Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'.
paper
Cited
Public
- Authors
- Hankin, B L; Nederhof, E; Oppenheimer, C W; Jenness, J; Young, J F; Abela, J R Z; Smolen, A; Ormel, J; Oldehinkel, A J
- Year
- 2011
- Journal
- Translational psychiatry
- PMID
- 22833190
- DOI
- 10.1038/tp.2011.44
- PMCID
- PMC3309487
Positive affect has been implicated in the phenomenological experience of various psychiatric disorders, vulnerability to develop psychopathology and overall socio-emotional functioning. However, developmental influences that may contribute to positive affect have been understudied. Here, we studied youths' 5-HTTLPR genotype and rearing environment (degree of positive and supportive parenting) to investigate the differential susceptibility hypothesis (DSH) that youth carrying short alleles of 5-HTTLPR would be more influenced and responsive to supportive and unsupportive parenting, and would exhibit higher and lower positive affect, respectively. Three independent studies tested this gene-environment interaction (GxE) in children and adolescents (age range 9-15 years; total N=1874). In study 1 (N=307; 54% girls), positive/supportive parenting was assessed via parent report, in study 2 (N=197; 58% girls) via coded observations of parent-child interactions in the laboratory and in study 3 (N=1370; 53% girls) via self report. Results from all the three studies showed that youth homozygous for the functional short allele of 5-HTTLPR were more responsive to parenting as environmental context in a 'for better and worse' manner. Specifically, the genetically susceptible youth (that is, S'S' group) who experienced unsupportive, non-positive parenting exhibited low levels of positive affect, whereas higher levels of positive affect were reported by genetically susceptible youth under supportive and positive parenting conditions. These GxE findings are consistent with the DSH and may inform etiological models and interventions in developmental psychopathology focused on positive emotion, parenting and genetic susceptibility.
Interaction between 5-HTTLPR genotype and parent-reported positive parenting predicting youths' level of positive affect in study 1. The shaded areas represent regions of significance.
Interaction between 5-HTTLPR genotype and observed parenting (ranging from lack of support/positivity to supportive/positive) predicting youths' level of positive affect in study 2. The shaded area represents the region of significance.
Interaction between 5-HTTLPR genotype and child-reported parental warmth predicting youths' level of positive affect in study 3. The shaded areas represent regions of significance.
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| AnchordoquyHCMcGearyCLiuLKrauterKLSmolenAGenotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cellsBehav Genet20033373781264582410.1023/a:1021007701808 | — | — | — |
| AnguelovaMBenkelfatCTureckiGA systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: IMol Psychiatry200385745911285163510.1038/sj.mp.4001328 | — | — | — |
| Bakermans-KranenburgMJvan IJzendoornMHGene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolersDev Psychobiol2006484064091677076510.1002/dev.20152 | — | — | — |
| BelskyJBakermans-KranenburgMJvan IJzendoornMHFor better and for worse: differential susceptibility to environmental influencesCurr Dir Psychol Sci200716300304 | — | — | — |
| BelskyJBeaverKMCumulative-genetic plasticity, parenting and adolescent self-regulationJ Child Psychol Psychiatry2011526196262103948710.1111/j.1469-7610.2010.02327.xPMC4357655 | — | — | — |
| BelskyJDifferential susceptibility to rearing influence: an evolutionary hypothesis and some evidenceIn Ellis B, Bjorklun D (eds).Origins of the Social Mind: Evolutionary Psychology and Child DevelopmentGuilford Press: New York2005139163 | — | — | — |
| BelskyJJaffeeSRThe multiple determinants of parentingIn Cicchetti D, Cohen D (eds).Developmental Psychopathology (2nd Edition)John Wiley and Sons: Hoboken, New Jersy20063885 | — | — | — |
| BelskyJJonassaintCPleussMStantonMBrummetBWilliamsRVulnerability genes or plasticity genesMol Psychiatry2009147467541945515010.1038/mp.2009.44PMC2834322 | — | — | — |
| BelskyJPleussMBeyond diathesis-stress: differential susceptibility to environmental influencesPsychol Bull20091358859081988314110.1037/a0017376 | — | — | — |
| BelskyJTheory testing, effect-size evaluation, and differential susceptibility to rearing influence: the case of mothering and attachmentChild Dev1997685986009306638 | — | — | — |
| CanliTLeschKLong story short: the serotonin transporter in emotion regulation and social cognitionNat Neurosci200710110311091772647610.1038/nn1964 | — | — | — |
| CarverCSWhiteTLBehavioral-inhibition, behavioral activation, and affective responses to impending reward and punishment—the bis bas scalesJ Pers Soc Psychol199467319333 | — | — | — |
| CaspiAHaririARHolmesAUherRMoffittTEGenetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traitsAm J Psychiatry20101675095272023132310.1176/appi.ajp.2010.09101452PMC2943341 | — | — | — |
| CaspiASugdenKMoffittTETaylorACraigIWHarringtonHInfluence of life stress on depression: moderation by a polymorphism in the 5-HTT geneScience20033013863891286976610.1126/science.1083968 | — | — | — |
| ColePMDeater-DeckardKEmotion regulation, risk, and psychopathologyJ Child Psychol Psychiatry200950132713301984319010.1111/j.1469-7610.2009.02180.x | — | — | — |
| CompasBEChampionJEForehandRColeDAReeslundKLFearJCoping and parenting: mediators of 12 month outcomes of a family group cognitive-behavioral preventive intervention with families of depressed parentsJ Consult Clin Psychol2010786236342087389810.1037/a0020459PMC3030923 | — | — | — |
| DaddsMRMaujeanAFraserJAParenting and conduct problems in children: Australian data and psychometric properties of the Alabama Parenting QuestionnnaireAust Psychol200338238241 | — | — | — |
| DaveyCGYucelMAllenNBThe emergence of depression in adolescence: development of the prefrontal cortex and the representation of rewardNeurosci Biobehav Rev2008321191757052610.1016/j.neubiorev.2007.04.016 | — | — | — |
| DavidsonRJPizzagalliDNitschkeJBThe representation and regulation of emotion in depression: perspectives from affective neuroscienceIn Gotlib I, Hammen C (eds).Handbook of Depression (2nd Edition)Guilford Press: New York2009218248 | — | — | — |
| De WinterAOldehinkelAJVeenstraRBrunnekreefJAVerhulstFCOrmelJEvaluation of non-response bias in mental health determinants and outcomes in a large sample of pre-adolescentsEur J Epidemiol2005201731811579228510.1007/s10654-004-4948-6 | — | — | — |
| DurbinCEKleinDNHaydenEPBuckleyMEMoerkKCTemperamental emotionality in preschoolers and parental mood disordersJ Abnorm Psychol200511428371570980910.1037/0021-843X.114.1.28 | — | — | — |
| DurbinCEShafirDMEmotion regulation and risk for depressionIn Abela JRZ, Hankin BL (eds).Handbook of Depression in Children and AdolescentsGuilford Press: New York2008149176 | — | — | — |
| EleyTCSugdenKCoriscoAGregoryAMShamPMcGuffinPGene-environment interaction analysis of serotonin system markers with adolescent depressionMol Psychiatry200499089151524143510.1038/sj.mp.4001546 | — | — | — |
| EllisBJBoyceWTBelskyJBakermans-KranenburgMJVan IJzendoornMHDifferential susceptibility to the environment: an evolutionary-neurodevelopmentalDev Psychopathol2011237282126203610.1017/S0954579410000611 | — | — | — |
| FengXKeenanKHipwellAEHennebergerAKRischallMSButchJLongitudinal associations between emotion regulation and depression in preadolescent girls: moderation by caregiving environmentDev Psychol2009457988081941343210.1037/a0014617PMC2679182 | — | — | — |
| FieldTThe effects of mother's physical and emotional unavailability on emotion regulationMonogr Soc Res Child Dev1994592082277984162 | — | — | — |
| ForbesEEDahlRENeural systems of positive affect: relevance to understanding child and adolescent depressionDev Psychopathol2005178278501626299410.1017/S095457940505039XPMC2129134 | — | — | — |
| ForbesEEHaririARMartinSLSilkJSMoylesDLFisherPMAltered striatal activation predicting real-world positive affect in adolescent major depressive disorderAm J Psychiatry200916664731904732410.1176/appi.ajp.2008.07081336PMC2701209 | — | — | — |
| GoldsmithHHPollackSDDavidsonRJDevelopmental neuroscience perspectives on emotion regulationChild Dev Perspect200821321401995678610.1111/j.1750-8606.2008.00055.xPMC2756715 | — | — | — |
| HawesDJDaddsMRAssessing parenting practices through parent-report and direct observations during parenting-trainingJ Child Fam Stud200615555568 | — | — | — |
| HayesAFMatthesJComputational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementationsBehav Res Methods2009419249361958720910.3758/BRM.41.3.924 | — | — | — |
| HellerASJohnstoneTShackmanAJLightSNPetersonMJKoldenGGReduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activationPNAS2009106224452245010.1073/pnas.0910651106PMC279690820080793 | — | — | — |
| HughesAAKendallPCPsychometric properties of the positive and negative affect scale for children (PANAS-C) in children with anxiety disordersChild Psychiatry Hum Dev2009403433521914272410.1007/s10578-009-0130-4 | — | — | — |
| HuismanMOldehinkelAJde WinterAMinderaaRBde BildtAHuizinkACCohort profile: The Dutch TRacking adolescents individual lives survey; TRAILSInt J Epidemiol200837122712351826364910.1093/ije/dym273 | — | — | — |
| HuXOrosziGChunJSmith TL GoldmanDSchuckitMAAn expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism riskAlcohol Clin Exp Res2005298161565428610.1097/01.alc.0000150008.68473.62 | — | — | — |
| JormAFChristensenHHendersonASJacombPAKortenAERodgersBUsing the BIS/BAS scales to measure behavioural inhibition and behavioural activation: factor structure, validity and norms in a large community samplePers Individ Differ1999264958 | — | — | — |
| KargKBurmeisterMSheddenKSenSThe serotonin transporter promoter variant (5-HTTLPR), stress, and depression: meta-analysis revisitedArch Gen Psychiatry2011684444542119995910.1001/archgenpsychiatry.2010.189PMC3740203 | — | — | — |
| KeenanKEmotion dysregulation as a risk factor for child psychopathologyClin Psychol Sci Prac20007418434 | — | — | — |
| Kim ParkIGarberJCieslaJEllisBConvergence among multiple methods of measuring positivity and negativity in the family environment: relation to depression in mothers and their childrenJ Fam Psychol2008221231341826653910.1037/0893-3200.22.1.123PMC2881156 | — | — | — |
| Kim-CohenJCaspiATaylorAWilliamsBNewcombeRCraigIWMAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysisMol Psychiatry2006119039131680195310.1038/sj.mp.4001851 | — | — | — |
| KochanskaGKimSBarryRAPhilibertRAChildren's genotypes interact with maternal responsive care in predicting children's competence: diathesis-stress or differential susceptibilityDev Psychopathol20112360561610.1017/S0954579411000071PMC369093223786699 | — | — | — |
| KovacsMSherrillJGeorgeCJPollockMTumuluruRVHoVContextual emotion-regulation therapy for childhood depression: description and pilot testing of a new interventionJ Am Acad Child Adolesc Psychiatry2006458929031686503110.1097/01.chi.0000222878.74162.5a | — | — | — |
| LaDouceurCDDahlREWilliamsonDEBirmaherBRyanNDCaseyBJAltered emotional processing in pediatric anxiety, depression, and comorbid anxiety-depressionJ Abnorm Child Psychol2005331651771583949510.1007/s10802-005-1825-z | — | — | — |
| LaurentJCatanzaroSJJoinerTERudolphKDPotterKILambertSA measure of positive and negative affect for children: scale development and preliminary validationPsychol Assess199911326338 | — | — | — |
| MaccobyEEParenting and its effects on children: on reading and misreading behavior geneticsAnnu Rev Psychol2000511271075196310.1146/annurev.psych.51.1.1 | — | — | — |
| MarkusMTLindhoutIEBoerFHoogendijkTHGArrindellWAFactors of perceived parental rearing styles: the EMBU-C examined in a sample of Dutch primary school childrenPers Individ Differ200334503519 | — | — | — |
| McLeodBDWeiszJRWoodJJExamining the association between parenting and childhood depression: a meta-analysisClin Psychol Rev200727968100310.1016/j.cpr.2007.03.00117449154 | — | — | — |
| MillerSADykesDDPoleskyHFA simple salting out procedure for extracting dna from human nucleated cellsNucleic Acids Res1988161215334421610.1093/nar/16.3.1215PMC334765 | — | — | — |
| MonroeSMSimonsADDiathesis-stress theories in the context of life stress research implications for the depressive disordersPsychol Bull1991110406425175891710.1037/0033-2909.110.3.406 | — | — | — |
| MunafòMBrownSHaririASerotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysisBiol Psychiatry2008638528851794969310.1016/j.biopsych.2007.08.016PMC2755289 | — | — | — |
| MurisPMeestersCvan BrakelAAssessment of anxious rearing behaviors with a modified version of ″egna minnen betraffande uppfostran″ questionnaire for childrenJ Psychopathol Behav Assess200325229237 | — | — | — |
| NederhofEBoumaEMCOldehinkelAJOrmelJInteraction between childhood adversity, brain-derived neurotrophic factor val/met and serotonin transporter promoter polymorphism on depression: the TRAILS studyBiol Psychiatry2010682092122055375110.1016/j.biopsych.2010.04.006 | — | — | — |
| NestlerEJCarlezonWAThe mesolimbic dopamine reward circuit in depressionBiol Psychiatry200659115111591656689910.1016/j.biopsych.2005.09.018 | — | — | — |
| OldehinkelAJVeenstraROrmelJde WinterAFVerhulstFCTemperament, parenting, and depressive symptoms in a population sample of preadolescentsJ Child Psychol Psychiatry2006476846951679000310.1111/j.1469-7610.2005.01535.x | — | — | — |
| OlssonCAByrnesGBLotfi-MiriMCollinsVWilliamsonRPattonCAssociation between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental healthMol Psychiatry2005108688761585206310.1038/sj.mp.4001677 | — | — | — |
| PropperCWilloughbyMHalpernCTCarboneMACoxMParenting quality, DRD4, and the prediction of externalizing and internalizing behaviors in early childhoodDev Psychobiol2007496196321768060910.1002/dev.20249 | — | — | — |
| RischNHerrellRLehnerTLiangKEavesLHohJInteraction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk for depression: a meta-analysisJAMA2009301246224711953178610.1001/jama.2009.878PMC2938776 | — | — | — |
| SheeberLBAllenNBLeveCDavisBShorttJWKatzLFDynamics of affective experience and behavior in depressed adolescentsJ Child Psychol Psychiatry200950141914271970266110.1111/j.1469-7610.2009.02148.xPMC2765483 | — | — | — |
| SheltonKKFrickPJWoottonJMAssessment of parenting practices in families of elementary school-age childrenJ Clin Child Psychol199625317329 | — | — | — |
| TaylorSEWayBMWelchWTHilmertCJLehmanBJEisenbergerNIEarly family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatologyBiol Psychiatry2006606716761693477510.1016/j.biopsych.2006.04.019 | — | — | — |
| WatsonDRethinking the mood and anxiety disorders: a quantitative hierarchical model for DSM–VJ Abnorm Psychol20051145225361635137510.1037/0021-843X.114.4.522 | — | — | — |
| WeiszJRSandlerINDurlakJAAntonBSPromoting and protecting youth mental health through evidence-based prevention and treatmentAm Psychol2005606286481617389510.1037/0003-066X.60.6.628 | — | — | — |
| WendlandJRMartinBJKruseMRLeschK-PMurphyDLSimultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531Mol Psychiatry2006112242261640213110.1038/sj.mp.4001789 | — | — | — |
| YapMBHAllenNBLadouceurCDMaternal socialization of positive affect: the impact of invalidation on adolescent emotion regulation and depressive symptomatologyChild Dev200879141514311882653310.1111/j.1467-8624.2008.01196.x | — | — | — |
| ZuckermanMVulnerability to PsychopathologyAmerican Psychological Association: Washington DC1999 | — | — | — |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic Predisposition and Genetic Resilience Factors in Stress-Related Disorders During the Developmental Age: A Narrative Review. | Raffagnato A et al. | — | 2025 | → |
| Wired for Intensity: The Neuropsychological Dynamics of Borderline Personality Disorders-An Integrative Review. | Giannoulis E et al. | — | 2025 | → |
| Genetic and subjective sensitivity, relationship dynamics, and psychological distress in couples. | Brown SM et al. | — | 2024 | → |
| Biological sensitivity to context as a dyadic construct: An investigation of child-parent RSA synchrony among low-SES youth. | Oshri A et al. | — | 2023 | → |
| A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence. | van de Weijer MP et al. | — | 2022 | → |
| Genetic Variants Associated With Resilience in Human and Animal Studies. | Cahill S et al. | — | 2022 | → |
| Three phases of Gene × Environment interaction research: Theoretical assumptions underlying gene selection. | Zhang X et al. | — | 2022 | → |
| Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study. | Liu HY et al. | — | 2021 | → |
| Genetic architecture of Environmental Sensitivity reflects multiple heritable components: a twin study with adolescents. | Assary E et al. | — | 2021 | → |
| The role of epigenetics in psychological resilience. | Smeeth D et al. | — | 2021 | → |
| Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population. | Keijser R et al. | — | 2021 | → |
| Using an adoption design to test genetically based differences in risk for child behavior problems in response to home environmental influences. | Cree RA et al. | — | 2021 | → |
| We Know Even More Things: A Decade Review of Parenting Research. | Morris AS et al. | — | 2021 | → |
| Parenting Interacts With Plasticity Genes in Predicting Behavioral Outcomes in Preschoolers. | Letourneau NL et al. | — | 2020 | → |
| Sex differences in antisocial and aggressive disorders that onset in childhood and persist into adulthood. | Hodgins S | — | 2020 | → |
| The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span. | Feder A et al. | — | 2019 | → |
| Amygdala reactivity as a marker of differential susceptibility to socioeconomic resources during early adulthood. | Gard AM et al. | — | 2018 | → |
| Developmental Patterns of Child Emotion Dysregulation as Predicted by Serotonin Transporter Genotype and Parenting. | Noroña AN et al. | — | 2018 | → |
| Does the Incredible Years reduce child externalizing problems through improved parenting? The role of child negative affectivity and serotonin transporter linked polymorphic region (5-HTTLPR) genotype. | Weeland J et al. | — | 2018 | → |
| Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions. | Nilsson KW et al. | — | 2018 | → |
| Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples. | Åslund C et al. | — | 2018 | → |
| Negative (but not Positive) Parenting Interacts with Infant Negative Affect to Predict Infant Approach: Evidence of Diathesis-Stress. | Holzman JB et al. | — | 2018 | → |
| Prenatal programming of postnatal plasticity revisited-And extended. | Hartman S et al. | — | 2018 | → |
| Prenatal stress and enhanced developmental plasticity. | Hartman S et al. | — | 2018 | → |
| A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders. | Rozenblat V et al. | — | 2017 | → |
| Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study. | Keers R et al. | — | 2017 | → |
| Gene × Environment Interactions: From Molecular Mechanisms to Behavior. | Halldorsdottir T et al. | — | 2017 | → |
| Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction. | Isbell E et al. | — | 2017 | → |
| Relationships Between Self-Reported and Observed Parenting Behaviour, Adolescent Disordered Eating Attitudes and Behaviours, and the 5-HTTLPR Polymorphism: Data From the Australian Temperament Project. | Rozenblat V et al. | — | 2017 | → |
| A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders. | Keers R et al. | — | 2016 | → |
| An Evolutionary Perspective on Family Studies: Differential Susceptibility to Environmental Influences. | Hartman S et al. | — | 2016 | → |
| Differential sensitivity to the environment: contribution of cognitive biases and genes to psychological wellbeing. | Fox E et al. | — | 2016 | → |
| Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress. | Boyce WT | — | 2016 | → |
| Genetic Moderation of Stress Effects on Corticolimbic Circuitry. | Bogdan R et al. | — | 2016 | → |
| Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord. | Starr LR et al. | — | 2016 | → |
| Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders. | Lester KJ et al. | — | 2016 | → |
| The Price of Perspective Taking: Child Depressive Symptoms Interact with Parental Empathy to Predict Immune Functioning in Parents. | Manczak EM et al. | — | 2016 | → |
| Why are some individuals more resilient than others: the role of social support. | Southwick SM et al. | — | 2016 | → |
| 5-HTTLPR Expression Outside the Skin: An Experimental Test of the Emotional Reactivity Hypothesis in Children. | Weeland J et al. | — | 2015 | → |
| A Hierarchical Factor Model of Executive Functions in Adolescents: Evidence of Gene-Environment Interplay. | Li JJ et al. | — | 2015 | → |
| BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. | Chen J et al. | — | 2015 | → |
| Cortisol reactivity to stress among youth: stability over time and genetic variants for stress sensitivity. | Hankin BL et al. | — | 2015 | → |
| Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress. | Hankin BL et al. | — | 2015 | → |
| Developmental psychopathology in an era of molecular genetics and neuroimaging: A developmental neurogenetics approach. | Hyde LW | — | 2015 | → |
| Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes. | Belsky J et al. | — | 2015 | → |
| Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour. | Richards JS et al. | — | 2015 | → |
| Emotion recognition specialization and context-dependent risk of anxiety and depression in adolescents. | Oldehinkel AJ et al. | — | 2015 | → |
| Maternal positive affect mediates the link between family risk and preschoolers' positive affect. | Davis M et al. | — | 2015 | → |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | — | 2015 | → |
| Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior. | Brett ZH et al. | — | 2015 | → |
| Short alleles, bigger smiles? The effect of 5-HTTLPR on positive emotional expressions. | Haase CM et al. | — | 2015 | → |
| Testing the temporal relationship between maternal and adolescent depressive and anxiety symptoms in a community sample. | Brown RC et al. | — | 2015 | → |
| Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. | Weeland J et al. | — | 2015 | → |
| What works for whom? Genetic moderation of intervention efficacy. | Belsky J et al. | — | 2015 | → |
| 5-HTTLPR moderates naltrexone and psychosocial treatment responses in heavy drinking men who have sex with men. | Chen AC et al. | — | 2014 | → |
| Childhood adversities and adolescent depression: a matter of both risk and resilience. | Oldehinkel AJ et al. | — | 2014 | → |
| Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children. | Ford BQ et al. | — | 2014 | → |
| Gene-environment interaction. | Manuck SB et al. | — | 2014 | → |
| Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene-environmentinteractions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR [corrected]. | Nilsson KW et al. | — | 2014 | → |
| In search of neural endophenotypes of postpartum psychopathology and disrupted maternal caregiving. | Moses-Kolko EL et al. | — | 2014 | → |
| Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension. | Bogdan R et al. | — | 2014 | → |
| The role of corticolimbic circuitry in the development of anxiety disorders in children and adolescents. | Swartz JR et al. | — | 2014 | → |
| 5-HTTLPR X stress in adolescent depression: moderation by MAOA and gender. | Priess-Groben HA et al. | — | 2013 | → |
| A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. | Bogdan R et al. | — | 2013 | → |
| Beyond risk, resilience, and dysregulation: phenotypic plasticity and human development. | Belsky J et al. | — | 2013 | → |
| Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene. | Bradley B et al. | — | 2013 | → |
| Gene-environment studies and borderline personality disorder: a review. | Carpenter RW et al. | — | 2013 | → |
| Neurogenetics of depression: a focus on reward processing and stress sensitivity. | Bogdan R et al. | — | 2013 | → |
| No moderating effect of 5-HTTLPR on associations between antenatal anxiety and infant behavior. | Braithwaite EC et al. | — | 2013 | → |
| Observed positive parenting behaviors and youth genotype: evidence for gene-environment correlations and moderation by parent personality traits. | Oppenheimer CW et al. | — | 2013 | → |
| Relational security moderates the effect of serotonin transporter gene polymorphism (5-HTTLPR) on stress generation and depression among adolescents. | Starr LR et al. | — | 2013 | → |
| Resilience in mental health: linking psychological and neurobiological perspectives. | Rutten BP et al. | — | 2013 | → |
| The 5-HTTLPR polymorphism in the serotonin transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time. | Haase CM et al. | — | 2013 | → |
| The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring. | Olivier JD et al. | — | 2013 | → |
| The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders. | Olivier JD et al. | — | 2013 | → |
| The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood. | Hayden EP et al. | — | 2013 | → |
| Understanding Youth Antisocial Behavior Using Neuroscience through a Developmental Psychopathology Lens: Review, Integration, and Directions for Research. | Hyde LW et al. | — | 2013 | → |
| Youth genetic vulnerability to maternal depressive symptoms: 5-HTTLPR as moderator of intergenerational transmission effects in a multiwave prospective study. | Oppenheimer CW et al. | — | 2013 | → |
| Appetitive motivation and negative emotion reactivity among remitted depressed youth. | Hankin BL et al. | — | 2012 | → |
| Behavioral resilience in the post-genomic era: emerging models linking genes with environment. | Rende R | — | 2012 | → |
| Future directions in vulnerability to depression among youth: integrating risk factors and processes across multiple levels of analysis. | Hankin BL | — | 2012 | → |
| Something old, something new, something false but much that's true. | Bateson P et al. | — | 2012 | → |
| The mismatch hypothesis of psychiatric disease. | Nederhof E | — | 2012 | → |
| The TRacking Adolescents' Individual Lives Survey (TRAILS): design, current status, and selected findings. | Ormel J et al. | — | 2012 | → |