Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.

This is a Manhattan plot showing the association between genetic variants and a trait across 22 chromosomes. The y-axis represents the $-\log_{10}(p\text{-value})$, with a prominent, highly significant peak of red data points on chromosome 4 reaching values above 40. Two horizontal lines indicate significance thresholds, with most other chromosomes showing values below these lines, except for a small peak on chromosome 17.

This figure consists of three regional Manhattan plots (A, B, and C) showing genetic associations across specific chromosomal regions. Each plot displays $-\log_{10}(p\text{-value})$ on the y-axis against genomic position (Mb) on the x-axis, with a secondary y-axis for recombination rate and color-coding for linkage disequilibrium ($r^2$). Plot A (EUR) and Plot B (AFR) focus on the *ADH* gene cluster on chromosome 4, while Plot C shows a meta-analysis of EUR and AFR populations for the *CRHR1* region on chromosome 17, with lead SNPs (rs1229984, rs2066702, and rs61667602) explicitly labeled.

This is a volcano-style scatter plot showing phenome-wide genetic correlations ($r_g$) on the x-axis and $-\log_{10}(P\text{ value})$ on the y-axis. Data points are color-coded by significance strength, ranging from white (non-significant) to dark blue (top 20 results). The plot reveals significant genetic correlations for various phenotypes, with the strongest positive correlations associated with current tobacco smoking and the strongest negative correlations associated with past tobacco smoking and educational attainment.

This is a Manhattan plot showing gene-based association results across 22 chromosomes. The y-axis represents the $-\log_{10}(P\text{ value})$, with a red dashed significance threshold line at approximately 5.5. Several genes, including *KANSL1*, *CRHR1*, and *WNT3*, are highlighted in red as significant outliers, with the highest association values appearing on chromosome 17.

This figure consists of five bar charts (A–E) showing the statistical significance of gene expression enrichments across various tissues and cell types, with the y-axis representing $-\log_{10}(P\text{ value})$. In each plot, bars are sorted by significance, with red bars indicating values above a dashed significance threshold and blue bars indicating values below it. The charts compare enrichments for general tissues (A), human cortex cell types (B), human midbrain cell types (C), human pancreas cell types (D), and conventional dendritic cell subtypes (E).