developmental delay phenotype

Aliases

DD, slowed developmental process

Related entities (7)

Mentioned in (167)

Papers in which this entity is mentioned.

• Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. (2025)
• Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition. (2025)
• Mutations in the bone morphogenetic protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations. (2025)
• Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. (2024)
• Subcortical Brain Volumes and Neurocognitive Function in Children With Perinatal HIV Exposure: A Population-Based Cohort Study in South Africa. (2024)
• Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study. (2024)
• Prenatal alcohol exposure and cognition at midlife: Evidence of fluid cognition deficits in two cohorts. (2023)
• Alcohol-related dysmorphic features as predictors of neurodevelopmental delay in infants and preschool-aged children: Results from a birth cohort in Ukraine. (2022)
• Stability and change in the interpretation of facial emotions in fetal alcohol spectrum disorders from childhood to adolescence. (2022)
• Lower Neurocognitive Functioning in HIV-Exposed Uninfected Children Compared With That in HIV-Unexposed Children. (2022)
• Newborn differential DNA methylation and subcortical brain volumes as early signs of severe neurodevelopmental delay in a South African Birth Cohort Study. (2022)
• Embryonic Nicotine Exposure Disrupts Adult Social Behavior and Craniofacial Development in Zebrafish. (2022)
• Early neurodevelopment of HIV-exposed uninfected children in the era of antiretroviral therapy: a systematic review and meta-analysis. (2022)
• Evidence for long-lasting alterations in the fecal microbiota following prenatal alcohol exposure. (2022)
• Fetal Alcohol Spectrum Disorders: Awareness to Insight in Just 50 Years. (2022)
• Early structural brain development in infants exposed to HIV and antiretroviral therapy in utero in a South African birth cohort. (2022)
• Maternal Obesity during Pregnancy is Associated with Lower Cortical Thickness in the Neonate Brain. (2021)
• Whole-genome analysis reveals the contribution of non-coding de novo transposon insertions to autism spectrum disorder. (2021)
• Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway. (2021)
• Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches. (2021)
• Neuroimaging young children and associations with neurocognitive development in a South African birth cohort study. (2020)
• Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders. (2020)
• Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling. (2020)
• Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
• Novel Ethanol-Sensitive Mutants Identified in an F3 Forward Genetic Screen. (2020)
• Amygdala-Prefrontal Structural Connectivity Mediates the Relationship between Prenatal Depression and Behavior in Preschool Boys. (2020)
• Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review. (2020)
• In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes. (2019)
• Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study. (2019)
• Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. (2019)
• De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies. (2019)
• Prevalence of fetal alcohol spectrum disorder among special subpopulations: a systematic review and meta-analysis. (2019)
• Risk and protective factors for child development: An observational South African birth cohort. (2019)
• Forty Years of Assessing Neurodevelopmental and Behavioral Effects of Prenatal Alcohol Exposure in Infants: What Have We Learned? (2019)
• Identification of common genetic risk variants for autism spectrum disorder. (2019)
• The Early Developmental Outcomes of Prenatal Alcohol Exposure: A Review. (2018)
• Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning. (2018)
• Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE. (2018)
• Neurodevelopment of breastfed HIV-exposed uninfected and HIV-unexposed children in South Africa. (2018)
• Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. (2018)
• Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. (2018)
• Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy. (2018)
• Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders. (2018)
• Case-control meta-analysis of blood DNA methylation and autism spectrum disorder. (2018)
• Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. (2018)
• Identification of novel candidate disease genes from de novo exonic copy number variants. (2017)
• The Use of Cardiac Orienting Responses as an Early and Scalable Biomarker of Alcohol-Related Neurodevelopmental Impairment. (2017)
• Genetic studies of alcohol dependence in the context of the addiction cycle. (2017)
• Human Brain Abnormalities Associated With Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder. (2017)
• Early childhood development coming of age: science through the life course. (2017)
• Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. (2017)
• Fetal Alcohol Spectrum Disorders: A Case Study. (2017)
• De Novo Coding Variants Are Strongly Associated with Tourette Disorder. (2017)
• Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition. (2017)
• Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation. (2017)
• Males are from Mars, and females are from Venus: sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity. (2016)
• Second-Trimester Ultrasound as a Tool for Early Detection of Fetal Alcohol Spectrum Disorders. (2016)
• Neurobiological phenotypes associated with a family history of alcoholism. (2016)
• Alcohol exposure in utero is associated with decreased gray matter volume in neonates. (2016)
• Ethanol exposure during development reduces GABAergic/glycinergic neuron numbers and lobule volumes in the mouse cerebellar vermis. (2016)
• Alcohol-Induced Developmental Origins of Adult-Onset Diseases. (2016)
• Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. (2016)
• The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming. (2016)
• Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. (2016)
• Plasma miRNA Profiles in Pregnant Women Predict Infant Outcomes following Prenatal Alcohol Exposure. (2016)
• The Impact of Prenatal Ethanol Exposure on Neuroanatomical and Behavioral Development in Mice. (2016)
• CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation. (2015)
• Fetal Alcohol Spectrum Disorders: An Overview from the Glia Perspective. (2015)
• What Happens When Children with Fetal Alcohol Spectrum Disorders Become Adults? (2015)
• Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. (2015)
• Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement. (2015)
• Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development. (2015)
• Development of the uncinate fasciculus: Implications for theory and developmental disorders. (2015)
• Low and moderate prenatal ethanol exposures of mice during gastrulation or neurulation delays neurobehavioral development. (2015)
• Investigating the psychosocial determinants of child health in Africa: The Drakenstein Child Health Study. (2015)
• Cerebral Lateralization is Protective in the Very Prematurely Born. (2015)
• Inappropriate feeding behaviors and dietary intakes in children with fetal alcohol spectrum disorder or probable prenatal alcohol exposure. (2014)
• Strain dependent neurochemical changes induced by embryonic alcohol exposure in zebrafish. (2014)
• Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. (2014)
• The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review. (2014)
• The role of BAF (mSWI/SNF) complexes in mammalian neural development. (2014)
• Pre-administration of G9a/GLP inhibitor during synaptogenesis prevents postnatal ethanol-induced LTP deficits and neurobehavioral abnormalities in adult mice. (2014)
• Pattern classification of response inhibition in ADHD: toward the development of neurobiological markers for ADHD. (2014)
• Heritability and genomics of gene expression in peripheral blood. (2014)
• Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. (2014)
• Dysmorphogenic effects of first trimester-equivalent ethanol exposure in mice: a magnetic resonance microscopy-based study. (2014)
• Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study. (2014)
• A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors. (2014)
• Renal dysfunction in fetal alcohol syndrome: a potential contributor on developmental disabilities of offspring. (2014)
• Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts. (2013)
• Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism. (2013)
• Modeling transformations of neurodevelopmental sequences across mammalian species. (2013)
• Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. (2013)
• Clinical whole-exome sequencing for the diagnosis of mendelian disorders. (2013)
• Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. (2013)
• Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid. (2013)
• Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. (2013)
• Is there a viability-vulnerability tradeoff? Sex differences in fetal programming. (2013)
• Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly. (2013)
• DNA methylation program in developing hippocampus and its alteration by alcohol. (2013)
• The Growing Importance of CNVs: New Insights for Detection and Clinical Interpretation. (2013)
• Central precocious puberty caused by mutations in the imprinted gene MKRN3. (2013)
• Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function. (2013)
• Magnetic resonance microscopy-based analyses of the neuroanatomical effects of gestational day 9 ethanol exposure in mice. (2013)
• Children with heavy prenatal alcohol exposure experience reduced control of isotonic force. (2013)
• Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner. (2012)
• SOX2 hypomorphism disrupts development of the prechordal floor and optic cup. (2012)
• Development of cortical surface area and gyrification in attention-deficit/hyperactivity disorder. (2012)
• Large-scale objective phenotyping of 3D facial morphology. (2012)
• Neuroanatomical assessment of biological maturity. (2012)
• Alcohol delays the emergence of the fetal elicited startle response, but only transiently. (2012)
• Predicting developmental status from 12 to 24 months in infants at risk for Autism Spectrum Disorder: a preliminary report. (2012)
• Fine-grained facial phenotype-genotype analysis in Wolf-Hirschhorn syndrome. (2012)
• Corpus callosum alterations in very preterm infants: perinatal correlates and 2 year neurodevelopmental outcomes. (2012)
• CNVs: harbingers of a rare variant revolution in psychiatric genetics. (2012)
• Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. (2012)
• Early presentation of gait impairment in Wolfram Syndrome. (2012)
• Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure. (2012)
• Fetal brain function in response to maternal alcohol consumption: early evidence of damage. (2012)
• Fetal alcohol spectrum disorders: an overview. (2011)
• The effects of prenatal alcohol exposure on behavior: rodent and primate studies. (2011)
• Epilepsy genetics--past, present, and future. (2011)
• Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. (2011)
• Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesis. (2011)
• A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. (2011)
• High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. (2011)
• Basal forebrain involvement in low-functioning autistic children: a voxel-based morphometry study. (2011)
• Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. (2011)
• Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. (2011)
• Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. (2011)
• Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study. (2011)
• Fetal alcohol spectrum disorders: an overview. (2011)
• Effects of early postnatal exposure to ethanol on retinal ganglion cell morphology and numbers of neurons in the dorsolateral geniculate in mice. (2011)
• Large-scale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience. (2011)
• Alteration of gene expression by alcohol exposure at early neurulation. (2011)
• Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome. (2010)
• Toward a neurobehavioral profile of fetal alcohol spectrum disorders. (2010)
• Iron deficiency anemia and cognitive function in infancy. (2010)
• A syndrome of short stature, microcephaly and speech delay is associated with duplications reciprocal to the common Sotos syndrome deletion. (2010)
• Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. (2010)
• Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. (2010)
• Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice. (2010)
• Down syndrome--recent progress and future prospects. (2009)
• A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder. (2009)
• Impaired language performance in young children with heavy prenatal alcohol exposure. (2009)
• Ethanol teratogenesis in five inbred strains of mice. (2009)
• Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. (2009)
• Psychological and/or educational interventions for reducing alcohol consumption in pregnant women and women planning pregnancy. (2009)
• Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. (2009)
• Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder. (2009)
• Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors. (2009)
• Impact of maternal stress, depression and anxiety on fetal neurobehavioral development. (2009)
• Comparison of adaptive behavior in children with heavy prenatal alcohol exposure or attention-deficit/hyperactivity disorder. (2009)
• Do multivitamin supplements modify the relationship between prenatal alcohol intake and miscarriage? (2009)
• Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. (2008)
• Fetal alcohol spectrum disorders and their persisting sequelae in adult life. (2008)
• Mapping white matter integrity and neurobehavioral correlates in children with fetal alcohol spectrum disorders. (2008)
• Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly. (2008)
• Familial recurrence of SOX2 anophthalmia syndrome: phenotypically normal mother with two affected daughters. (2008)
• Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the Congo. (2008)
• Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos. (2007)
• Holoprosencephaly. (2007)
• Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. (2006)
• Impaired neural networks for approximate calculation in dyscalculic children: a functional MRI study. (2006)
• Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. (2002)
• Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos. (1997)
• Effects of Prenatal Exposure to Alcohol Across the Life Span. (1996)

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