Recent research on impulsivity in individuals with drug use and mental health disorders: implications for alcoholism.
paper
Cited
Public
- Authors
- Rogers, Robert D; Moeller, Frederick G; Swann, Alan C; Clark, Luke
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20528825
- DOI
- 10.1111/j.1530-0277.2010.01216.x
- PMCID
- PMC4777895
Alcohol misuse and dependence, and many of its accompanying psychological problems, are associated with heightened levels of impulsivity that both accelerate the development of clinically significant illness and complicate clinical outcome. This article reviews recent developments in our understanding of impulsivity as they relate to brain circuitry that might underlie these comorbid factors, focusing upon the clinical features of substance use (and dependence), bipolar disorder, and pathological gambling. Individuals who are affected by these disorders exhibit problems in several domains of impulsive behavior including deficient response or "motor" control, and the tolerance of prolonged delays prior to larger rewards at the expense of smaller rewards ("delay-discounting"). These populations, like alcoholic dependents, also exhibit impairments in risky decision-making that may reflect dysfunction of monoamine and catecholamine pathways. However, several areas of uncertainty exist including the specificity of impairments across disorders and the relationship between impulse control problems and altered evaluation of reward outcomes underlying observed impairments in action selection.
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| Name | Type |
|---|---|
| 38 pathological gamblers local | cohort |
| Accelerated speech local | phenotype |
| action cancellation local | phenotype |
| action restraint local | phenotype |
| action set switching local | phenotype |
| addiction | phenotype |
| ADHD | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol_dependence | phenotype |
| alcohol dependents local | cohort |
| alcoholism | phenotype |
| alcohol self-administration | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use disorders | phenotype |
| Altered myelin local | phenotype |
| amygdala | anatomy |
| anhedonia | phenotype |
| anterior cingulate cortex | anatomy |
| anterior cingulate cortex (area 24) local | anatomy |
| anticipated aversive consequences local | phenotype |
| Anticipation of negative outcomes local | phenotype |
| Antisocial impulsive subtype local | phenotype |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| arousal | phenotype |
| atomoxetine | drug |
| behavioral control | phenotype |
| behavioral sensitization | phenotype |
| belief in imminent winning local | phenotype |
| bipolar disorder | phenotype |
| BIS | phenotype |
| BIS-11 score | phenotype |
| Campbell-Meiklejohn et al. 2008 local | cohort |
| catecholamine activity local | drug |
| Catecholamine activity local | drug |
| catecholamines | drug |
| chase-loss local | phenotype |
| chase-quit local | phenotype |
| chase-win local | phenotype |
| Clark et al. 2009 local | cohort |
| clearing losses local | phenotype |
| cocaine | phenotype |
| Cocaine-abusing individuals local | cohort |
| Cocaine-dependent individuals local | cohort |
| cocaine-treated rodents local | cohort |
| cocaine use disorder | phenotype |
| cognition | phenotype |
| cognitive distortions local | phenotype |
| Cognitive distortions local | phenotype |
| compulsivity | phenotype |
| conflict | phenotype |
| Continuous performance test | phenotype |
| control | cohort |
| control participants | cohort |
| controls | cohort |
| control subjects | cohort |
| corpus callosum | anatomy |
| correct inhibition local | phenotype |
| craving | phenotype |
| decision-making | phenotype |
| Decision-making deficit local | phenotype |
| Decision-making impairment local | phenotype |
| decisions to chase losses local | phenotype |
| decision to chase local | phenotype |
| decision to chase or quit local | phenotype |
| decision to gamble local | phenotype |
| decision to quit local | phenotype |
| delay discounting | phenotype |
| delay-discounting local | phenotype |
| Delayed discounting local | phenotype |
| Delay tolerance local | phenotype |
| depression | phenotype |
| depressive illness | phenotype |
| depressive symptoms | phenotype |
| Desipramine | drug |
| Disadvantageous choices on IGT local | phenotype |
| Disgust local | phenotype |
| dopamine | drug |
| dorsomedial-striatal circuitry local | anatomy |
| DRD2 | gene |
| drug | drug |
| Drug-dependent individuals local | cohort |
| Dysexecutive syndrome local | phenotype |
| dysphoria | phenotype |
| Early onset of illness local | phenotype |
| elevated wagers local | phenotype |
| endophenotype | phenotype |
| errors of commission | phenotype |
| Euthymic bipolar subjects local | cohort |
| Euthymic state local | phenotype |
| FA reduction | phenotype |
| Faster reaction times local | phenotype |
| First-degree relatives of alcoholics local | cohort |
| First-degree relatives of bipolar disorder patients local | cohort |
| fractional anisotropy | phenotype |
| frontal-striatal circuits local | anatomy |
| full-miss local | phenotype |
| Gambler's fallacy local | phenotype |
| Gamblers with co-morbid ADHD local | cohort |
| Go-no go performance local | phenotype |
| Go reaction time local | phenotype |
| Head of the caudate local | anatomy |
| healthy adult volunteers local | cohort |
| healthy controls | cohort |
| Hedonic thrill local | phenotype |
| heightened mood local | phenotype |
| hope local | phenotype |
| hopelessness | phenotype |
| hunger | phenotype |
| hyperactivity | phenotype |
| hypomania | phenotype |
| Illusion of control local | phenotype |
| Impaired decision-making local | phenotype |
| Impulse Control Disorder local | phenotype |
| Impulsive attempters local | phenotype |
| Impulsive disorders local | phenotype |
| Impulsive suicide attempts local | phenotype |
| impulsivity | phenotype |
| Impulsivity (BIS-11 score) local | phenotype |
| Impulsivity-related measures local | phenotype |
| increased commission errors local | phenotype |
| Increased energy local | phenotype |
| inferior frontal gyrus | anatomy |
| insula | anatomy |
| internal capsule | anatomy |
| Intolerance of longer delays to larger rewards local | phenotype |
| lateral orbitofrontal cortex | anatomy |
| left anterior insula local | anatomy |
| left inferior frontal gyrus | anatomy |
| lifetime alcohol use | phenotype |
| longer deliberation times local | phenotype |
| loss-chasing local | phenotype |
| Loss-chasing local | phenotype |
| loss-chasing behavior local | phenotype |
| lower socialization scores local | phenotype |
| low mood | phenotype |
| mania | phenotype |
| Manic episode | phenotype |
| manic or depressive episodes local | phenotype |
| manic patients local | cohort |
| Many depressive episodes local | phenotype |
| Many manic episodes local | phenotype |
| medial prefrontal cortex | anatomy |
| medial superior frontal gyrus | anatomy |
| mesolimbic circuits local | anatomy |
| mesolimbic pathways local | anatomy |
| methamphetamine | drug |
| methamphetamine dependence | phenotype |
| middle frontal gyrus | anatomy |
| mixed manic-depressive group local | cohort |
| monetary win local | phenotype |
| mood disorders | phenotype |
| motivation | phenotype |
| myelin basic protein local | phenotype |
| near-miss local | phenotype |
| Negative reinforcement model local | phenotype |
| Negative states local | phenotype |
| neurofilaments local | phenotype |
| neuromodulators local | drug |
| Neuronal changes local | phenotype |
| nonplanning impulsiveness | phenotype |
| Nonusing controls local | cohort |
| noradrenaline | drug |
| Noradrenaline metabolite local | drug |
| Noradrenergic function local | phenotype |
| novelty seeking | phenotype |
| obsessive-compulsive disorder | phenotype |
| outcome | phenotype |
| pain | phenotype |
| paracingulate cortex (area 32) local | anatomy |
| parietal cortex | anatomy |
| paroxetine | drug |
| participants | cohort |
| pathological gamblers | cohort |
| pathological gambling | phenotype |
| patients with bipolar disorder | phenotype |
| Patients with bipolar disorder with highly recurrent illness or history of alcohol- or substance-use disorders local | cohort |
| Patients with bipolar disorder without these features local | cohort |
| Poorer IGT performance local | phenotype |
| posterior cingulate cortex | anatomy |
| Posterior mesofrontal cortex local | anatomy |
| prefrontal cortex | anatomy |
| Presupplementary motor area local | anatomy |
| propensity to chase local | phenotype |
| quit chasing losses local | phenotype |
| radial diffusivity | phenotype |
| rapid responding local | phenotype |
| Rapid-response impulsivity local | phenotype |
| rats | cohort |
| Recreational gamblers local | cohort |
| Reduced accuracy | phenotype |
| Reduced attention local | phenotype |
| relapse | phenotype |
| response inhibition | phenotype |
| reward | phenotype |
| reward expectancy local | phenotype |
| reward expectancy pathway local | anatomy |
| reward expectation local | phenotype |
| reward processing | phenotype |
| right medial frontal gyrus | anatomy |
| right prefrontal cortex | anatomy |
| Risk decision-making local | phenotype |
| Risk-free choices local | phenotype |
| risky choice local | phenotype |
| Risky choice local | phenotype |
| risky decision-making | phenotype |
| sadness local | phenotype |
| saline-treated rodents local | cohort |
| self-control | phenotype |
| sense of dread local | phenotype |
| serotonin | drug |
| severe bipolar disorder local | phenotype |
| severity of drug use | phenotype |
| Severity of past attempt local | phenotype |
| slower reaction times | phenotype |
| Socialization scores local | phenotype |
| state negative affect local | phenotype |
| Steeper delay-discounting local | phenotype |
| stimulants | drug |
| Stop-signal reaction time (SSRT) local | phenotype |
| stressors | phenotype |
| subjective aversive rating local | phenotype |
| subjective sensitivity to reward gradients local | phenotype |
| Subjective sensitivity to reward gradients local | phenotype |
| substance use | phenotype |
| Substance-use disorder local | phenotype |
| suicide | phenotype |
| Sustained attention deficit local | phenotype |
| tolerance | phenotype |
| Trait harm avoidance local | phenotype |
| treatment response | phenotype |
| Treatment-seeking pathological gamblers local | cohort |
| value-based choices local | phenotype |
| ventral striatum | anatomy |
| ventromedial prefrontal cortex | anatomy |
| ventromedial prefrontal lesions local | anatomy |
| Violent methods local | phenotype |
| visceral arousal circuit local | anatomy |
| white matter | anatomy |
| withdrawal | phenotype |
| Worse treatment response local | phenotype |
| yohimbine | drug |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | 2015 | 26388585 |
External
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