. | Gomaa N et al. | β | 2020 | β |
| The association between loneliness, social isolation and inflammation: A systematic review and meta-analysis. | Smith KJ et al. | β | 2020 | β |
| The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity? | Holuka C et al. | β | 2020 | β |
| The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging. | Shiau S et al. | β | 2020 | β |
| The Neurobiology of Social Distance. | Bzdok D et al. | β | 2020 | β |
| The relationship between minority stress and biological outcomes: A systematic review. | Flentje A et al. | β | 2020 | β |
| The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness. | Li H et al. | β | 2020 | β |
| Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs. | Le-Niculescu H et al. | β | 2020 | β |
| Understanding loneliness in the twenty-first century: an update on correlates, risk factors, and potential solutions. | Lim MH et al. | β | 2020 | β |
| An Embodied Neurocomputational Framework for Organically Integrating Biopsychosocial Processes: An Application to the Role of Social Support in Health and Disease. | Smith R et al. | β | 2019 | β |
| A proinflammatory diet is associated with inflammatory gene expression among healthy, non-obese adults: Can social ties protect against the risks? | Padin AC et al. | β | 2019 | β |
| Are Perceived Stress and Cytokine Genotypes Clinically Feasible as Predictors of Psychoneuroimmune Symptoms in Advanced Cancer? | Gilbertson-White S et al. | β | 2019 | β |
| Associations of Personality Traits With Chronic Low-Grade Inflammation in a Swiss Community Sample. | Wagner EN et al. | β | 2019 | β |
| Daily hassles, loneliness, and diurnal salivary cortisol in emerging adults. | Lai JCL et al. | β | 2019 | β |
| Early adversity and the regulation of gene expression: Implications for prenatal health. | Gillespie SL et al. | β | 2019 | β |
| Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis. | Brown KM et al. | β | 2019 | β |
| Falling in love is associated with immune system gene regulation. | Murray DR et al. | β | 2019 | β |
| Genetic Contributions to Loneliness and Their Relevance to the Evolutionary Theory of Loneliness. | Spithoven AWM et al. | β | 2019 | β |
| History of Depression and Increased Risk of Sternal Wound Infection After Cardiothoracic Surgery: A Novel and Potentially Modifiable Risk Factor. | Theodore DA et al. | β | 2019 | β |
| Inflammation and breast density among female Chinese immigrants: exploring variations across neighborhoods. | Fang CY et al. | β | 2019 | β |
| Interactive effects of social environment, age and sex on immune responses in Drosophila melanogaster. | Leech T et al. | β | 2019 | β |
| Loneliness and biological responses to acute stress in people with Type 2 diabetes. | Hackett RA et al. | β | 2019 | β |
| Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo. | Balter LJT et al. | β | 2019 | β |
| Loneliness in monkeys: Neuroimmune mechanisms. | Capitanio JP et al. | β | 2019 | β |
| Lonely young adults in modern Britain: findings from an epidemiological cohort study. | Matthews T et al. | β | 2019 | β |
| Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing. | Vingeliene S et al. | β | 2019 | β |
| Male infants and birth complications are associated with increased incidence of postnatal depression. | Myers S et al. | β | 2019 | β |
| Molecular Correlates of Socioeconomic Status and Clinical Outcomes Following Hematopoietic Cell Transplantation for Leukemia. | Knight JM et al. | β | 2019 | β |
| Neural mechanisms of social homeostasis. | Matthews GA et al. | β | 2019 | β |
| Neuroendocrine Regulation of Tumor-Associated Immune Cells. | Colon-Echevarria CB et al. | β | 2019 | β |
| Oxytocin administration prevents cellular aging caused by social isolation. | Stevenson JR et al. | β | 2019 | β |
| Parental Depressive Symptoms Potentiate the Effect of Youth Negative Mood Symptoms on Gene Expression in Children with Asthma. | Manczak EM et al. | β | 2019 | β |
| Physiological and behavioral reactivity to social exclusion: a functional infrared thermal imaging study in patients with psoriasis. | Ponsi G et al. | β | 2019 | β |
| PsychoBehavioroimmunology: Connecting the Behavioral Immune System to Its Physiological Foundations. | Murray DR et al. | β | 2019 | β |
| Relationships Between Life Stressors, Health Behaviors, and Chronic Medical Conditions in Mid-Life Adults: A Narrative Review. | Gomez-Bernal F et al. | β | 2019 | β |
| Social engagement and loneliness are differentially associated with neuro-immune markers in older age: Time-varying associations from the English Longitudinal Study of Ageing. | Walker E et al. | β | 2019 | β |
| Sociodemographic and clinical characteristics of persons who experienced spontaneous hepatitis C viral clearance. | Kimble MM et al. | β | 2019 | β |
| The Biology of Social Adversity Applied to Oral Health. | Gomaa N et al. | β | 2019 | β |
| The Conserved Transcriptional Response to Adversity. | Cole SW | β | 2019 | β |
| The impact of social-emotional context in chronic cancer pain: patient-caregiver reverberations : Social-emotional context in chronic cancer pain. | De Laurentis M et al. | β | 2019 | β |
| The relationship between loneliness and cognition in healthy older men and women: The role of cortisol. | Montoliu T et al. | β | 2019 | β |
| Traumagenics: At the intersect of childhood trauma, immunity and psychosis. | Chase KA et al. | β | 2019 | β |
| Two Distinct Immune Pathways Linking Social Relationships With Health: Inflammatory and Antiviral Processes. | Leschak CJ et al. | β | 2019 | β |
| Additive effects of obesity and loneliness on C-reactive protein. | Pavela G et al. | β | 2018 | β |
| A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila. | Liu G et al. | β | 2018 | β |
| Chronic Stress, Social Isolation, and Perceived Loneliness in Dementia Caregivers. | Kovaleva M et al. | β | 2018 | β |
| C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review. | Fond G et al. | β | 2018 | β |
| Differential regulation of NF-kB and IRF target genes as they relate to fatigue in patients with head and neck cancer. | Xiao C et al. | β | 2018 | β |
| Dominance rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons. | Lea AJ et al. | β | 2018 | β |
| Dvl3 polymorphism interacts with life events and pro-inflammatory cytokines to influence major depressive disorder susceptibility. | Zhang J et al. | β | 2018 | β |
| Exon Array Biomarkers for the Differential Diagnosis of Schizophrenia and Bipolar Disorder. | Vawter MP et al. | β | 2018 | β |
| Family environments and leukocyte transcriptome indicators of a proinflammatory phenotype in children and parents. | Robles TF et al. | β | 2018 | β |
| Fermented Soybean Meal Increases Lactic Acid Bacteria in Gut Microbiota of Atlantic Salmon (Salmo salar). | CatalΓ‘n N et al. | β | 2018 | β |
| Impact of caregiving for older people and pro-inflammatory biomarkers among caregivers: a systematic review. | Potier F et al. | β | 2018 | β |
| Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. | AgustΓ A et al. | β | 2018 | β |
| Is lack of social support associated with a delay in seeking medical care? A cross-sectional study of Minnesota and Tennessee residents using data from the Behavioral Risk Factor Surveillance System. | Reisinger MW et al. | β | 2018 | β |
| Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex. | Canli T et al. | β | 2018 | β |
| Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. | Nersesian PV et al. | β | 2018 | β |
| Loneliness, Social Isolation, and Cardiovascular Health. | Xia N et al. | β | 2018 | β |
| Maternal stress and early-onset colorectal cancer. | Zhang Q et al. | β | 2018 | β |
| Minority stress and leukocyte gene expression in sexual minority men living with treated HIV infection. | Flentje A et al. | β | 2018 | β |
| Optimism and the conserved transcriptional response to adversity. | Uchida Y et al. | β | 2018 | β |
| Perioperative inhibition of Ξ²-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome. | Haldar R et al. | β | 2018 | β |
| Persistent Social Networks: Civil War Veterans Who Fought Together Co-Locate in Later Life. | Costa DL et al. | β | 2018 | β |
| Predicting loneliness with polygenic scores of social, psychological and psychiatric traits. | Abdellaoui A et al. | β | 2018 | β |
| Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation. | Knight JM et al. | β | 2018 | β |
| Social genomics of healthy and disordered internet gaming. | Snodgrass JG et al. | β | 2018 | β |
| The Role of Social and Interpersonal Factors in Placebo Analgesia. | Necka EA et al. | β | 2018 | β |
| The role of social frailty in explaining the association between hearing problems and mild cognitive impairment in older adults. | Bae S et al. | β | 2018 | β |
| Threats to Belonging, Immune Function, and Eating Behavior: an Examination of Sex and Gender Differences. | Jaremka LM et al. | β | 2018 | β |
| Affective immunology: where emotions and the immune response converge. | D'Acquisto F | β | 2017 | β |
| A multispecies approach for understanding neuroimmune mechanisms of stress. | Deak T et al. | β | 2017 | β |
| A review of Tunisian medicinal plants with anticancer activity. | Aidi Wannes W et al. | β | 2017 | β |
| Attending, learning, and socioeconomic disadvantage: developmental cognitive and social neuroscience of resilience and vulnerability. | Schibli K et al. | β | 2017 | β |
| Black-White Disparities in Breast Cancer Subtype: The Intersection of Socially Patterned Stress and Genetic Expression. | Linnenbringer E et al. | β | 2017 | β |
| Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease. | Kuhlman KR et al. | β | 2017 | β |
| Differential transcriptome expression in human nucleus accumbens as a function of loneliness. | Canli T et al. | β | 2017 | β |
| Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. | Gao J et al. | β | 2017 | β |
| How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age? | Wilson RS et al. | β | 2017 | β |
| In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior. | Eisenberger NI et al. | β | 2017 | β |
| Kindness in the blood: A randomized controlled trial of the gene regulatory impact of prosocial behavior. | Nelson-Coffey SK et al. | β | 2017 | β |
| Maternal socioeconomic disadvantage is associated with transcriptional indications of greater immune activation and slower tissue maturation in placental biopsies and newborn cord blood. | Miller GE et al. | β | 2017 | β |
| Mothers' Attachment is Linked to their Children's Anti-Inflammatory Gene Expression via Maternal Warmth. | Stanton SCE et al. | β | 2017 | β |
| Natural language indicators of differential gene regulation in the human immune system. | Mehl MR et al. | β | 2017 | β |
| Social regulation of the lymph node transcriptome in rhesus macaques (Macaca mulatta). | Chun K et al. | β | 2017 | β |
| Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer. | Jutagir DR et al. | β | 2017 | β |
| Studying brain-regulation of immunity with optogenetics and chemogenetics; A new experimental platform. | Ben-Shaanan T et al. | β | 2017 | β |
| The application of protein microarray assays in psychoneuroimmunology. | Ayling K et al. | β | 2017 | β |
| The embodied mind: A review on functional genomic and neurological correlates of mind-body therapies. | Muehsam D et al. | β | 2017 | β |
| The impact of environmental enrichment on the murine inflammatory immune response. | Brod S et al. | β | 2017 | β |
| Unable to be a Human Being in Front of Other People: A Qualitative Study of Self-Isolation Among People Living with HIV/AIDS in China. | Xie T et al. | β | 2017 | β |
| Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena. | Brown SM et al. | β | 2017 | β |
| What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices. | Buric I et al. | β | 2017 | β |
| Why are behavioral and immune traits linked? | Lopes PC | β | 2017 | β |
| Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy. | Rush G et al. | β | 2016 | β |
| Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment. | Mellon SH et al. | β | 2016 | β |
| Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity. | Schwaiger M et al. | β | 2016 | β |
| Associations Among Child Abuse, Depression, and Interleukin-6 in Pregnant Adolescents: Paradoxical Findings. | Walsh K et al. | β | 2016 | β |
| Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome. | CastagnΓ© R et al. | β | 2016 | β |
| Breast cancer and social environment: getting by with a little help from our friends. | Hinzey A et al. | β | 2016 | β |
| Chemical composition and inΒ vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil. | Hajlaoui H et al. | β | 2016 | β |
| Differential Effects of Personal-Level vs Group-Level Racial Discrimination on Health among Black Americans. | Hagiwara N et al. | β | 2016 | β |
| Gene expression in major depressive disorder. | Jansen R et al. | β | 2016 | β |
| Genome-Wide Profiling of RNA from Dried Blood Spots: Convergence with Bioinformatic Results Derived from Whole Venous Blood and Peripheral Blood Mononuclear Cells. | McDade TW et al. | β | 2016 | β |
| Has bioscience reconciled mind and body? | Davies C et al. | β | 2016 | β |
| Impact of functional and structural social relationships on two year depression outcomes: A multivariate analysis. | Davidson SK et al. | β | 2016 | β |
| Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus. | Felger JC et al. | β | 2016 | β |
| Life Stress and Health: A Review of Conceptual Issues and Recent Findings. | Slavich GM | β | 2016 | β |
| Loneliness, Depression, and Inflammation: Evidence from the Multi-Ethnic Study of Atherosclerosis. | Mezuk B et al. | β | 2016 | β |
| Low Socioeconomic Status, Adverse Gene Expression Profiles, and Clinical Outcomes in Hematopoietic Stem Cell Transplant Recipients. | Knight JM et al. | β | 2016 | β |
| Mindfulness-Based Interventions for Older Adults: A Review of the Effects on Physical and Emotional Well-being. | Geiger PJ et al. | β | 2016 | β |
| Mood, stress and longevity: convergence on ANK3. | Rangaraju S et al. | β | 2016 | β |
| Neuroinflammation in suicide: Toward a comprehensive model. | Courtet P et al. | β | 2016 | β |
| Opportunities and challenges of big data for the social sciences: The case of genomic data. | Liu H et al. | β | 2016 | β |
| PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain. | Hegde S et al. | β | 2016 | β |
| Pervasive Effects of Aging on Gene Expression in Wild Wolves. | Charruau P et al. | β | 2016 | β |
| Postsurgical Depressive Symptoms and Proinflammatory Cytokine Elevations in Women Undergoing Primary Treatment for Breast Cancer. | Bouchard LC et al. | β | 2016 | β |
| Psychological Stress, Immunity, and the Effects on Indigenous Microflora. | Bailey MT | β | 2016 | β |
| Sex Differences in Associations Between Subjective Social Status and C-Reactive Protein in Young Adults. | Freeman JA et al. | β | 2016 | β |
| Social pain and physical pain: shared paths to resilience. | Sturgeon JA et al. | β | 2016 | β |
| Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis. | Antoni MH et al. | β | 2016 | β |
| Surgery accelerates the development of endometriosis inΒ mice. | Long Q et al. | β | 2016 | β |
| Surgical History and the Risk of Endometriosis: A Hospital-Based Case-Control Study. | Liu X et al. | β | 2016 | β |
| The Developmental Systems Approach and the Analysis of Behavior. | Moore DS | β | 2016 | β |
| TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation. | Aurelian L et al. | β | 2016 | β |
| Using Gene Expression Analysis to Examine Changes in Loneliness, Depression and Systemic Inflammation in Lonely Chronically Ill Older Adults. | Theeke LA et al. | β | 2016 | β |
| Well-being and immune response: a multi-system perspective. | Lasselin J et al. | β | 2016 | β |
| Work, meaning, and gene regulation: Findings from a Japanese information technology firm. | Kitayama S et al. | β | 2016 | β |
| Acute psychosocial stress induces differential short-term changes in catecholamine sensitivity of stimulated inflammatory cytokine production. | Strahler J et al. | β | 2015 | β |
| Association of suboptimal health status with psychosocial stress, plasma cortisol and mRNA expression of glucocorticoid receptor Ξ±/Ξ² in lymphocyte. | Yan YX et al. | β | 2015 | β |
| Childhood and later life stressors and increased inflammatory gene expression at older ages. | Levine ME et al. | β | 2015 | β |
| Depressogenic vulnerability and gender-specific patterns of neuro-immune dysregulation: What the ratio of cortisol to C-reactive protein can tell us about loss of normal regulatory control. | Suarez EC et al. | β | 2015 | β |
| Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1Ξ² in youth. | Tartter M et al. | β | 2015 | β |
| Loneliness across phylogeny and a call for comparative studies and animal models. | Cacioppo JT et al. | β | 2015 | β |
| Loneliness: clinical import and interventions. | Cacioppo S et al. | β | 2015 | β |
| Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. | Cole SW et al. | β | 2015 | β |
| Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation. | Cole SW et al. | β | 2015 | β |
| One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition. | Friedler B et al. | β | 2015 | β |
| Perceived social isolation, evolutionary fitness and health outcomes: a lifespan approach. | Hawkley LC et al. | β | 2015 | β |
| Prestroke living situation and depression contribute to initial stroke severity and stroke recovery. | Aron AW et al. | β | 2015 | β |
| Response and habituation of pro- and anti-inflammatory gene expression to repeated acute stress. | McInnis CM et al. | β | 2015 | β |
| Shift-and-Persist Strategies: Associations With Socioeconomic Status and the Regulation of Inflammation Among Adolescents and Their Parents. | Chen E et al. | β | 2015 | β |
| Social instability and immunity in rhesus monkeys: the role of the sympathetic nervous system. | Capitanio JP et al. | β | 2015 | β |
| Social isolation and mental health at primary and secondary school entry: a longitudinal cohort study. | Matthews T et al. | β | 2015 | β |
| The effect of listening to music on human transcriptome. | Kanduri C et al. | β | 2015 | β |
| The effect of music performance on the transcriptome of professional musicians. | Kanduri C et al. | β | 2015 | β |
| The neuroendocrinology of social isolation. | Cacioppo JT et al. | β | 2015 | β |
| The role of glucocorticoid receptor phosphorylation in the model of negative affective states. | Jovicic M et al. | β | 2015 | β |
| Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin. | Moieni M et al. | β | 2015 | β |
| Why may allopregnanolone help alleviate loneliness? | Cacioppo S et al. | β | 2015 | β |
| A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response. | Cruces J et al. | β | 2014 | β |
| Association of hearing impairment with brain volume changes in older adults. | Lin FR et al. | β | 2014 | β |
| Behavioral and Transcriptomic Fingerprints of an Enriched Environment in Horses (Equus caballus). | Lansade L et al. | β | 2014 | β |
| Behavioral Genetic Approaches and Family Theory. | Moore GA et al. | β | 2014 | β |
| Cancer-related fatigue--mechanisms, risk factors, and treatments. | Bower JE | β | 2014 | β |
| Can social support alleviate inflammation associated with childhood adversities? | Runsten S et al. | β | 2014 | β |
| Cultural neuroscience: biology of the mind in cultural contexts. | Kim HS et al. | β | 2014 | β |
| Divergent gene expression responses to complicated grief and non-complicated grief. | O'Connor MF et al. | β | 2014 | β |
| Evolutionary mechanisms for loneliness. | Cacioppo JT et al. | β | 2014 | β |
| Expression profiles of loneliness-associated genes for survival prediction in cancer patients. | You LF et al. | β | 2014 | β |
| From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. | Slavich GM et al. | β | 2014 | β |
| Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. | Miller GE et al. | β | 2014 | β |
| Hearing loss and cognitive decline in older adults: questions and answers. | Bernabei R et al. | β | 2014 | β |
| Human social genomics. | Cole SW | β | 2014 | β |
| Life rhythm as a symphony of oscillatory patterns: electromagnetic energy and sound vibration modulates gene expression for biological signaling and healing. | Muehsam D et al. | β | 2014 | β |
| Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy. | Fernandez R et al. | β | 2014 | β |
| Perceived discrimination as a stressor for close relationships: identifying psychological and physiological pathways. | Doyle DM et al. | β | 2014 | β |
| Relational victimization, friendship, and adolescents' hypothalamic-pituitary-adrenal axis responses to an in vivo social stressor. | Calhoun CD et al. | β | 2014 | β |
| Smile--It's in your blood! | D'Acquisto F et al. | β | 2014 | β |
| Smoking, physical activity and healthy aging in India. | Cramm JM et al. | β | 2014 | β |
| Sociality and sickness: have cytokines evolved to serve social functions beyond times of pathogen exposure? | Hennessy MB et al. | β | 2014 | β |
| Social neuroscience and its potential contribution to psychiatry. | Cacioppo JT et al. | β | 2014 | β |
| Social Relationships and Health: The Toxic Effects of Perceived Social Isolation. | Cacioppo JT et al. | β | 2014 | β |
| Tai chi meditation effects on nuclear factor-ΞΊB signaling in lonely older adults: a randomized controlled trial. | Black DS et al. | β | 2014 | β |
| The effects of mind-body therapies on the immune system: meta-analysis. | Morgan N et al. | β | 2014 | β |
| The effects of social isolation on steroid hormone levels are modulated by previous social status and context in a cichlid fish. | Galhardo L et al. | β | 2014 | β |
| The social network of loneliness. | Castillo M | β | 2014 | β |
| Toward a neurology of loneliness. | Cacioppo S et al. | β | 2014 | β |
| Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing. | Mostafavi S et al. | β | 2014 | β |
| A functional genomic perspective on human well-being. | Fredrickson BL et al. | β | 2013 | β |
| A mega-analysis of genome-wide association studies for major depressive disorder. | Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium et al. | β | 2013 | β |
| An empirical review of the neural underpinnings of receiving and giving social support: implications for health. | Eisenberger NI | β | 2013 | β |
| A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. | Simic I et al. | β | 2013 | β |
| Behavior genetics: past, present, future. | Jaffee SR et al. | β | 2013 | β |
| Engagement with Cognitively-Based Compassion Training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents. | Pace TW et al. | β | 2013 | β |
| Geographical, environmental and pathophysiological influences on the human blood transcriptome. | Tabassum R et al. | β | 2013 | β |
| Immunology: The pursuit of happiness. | Marchant J | β | 2013 | β |
| Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications. | Bower JE et al. | β | 2013 | β |
| Inter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response. | Maranville JC et al. | β | 2013 | β |
| Invited commentary: Personality phenotype and mortality--new avenues in genetic, social, and clinical epidemiology. | Chapman BP | β | 2013 | β |
| Loneliness and quality of life in chronically ill rural older adults. | Theeke LA et al. | β | 2013 | β |
| Loneliness at the bench. Is the PhD experience as emotionally taxing as it is mentally challenging? | Brown P | β | 2013 | β |
| Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation. | Jaremka LM et al. | β | 2013 | β |
| Loneliness promotes inflammation during acute stress. | Jaremka LM et al. | β | 2013 | β |
| Low social support is associated with shorter leukocyte telomere length in late life: multi-ethnic study of atherosclerosis. | Carroll JE et al. | β | 2013 | β |
| Mind the fish: zebrafish as a model in cognitive social neuroscience. | Oliveira RF | β | 2013 | β |
| Nervous system regulation of the cancer genome. | Cole SW | β | 2013 | β |
| Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. | Hirose Y et al. | β | 2013 | β |
| Population disparities in mental health: insights from cultural neuroscience. | Chiao JY et al. | β | 2013 | β |
| Psychosocial factors and hematopoietic stem cell transplantation: potential biobehavioral pathways. | Knight JM et al. | β | 2013 | β |
| Reply to Coyne: Genomic analyses are unthwarted. | Cole SW et al. | β | 2013 | β |
| Social environmental effects on gene regulation. | Tung J et al. | β | 2013 | β |
| Social environment influences the relationship between genotype and gene expression in wild baboons. | Runcie DE et al. | β | 2013 | β |
| Social isolation: a predictor of mortality comparable to traditional clinical risk factors. | Pantell M et al. | β | 2013 | β |
| Social isolation, loneliness, and all-cause mortality in older men and women. | Steptoe A et al. | β | 2013 | β |
| Social regulation of human gene expression: mechanisms and implications for public health. | Cole SW | β | 2013 | β |
| Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via Ξ²-adrenergic induction of myelopoiesis. | Powell ND et al. | β | 2013 | β |
| Social ties and health: a social neuroscience perspective. | Eisenberger NI | β | 2013 | β |
| Socioeconomic status and health: mediating and moderating factors. | Chen E et al. | β | 2013 | β |
| Synergistic relationships among stress, depression, and troubled relationships: insights from psychoneuroimmunology. | Jaremka LM et al. | β | 2013 | β |
| Targeted Rejection Triggers Differential Pro- and Anti-Inflammatory Gene Expression in Adolescents as a Function of Social Status. | Murphy ML et al. | β | 2013 | β |
| The Emerging Field of Human Social Genomics. | Slavich GM et al. | β | 2013 | β |
| Yogic meditation reverses NF-ΞΊB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. | Black DS et al. | β | 2013 | β |
| Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems --2011 Curt Richter Award Winner. | Rohleder N | β | 2012 | β |
| Associations between health-related self-protection, diurnal cortisol, and C-reactive protein in lonely older adults. | Rueggeberg R et al. | β | 2012 | β |
| Chronic psychosocial stressors and salivary biomarkers in emerging adults. | Bergen AW et al. | β | 2012 | β |
| Cochlear implantation in older adults. | Lin FR et al. | β | 2012 | β |
| Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. | Antoni MH et al. | β | 2012 | β |
| Divorce and Death: A Case Study for Health Psychology. | Sbarra DA et al. | β | 2012 | β |
| Effects of social isolation on glucocorticoid regulation in social mammals. | Hawkley LC et al. | β | 2012 | β |
| Ex vivo stimulation of whole blood as a means to determine glucocorticoid sensitivity. | Burnsides C et al. | β | 2012 | β |
| Genetic and environmental causes of variation in perceived loneliness in young people. | Waaktaar T et al. | β | 2012 | β |
| Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women. | Hackett RA et al. | β | 2012 | β |
| Loneliness and vascular biomarkers: the Dublin Healthy Ageing Study. | O'Luanaigh C et al. | β | 2012 | β |
| Loneliness, health, and mortality in old age: a national longitudinal study. | Luo Y et al. | β | 2012 | β |
| Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. | Creswell JD et al. | β | 2012 | β |
| NF-ΞΊB contributes to the detrimental effects of social isolation after experimental stroke. | Venna VR et al. | β | 2012 | β |
| On the reciprocal association between loneliness and subjective well-being. | VanderWeele TJ et al. | β | 2012 | β |
| Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. | Haroon E et al. | β | 2012 | β |
| Sleep disturbance and older adults' inflammatory responses to acute stress. | Heffner KL et al. | β | 2012 | β |
| Social environment is associated with gene regulatory variation in the rhesus macaque immune system. | Tung J et al. | β | 2012 | β |
| Social influences on clinical outcomes of patients with ovarian cancer. | Lutgendorf SK et al. | β | 2012 | β |
| Socially isolated mice exhibit a blunted homeostatic sleep response to acute sleep deprivation compared to socially paired mice. | Kaushal N et al. | β | 2012 | β |
| Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health. | Eisenberger NI et al. | β | 2012 | β |
| Social neuroscience: the social brain, oxytocin, and health. | Norman GJ et al. | β | 2012 | β |
| Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants. | Littrell JL | β | 2012 | β |
| The integrality of situated caring in nursing and the environment. | JarrΓn OF et al. | β | 2012 | β |
| The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. | Eisenberger NI | β | 2012 | β |
| The Phenotype of Loneliness. | Cacioppo JT et al. | β | 2012 | β |
| Transcriptional modulation of the developing immune system by early life social adversity. | Cole SW et al. | β | 2012 | β |
| Allele-specific gene expression in a wild nonhuman primate population. | Tung J et al. | β | 2011 | β |
| A marginal structural model analysis for loneliness: implications for intervention trials and clinical practice. | VanderWeele TJ et al. | β | 2011 | β |
| A meta-analysis of interventions to reduce loneliness. | Masi CM et al. | β | 2011 | β |
| Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence. | Cole SW et al. | β | 2011 | β |
| Association between social isolation and inflammatory markers in depressed and non-depressed individuals: results from the MONICA/KORA study. | HΓ€fner S et al. | β | 2011 | β |
| As We Said, Loneliness (Not Living Alone) Explains Individual Differences in Sleep Quality: Reply. | Hawkley L et al. | β | 2011 | β |
| Biobehavioral influences on cancer progression. | Costanzo ES et al. | β | 2011 | β |
| Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. | Le-Niculescu H et al. | β | 2011 | β |
| Emerging perspectives in social neuroscience and neuroeconomics of aging. | Nielsen L et al. | β | 2011 | β |
| Emotional experience improves with age: evidence based on over 10 years of experience sampling. | Carstensen LL et al. | β | 2011 | β |
| Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress. | Mathews HL et al. | β | 2011 | β |
| Fatigue and gene expression in human leukocytes: increased NF-ΞΊB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. | Bower JE et al. | β | 2011 | β |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | β | 2011 | β |
| Hearing loss and cognition in the Baltimore Longitudinal Study of Aging. | Lin FR et al. | β | 2011 | β |
| Individual vulnerability to addiction. | Swendsen J et al. | β | 2011 | β |
| Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms. | Lahey BB et al. | β | 2011 | β |
| Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. | Chen E et al. | β | 2011 | β |
| Population differences in proinflammatory biology: Japanese have healthier profiles than Americans. | Coe CL et al. | β | 2011 | β |
| Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. | Miller GE et al. | β | 2011 | β |
| Reciprocal regulation of the neural and innate immune systems. | Irwin MR et al. | β | 2011 | β |
| Restorative biological processes and health. | Robles TF et al. | β | 2011 | β |
| Sleep quality, social well-being, gender, and inflammation: an integrative analysis in a national sample. | Friedman EM | β | 2011 | β |
| Social isolation. | Cacioppo JT et al. | β | 2011 | β |
| Social neuroscience: challenges and opportunities in the study of complex behavior. | Cacioppo JT et al. | β | 2011 | β |
| Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. | Cole SW et al. | β | 2011 | β |
| TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. | Weigelt K et al. | β | 2011 | β |
| Variability in stress system regulatory control of inflammation: a critical factor mediating health effects of stress. | Rohleder N | β | 2011 | β |
| Allostasis and the human brain: Integrating models of stress from the social and life sciences. | Ganzel BL et al. | β | 2010 | β |
| Biosocial Influences on the Family: A Decade Review. | D'Onofrio BM et al. | β | 2010 | β |
| Black sheep get the blues: a psychobiological model of social rejection and depression. | Slavich GM et al. | β | 2010 | β |
| Close relationships, inflammation, and health. | Kiecolt-Glaser JK et al. | β | 2010 | β |
| Computational identification of gene-social environment interaction at the human IL6 locus. | Cole SW et al. | β | 2010 | β |
| Depressive symptoms, social support, and risk of adult asthma in a population-based cohort study. | Loerbroks A et al. | β | 2010 | β |
| Elevated macrophage migration inhibitory factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol. | Edwards KM et al. | β | 2010 | β |
| Familial resemblance for loneliness. | Distel MA et al. | β | 2010 | β |
| Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder. | Rohleder N et al. | β | 2010 | β |
| Health, wartime stress, and unit cohesion: evidence from Union Army veterans. | Costa DL et al. | β | 2010 | β |
| Host factors and cancer progression: biobehavioral signaling pathways and interventions. | Lutgendorf SK et al. | β | 2010 | β |
| Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. | Eisenberger NI et al. | β | 2010 | β |
| Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. | Raison CL et al. | β | 2010 | β |
| Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study. | Buchman AS et al. | β | 2010 | β |
| Loneliness matters: a theoretical and empirical review of consequences and mechanisms. | Hawkley LC et al. | β | 2010 | β |
| Loneliness predicts increased blood pressure: 5-year cross-lagged analyses in middle-aged and older adults. | Hawkley LC et al. | β | 2010 | β |
| Mates and marriage matter: genetic and environmental influences on subjective wellbeing across marital status. | Nes RB et al. | β | 2010 | β |
| Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. | Cacioppo JT et al. | β | 2010 | β |
| Probe set filtering increases correlation between Affymetrix GeneChip and qRT-PCR expression measurements. | Mieczkowski J et al. | β | 2010 | β |
| Social interaction modulates autonomic, inflammatory, and depressive-like responses to cardiac arrest and cardiopulmonary resuscitation. | Norman GJ et al. | β | 2010 | β |
| Socio-economic differentials in peripheral biology: cumulative allostatic load. | Seeman T et al. | β | 2010 | β |
| Systems biology and modeling in neuroblastoma: practicalities and perspectives. | Logan JA et al. | β | 2010 | β |
| Alone in the crowd: the structure and spread of loneliness in a large social network. | Cacioppo JT et al. | β | 2009 | β |
| A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. | Williams JB et al. | β | 2009 | β |
| Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohort. | Sanderson SC et al. | β | 2009 | β |
| Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later. | Miller GE et al. | β | 2009 | β |
| Decreased cancer survival in individuals separated at time of diagnosis: critical period for cancer pathophysiology? | Sprehn GC et al. | β | 2009 | β |
| Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. | Lutgendorf SK et al. | β | 2009 | β |
| Health psychology: developing biologically plausible models linking the social world and physical health. | Miller G et al. | β | 2009 | β |
| Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men. | Nater UM et al. | β | 2009 | β |
| Loneliness, social support networks, mood and wellbeing in community-dwelling elderly. | Golden J et al. | β | 2009 | β |
| Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. | Miller GE et al. | β | 2009 | β |
| Parental support and cytokine activity in childhood asthma: the role of glucocorticoid sensitivity. | Miller GE et al. | β | 2009 | β |
| Perceived social isolation and cognition. | Cacioppo JT et al. | β | 2009 | β |
| Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology. | Kemeny ME | β | 2009 | β |
| Social isolation alters neuroinflammatory response to stroke. | Karelina K et al. | β | 2009 | β |
| Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. | Hermes GL et al. | β | 2009 | β |
| Social regulation of human gene expression. | Cole SW | β | 2009 | β |
| Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaques. | Cole SW et al. | β | 2009 | β |
| Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells. | Bailey MT et al. | β | 2009 | β |
| The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients. | Frasure-Smith N et al. | β | 2009 | β |
| What Are the Brain Mechanisms on Which Psychological Processes Are Based? | Cacioppo JT et al. | β | 2009 | β |
| Women, loneliness, and incident coronary heart disease. | Thurston RC et al. | β | 2009 | β |
| A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. | Miller GE et al. | β | 2008 | β |
| A weighted average difference method for detecting differentially expressed genes from microarray data. | Kadota K et al. | β | 2008 | β |
| Computational challenges of personal genomics. | Bolouri H | β | 2008 | β |
| Current issues and new directions in Psychology and Health: bringing basic and applied research together to address underlying mechanisms. | Taylor SE | β | 2008 | β |
| Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood. | Aspler AL et al. | β | 2008 | β |
| From social structural factors to perceptions of relationship quality and loneliness: the Chicago health, aging, and social relations study. | Hawkley LC et al. | β | 2008 | β |
| Overview of pain management in older persons. | Deane G et al. | β | 2008 | β |
| Role of income and family influence on child outcomes. | Heckman JJ | β | 2008 | β |
| Schools, Skills, and Synapses. | Heckman JJ | β | 2008 | β |
| Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity. | Cole SW | β | 2008 | β |