Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.
paper
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Public
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- Authors
- Barr, Peter B; Neale, Zoe; Chatzinakos, Chris; Schulman, Jessica; Mullins, Niamh; Zhang, Jian; Chorlian, David B; Kamarajan, Chella; Kinreich, Sivan; Pandey, Ashwini K; Pandey, Gayathri; Saenz de Viteri, Stacey; Acion, Laura; Bauer, Lance; Bucholz, Kathleen K; Chan, Grace; Dick, Danielle M; Edenberg, Howard J; Foroud, Tatiana; Goate, Alison; Hesselbrock, Victor; Johnson, Emma C; Kramer, John; Lai, Dongbing; Plawecki, Martin H; Salvatore, Jessica E; Wetherill, Leah; Agrawal, Arpana; Porjesz, Bernice; Meyers, Jacquelyn L
- Year
- 2024
- Journal
- medRxiv : the preprint server for health sciences
- PMID
- 37162915
- DOI
- 10.1101/2023.04.28.23289173
- PMCID
- PMC10168504
- Published as
- Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder. β
Research has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 individuals with DSM-IV alcohol dependence from the Collaborative Study on the Genetics of Alcoholism (23% lifetime suicide attempt; 53% female; mean age: 38). Within participants with an AUD diagnosis, we explored risk across other clinical conditions, polygenic scores (PGS) for comorbid psychiatric problems, and neurocognitive functioning for lifetime suicide attempt. Participants with an AUD who had attempted suicide had greater rates of trauma exposure, major depressive disorder, post-traumatic stress disorder, and other substance use disorders compared to those who had not attempted suicide. Polygenic scores for suicide attempt, depression, and PTSD were associated with reporting a suicide attempt (ORs = 1.22 - 1.44). Participants who reported a SA also had decreased right hemispheric frontal-parietal theta and decreased interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences relative to those who did not, but differences were small. Overall, individuals with an AUD who report a lifetime suicide attempt appear to experience greater levels of trauma, have more severe comorbidities, and carry polygenic risk for a variety of psychiatric problems. Our results demonstrate the need to further investigate suicide attempts in the presence of substance use disorders.
Figure 1:
Clinical comorbidities across those who have and have not reported a suicide attemptPercentages and means for psychiatric and substance use comorbidities for those who have attempted (SA) and have not attempted (No SA) suicide. Significant differences (p < .05) indicated by dashed lines around bars.
Figure 2:
Polygenic scores across those who have and have not reported a suicide attemptPanel A presents odds ratios (OR) for AUD, DEP, and SUI PGSs from logistic regression models in persons with AUD who had and had not attempted suicide. Panel B presents OR from multinomial logistic models (no AUD, no suicide attempt as reference group). All models include cohort, sex, PC1-PC3, array, and site as covariates. SEs adjusted for familial clustering using cluster-robust standard errors. AFR = African-like genetic similarity grouping, EUR = European like genetic similarity grouping, AUD = alcohol use disorder polygenic score, DEP = depression polygenic score, = SUI suicide attempt polygenic score, SAβ = no lifetime suicide attempt, AUDβ = does not meet criteria for alcohol use disorder, SA+ = lifetime suicide attempt, AUD+ = meets criteria for alcohol use disorder.
Figure 3.
Neurophysiological measures across those with and without a reported suicide attempt.Decreased right hemispheric frontal-parietal theta (3β7 Hz @ F8-F4--P8-P4) and decreased interhemispheric temporal-parietal (7β12 Hz @ T8-P8--T7-P7) alpha EEG resting-state coherences. A) Decreased right hemispheric frontal-parietal theta (3β7 Hz @ F8-F4--P8-P4) resting-state EEG coherence. B) Decreased interhemispheric temporal-parietal alpha (7β12 Hz @ T8-P8--T7-P7) resting-state EEG coherence
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Relationship between Alcohol Use Disorder, Measures of Cognitive Decline, and Alzheimer Disease Biomarkers in Older Adults | Hayibor LA et al. | β | 2025 | β |