Edenberg, Howard J

Also known as: Edenberg, H, Edenberg, Howard, Edenberg, H J

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

Research Summary

Howard J. Edenberg’s research centers on the genetics and neurobiology of substance‑use disorders, especially alcohol use disorder (AUD), using large‑scale GWAS, polygenic‑score analyses, and functional genomics. He has contributed dozens of genome‑wide risk loci for AUD, nicotine dependence, and obsessive‑compulsive disorder, demonstrated how AUD‑associated variants drive cell‑type‑specific transcriptional and chromatin changes in the human caudate (including dysregulated medium‑spiny neurons, microglia, and astrocytes), and linked polygenic risk to clinical outcomes such as suicide attempts, remission trajectories, developmental patterns of drinking, and gene‑environment interplay (e.g., genetic nurture, social support). His work also bridges genetics to mechanistic studies in human iPSC‑derived neurons and microglia, revealing how variants in genes like KCNJ6 (GIRK2) modulate neuronal excitability and ethanol responses.

Title	Year	PMID
The collaborative study on the genetics of alcoholism: Sample and clinical data.	2023	37581339
Binge and high-intensity drinking-Associations with intravenous alcohol self-administration and underlying risk factors.	2022	36301209
Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts.	2022	36195638
Deriving a Measure of Social Recovery Capital From the Important People and Activities Instrument: Construction and Psychometric Properties.	2022	35356964
Evaluating risk for alcohol use disorder: Polygenic risk scores and family history.	2022	35267208
Examining social genetic effects on educational attainment via parental educational attainment, income, and parenting.	2022	35666911
Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans.	2022	35790736
High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.	2022	36324664
Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts.	2022	33985350
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.	2022	36207451
Principal Component Analysis Reduces Collider Bias in Polygenic Score Effect Size Estimation.	2022	35674916
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates.	2022	34750568
A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior. PDF	2021	32433515
Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders.	2021	31477794
Associations between Suicidal Thoughts and Behaviors and Genetic Liability for Cognitive Performance, Depression, and Risk-Taking in a High-Risk Sample.	2021	35592092
Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.	2021	32652861
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.	2021	34002096
Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.	2021	34124712
Genome-wide association study of stimulant dependence.	2021	34226506
Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.	2021	34117972

Resolved affiliation

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

May be outdated — new papers have been added.

Raw imported affiliations (112)

Affiliation
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. edenberg@iu.edu.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana.
Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN.
Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA.
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Molecular Biology, Indiana University, Indianapolis, IN, United States of America.
Department of Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Psychiatry and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Department of Psychology, University of Texas at Austin (Mallard, Grotzinger, Harden); Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam (Savage); Department of Psychiatry, Washington University School of Medicine, Saint Louis (Johnson, Anokhin, Agrawal); Department of Psychiatry (Huang, Jennings, Palmer, Sanchez-Roige) and Institute for Genomic Medicine (Palmer), University of California San Diego, La Jolla; Virginia Institute for Psychiatric and Behavioral Genetics, Richmond (Edwards); Department of Biological Psychiatry, Vrije Universiteit Amsterdam (Hottenga, Nivard, de Geus, Boomsma); Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tenn. (Gustavson, Davis, Sanchez-Roige); Department of Psychology, Virginia Commonwealth University, Richmond (Dick); Department of Biochemistry and Molecular Biology (Edenberg) and Department of Medical and Molecular Genetics (Lai), Indiana University School of Medicine, Indianapolis; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City (Kramer); Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, N.Y. (Meyers, Pandey); Department of Psychiatry and Behavioral Sciences and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tenn. (Davis); Division of Psychiatry, University of Edinburgh, Edinburgh, U.K. (Clarke).
Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Departments of Biochemistry and Molecular Biology and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: edenberg@iu.edu.