lung cancer phenotype
Evidence from:
primary |
all sources
Related entities (57)
Mentioned in (190)
Papers in which this entity is mentioned.
- Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types. (2026)
- Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
- Whole-genome landscapes of 1,364 breast cancers. (2026)
- Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
- Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers. (2025)
- Tumour-wide RNA splicing aberrations generate actionable public neoantigens. (2025)
- Rapid brain tumor classification from sparse epigenomic data. (2025)
- Chromosomal instability as a driver of cancer progression. (2025)
- Functional analysis of cancer-associated germline risk variants. (2025)
- Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. (2025)
- OXSeg: Multidimensional Attention UNet-Based Lip Segmentation Using Semi-Supervised Lip Contours. (2025)
- Transcription start sites experience a high influx of heritable variants fueled by early development. (2025)
- Tumor-informed deep sequencing of ctDNA detects minimal residual disease and predicts relapse in osteosarcoma. (2024)
- Principles and methods for transferring polygenic risk scores across global populations. (2024)
- Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)
- Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology. (2024)
- The Application of Long-Read Sequencing to Cancer. (2024)
- A New Era of Data-Driven Cancer Research and Care: Opportunities and Challenges. (2024)
- ENPP1 Immunobiology as a Therapeutic Target. (2023)
- Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma. (2023)
- A Novel Tissue-Free Method to Estimate Tumor-Derived Cell-Free DNA Quantity Using Tumor Methylation Patterns. (2023)
- Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patients (2023)
- Predicting tumour content of liquid biopsies from cell-free DNA. (2023)
- An overview of DNA methylation-derived trait score methods and applications. (2023)
- Heritable defects in telomere and mitotic function selectively predispose to sarcomas. (2023)
- Cell-Free DNA Fragmentomics: The Novel Promising Biomarker. (2023)
- Machine learning for genetics-based classification and treatment response prediction in cancer of unknown primary. (2023)
- Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome. (2023)
- Towards understandings of serine/arginine-rich splicing factors. (2023)
- RNA splicing dysregulation and the hallmarks of cancer. (2023)
- Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. (2022)
- At the dawn: cell-free DNA fragmentomics and gene regulation. (2022)
- Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. (2022)
- Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. (2022)
- Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing. (2022)
- Inferring gene expression from cell-free DNA fragmentation profiles. (2022)
- Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma. (2022)
- Enhanced detection of minimal residual disease by targeted sequencing of phased variants in circulating tumor DNA. (2021)
- Nanopore sequencing technology, bioinformatics and applications. (2021)
- Application of third-generation sequencing in cancer research. (2021)
- Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing. (2021)
- Therapeutic Implications of Germline Testing in Patients With Advanced Cancers. (2021)
- Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. (2021)
- Detection and characterization of lung cancer using cell-free DNA fragmentomes. (2021)
- kataegis: an R package for identification and visualization of the genomic localized hypermutation regions using high-throughput sequencing. (2021)
- Genetics of substance use disorders in the era of big data. (2021)
- Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases. (2021)
- Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma. (2021)
- Macrophage Polarization States in the Tumor Microenvironment. (2021)
- Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
- TRUST4: immune repertoire reconstruction from bulk and single-cell RNA-seq data. (2021)
- Polygenic risk scores: from research tools to clinical instruments. (2020)
- DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers. (2020)
- Immuno-genomic landscape of osteosarcoma. (2020)
- Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring. (2020)
- Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. (2020)
- The repertoire of mutational signatures in human cancer. (2020)
- Pan-cancer landscape of homologous recombination deficiency. (2020)
- Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks. (2020)
- Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers. (2020)
- AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications. (2020)
- Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. (2020)
- Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA. (2020)
- Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project. (2020)
- Super-enhancers: critical roles and therapeutic targets in hematologic malignancies. (2019)
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. (2019)
- Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. (2019)
- Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis. (2019)
- Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions. (2019)
- The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. (2019)
- Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
- Genome-wide cell-free DNA fragmentation in patients with cancer. (2019)
- Best practices for bioinformatic characterization of neoantigens for clinical utility. (2019)
- A Compendium of Mutational Signatures of Environmental Agents. (2019)
- Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
- Circular DNA elements of chromosomal origin are common in healthy human somatic tissue. (2018)
- The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer. (2018)
- Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. (2018)
- Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors. (2018)
- A fast detection of fusion genes from paired-end RNA-seq data. (2018)
- Quantification of subclonal selection in cancer from bulk sequencing data. (2018)
- Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. (2018)
- Enhanced detection of circulating tumor DNA by fragment size analysis. (2018)
- Human Genetics of Addiction: New Insights and Future Directions. (2018)
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (2018)
- Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. (2018)
- Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2018)
- Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. (2018)
- EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018)
- Patterns and mechanisms of structural variations in human cancer. (2018)
- Thymic involution and rising disease incidence with age. (2018)
- Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. (2017)
- OncoKB: A Precision Oncology Knowledge Base. (2017)
- One-Carbon Metabolism in Health and Disease. (2017)
- Patient-derived xenografts undergo mouse-specific tumor evolution. (2017)
- Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. (2017)
- A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
- Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. (2017)
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. (2017)
- A method to reduce ancestry related germline false positives in tumor only somatic variant calling. (2017)
- Comprehensive Analysis of Hypermutation in Human Cancer. (2017)
- Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin. (2016)
- B lymphocytes and cancer: a love-hate relationship. (2016)
- G = E: What GWAS Can Tell Us about the Environment. (2016)
- Fragment Length of Circulating Tumor DNA. (2016)
- Substantial contribution of extrinsic risk factors to cancer development. (2016)
- FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing. (2016)
- Oxidative stress signaling to chromatin in health and disease. (2016)
- Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. (2016)
- APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication. (2016)
- Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
- DGIdb 2.0: mining clinically relevant drug-gene interactions. (2016)
- Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution. (2016)
- Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. (2015)
- A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. (2015)
- BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. (2015)
- Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial. (2015)
- The landscape of long noncoding RNAs in the human transcriptome. (2015)
- A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. (2014)
- MBASED: allele-specific expression detection in cancer tissues and cell lines. (2014)
- Unraveling the clonal hierarchy of somatic genomic aberrations. (2014)
- Hidden Markov Model-Based CNV Detection Algorithms for Illumina Genotyping Microarrays. (2014)
- RADIA: RNA and DNA integrated analysis for somatic mutation detection. (2014)
- Genome-wide analysis of noncoding regulatory mutations in cancer. (2014)
- MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens. (2014)
- CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. (2014)
- PVT1 dependence in cancer with MYC copy-number increase. (2014)
- Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. (2014)
- Screening tests: a review with examples. (2014)
- An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. (2014)
- Genetic variability in the regulation of gene expression in ten regions of the human brain. (2014)
- The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. (2014)
- PyClone: statistical inference of clonal population structure in cancer. (2014)
- DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy. (2013)
- Cancer genome landscapes. (2013)
- Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. (2013)
- Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. (2013)
- Ewing sarcoma protein: a key player in human cancer. (2013)
- A mega-analysis of genome-wide association studies for major depressive disorder. (2013)
- Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. (2013)
- Copy number variation: what is it and what has it told us about child psychiatric disorders? (2013)
- Signatures of mutational processes in human cancer. (2013)
- A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. (2013)
- Mutational heterogeneity in cancer and the search for new cancer-associated genes. (2013)
- DGIdb: mining the druggable genome. (2013)
- Computational approaches to identify functional genetic variants in cancer genomes. (2013)
- Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. (2013)
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
- The Genomic Revolution and Beliefs about Essential Racial Differences: A Backdoor to Eugenics? (2013)
- Absolute quantification of somatic DNA alterations in human cancer. (2012)
- Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. (2012)
- The co-occurring use and misuse of cannabis and tobacco: a review. (2012)
- High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. (2012)
- Myeloid cells in tumor inflammation. (2012)
- Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice. (2012)
- Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. (2012)
- Mutational processes molding the genomes of 21 breast cancers. (2012)
- A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. (2012)
- The genetic basis of addictive disorders. (2012)
- Patient-derived tumour xenografts as models for oncology drug development. (2012)
- Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. (2012)
- HLA typing from RNA-Seq sequence reads. (2012)
- Massive genomic rearrangement acquired in a single catastrophic event during cancer development. (2011)
- Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. (2011)
- TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (2011)
- Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. (2011)
- A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (2011)
- Outlier-Based Differential Expression Analysis in Proteomics Studies. (2011)
- Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. (2011)
- Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. (2011)
- Integrative analysis of the melanoma transcriptome. (2010)
- Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. (2010)
- Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010)
- Cannabis and psychosis/schizophrenia: human studies. (2009)
- Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (2009)
- The epigenetics of sex differences in the brain. (2009)
- Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. (2009)
- The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. (2009)
- A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. (2009)
- New insights into the genetics of addiction. (2009)
- Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009)
- Circulating microRNAs as stable blood-based markers for cancer detection. (2008)
- Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys. (2008)
- One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility. (2008)
- Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. (2008)
- Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. (2007)
- Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. (2006)
- SNPs3D: candidate gene and SNP selection for association studies. (2006)
- Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. (2005)
- Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. (2005)
Merged raw entities (4)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| lung cancer | phenotype | 186 | 542 |
| lung carcinoma | phenotype | 7 | 11 |
| human lung cancer | phenotype | 1 | 1 |
| lc | phenotype | — | — |