Antenatal prediction of postpartum depression with blood DNA methylation biomarkers.
paper
Cited
Public
- Authors
- Guintivano, J; Arad, M; Gould, T D; Payne, J L; Kaminsky, Z A
- Year
- 2014
- Journal
- Molecular psychiatry
- PMID
- 23689534
- DOI
- 10.1038/mp.2013.62
- PMCID
- PMC7039252
Postpartum depression (PPD) affects βΌ10-18% of women in the general population and results in serious consequences to both the mother and offspring. We hypothesized that predisposition to PPD risk is due to an altered sensitivity to estrogen-mediated epigenetic changes that act in a cell autonomous manner detectable in the blood. We investigated estrogen-mediated epigenetic reprogramming events in the hippocampus and risk to PPD using a cross-species translational design. DNA methylation profiles were generated using methylation microarrays in a prospective sample of the blood from the antenatal period of pregnant mood disorder patients who would and would not develop depression postpartum. These profiles were cross-referenced with syntenic locations exhibiting hippocampal DNA methylation changes in the mouse responsive to long-term treatment with 17Ξ²-estradiol (E2). DNA methylation associated with PPD risk correlated significantly with E2-induced DNA methylation change, suggesting an enhanced sensitivity to estrogen-based DNA methylation reprogramming exists in those at risk for PPD. Using the combined mouse and human data, we identified two biomarker loci at the HP1BP3 and TTC9B genes that predicted PPD with an area under the receiver operator characteristic (ROC) curve (area under the curve (AUC)) of 0.87 in antenatally euthymic women and 0.12 in a replication sample of antenatally depressed women. Incorporation of blood count data into the model accounted for the discrepancy and produced an AUC of 0.96 across both prepartum depressed and euthymic women. Pathway analyses demonstrated that DNA methylation patterns related to hippocampal synaptic plasticity may be of etiological importance to PPD.
Estradiol (E2)-mediated DNA methylation change is associated with postpartum depression (PPD) risk. (a) Volcano plot depicting the difference in DNA methylation between women who suffered PPD vs those who did not (x axis) against the negative natural log of the P-value of association between groups (y axis). (b) A volcano plot depicting DNA methylation differences between the ovariectomy (OVX) and OVX+E2 groups per DMR (x axis) and theβnatural log of the P-value for each comparison. Horizontal red lines depict the significance of threshold of 5%. (c) Scatter plot of the βlog of the P-value of association to discovery sample PPD status and the effect size E2-mediated DNA methylation change at 103 overlapping loci nominally significant in both humans and mice. (d) Scatter plot of the difference between PPD and non-PPD women in the discovery sample (y axis) as a function of that in the replication sample (x axis).
Validation of biomarker loci. Boxplots of the percentage of DNA methylation in the non-postpartum depression (PPD) and PPD groups for HP1BP3 microarray (a) and pyrosequencing (b) and TTC9B microarray (e) and pyrosequencing (f) values. Scatter plots of the % DNA methylation difference between PPD minus non-PPD samples in the prepartum euthymic sample obtained by pyrosequencing (y axis) and microarray (x axis) is depicted for HP1BP3 (c) and TTC9B (g). Boxplots of the percentage of DNA methylation in the non-PPD and PPD groups for HP1BP3 pyrosequencing (d) and pyrosequencing (h) values obtained from the independent replication cohort of prepartum depressed women.
Cell proportion and biomarker DNA methylation predict postpartum depression (PPD). (a) Boxplot of the ratio of monocyte percentage over the sum of T-cell, B-cell and granulocyte percentages as a function of prepartum depression status and PPD diagnosis. (b) Boxplot of the HP1BP3 DNA methylation percentage as a function of prepartum depression status and PPD diagnosis. (c) Scatterplot of the ratio of monocyte percentage over the sum of white blood cell and monocyte percentages as a function of the HP1BP3 DNA methylation percentage. (d) Receiver operator characteristic (ROC) curve of the sensitivity (y axis) vs specificity (x axis) of PPD prediction from the linear model of the HP1BP3 DNA methylation and cell-type ratio interaction, with TTC9B DNA methylation as a covariate. The solid line represents the ROC curve from the proxy-based cell proportion measurement and the dashed line represents that of the complete blood count-derived subsample.
1β20 of 36
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AlbacarG, SansT, Martin-SantosR, Garcia-EsteveL, GuillamatR, SanjuanJ Thyroid function 48h after delivery as a marker for subsequent postpartum depression. Psychoneuroendocrinology 2010; 35: 738β742.1993957410.1016/j.psyneuen.2009.10.015 | β | β | β |
| BartellaV, RizzaP, BaroneI, ZitoD, GiordanoF, GiordanoC Estrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha genepromoter. Breast Cancer Res Treat 2012; 134: 569β581.2262280810.1007/s10549-012-2090-9PMC4484599 | β | β | β |
| BeissbarthT, SpeedTP. GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics 2004; 20: 1464β1465.1496293410.1093/bioinformatics/bth088 | β | β | β |
| BlochM, RubinowDR, SchmidtPJ, LotsikasA, ChrousosGP, CizzaG. Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depression. J Clin Endocrinol Metab 2005; 90: 695β699.1554689910.1210/jc.2004-1388 | β | β | β |
| BlochM, SchmidtPJ, DanaceauM, MurphyJ, NiemanL, RubinowDR. Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 2000; 157: 924β930.1083147210.1176/appi.ajp.157.6.924 | β | β | β |
| Breese McCoySJ. Postpartum depression: an essential overview for the practitioner. South Med J 2011; 104: 128β132.2120641710.1097/SMJ.0b013e318200c221 | β | β | β |
| CaoS, IyerJK, LinV. Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein. Biochem Biophys Res Commun 2006; 345: 310β317.1667879410.1016/j.bbrc.2006.04.091 | β | β | β |
| CuijpersP, BrannmarkJG, van StratenA. Psychological treatment of postpartum depression:a meta-analysis. J Clin Psychol 2008; 64: 103β118.1816103610.1002/jclp.20432 | β | β | β |
| FieldT. Prenatal depression effects on early development: a review. Infant Behav Dev 2011; 34: 1β14.2097019510.1016/j.infbeh.2010.09.008 | β | β | β |
| GergesNZ, TranIC, BackosDS, HarrellJM, ChinkersM, PrattWB Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. J Neurosci 2004; 24: 4758β4766.1515203610.1523/JNEUROSCI.0594-04.2004PMC6729466 | β | β | β |
| GreenAD, GaleaLA. Adult hippocampal cell proliferation is suppressed with estrogen withdrawal after a hormone-simulated pregnancy. Horm Behav 2008; 54: 203β211.1842363510.1016/j.yhbeh.2008.02.023 | β | β | β |
| GuidoC, PanzaS, SantoroM, AvenaP, PannoML, PerrottaI Estrogen receptor beta (ERbeta) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle 2012; 11: 2911β2921.2281000410.4161/cc.21336 | β | β | β |
| GuintivanoJ, AradM, TamashiroKL, GouldTD, KaminskyZA. BioTile, A Perl based toolfor the identification of differentially enriched regions in tiling microarray data. BMC Bioinform 2013; 14: 76.10.1186/1471-2105-14-76PMC359976723452827 | β | β | β |
| HirstKP, MoutierCY. Postpartum major depression. Am Fam Physician 2010; 82: 926β933.20949886 | β | β | β |
| HousemanEA, AccomandoWP, KoestlerDC, ChristensenBC, MarsitCJ, NelsonHH DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinform 2012; 13: 86.10.1186/1471-2105-13-86PMC353218222568884 | β | β | β |
| KaminskyZA, TangT, WangSC, PtakC, OhGH, WongAH DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet 2009; 41: 240β245.1915171810.1038/ng.286 | β | β | β |
| KangaspeskaS, StrideB, MetivierR, Polycarpou-SchwarzM, IbbersonD, CarmoucheRP Transient cyclical methylation of promoter DNA. Nature 2008; 452:112β115.1832253510.1038/nature06640 | β | β | β |
| KuijpensJL, VaderHL, DrexhageHA, WiersingaWM, van SonMJ, PopVJ. Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum. Eur J Endocrinol 2001; 145: 579β584.1172087510.1530/eje.0.1450579 | β | β | β |
| LangfelderP, HorvathS. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform 2008; 9: 559.10.1186/1471-2105-9-559PMC263148819114008 | β | β | β |
| LicinioJ. Potential diagnostic markers for postpartum depression point out to altered immune signaling. Mol Psychiatry 2010; 1510.1038/mp.2009.14220029403 | β | β | β |
| LundTD, RovisT, ChungWC, HandaRJ. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology 2005; 146: 797β807.1551408110.1210/en.2004-1158 | β | β | β |
| LutgendorfSK, LamkinDM, DeGeestK, AndersonB, DaoM, McGinnS Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients. Brain Behav Immun 2008; 22: 890β900.1827610510.1016/j.bbi.2007.12.012PMC2605940 | β | β | β |
| MacLuskyNJ, LuineVN, HajszanT, LeranthC. The 17alpha and 17beta isomers of estradiol both induce rapid spine synapse formation in the CA1 hippocampal subfield of ovariectomized female rats. Endocrinology 2005; 146: 287β293.1548622010.1210/en.2004-0730 | β | β | β |
| MarcusSM. Depression during pregnancy: rates, risks and consequencesβMotherisk Update 2008. Can J Clin Pharmacol 2009; 16: e15βe22.19164843 | β | β | β |
| NassaG, TaralloR, AmbrosinoC, BamundoA, FerraroL, ParisO A large set of estrogen receptor beta-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics 2011; 11:159β165.2118220310.1002/pmic.201000344 | β | β | β |
| OsterlundMK, WittMR, GustafssonJA. Estrogen action in mood and neurode-generative disorders: estrogenic compounds with selective properties-the next generation of therapeutics. Endocrine 2005; 28: 235β242.1638811310.1385/ENDO:28:3:235 | β | β | β |
| OβHaraMW. Postpartum depression: what we know. J Clin Psychol 2009; 65:1258β12691982711210.1002/jclp.20644 | β | β | β |
| PinetteMG, WaxJR. The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists. Obstet Gynecol 2010; 115: 188β189 author reply 189.2002706410.1097/AOG.0b013e3181c8b21d | β | β | β |
| RamananVK, KimS, HolohanK, ShenL, NhoK, RisacherSL Genome-wide pathway analysis of memory impairment in the Alzheimerβs Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks. Brain Imaging Behav 2012; 6: 634β648.2286505610.1007/s11682-012-9196-xPMC3713637 | β | β | β |
| ReimandJ, KullM, PetersonH, HansenJ, ViloJ. g:Profilerβa web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res 2007;35: W193βW200.1747851510.1093/nar/gkm226PMC1933153 | β | β | β |
| RueggJ, CaiW, KarimiM, KissNB, SwedenborgE, LarssonC Epigenetic regulation of glucose transporter 4 by estrogen receptor beta. Mol Endocrinol 2011;25: 2017β2028.2201656410.1210/me.2011-1054PMC3231832 | β | β | β |
| SchumacherA, KapranovP, KaminskyZ, FlanaganJ, AssadzadehA, YauP Microarray-based DNA methylation profiling: technology and applications. Nucleic Acids Res 2006; 34: 528β542.1642824810.1093/nar/gkj461PMC1345696 | β | β | β |
| SegmanRH, Goltser-DubnerT, WeinerI, CanettiL, Galili-WeisstubE, MilwidskyA Blood mononuclear cell gene expression signature of postpartum depression. Mol Psychiatry 2010; 15: 93β100, 102.1958191110.1038/mp.2009.65 | β | β | β |
| ShimamiyaT, TeradaN, WakabayashiS, MohriM. Mood change and immune status of human subjects in a 10-day confinement study. Aviat Space Environ Med 2005;76: 481β485.15892547 | β | β | β |
| SkrundzM, BoltenM, NastI, HellhammerDH, MeinlschmidtG. Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology 2011; 36: 1886β1893.2156248210.1038/npp.2011.74PMC3154107 | β | β | β |
| SnelB, LehmannG, BorkP, HuynenMA. STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res 2000; 28:3442β3444.1098286110.1093/nar/28.18.3442PMC110752 | β | β | β |
| SoufiaM, AounJ, GorsaneMA, KrebsMO. SSRIs and pregnancy: a review of the literature]. Encephale 2010; 36: 513β516.2113023710.1016/j.encep.2010.02.003 | β | β | β |
| StuddJW. A guide to the treatment of depression in women by estrogens. Climacteric 2011; 14:637β642.2187805310.3109/13697137.2011.609285 | β | β | β |
| SudaS, Segi-NishidaE, NewtonSS, DumanRS. A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation. Biol Psychiatry 2008; 64: 311β319.1847180210.1016/j.biopsych.2008.03.029PMC3714803 | β | β | β |
| ter HorstGJ. Estrogen in the limbic system. Vitam Horm 2010; 82: 319β338.2047214610.1016/S0083-6729(10)82017-5 | β | β | β |
| VivarOI, ZhaoX, SaunierEF, GriffinC, MaybaOS, TagliaferriM Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem 2010; 285: 22059β22066.2040431810.1074/jbc.M110.114116PMC2903369 | β | β | β |
| WalfAA, FryeCA. ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology 2005; 30: 1598β1609.1579878010.1038/sj.npp.1300713 | β | β | β |
| WalfAA, KoonceCJ, FryeCA. Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice. Behav Neurosci 2008; 122: 974β981.1882315410.1037/a0012749PMC2562611 | β | β | β |
| WalfAA, RhodesME, FryeCA. Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test. Pharmacol Biochem Behav 2004; 78: 523β529.1525126110.1016/j.pbb.2004.03.023 | β | β | β |
| YimIS, GlynnLM, SchetterCD, HobelCJ, Chicz-DemetA, SandmanCA. Prenatal beta-endorphin as an early predictor of postpartum depressive symptoms in euthymic women. J Affect Disord 2010; 125: 128β133.2005129210.1016/j.jad.2009.12.009PMC2891592 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | 2013 | 23981442 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Biomarkers for the Diagnosis of Perinatal Mood and Anxiety Disorders: Existing Landscapes and Emerging Frontiers. | Kiel M et al. | β | 2026 | β |
| MKRN1 as a prioritized drug target for postpartum depression: evidence from druggable proteome profiling and multi-layer validation. | Jia T et al. | β | 2026 | β |
| Association of estrogen receptor single nucleotide polymorphisms and perinatal depression. | BjΓΆrvang RD et al. | β | 2025 | β |
| Biomarkers of reproductive psychiatric disorders. | Etyemez S et al. | β | 2025 | β |
| Epigenome-wide association study identifies a specific panel of DNA methylation signatures for antenatal and postpartum depressive symptoms. | Thirumoorthy C et al. | β | 2025 | β |
| FDA-Approved Zuranolone: First Oral Treatment for Postpartum Depression, Ushering in a New Era of Hope; A Narrative Review. | Haris M et al. | β | 2025 | β |
| Ketamine assisted psychotherapy in postpartum mood and anxiety disorders: a limited case series. | Christnacht A et al. | β | 2025 | β |
| Longitudinal Analysis of Estrogen Receptor Gene Methylation, Estradiol, and Depressive Symptoms During the Perinatal Period. | Zorzini G et al. | β | 2025 | β |
| Scalable screening of ternary-code DNA methylation dynamics associated with human traits. | Goldberg DC et al. | β | 2025 | β |
| The neurobiology of postpartum depression. | Wenzel ES et al. | β | 2025 | β |
| The Relationship Between Menopausal Status and Depression in U.S. Women: Insights from the NHANES 2017-March 2020 Cross-Sectional Study. | Pei J et al. | β | 2025 | β |
| The role of natural products and traditional Chinese medicine formulas in postpartum depression: mechanism and prospects. | Shang R et al. | β | 2025 | β |
| Women's perceptions of biological causes and potentials of genomic risk markers in postpartum depression: A qualitative study. | HΓΈgh S et al. | β | 2025 | β |
| Current Developments in the Treatment of Postpartum Depression: Zuranolone. | Sonmez D et al. | β | 2024 | β |
| Deciphering and Targeting the ESR2-miR-10a-5p-BDNF Axis in the Prefrontal Cortex: Advancing Postpartum Depression Understanding and Therapeutics. | Luo F et al. | β | 2024 | β |
| Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: A cross-species translational study. | Niwa M et al. | β | 2024 | β |
| Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior. | Teruyama R et al. | β | 2024 | β |
| The incidence and risk factors of depression across six time points in the perinatal period: a prospective study in China. | Zhu J et al. | β | 2024 | β |
| The pathophysiology of estrogen in perinatal depression: conceptual update. | Nielsen AM et al. | β | 2024 | β |
| Unveiling the potential of estrogen: Exploring its role in neuropsychiatric disorders and exercise intervention. | He W et al. | β | 2024 | β |
| Biological age is increased by stress and restored upon recovery. | Poganik JR et al. | β | 2023 | β |
| Cohort profile: the U-BIRTH study on peripartum depression and child development in Sweden. | Tu HF et al. | β | 2023 | β |
| Divergent Transcriptomic Effects of Allopregnanolone in Postpartum Depression. | Rudzinskas SA et al. | β | 2023 | β |
| Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy. | Schneider MO et al. | β | 2023 | β |
| High psychological stress levels related to delivery can increase the occurrence of postpartum mental disorders. | Sun R et al. | β | 2023 | β |
| Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression. | Rudzinskas SA et al. | β | 2023 | β |
| Long noncoding RNA NONHSAG045500 regulates serotonin transporter to ameliorate depressive-like behavior via the cAMP-PKA-CREB signaling pathway in a model of perinatal depression. | Cui X et al. | β | 2023 | β |
| Postpartum depression: aetiology, pathogenesis and the role of nutrients and dietary supplements in prevention and management. | Rupanagunta GP et al. | β | 2023 | β |
| Post-partum depression: From clinical understanding to preclinical assessments. | Moreira LKS et al. | β | 2023 | β |
| Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions. | Luo F et al. | β | 2023 | β |
| Sex Differences in Depression and Anxiety. | Pavlidi P et al. | β | 2023 | β |
| The role of gut microbiota in the pathogenesis and treatment of postpartum depression. | Zhang S et al. | β | 2023 | β |
| Cognitive processing of emotional information during menstrual phases in women with and without postpartum depression: differential sensitivity to changes in gonadal steroids. | Bloch M et al. | β | 2022 | β |
| DNA Methylation as a Therapeutic and Diagnostic Target in Major Depressive Disorder. | Lax E | β | 2022 | β |
| DNA methylation-based predictors of health: applications and statistical considerations. | Yousefi PD et al. | β | 2022 | β |
| DNA Methylation Markers and Prediction Model for Depression and Their Contribution for Breast Cancer Risk. | Wang N et al. | β | 2022 | β |
| Elevated <i>BICD2</i> DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal <i>Bicd2</i>-knockdown mice. | Xiu J et al. | β | 2022 | β |
| Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event. | Andrawus M et al. | β | 2022 | β |
| Exposure to environmental chemicals and perinatal psychopathology. | Jacobson MH et al. | β | 2022 | β |
| Genome-wide DNA methylation profiling in differentiating Crohn's disease from intestinal tuberculosis. | Wu H et al. | β | 2022 | β |
| Hippocampal volume changes in a pharmacological sex-hormone manipulation risk model for depression in women. | Borgsted C et al. | β | 2022 | β |
| Machine learning in the prediction of postpartum depression: A review. | Cellini P et al. | β | 2022 | β |
| Maternal separation: Does it hold the potential to model consequences of postpartum depression? | Mundorf A et al. | β | 2022 | β |
| Meta-analysis of epigenome-wide association studies of major depressive disorder. | Li QS et al. | β | 2022 | β |
| The role of central serotonergic markers and estradiol changes in perinatal mental health. | Borgsted C et al. | β | 2022 | β |
| A Primer on DNA Methylation and Its Potential to Impact Maternal Depression Risk and Assessment During Pregnancy and the Postpartum. | Lapato DM et al. | β | 2021 | β |
| Biopsychosocial predictors of depressive symptoms in the perimenopause-findings from the Swiss Perimenopause Study. | Willi J et al. | β | 2021 | β |
| Combined identification of lncRNA NONHSAG004550 and NONHSAT125420 as a potential diagnostic biomarker of perinatal depression. | Wang L et al. | β | 2021 | β |
| Conducting epigenetics research with refugees and asylum seekers: attending to the ethical challenges. | Taki F et al. | β | 2021 | β |
| Cross-evaluation of social mining for classification of depressed online personas. | Trifan A et al. | β | 2021 | β |
| Lack of psychotropic medication changes among mood disordered women across the peripartum period. | Standeven LR et al. | β | 2021 | β |
| Migraine associated with early onset postpartum depression in women with major depressive disorder. | Gordon-Smith K et al. | β | 2021 | β |
| Postpartum Depression: Current Status and Possible Identification Using Biomarkers. | Yu Y et al. | β | 2021 | β |
| Short-term oestrogen as a strategy to prevent postpartum depression in high-risk women: protocol for the double-blind, randomised, placebo-controlled MAMA clinical trial. | HΓΈgh S et al. | β | 2021 | β |
| Variation in genes and hormones of the hypothalamic-pituitary-ovarian axis in female mood disorders - A systematic review and meta-analysis. | Amiel Castro RT et al. | β | 2021 | β |
| Characteristics of women with different perinatal depression trajectories. | Wikman A et al. | β | 2020 | β |
| DNA methylation biomarkers prospectively predict both antenatal and postpartum depression. | Payne JL et al. | β | 2020 | β |
| Epigenetic intersection of BDNF Val66Met genotype with premenstrual dysphoric disorder transcriptome in a cross-species model of estradiol add-back. | Marrocco J et al. | β | 2020 | β |
| Epigenetics, Development, and Psychopathology. | O'Donnell KJ et al. | β | 2020 | β |
| Epigenetic signatures of attachment insecurity and childhood adversity provide evidence for role transition in the pathogenesis of perinatal depression. | Robakis TK et al. | β | 2020 | β |
| [GABAergic approach of postpartum depression: A translational review of literature]. | Verbe J et al. | β | 2020 | β |
| Is Postpartum Depression Different From Depression Occurring Outside of the Perinatal Period? A Review of the Evidence. | Batt MM et al. | β | 2020 | β |
| Pharmacological sex hormone manipulation as a risk model for depression. | Frokjaer VG | β | 2020 | β |
| Precision medicine in perinatal depression in light of the human microbiome. | PeΓ±alver BernabΓ© B et al. | β | 2020 | β |
| Predictive validity of a DNA methylation-based screening panel for postpartum depression | Lapato DM et al. | β | 2020 | β |
| Protocol for Pilot Study on Self-Management of Depressive Symptoms in Pregnancy. | Kinser PA et al. | β | 2020 | β |
| The peripartum human brain: Current understanding and future perspectives. | Sacher J et al. | β | 2020 | β |
| The study protocol: Neuroendocrinology and (epi-) genetics of female reproductive transition phase mood disorder - an observational, longitudinal study from pregnancy to postpartum. | Johann A et al. | β | 2020 | β |
| Vascular endothelial growth factor in major depressive disorder, schizophrenia, and bipolar disorder: A network meta-analysis. | Pu J et al. | β | 2020 | β |
| A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression. | Elwood J et al. | β | 2019 | β |
| DNA methylation correlates of PTSD: Recent findings and technical challenges. | Morrison FG et al. | β | 2019 | β |
| DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis. | Humphreys KL et al. | β | 2019 | β |
| Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness. | Toepfer P et al. | β | 2019 | β |
| Evidence for oestrogen sensitivity in perinatal depression: pharmacological sex hormone manipulation study. | Mehta D et al. | β | 2019 | β |
| Intergenerational transmission of depression: clinical observations and molecular mechanisms. | Sawyer KM et al. | β | 2019 | β |
| Management of perinatal depression with non-drug interventions. | Johansen SL et al. | β | 2019 | β |
| Methylation analysis for postpartum depression: a case control study. | Nakamura Y et al. | β | 2019 | β |
| Pathophysiological mechanisms implicated in postpartum depression. | Payne JL et al. | β | 2019 | β |
| Perinatal Depression: Embracing Variability toward Better Treatment and Outcomes. | Galea LAM et al. | β | 2019 | β |
| Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development. | Frieder A et al. | β | 2019 | β |
| Polygenic risk for circulating reproductive hormone levels and their influence on hippocampal volume and depression susceptibility. | Smeeth DM et al. | β | 2019 | β |
| Postpartum Depression: Pathophysiology, Treatment, and Emerging Therapeutics. | Stewart DE et al. | β | 2019 | β |
| What do DNA methylation studies tell us about depression? A systematic review. | Li M et al. | β | 2019 | β |
| Adverse life events, psychiatric history, and biological predictors of postpartum depression in an ethnically diverse sample of postpartum women. | Guintivano J et al. | β | 2018 | β |
| DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. | O'Donnell KJ et al. | β | 2018 | β |
| Inside-out: the role of anger experience and expression in the development of postpartum mood disorders. | Bruno A et al. | β | 2018 | β |
| Maternal programming: Application of a developmental psychopathology perspective. | Glynn LM et al. | β | 2018 | β |
| Postpartum psychiatric disorders. | Meltzer-Brody S et al. | β | 2018 | β |
| Predictors of Postpartum Depression: A Comprehensive Review of the Last Decade of Evidence. | Guintivano J et al. | β | 2018 | β |
| Protocol for a randomised, double-blind, placebo-controlled trial to explore the effect of tramadol in the prevention of postpartum depression (ETPPD). | Duan G et al. | β | 2018 | β |
| SLC9B1 methylation predicts fetal intolerance of labor. | Knight AK et al. | β | 2018 | β |
| The early care environment and DNA methylome variation in childhood. | Garg E et al. | β | 2018 | β |
| The impact of epigenomic next-generation sequencing approaches on our understanding of neuropsychiatric disorders. | Schang AL et al. | β | 2018 | β |
| Distinctive gene expression profile in women with history of postpartum depression. | Landsman A et al. | β | 2017 | β |
| Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study. | BrΓ€nn E et al. | β | 2017 | β |
| Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction. | Edvinsson Γ et al. | β | 2017 | β |
| Pharmacologically Induced Sex Hormone Fluctuation Effects on Resting-State Functional Connectivity in a Risk Model for Depression: A Randomized Trial. | Fisher PM et al. | β | 2017 | β |
| Postpartum estrogen withdrawal impairs GABAergic inhibition and LTD induction in basolateral amygdala complex via down-regulation of GPR30. | Yang R et al. | β | 2017 | β |
| Reproductive Affective Disorders: a Review of the Genetic Evidence for Premenstrual Dysphoric Disorder and Postpartum Depression. | McEvoy K et al. | β | 2017 | β |
| The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. | Dubey N et al. | β | 2017 | β |
| Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder. | Na KS et al. | β | 2016 | β |
| Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model. | Clive ML et al. | β | 2016 | β |
| DNA methylation: conducting the orchestra from exposure to phenotype? | Leenen FA et al. | β | 2016 | β |
| Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance. | Hadac JN et al. | β | 2016 | β |
| Maternal attachment insecurity is a potent predictor of depressive symptoms in the early postnatal period. | Robakis TK et al. | β | 2016 | β |
| Neuroendocrinology of a Male-Specific Pattern for Depression Linked to Alcohol Use Disorder and Suicidal Behavior. | Walther A et al. | β | 2016 | β |
| Oxytocin receptor DNA methylation in postpartum depression. | Kimmel M et al. | β | 2016 | β |
| Perinatal Major Depression Biomarkers: A systematic review. | Serati M et al. | β | 2016 | β |
| Postpartum Depression. | Stewart DE et al. | β | 2016 | β |
| Postpartum depression: Etiology, treatment and consequences for maternal care. | Brummelte S et al. | β | 2016 | β |
| Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels. | Osborne L et al. | β | 2016 | β |
| Role of epigenetic factors in the development of mental illness throughout life. | Guintivano J et al. | β | 2016 | β |
| Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data. | Morris TJ et al. | β | 2015 | β |
| Bidirectional psychoneuroimmune interactions in the early postpartum period influence risk of postpartum depression. | Corwin EJ et al. | β | 2015 | β |
| Biological and psychosocial predictors of postpartum depression: systematic review and call for integration. | Yim IS et al. | β | 2015 | β |
| Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese. | Li X et al. | β | 2015 | β |
| Epigenetics of Stress-Related Psychiatric Disorders and Gene Γ Environment Interactions. | Klengel T et al. | β | 2015 | β |
| Family history, not lack of medication use, is associated with the development of postpartum depression in a high-risk sample. | Kimmel M et al. | β | 2015 | β |
| Psychiatric consultation to the postpartum mother. | Anderson EA et al. | β | 2015 | β |
| Role of emotional processing in depressive responses to sex-hormone manipulation: a pharmacological fMRI study. | Henningsson S et al. | β | 2015 | β |
| Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. | Shrestha S et al. | β | 2015 | β |
| The Influence of genetic factors on peripartum depression: A systematic review. | Figueiredo FP et al. | β | 2015 | β |
| The promise of biomarkers in diagnosing major depression in primary care: the present and future. | Redei EE et al. | β | 2015 | β |
| The role of reproductive hormones in postpartum depression. | Schiller CE et al. | β | 2015 | β |
| Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. | Davis J et al. | β | 2015 | β |
| Allopregnanolone as a mediator of affective switching in reproductive mood disorders. | Schiller CE et al. | β | 2014 | β |
| Blood-based biomarkers in depression: emerging themes in clinical research. | Uddin M | β | 2014 | β |
| DNA methylation as an early diagnostic marker of cancer (Review). | Dong Y et al. | β | 2014 | β |
| DNA methylation biomarkers: cancer and beyond. | Mikeska T et al. | β | 2014 | β |
| Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. | Guintivano J et al. | β | 2014 | β |
| Pharmacotherapy of postpartum depression: an update. | Kim DR et al. | β | 2014 | β |
| Seeing the future: epigenetic biomarkers of postpartum depression. | Kaminsky Z et al. | β | 2014 | β |
| Biomarker or pathophysiology? The role of DNA methylation in postpartum depression. | Kimmel M et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |