Transgenic mouse models of Alzheimer's disease.

paper Cited Public

Authors: Elder, Gregory A; Gama Sosa, Miguel A; De Gasperi, Rita
Year: 2010
Journal: The Mount Sinai journal of medicine, New York
PMID: 20101721
DOI: 10.1002/msj.20159
PMCID: PMC2925685

#	Section	Preview
20	TRANSGENIC MODELING WITH PRESENILIN MUTATIONS	PS1 FAD mutant line,44 and age-related NFT-like inclusions have been described in a PS1 knock-in…
21	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Transgenic mouse models now exist that mimic a range of AD-related pathologies. Table 1 contains a…
22	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	It is interesting in this context to compare the overexpression models to APP knock-in mice…
23	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Overexpression of APP in Down’s syndrome is associated with AD pathology in humans.49 Recently,…
24	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	It is also not clear that the temporal appearance of plaque pathology and cognitive deficits in the…
25	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Transgenic mouse models have also been troubled by the difficulty of producing the full spectrum of…
26	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Another problem with the models has been the general difficulty of inducing the characteristic…
27	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Recently, mice that exhibit NFT-like lesions and plaques have been produced by combining FAD…
28	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Lewis et al.62 first crossed a transgenic line known as JPNL3, which expresses the P301L mutation…
29	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	TAPP and 3xTg-AD thus exhibit a broader spectrum of AD pathologies. The question, however, again…
30	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	animals. In addition, intracerebral injections of anti-Aβ antibodies into the hippocampus of…
31	RELEVANCE AS MODELS OF ALZHEIMER’S DISEASE	Finally, all the transgenic mouse models discussed are based on the expression of mutant genes…
32	USE OF TRANSGENIC MODELS TO STUDY THE PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE: EFFECTS OF DIFFERENT β-AMYLOID SPECIES	Transgenic mice have been used to study many aspects of AD pathophysiology. Two recent examples of…
33	USE OF TRANSGENIC MODELS TO STUDY THE PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE: EFFECTS OF DIFFERENT β-AMYLOID SPECIES	systems were created by the replacement of the 23–amino acid BRI peptide region with human Aβ40…
34	USE OF TRANSGENIC MODELS TO STUDY THE PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE: EFFECTS OF DIFFERENT β-AMYLOID SPECIES	Both parenchymal and vascular deposits of amyloid are typical of AD. There are, however, mutations…
35	USE OF TRANSGENIC MODELS TO STUDY THE PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE: EFFECTS OF DIFFERENT β-AMYLOID SPECIES	Herzig et al.47 developed transgenic lines that expressed human wild-type APP, APP-Dutch, or…
36	TRANSGENIC MODELS AND THE RISE OF THE β-AMYLOID OLIGOMER	The original amyloid hypothesis regarded Aβ deposited in plaque amyloid as the toxic species.…
37	TRANSGENIC MODELS AND THE RISE OF THE β-AMYLOID OLIGOMER	Soluble Aβ species are toxic in cell culture.74 APP transgenic mice have provided strong…
38	TRANSGENIC MODELS AND THE RISE OF THE β-AMYLOID OLIGOMER	Recently, a 56-kDa oligomeric Aβ species identified in Tg2576 mice81 has been proposed as a…
39	β-AMYLOID IMMUNIZATION AS A THERAPEUTIC STRATEGY IN ALZHEIMER’S DISEASE	Transgenic animals have been widely used to study factors that affect Aβ deposition. For example,…

Name	Type
3xTg-AD local	cohort
3xTg-AD mice local	cohort
5X FAD local	cohort
AAB-001 local	drug
AD-like pathology local	phenotype
AD pathologies local	phenotype
AD-type pathology local	phenotype
age-related NFT-like inclusions local	phenotype
Altered long-term potentiation local	phenotype
Alzheimer's disease	phenotype
Alzheimer's disease pathology local	phenotype
amyloid local	drug
Amyloid beta	drug
Amyloid-beta	drug
Amyloid beta 42 peptide local	drug
Amyloid beta peptide local	drug
amyloid deposition local	phenotype
Amyloid deposition local	phenotype
amyloid deposits local	phenotype
amyloid plaques	phenotype
AN1792 trial local	cohort
animal models	cohort
anti‑Aβ antibodies local	drug
anti-Aβ titers local	drug
apoE	gene
APOE ε4	gene
apolipoprotein ε4 knockout mice local	cohort
apolipoprotein ε4 transgenic mice local	cohort
APP	gene
APP23 local	cohort
APP-Dutch local	variant
APP-Dutch mice local	cohort
APP-Dutch/PS1 mice local	cohort
APP FAD mutant mice local	cohort
APP-Indiana local	variant
APP knock-in mice local	cohort
APP London local	variant
APP Swedish local	variant
APP-Swedish local	variant
APP transgenic mice local	cohort
astrocytes	phenotype
autoimmune meningoencephalitis local	phenotype
axonal swellings local	phenotype
Aβ40 local	drug
Aβ42 local	drug
Aβ*56 local	drug
Aβ accumulation	phenotype
Aβ domain local	drug
Aβ vaccination local	drug
bapineuzumab local	drug
behavioral changes local	phenotype
behavioral deficits	phenotype
behavioral phenotypes	phenotype
brain	anatomy
BRI local	gene
BRI-Aβ40 transgenic mice local	cohort
BRI-Aβ42 transgenic mice local	cohort
C57BL6/DBA/Swiss-Webster background local	cohort
C57BL6/SJL background local	cohort
Caenorhabditis elegans	cohort
caloric restriction	phenotype
central nervous system	anatomy
cerebral hemorrhage	phenotype
chromosome 14 locus local	cohort
chromosome 1 locus local	cohort
cognition	phenotype
cognitive decline	phenotype
Compact plaques local	phenotype
Congophilic angiopathy local	phenotype
Congo red local	drug
cornu ammonis 1 local	anatomy
cortex	anatomy
Corticobasal degeneration local	phenotype
death	phenotype
dementia	phenotype
Dense cored plaques local	phenotype
dentate gyrus	anatomy
diffuse deposits local	phenotype
Diffuse deposits local	phenotype
Down syndrome	phenotype
Drosophila melanogaster	cohort
dystrophic neurites local	phenotype
Dystrophic neurites local	phenotype
E693G/Arctic local	variant
E693G/Arctic/APP-Swedish/APP-Indiana mice local	cohort
E693Q local	variant
early age of onset	phenotype
early-onset familial Alzheimer's disease local	phenotype
early-stage tau pathology local	phenotype
Elan/Wyeth trial local	cohort
electro-physiological changes local	phenotype
Electrophysiological changes local	phenotype
endogenous gene local	gene
entorhinal cortex	anatomy
environmental enrichment	drug
exercise local	drug
Exonic point mutations local	variant
fAD	gene
FAD-associated mutation local	variant
FAD mutant local	variant
FAD mutation local	variant
FAD mutations local	variant
Frontotemporal dementias local	phenotype
FTDP-17 local	phenotype
FVB/N background local	cohort
Giant plaques local	phenotype
gliosis	phenotype
hemizygous local	phenotype
heterologous promoter local	drug
hippocampal damage	phenotype
hippocampus	anatomy
Human Alzheimer's disease local	phenotype
human Aβ local	drug
human FAD local	phenotype
hyperphosphorylated tau	drug
Hyperphosphorylated tau local	variant
impaired hippocampal neurogenesis local	phenotype
Intronic mutations local	variant
JPNL3 local	cohort
kainate	drug
learning and memory performance local	phenotype
Learning defects local	phenotype
limbic system	anatomy
lipid peroxidation	phenotype
M146V local	variant
m266 local	drug
Mapt	gene
memory	phenotype
metal chelators local	drug
mice	cohort
microglial activation	phenotype
microvascular pathology local	phenotype
mouse APP local	gene
mouse Aβ local	drug
Mutant tau local	variant
natural products local	drug
neocortex	anatomy
neuritic plaques	phenotype
Neurochemical changes local	phenotype
neurofibrillary tangles	phenotype
neuronal loss	phenotype
Neuropathological changes local	phenotype
neuropathology local	phenotype
NFT-like inclusions local	phenotype
P301L local	variant
parenchyma local	anatomy
Parenchymal amyloid deposition local	phenotype
Parenchymal deposits local	phenotype
Parenchymal plaques local	phenotype
parental presenilin lines local	cohort
pathology	phenotype
pathophysiological changes local	phenotype
PDAPP local	cohort
PDAPP mice local	cohort
PDGF	drug
PDGF24 local	drug
PDGF promoter local	drug
perforant path	anatomy
Pick’s disease local	phenotype
plaque	phenotype
plaque amyloid local	phenotype
Plaque burden local	phenotype
plaque deposits local	phenotype
plaque pathology local	phenotype
Plaque pathology local	phenotype
plasma Aβ local	drug
presenilin	gene
progressive supranuclear palsy	phenotype
protein oxidation	phenotype
PrP local	drug
PS1	gene
PS1/APP bigenic mice local	cohort
PS1 FAD mutant local	variant
PS1 FAD mutant line local	cohort
PS1 FAD mutant lines local	cohort
PS1 FAD mutant mice local	cohort
PS1 knock-in line local	cohort
PS1 transgenic mouse model local	cohort
PS2 FAD mutant lines local	cohort
PSEN1	gene
PSEN1 L235P local	variant
PSEN1 M233T local	variant
PSEN1 ΔE9 local	variant
PSEN2	gene
rats	cohort
Saline-injected controls local	cohort
senile plaques	phenotype
Soluble Aβ species local	drug
spatial memory	phenotype
spine morphology impairment local	phenotype
statins	drug
Swedish FAD mutation local	variant
Swedish mutation	variant
synapse loss	phenotype
synaptic dysfunction	phenotype
synaptic loss local	phenotype
synaptic plasticity impairment local	phenotype
tangle pathology local	phenotype
TAPP local	cohort
tau-null mice local	cohort
tau pathology	phenotype
Tg2576 local	cohort
Tg2576 mice local	cohort
TgCRND8 local	cohort
thioflavin-S	drug
Thioflavin-S–positive plaques local	phenotype
total cholesterol	phenotype
transgene local	variant
transgenic mice	cohort
transgenic mouse models local	cohort
transgenic protein local	drug
trimethyltin local	drug
V717F local	variant
vascular amyloid local	phenotype
vascular amyloid deposition local	phenotype
Vascular amyloid deposition local	phenotype
volume loss local	phenotype
wild-type APP local	variant
Wild-type APP mice local	cohort
wine	drug
α-secretase local	drug
β-amyloid peptide local	drug
β-secretase	drug
γ-secretase	drug
γ-secretase activity local	drug

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In this knowledge base

Title	Year	PMID
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	2018	29897633

External

Title	Authors	Journal	Year	Link
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Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States.	Kuhn MK et al.	—	2025	→
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Pharmacological Potential of Bioactive Peptides for the Treatment of Diseases Associated with Alzheimer's and Brain Disorders.	Gupta JK et al.	—	2024	→
Radiolabeled Probes from Derivatives of Natural Compounds Used in Nuclear Medicine.	Tesse G et al.	—	2024	→
Therapeutic Effects of Aβ-Specific Regulatory T Cells in Alzheimer's Disease: A Study in 5xFAD Mice.	Park SY et al.	—	2024	→
Aberrant accumulation of age- and disease-associated factors following neural probe implantation in a mouse model of Alzheimer's disease.	Wellman SM et al.	—	2023	→
Animal models of Alzheimer's disease: An originof innovativetreatments and insight to the disease's etiology.	Chavan RS et al.	—	2023	→
Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease.	Nowell J et al.	—	2023	→
Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer's disease.	Finney CA et al.	—	2023	→
Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project.	Bray EE et al.	—	2023	→
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice.	Zeng X et al.	—	2023	→
A three-dimensional spheroid co-culture system of neurons and astrocytes derived from Alzheimer's disease patients for drug efficacy testing.	Park H et al.	—	2023	→
Costs and Benefits of Popular <i>P</i>-Value Correction Methods in Three Models of Quantitative Omic Experiments.	Shuken SR et al.	—	2023	→
Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer's Disease.	Bhanukiran K et al.	—	2023	→
Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin-alkylbenzylamine hybrids.	Liu P et al.	—	2023	→
Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent.	Mehdi SF et al.	—	2023	→
Hebbian plasticity: the elusive missing link at the heart of Alzheimer's disease pathogenesis?	Jeans AF	—	2023	→
Insight into the emerging and common experimental in-vivo models of Alzheimer's disease.	Dhapola R et al.	—	2023	→
Microglial Expression of the Wnt Signaling Modulator <i>DKK2</i> Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models.	Aghaizu ND et al.	—	2023	→
Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice.	Jermakow N et al.	—	2023	→
Perinatal diesel exhaust exposure causes persistent changes in the brains of aged mice: An assessment of behavioral and biochemical endpoints related to neurodegenerative disease.	Garrick JM et al.	—	2023	→
Spatial Disorientation Under Dark Conditions Across Development in an Alzheimer's Disease Mouse Model.	Blackwell AA et al.	—	2023	→
Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.	Maharjan S et al.	—	2022	→
Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels.	Patel B et al.	—	2022	→
APOE4 confers transcriptomic and functional alterations to primary mouse microglia.	Machlovi SI et al.	—	2022	→
APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer's Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression.	Maki T et al.	—	2022	→
Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer’s Disease	Finney CA et al.	—	2022	—
Bacterial Amyloid Curli Associated Gut Epithelial Neuroendocrine Activation Predominantly Observed in Alzheimer's Disease Mice with Central Amyloid-β Pathology.	Das TK et al.	—	2022	→
Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease.	Pinals RL et al.	—	2022	→
Characterization of Early Alzheimer's Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study.	Jester HM et al.	—	2022	→
Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease.	Davies ES et al.	—	2022	→
Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer's disease.	Mumtaz I et al.	—	2022	→
DNA Damage Increases Secreted Aβ40 and Aβ42 in Neuronal Progenitor Cells: Relevance to Alzheimer's Disease.	Welty S et al.	—	2022	→
Harnessing cerebral organoids for Alzheimer's disease research.	Bubnys A et al.	—	2022	→
Inflammation context in Alzheimer's disease, a relationship intricate to define.	Novoa C et al.	—	2022	→
Mitochondrial Alterations in Neurons Derived from the Murine AppNL-F Knock-In Model of Alzheimer's Disease.	Dentoni G et al.	—	2022	→
The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier.	Lopes van den Broek S et al.	—	2022	→
The Impact of the hAPP695SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical Pathways.	Khorani M et al.	—	2022	→
The Molecular Effects of Environmental Enrichment on Alzheimer's Disease.	Liew AKY et al.	—	2022	→
Alzheimer Disease Clinical Trials Targeting Amyloid: Lessons Learned From Success in Mice and Failure in Humans.	Reiss AB et al.	—	2021	→
Alzheimer's Disease: Current Perspectives and Advances in Physiological Modeling.	Josephine Boder E et al.	—	2021	→
An Analysis of the Neurological and Molecular Alterations Underlying the Pathogenesis of Alzheimer's Disease.	Vidal C et al.	—	2021	→
Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry.	Mari M et al.	—	2021	→
A regional and cellular analysis of the early intracellular and extracellular accumulation of Aβ in the brain of 5XFAD mice.	Daini E et al.	—	2021	→
Cholinergic neurodegeneration in Alzheimer disease mouse models.	Shekari A et al.	—	2021	→
Gamma Oscillations in Alzheimer's Disease and Their Potential Therapeutic Role.	Traikapi A et al.	—	2021	→
Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory.	Honoré E et al.	—	2021	→
Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer's Disease.	Labban S et al.	—	2021	→
Metabolism navigates neural cell fate in development, aging and neurodegeneration.	Traxler L et al.	—	2021	→
MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease.	Kumar S et al.	—	2021	→
Modeling neurological disorders using brain organoids.	Zhang DY et al.	—	2021	→
Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration.	Lin A et al.	—	2021	→
Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog.	Chandrasekaran A et al.	—	2021	→
Neuronal Network Excitability in Alzheimer's Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau.	Kazim SF et al.	—	2021	→
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.	Wu Z et al.	—	2021	→
Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model.	Smit T et al.	—	2021	→
Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer's disease.	McAnany JJ et al.	—	2021	→
Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism.	Xing S et al.	—	2021	→
Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review.	Kioussis B et al.	—	2021	→
The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.	MacDougall G et al.	—	2021	→
Alzheimer's Disease is Driven by Intraneuronally Retained Beta-Amyloid Produced in the AD-Specific, βAPP-Independent Pathway: Current Perspective and Experimental Models for Tomorrow.	Volloch V et al.	—	2020	→
Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action.	Bondžić AM et al.	—	2020	→
An Overview of Astrocyte Responses in Genetically Induced Alzheimer's Disease Mouse Models.	Spanos F et al.	—	2020	→
Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila.	De Mena L et al.	—	2020	→
Can mouse models mimic sporadic Alzheimer's disease?	Foidl BM et al.	—	2020	→
Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches.	Ejaz HW et al.	—	2020	→
Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer's disease.	Töpperwien M et al.	—	2020	→
Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits.	Kim B et al.	—	2020	→
Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor.	Li Q et al.	—	2020	→
Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice.	Honarpisheh P et al.	—	2020	→
From Mouse to Human: Comparative Analysis between Grey and White Matter by Synchrotron-Fourier Transformed Infrared Microspectroscopy.	Sanchez-Molina P et al.	—	2020	→
GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.	Gil-Iturbe E et al.	—	2020	→
How to choose your research organism.	Dietrich MR et al.	—	2020	→
On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications.	Inyushin M et al.	—	2020	→
P-glycoprotein: a role in the export of amyloid-β in Alzheimer's disease?	Chai AB et al.	—	2020	→
Prolonged isolation stress accelerates the onset of Alzheimer's disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment.	Peterman JL et al.	—	2020	→
TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.	Gao J et al.	—	2020	→
The first <i>Antechinus</i> reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies.	Brandies PA et al.	—	2020	→
The role of TREM2 in Alzheimer's disease; evidence from transgenic mouse models.	Karanfilian L et al.	—	2020	→
Transgene integration causes RARB downregulation in homozygous Tg4-42 mice.	Hinteregger B et al.	—	2020	→
Age-Associated Changes in the Immune System and Blood⁻Brain Barrier Functions.	Erickson MA et al.	—	2019	→
An Animal Model to Test Reversal of Cognitive Decline Associated with Beta-Amyloid Pathologies.	Deba F et al.	—	2019	→
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease.	Bellozi PMQ et al.	—	2019	→
Bidirectional relationships between sleep and amyloid-beta in the hippocampus.	Dufort-Gervais J et al.	—	2019	→
Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease.	Frederiksen HR et al.	—	2019	→
Cerebral Amyloid Angiopathy, Alzheimer's Disease and MicroRNA: miRNA as Diagnostic Biomarkers and Potential Therapeutic Targets.	Weldon Furr J et al.	—	2019	→
Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease.	Ştefănescu R et al.	—	2019	→
Generation of genetically engineered non-human primate models of brain function and neurological disorders.	Park JE et al.	—	2019	→
Identification of Pre-symptomatic Gene Signatures That Predict Resilience to Cognitive Decline in the Genetically Diverse AD-BXD Model.	Neuner SM et al.	—	2019	→
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.	Karagiannis P et al.	—	2019	→
Label-free multiphoton imaging of <i>β</i>-amyloid plaques in Alzheimer's disease mouse models.	Wang S et al.	—	2019	→
Lasting effects of general anesthetics on the brain in the young and elderly: "mixed picture" of neurotoxicity, neuroprotection and cognitive impairment.	Wu L et al.	—	2019	→
Low-cost solution for rodent home-cage behaviour monitoring.	Singh S et al.	—	2019	→
Modeling neural circuit, blood-brain barrier, and myelination on a microfluidic 96 well plate.	Lee SR et al.	—	2019	→
Motor deficits in 16-month-old male and female 3xTg-AD mice.	Garvock-de Montbrun T et al.	—	2019	→
Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding.	Scharfenberg F et al.	—	2019	→
Studying humane endpoints in a rat model of mammary carcinogenesis.	Faustino-Rocha AI et al.	—	2019	→
<sup>18</sup>F-FDG-PET in Mouse Models of Alzheimer's Disease.	Bouter C et al.	—	2019	→
Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease.	Mango D et al.	—	2019	→
Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease.	Pan X et al.	—	2019	→
Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden.	Esquerda-Canals G et al.	—	2019	→
Alterations of functional circuitry in aging brain and the impact of mutated APP expression.	Bearer EL et al.	—	2018	→
Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model.	Smith LA et al.	—	2018	→
Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial.	Lamb SE et al.	—	2018	→
Early Detection of A<i>β</i> Deposition in the 5xFAD Mouse by Amyloid PET.	Oh SJ et al.	—	2018	→
Establishment of an Alzheimer's disease model with latent herpesvirus infection using PS2 and Tg2576 double transgenic mice.	Tanaka S et al.	—	2018	→
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?	Prytkova I et al.	—	2018	→
Intranasally Administered S100A9 Amyloids Induced Cellular Stress, Amyloid Seeding, and Behavioral Impairment in Aged Mice.	Iashchishyn IA et al.	—	2018	→
Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease.	Caraci F et al.	—	2018	→
Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword.	Trotta T et al.	—	2018	→
MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice.	Ham S et al.	—	2018	→
Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component.	Albanese S et al.	—	2018	→
Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches.	Corrêa-Velloso JC et al.	—	2018	→
Stem cells: a promising candidate to treat neurological disorders.	Song CG et al.	—	2018	→
<sup>18</sup>F-FDG-PET Detects Drastic Changes in Brain Metabolism in the Tg4-42 Model of Alzheimer's Disease.	Bouter C et al.	—	2018	→
Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase.	Brimijoin S et al.	—	2018	→
An ultra-high field strength MR image-guided robotic needle delivery system for in-bore small animal interventions.	Gravett M et al.	—	2017	→
Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology.	Miedel CJ et al.	—	2017	→
Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord.	Chu TH et al.	—	2017	→
Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease.	Finnie GS et al.	—	2017	→
Comparative study of the transfection efficiency of commonly used viral vectors in rhesus monkey (<i>Macaca mulatta</i>) brains.	Wu SH et al.	—	2017	→
Hippocampal GABAergic Inhibitory Interneurons.	Pelkey KA et al.	—	2017	→
Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats.	Selvi Y et al.	—	2017	→
Impact of high iron intake on cognition and neurodegeneration in humans and in animal models: a systematic review.	Agrawal S et al.	—	2017	→
Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging.	O'Reilly MA et al.	—	2017	→
Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective.	Uhlhaas PJ et al.	—	2017	→
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.	Mariani MM et al.	—	2017	→
Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.	Cai H et al.	—	2017	→
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.	Michalski D et al.	—	2017	→
Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models.	Kodamullil AT et al.	—	2017	→
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.	Franco R et al.	—	2017	→
Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease.	Ameen-Ali KE et al.	—	2017	→
Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals.	Bagheri S et al.	—	2017	→
Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease.	Haberman RP et al.	—	2017	→
Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer's disease.	Chiasseu M et al.	—	2017	→
The contribution of transgenic and nontransgenic animal models in Alzheimer's disease drug research and development.	Mhillaj E et al.	—	2017	→
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Dissecting Alzheimer disease in Down syndrome using mouse models.	Choong XY et al.	—	2015	→
Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig.	Hall VJ et al.	—	2015	→
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.	Huang Y et al.	—	2015	→
Memory formation and retention are affected in adult miR-132/212 knockout mice.	Hernandez-Rapp J et al.	—	2015	→
Metabolic profiling of a transgenic <i>Caenorhabditis elegans</i> Alzheimer model.	Van Assche R et al.	—	2015	→
Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment.	Chakrabarti S et al.	—	2015	→
Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.	Porcellotti S et al.	—	2015	→
Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues.	Jonson M et al.	—	2015	→
T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease.	Haris M et al.	—	2015	→
β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease.	Sun X et al.	—	2015	→
Animal models of dementia and cognitive dysfunction.	Neha et al.	—	2014	→
A review of β-amyloid neuroimaging in Alzheimer's disease.	Adlard PA et al.	—	2014	→
Considering a new paradigm for Alzheimer's disease research.	Langley GR	—	2014	→
Cortical odor processing in health and disease.	Wilson DA et al.	—	2014	→
Integrating the molecular and the population approaches to dementia research to help guide the future development of appropriate therapeutics.	Hunter S et al.	—	2014	→
Ocular changes in TgF344-AD rat model of Alzheimer's disease.	Tsai Y et al.	—	2014	→
Retinal manifestations of Alzheimer's disease.	Dehabadi MH et al.	—	2014	→
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.	Webster SJ et al.	—	2014	→
An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.	Lee JE et al.	—	2013	→
Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease.	Webster SJ et al.	—	2013	→
Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease.	Li C et al.	—	2013	→
ER-stress in Alzheimer's disease: turning the scale?	Endres K et al.	—	2013	→
Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer's disease.	Yamamoto S et al.	—	2013	→
Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice.	Darlington D et al.	—	2013	→
Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice.	Kastyak-Ibrahim MZ et al.	—	2013	→
Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia.	Van der Jeugd A et al.	—	2013	→
The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes.	Sharman MJ et al.	—	2013	→
Tissue resident stem cells: till death do us part.	Raveh-Amit H et al.	—	2013	→
Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where.	Lai AY et al.	—	2012	→
Designing phenotyping studies for genetically engineered mice.	Zeiss CJ et al.	—	2012	→
Modeling human neurodegenerative diseases in transgenic systems.	Gama Sosa MA et al.	—	2012	→
Ocular manifestations of Alzheimer's disease in animal models.	Parnell M et al.	—	2012	→
Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease.	Svedberg MM et al.	—	2012	→
The use of mouse models for understanding the biology of down syndrome and aging.	Vacano GN et al.	—	2012	→
Translational research challenges: finding the right animal models.	Prabhakar S	—	2012	→
Alzheimer's disease: pathological mechanisms and recent insights.	Niedowicz DM et al.	—	2011	→
Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.	Schieb H et al.	—	2011	→
Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models?	Marchetti C et al.	—	2011	→
Insights into Alzheimer disease pathogenesis from studies in transgenic animal models.	Schaeffer EL et al.	—	2011	→
In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.	Cheng N et al.	—	2011	→
Neurobiological aspects of Alzheimer's disease.	Chopra K et al.	—	2011	→
Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.	van Tijn P et al.	—	2011	→
Should EOAD patients be included in clinical trials?	Szigeti K et al.	—	2011	→
Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model.	Martin SB et al.	—	2011	→
Therapeutic potential of vaccines for Alzheimer's disease.	Shah S et al.	—	2011	→
Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins.	Lai AY et al.	—	2010	→